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chemical probes

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302

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7

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16

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2

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5

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7

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108886
    JWG-071
    3 Publications Verification

    		 ERK Cancer
    JWG-071 is the kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively .
    JWG-071
  • HY-103305
    cis-Ned19

    		Fluorescent Dye Cancer
    cis-Ned19 is a chemical probe. cis-Ned19 blocks NAADP signaling and fluorescently labeled NAADP receptors in cell .
    cis-Ned19
  • HY-161296
    TH6342

    		Bacterial HIV Infection
    TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe .
    TH6342
  • HY-134673A
    UZH1a
    2 Publications Verification

    		 Apoptosis Cancer
    UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1a can be used for epitranscriptomic modulation of cellular processes. UZH1a has antitumor activity. UZH1a also can be used as a chemical probe for studying METTL3 .
    UZH1a
  • HY-134673
    UZH1
    3 Publications Verification

    		 Apoptosis Cancer
    UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1b (IC50=28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3 .
    UZH1
  • HY-151473
    PIKfyve-IN-1

    		PIKfyve Infection Cancer
    PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology . PIKfyve-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    PIKfyve-IN-1
  • HY-149026
    GNE-064

    		Epigenetic Reader Domain Others
    GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis .
    GNE-064
  • HY-149761
    GSK023

    		Epigenetic Reader Domain Others
    GSK023 (compound 31) is a selective chemical probe targeting the BET BD1 domain .
    GSK023
  • HY-139009
    HA15-Biotin

    		HSP Cancer
    HA15-Biotin is a chemical probe that consists of HA15 and biotin attached on the amide part of HA15. HA15-Biotin exhibits similar levels of activity to HA15. HA15-Biotin can be used for proteomic analysis .
    HA15-Biotin
  • HY-178129
    MRL-SYKi

    		Syk Inflammation/Immunology
    MRL-SYKi is a chemical probe with high selectivity and potent activity against spleen tyrosine kinase (SYK). MRL-SYKi potently binds to SYK gain-of-function (GoF) variants (SYK(S550Y), SYK(S550F), and SYK(P342T)) in intact live cells, with IC50 values of 2.1 nM, 14 nM, and 4.6 nM respectively in digitonin-permeabilized cell assays. MRL-SYKi effectively reduces catalytic activity (IC50 = 63 nM for SYK(S550F) and 95 nM for SYK(P342T) in PhosphoSens SOX peptide assays). MRL-SYKi can decrease the phosphorylation level of SYK(S550Y) at Y525/526 in SW480 cells. MRL-SYKi can be used for the study of inflammation .
    MRL-SYKi
  • HY-120018
    VPC-13566

    		Androgen Receptor Cancer
    VPC-13566, a BF3-specific small molecule, is an androgen receptor (AR) inhibitor. VPC-13566 is effective in inhibiting AR transcriptional activity in vitro as well as the growth of AR-dependent PCa cell lines. VPC-13566 can be used as a chemical probe to help identify unknown AR partners.VPC-13566 can be used for the research of cancer.
    VPC-13566
  • HY-122653
    CCT367766

    		PROTACs Cancer
    CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein .
    CCT367766
  • HY-150064
    SARS-CoV-2 nsp3-IN-2

    		SARS-CoV Infection
    SARS-CoV-2 nsp3-IN-2 is a macrodomain (Mac1) inhibitor with IC50 value of 180 μM. SARS-CoV-2 nsp3-IN-2 is a small molecule chemical probe and can be used for the research of viral .
    SARS-CoV-2 nsp3-IN-2
  • HY-122653A
    CCT367766 formic

    		PROTACs Cancer
    CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .
    CCT367766 formic
  • HY-P10649A
    CPP12 TFA

    		Fluorescent Dye Cancer
    CPP12 TFA is a small, amphiphilic, cyclic cell-penetrating peptide (CPP) in salt form. CPP12 TFA binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and is then efficiently released from endosomes. CPP12 TFA can be used for intracellular delivery of drugs and chemical probes .
    CPP12 TFA
  • HY-151813
    NNMT-IN-4

    		Fluorescent Dye Cancer
    NNMT-IN-4 (compound 38) is a selective, uncompetitive and membrane permeability nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 values of 42 and 38 nM in vitro biochemical and cell-based assays, respectively. NNMT-IN-4 shows favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. NNMT-IN-4 can be used as a vivo chemical probe of NNMT .
    NNMT-IN-4
  • HY-171179
    BD-Oligo

    		Fluorescent Dye Neurological Disease
    BD-Oligo is an oligomer-specific fluorescent chemical probe. BD-Oligo preferentially identifies Aβ oligomer assemblies over monomers or fibrils by using diversity-directed fluorescent library (DOFL) screening and computational techniques. BD-Oligo exhibits dynamic oligomer monitoring capabilities during Aβ peptide fibril formation as Aβ is induced to form oligomers and ultimately fibrils over time. BD-Oligo also exhibits blood-brain barrier permeability with the ability to stain Aβ oligomers in vivo .
    BD-Oligo
  • HY-19336
    BAZ2-ICR
    1 Publications Verification

    		 Epigenetic Reader Domain Cancer
    BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe .
    BAZ2-ICR
  • HY-135846
    PDD00031705
    1 Publications Verification

    		 Poly(ADP-ribose) Glycohydrolase (PARG) Cancer
    PDD00031705 is a benzimidazolone core cell-inactive inhibitor of Poly (ADP-ribose) glycohydrolase (PARG) .
    PDD00031705
  • HY-115402
    DAz-1

    		Fluorescent Dye Others
    DAz-1 is a sulfonic acid probe for living cells, which can directly detect sulfonic acid-modified proteins in living cells and is cell-permeable .
    DAz-1
  • HY-178065
    PROTAC G9a/GLP degrader 1

    		PROTACs Histone Methyltransferase GLP Receptor Cancer
    PROTAC G9a/GLP degrader 1 is a G9a/GLP PROTAC degrader with DC50s of 336 nM (G9a) and 988 nM (GLP). PROTAC G9a/GLP degrader 1 exhibits inhibitory activity against G9a with an IC50 of 98 nM. PROTAC G9a/GLP degrader 1 effectively inhibits the migration of breast cancer MCF-7 cells without inhibiting cell proliferation. PROTAC G9a/GLP degrader 1 can be used for the study of breast cancer (Pink: G9a/GLP ligand (HY-152775); Blue: VHL ligand (HY-125845); Black: Linker (HY-140468)) .
    PROTAC G9a/GLP degrader 1
  • HY-176846
    HIPS probe-1

    		Biochemical Assay Reagents Others
    HIPS probe-1 (Compound 1) is a click chemistry reagent containing a alkyne group. HIPS probe-1 can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. HIPS probe-1 can be used as a chemical probe to specifically recognize and label aldehyde functional groups in DNA, especially abasic sites (AP sites) for DNA damage research .
    HIPS probe-1
  • HY-130680
    Syk-IN-3

    		Syk Cancer
    Syk-IN-3, a potent spleen tyrosine kinase (Syk) inhibitor, extracted from patent WO2011075515A1, compound example 152, has an IC50 of 1 nM .
    Syk-IN-3
  • HY-161796
    UNC8732

    		Molecular Glues Cancer
    UNC8732, a chemical probe, is an NSD2 inhibitor and degrader.
    UNC8732
  • HY-135639
    Alkyne-probe 1

    		Fluorescent Dye Others
    Alkyne-probe 1 is usually used as a Alkyne-labeled chemical or fluorescent probe. Alkyne-probe 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-probe 1
  • HY-160212
    JP3000

    		RAR/RXR Metabolic Disease
    JP3000, a chemical probe, is an agonist of RXRA, RXRB, RXRG .
    JP3000
  • HY-135637
    Nilotinib Acid

    		Fluorescent Dye Others
    Nilotinib Acid, an analogue of Nilotinib, is usually used as a labeled chemical or fluorescent probe.
    Nilotinib Acid
  • HY-121637
    IDFP

    iso-Prdodecylfluorophosphonate

    		 Cannabinoid Receptor Neurological Disease
    IDFP (iso-Prdodecylfluorophosphonate) is a chemical affinity probe for the cannabinoid CB1 receptor .
    IDFP
  • HY-148249
    NVS-MALT1

    		MALT1 Cancer
    NVS-MALT1, a chemical probe, is a MALT1 allosteric inhibitor .
    NVS-MALT1
  • HY-172196
    LH168

    		WDR5 Others
    LH168 is a potent and selective chemical probe for WDR5, with a SPR Kd value of 13 nM .
    LH168
  • HY-13500
    GSK343
    25+ Cited Publications

    		 Histone Methyltransferase Autophagy Cancer
    GSK343, a chemical probe, is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
    GSK343
  • HY-145103
    UNC6934

    		Histone Methyltransferase Cancer
    UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization.
    UNC6934
  • HY-139907B
    DG013A formate

    		Aminopeptidase Inflammation/Immunology Cancer
    DG013A (formate) is a phosphinic acid tripeptide mimetic inhibitor. DG013A (formate) displays significantly weak affinity for both ERAP1 (IC50=33 nM) and ERAP2 (IC50=11 nM). DG013A (formate) can be used for the research of autoimmune disease and cancer .
    DG013A formate
  • HY-139907
    DG013A

    		Aminopeptidase Inflammation/Immunology Cancer
    DG013A is a phosphinic acid tripeptide mimetic inhibitor. DG013A displays significantly weak affinity for both ERAP1 (IC50=33 nM) and ERAP2 (IC50=11 nM). DG013A can be used for the research of autoimmune disease and cancer .
    DG013A
  • HY-145922
    ChemR23 ligand-1

    		Fluorescent Dye Inflammation/Immunology
    ChemR23 ligand-1 is a chemical probe that contributes to the elucidation and analysis of the functions of ChemR23.
    ChemR23 ligand-1
  • HY-148240
    JNJ-65355394

    		OGA Neurological Disease
    JNJ-65355394 (Compound 28), a chemical probe, is an O-GlcNAc hydrolase (OGA) inhibitor .
    JNJ-65355394
  • HY-15300
    Skepinone-L
    1 Publications Verification

    CBS3830

    		 p38 MAPK Autophagy Inflammation/Immunology
    Skepinone-L (CBS3830), a chemical probe, is a selective p38 mitogen-activated protein kinase inhibitor.
    Skepinone-L
  • HY-148241
    A-446

    		Glutaminase Cancer
    A-446, a chemical probe, is a potent glutaminase (GLS) inhibitor with an IC50 value of 31 nM .
    A-446
  • HY-148248
    BI-2540

    		HIV Infection
    BI-2540, a chemical probe, is a HIV non-nucleoside reverse transcriptase (NNRT) inhibitor .
    BI-2540
  • HY-139868
    BAY-091

    		PI5P4K Cancer
    BAY-091, a chemical probe, is a potent and highly selective inhibitor of the kinase PIP4K2A.
    BAY-091
  • HY-100756
    BAY-826
    1 Publications Verification

    		 Discoidin Domain Receptor Tie Cancer
    BAY-826, a chemical probe, is a selective and potent TIE-2 inhibitor with a Kd of 1.6 nM, respectively.
    BAY-826
  • HY-D2322
    SupraFlipper 31

    		Fluorescent Dye Others
    SupraFlipper 31 is a fluorescent probe. SupraFlipper 31 can be released in the membrane of interest (MOI) via chemical stimulation.
    SupraFlipper 31
  • HY-126300
    SGC6870
    1 Publications Verification

    		 Histone Methyltransferase Cancer
    SGC6870, a chemical probe, is a potent, selective and cytoactive allosteric inhibitor of PRMT6 with IC50 of 77 nM .
    SGC6870
  • HY-169295
    RAP 1

    		Biochemical Assay Reagents Others
    RAP 1 is a reactive affinity probe (RAP) that selectively labels SLC6A8 in the presence of guanine alanine (GPA). RAP 1 can be used as a chemical probe for identifying and studying potential drug binding sites on SLC6A8 .
    RAP 1
  • HY-111976
    MT1

    		Epigenetic Reader Domain Cancer
    MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1) .
    MT1
  • HY-19546
    BAY-598
    5+ Cited Publications

    		 Histone Methyltransferase Cancer
    BAY-598, a chemical probe, is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM .
    BAY-598
  • HY-135634
    GNF-2-PEG-acid

    		Fluorescent Dye Others
    GNF-2-PEG-acid, an analogue of GNF-2, is usually used as a labeled chemical or fluorescent probe.
    GNF-2-PEG-acid
  • HY-132969
    SBP-3264
    2 Publications Verification

    		 Fluorescent Dye Cancer
    SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in acute myeloid leukemia (AML).
    SBP-3264
  • HY-13019
    BI605906
    5+ Cited Publications

    		 IKK Others
    BI605906, a chemical probe, is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
    BI605906
  • HY-100519
    NVS-PAK1-1
    3 Publications Verification

    		 PAK Cancer
    NVS-PAK1-1, a chemical probe, is a potent and selective allosteric PAK1 inhibitor with an IC50 of 5 nM .
    NVS-PAK1-1

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