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Results for "

antidepressant effects

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (46) Adenylate Cyclase (1) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Adrenergic Receptor (23) Akt (1) Amino Acid Derivatives (5) AMPK (1) Antibiotic (11) Apoptosis (40) Autophagy (17) Bacterial (11) Calcium Channel (7) COX (1) CRFR (2) Cytochrome P450 (7) Dopamine Receptor (18) Dopamine Transporter (2) Dopamine β-hydroxylase (1) Drug Derivative (1) Drug Isomer (2) Drug Metabolite (8) Endogenous Metabolite (18) ERK (8) FAAH (3) Fungal (4) GABA Receptor (13) Galectin (1) Guanylate Cyclase (1) HCN Channel (1) HDAC (3) HIF/HIF Prolyl-Hydroxylase (7) Histamine Receptor (2) Histone Demethylase (2) HIV (1) IGF-1R (1) iGluR (28) Imidazoline Receptor (3) Interleukin Related (3) Isotope-Labeled Compounds (28) JAK (2) JNK (2) mAChR (1) MCHR1 (GPR24) (1) MDM-2/p53 (7) Melatonin Receptor (1) mGluR (10) Mitophagy (2) Monoamine Oxidase (10) Monoamine Transporter (1) mTOR (2) nAChR (5) Neurokinin Receptor (4) Neuropeptide Y Receptor (2) Neurotensin Receptor (1) NF-κB (10) NO Synthase (2) Opioid Receptor (9) P2X Receptor (5) p38 MAPK (2) PAK (1) Parasite (2) Phosphodiesterase (PDE) (5) Phospholipase (1) PI3K (2) Potassium Channel (10) PPAR (6) Reactive Oxygen Species (ROS) (2) Reference Standards (15) Serotonin Transporter (14) Sigma Receptor (8) Sodium Channel (1) Somatostatin Receptor (2) STAT (2) TNF Receptor (4) Toll-like Receptor (TLR) (1) TRP Channel (2) Wnt (2)
By Research Areas:	Cancer (53) Cardiovascular Disease (14) Endocrinology (3) Infection (15) Inflammation/Immunology (53) Metabolic Disease (25) Neurological Disease (216)

By Targets:

5-HT Receptor (46)

Adenylate Cyclase (1)

Adhesion G Protein-coupled Receptors (AGPCRs) (1)

Adrenergic Receptor (23)

Akt (1)

Amino Acid Derivatives (5)

AMPK (1)

Antibiotic (11)

Apoptosis (40)

Autophagy (17)

Bacterial (11)

Calcium Channel (7)

COX (1)

CRFR (2)

Cytochrome P450 (7)

Dopamine Receptor (18)

Dopamine Transporter (2)

Dopamine β-hydroxylase (1)

Drug Derivative (1)

Drug Isomer (2)

Drug Metabolite (8)

Endogenous Metabolite (18)

ERK (8)

FAAH (3)

Fungal (4)

GABA Receptor (13)

Galectin (1)

Guanylate Cyclase (1)

HCN Channel (1)

HDAC (3)

HIF/HIF Prolyl-Hydroxylase (7)

Histamine Receptor (2)

Histone Demethylase (2)

HIV (1)

IGF-1R (1)

iGluR (28)

Imidazoline Receptor (3)

Interleukin Related (3)

Isotope-Labeled Compounds (28)

JAK (2)

JNK (2)

mAChR (1)

MCHR1 (GPR24) (1)

MDM-2/p53 (7)

Melatonin Receptor (1)

mGluR (10)

Mitophagy (2)

Monoamine Oxidase (10)

Monoamine Transporter (1)

mTOR (2)

nAChR (5)

Neurokinin Receptor (4)

Neuropeptide Y Receptor (2)

Neurotensin Receptor (1)

NF-κB (10)

NO Synthase (2)

Opioid Receptor (9)

P2X Receptor (5)

p38 MAPK (2)

PAK (1)

Parasite (2)

Phosphodiesterase (PDE) (5)

Phospholipase (1)

PI3K (2)

Potassium Channel (10)

PPAR (6)

Reactive Oxygen Species (ROS) (2)

Reference Standards (15)

Serotonin Transporter (14)

Sigma Receptor (8)

Sodium Channel (1)

Somatostatin Receptor (2)

STAT (2)

TNF Receptor (4)

Toll-like Receptor (TLR) (1)

TRP Channel (2)

Wnt (2)

By Research Areas:

Cancer (53)

Cardiovascular Disease (14)

Endocrinology (3)

Infection (15)

Inflammation/Immunology (53)

Metabolic Disease (25)

Neurological Disease (216)

225

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103024

ICI-63197	Phosphodiesterase (PDE)	Neurological Disease
ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with K_i values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects .

HY-101316

TRIM	NO Synthase	Neurological Disease
TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC₅₀ values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects .

HY-114814

ORM-10921 free base	Adrenergic Receptor	Neurological Disease
ORM-10921 free base is a selective α-2C adrenergic receptor antagonist with a K_i of 1.4 nM. ORM-10921 free base displays potent antidepressant and antipsychotic-like effects .

HY-136171

Antidepressant agent 1	Drug Derivative	Neurological Disease
Antidepressant agent 1 is a pyrazidole-halogeno-derivative with antidepressant effects. Antidepressant agent 1 also can be used to increase body temperature .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis	Neurological Disease Inflammation/Immunology
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-106407

Beloxepin Org 4428; ADL 6906	Adrenergic Receptor 5-HT Receptor	Neurological Disease
Beloxepin (Org 4428) is an orally active synaptosomal noradrenalin reuptake inhibitor and a 5-HT2 receptor antagonist. Beloxepin shows about 100-fold less affine for other monoamine carriers. Beloxepin has antidepressant and pain-relieving effects .

HY-162585

5-HT1AR agonist 1	5-HT Receptor	Neurological Disease
5-HT1AR agonist 1 (Compound A3) emerges as a relatively balanced multi-target activity profile, including 5-HT1AR agonist with an EC₅₀ value of 34 nM, SERT reuptake ihibitor (IC₅₀ =12 nM), NET reuptake inhibitor (IC₅₀ =78 nM) and DAT reuptake inhibitor (IC₅₀ =135 nM). 5-HT1AR agonist 1 performs significant antidepressant effects and exhibits excellent bioavailability and low clearance in mice, which is promising for research in the field of antidepressant drugs .

HY-139806

SRA880 free base	Somatostatin Receptor	Others
SRA880 (free base) is a compound with antidepressant-modulating effects. It is a somatostatin-1 autoreceptor antagonist that can synergize with imipramine to produce antidepressant-like effects and affect BDNF mRNA expression and phosphorylation of related proteins.

HY-119223

Desmethylmirtazapine Normirtazapine	Drug Metabolite	Neurological Disease
Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects .

HY-157792

Antidepressant agent 6	mAChR	Neurological Disease
Antidepressant agent 6 (S-3a) is a lead compound with potent and sustained antidepressant effects. Antidepressant agent 6 (S-3a) displays high cognitive safety margin.Antidepressant agent 6 (S-3a) antagonizes M1 receptors and elevates BDNF levels, suggesting its potential as an antidepressant for further exploration .

HY-N13088

Hyperidione D	Others	Neurological Disease
Hyperidione D is apotent antidepressant agent. Hyperidione D shows neuroprotective effects .

HY-170898

Antidepressant agent 8	iGluR	Neurological Disease
Antidepressant agent 8 (Compound 1f) is a selective antagonist for the NMDA receptor GluN1/2A with an IC₅₀ of 2.94 μmol/L. Antidepressant agent 8 exhibits antidepressant-like effects in Hydrocortisone (HY-N0583)-induced zebrafish depression model. Antidepressant agent 8 can cross blood-brain barrier .

HY-N0571

Purpurin	Fungal Bacterial Antibiotic	Infection Neurological Disease
Purpurin is a natural anthraquinone compound from Rubia cordifolia L.. Purpurin has antidepressant-like effects .

HY-103098

EMDT oxalate	5-HT Receptor	Neurological Disease
EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects .

HY-162613

ASM-IN-2	Phospholipase	Neurological Disease
ASM-IN-2 (Compound 46) is a potent ASM inhibitor with an IC₅₀ value of 0.87 μM, displaying good drug-like properties. ASM-IN-2 involves in multiple antidepressant mechanisms of actionin, which are associated with a decline of ceramide. It demostrates remarkable antidepressant effects in the CUMS-induced mouse, which is promising for research in the field of antidepressant drugs .

HY-14551

Osanetant SR142801	Neurokinin Receptor	Neurological Disease
Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia .

HY-14551C

Osanetant monohydrochloride SR142801 monohydrochloride	Neurokinin Receptor	Neurological Disease
Osanetant (SR142801) monohydrochloride is a selective NK3 receptor antagonist. Osanetant monohydrochloride produces anxiolytic- and antidepressant-like effects .

HY-18940A

Cilobradine hydrochloride DK-AH 269	HCN Channel	Cardiovascular Disease Neurological Disease
Cilobradine hydrochloride is a HCN channel blocker. Cilobradine hydrochloride induces cardiac pacemaker currents and produces antidepressant effects .

HY-76542BR

(R)-Vitamin D2 (Standard)	Drug Isomer	Metabolic Disease Cancer
Desmethylmirtazapine (Standard) is the analytical standard of Desmethylmirtazapine. This product is intended for research and analytical applications. Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects .

HY-B1417

Nortriptyline hydrochloride 2 Publications Verification Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride	Autophagy Drug Metabolite Apoptosis	Neurological Disease Cancer
Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects .

HY-119223R

Desmethylmirtazapine (Standard) Normirtazapine (Standard)	Reference Standards Drug Metabolite	Neurological Disease
Desmethylmirtazapine (Standard) is the analytical standard of Desmethylmirtazapine. This product is intended for research and analytical applications. Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects .

HY-107741

SNC162	Opioid Receptor	Neurological Disease
SNC162 is a delta-opioid receptor agonist with an IC₅₀ of 0.94 nM. SNC162 has antidepressant-like and antinociceptiv effects .

HY-118620

Nortriptyline 2 Publications Verification Desmethylamitriptyline; Desitriptilina	Autophagy Drug Metabolite Apoptosis	Neurological Disease Cancer
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects . N

HY-17018

Napitane ABT 200 free acid; A-75200	Adrenergic Receptor	Neurological Disease
Napitane (A 75200) is a groundbreaking catecholamine uptake inhibitor that exhibits inhibitory effects on α-adrenergic receptors and shows promise for antidepressant activity in depression research.

HY-N6076

Tenuifoliside A	ERK	Neurological Disease
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells .

HY-B0031S

Quetiapine-d4 fumarate	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine-d₄ (fumarate) is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects .

HY-A0175

Butriptyline Butriptylene	5-HT Receptor	Neurological Disease
Butriptyline (Butriptylene) is an orally active tricyclic antidepressant that slightly enhances central 5-HT effects. Butriptyline does not inhibit brain norepinephrine uptake .

HY-N0705

Curculigoside 5+ Cited Publications	JAK STAT NF-κB	Neurological Disease Inflammation/Immunology Cancer
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-14551B

(S)-Osanetant (S)-SR142801	Neurotensin Receptor	Neurological Disease
(S)-Osanetant is the S-enantiomer of Osanetant. Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia .

HY-N4161

Euparin	Reactive Oxygen Species (ROS)	Infection Neurological Disease
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-N3204

Neoechinulin A	Apoptosis	Neurological Disease
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-B0031S1

Quetiapine-d4 hemifumarate	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine-d₄ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects .

HY-107702

CGP 37849	iGluR	Neurological Disease
CGP 37849 is a potent, competitive and orally active N-methyl-D-aspartate (NMDA) receptor antagonist. CGP 37849 is an anticonvulsant in rodents and has antidepressant and anxiolytic-like effects .

HY-107751

BW373U86 SNC86	Opioid Receptor	Neurological Disease
BW373U86 (SNC86) is a δ-opioid receptor agonist with an IC₅₀ of 1.49 nM. BW373U86 shows antidepressant-like effects .

HY-15527

Emapunil 3 Publications Verification AC-5216; XBD-173	Antibiotic	Neurological Disease Metabolic Disease
Emapunil (AC-5216), an orally active and selective TSPO (a mitochondrial benzodiazepine receptor) ligand, produces anti-anxiety and antidepressant-like effects in various animal models .

HY-N0571R

Purpurin (Standard)	Fungal Bacterial Antibiotic	Infection Neurological Disease
Purpurin (Standard) is the analytical standard of Purpurin. This product is intended for research and analytical applications. Purpurin is a natural anthraquinone compound from Rubia cordifolia L.. Purpurin has antidepressant-like effects .

HY-N2439

Methyl isoeugenol	Others	Neurological Disease
Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active .

HY-168508

PB200	HDAC	Neurological Disease
PB200 is an HDAC6 inhibitor with an IC₅₀ value of 1.97 nM. PB200 demonstrates significant antidepressant effects by restoring abnormal HDAC6 expression levels and alleviating neuroinflammation .

HY-N0765

Isoliquiritin 1 Publications Verification	Fungal	Infection Neurological Disease Inflammation/Immunology
Isoliquiritin, isolated from Licorice Root, inhibits angiogenesis and tube formation. Isoliquiritin also exhibits antidepressant-like, anti-oxidative, anti-Inflammatory effects and antifungal activity .

HY-123499

SRA880	Somatostatin Receptor	Cardiovascular Disease
SRA880 is a non-peptide and selective somatostatin sst(1) receptor antagonist. SRA880 exhibits antidepressant-like effects when in combination with Imipramine (HY-B1490A) .

HY-110379

M084 hydrochloride	TRP Channel	Neurological Disease
M084 hydrochloride is a TRPC4/5 channel blocker, with IC₅₀ values of 10.3 μM and 8.2 μM, respectively. M084 hydrochloride has antidepressant and anxiolytic effects .

HY-122300B

R-(-)-Oxaprotiline Levoprotiline	Adrenergic Receptor	Neurological Disease
R-(-)-Oxaprotiline (Levoprotiline) is an antidepressant with anticholinergic and sympathostimulatory activities. R-(-)-Oxaprotiline exhibits different abilities to block norepinephrine uptake and anticholinergic activity compared to its enantiomer C 49802 B-Ba. R-(-)-Oxaprotiline in human studies shows physiological effects consistent with those in animals. Administration of R-(-)-Oxaprotiline results in a modest increase in heart rate and arterial blood pressure. Salivation is inhibited with R-(-)-Oxaprotiline, consistent with its anticholinergic properties. R-(-)-Oxaprotiline has similar effects to the established antidepressant compound Levoprotiline and has a shorter onset of action .

HY-90003S

Tianeptine-d12	Isotope-Labeled Compounds	Neurological Disease
Tianeptine-d12 is a deuterated analog of Tianeptine. Tianeptine is an antidepressant with oral activity and neurochemical properties. Tianeptine has neuroprotective effects against hypoxia in tissue culture and against the deleterious effects of cytokines in the cortex and white matter, but not against NMDA receptor-mediated excitotoxicity .

HY-15084A

(-)-Dizocilpine maleate (-)-MK-801 maleate	iGluR	Neurological Disease
(-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a K_i of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects .

HY-122135

A-317567	Sodium Channel	Neurological Disease
A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC₅₀ of 1.025 μM. A-317567 has antidepressant and antinociception effects .

HY-123498

MCI-225 (dehydratase) DDP 225 (dehydratase)	5-HT Receptor Adrenergic Receptor	Neurological Disease
MCI-225 dehydratase is an orally active and selective noradrenaline reuptake inhibitor. MCI-225 dehydratase also is a 5-HT3 antagonist and shows antidepressant effects in vivo .

HY-105058A

14α/β-Vindeburnol 14α/β-RU 24722	Others	Neurological Disease
14α/β-Vindeburnol (14α/β-RU 24722) a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological and antidepressant-like effects .

HY-W979493

TC-2216	nAChR	Others
TC-2216 is a compound with antidepressant and anxiolytic activity that has shown activity in multiple animal models and may exert its effects by acting on α4β2 neuronal nicotinic receptors.

HY-B0444A

Maprotiline	Autophagy Apoptosis ERK	Neurological Disease Cancer
Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1 .

HY-115645

R121919 hydrochloride NBI30775 hydrochloride	CRFR	Neurological Disease Metabolic Disease
R121919 (NBI30775) hydrochloride is a potent and selective CRF1R antagonist with a K_i of 2 to 5 nM. R121919 hydrochloride has antidepressant and anxiolytic effects. R121919 hydrochloride alleviates defensive withdrawal in rats .

Cat. No.	Product Name	Type

HY-D0004

Azure B Azure B chloride	Dyes
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC₅₀s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

HY-D0004R

Azure B (Standard)

Dyes

Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

Cat. No.	Product Name	Type

HY-B0617

S-Adenosyl-L-methionine S-Adenosyl methionine; Ademetionine; AdoMet	Biochemical Assay Reagents
S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

Cat. No.	Product Name	Target	Research Area

HY-W001158

N,N-Dimethylglycine hydrochloride 1 Publications Verification Dimethylglycine hydrochloride; DMG hydrochloride; N-Methylsarcosine hydrochloride	Endogenous Metabolite iGluR Amino Acid Derivatives	Neurological Disease Metabolic Disease
N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects .

HY-14614D

S-Adenosyl-L-methionine iodide 10+ Cited Publications S-Adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide	Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Cancer
S-Adenosyl-L-methionine (S-Adenosyl methionine) iodide is an orally active methyl group donor. S-Adenosyl-L-methionine iodide is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine iodide also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine iodide has the potential for, cancer, liver disease and osteoarthritis research .

HY-P3355

p-fin4	iGluR	Neurological Disease
p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-P3354

p3Ysh-3	iGluR	Neurological Disease
p3Ysh-3 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 1.09 μM. p3Ysh-3 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p3Ysh-3 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Structural Classification Chalcones Monophenols Flavonoids Phenols Umbelliferae Plants Ondetia linearis Benth.	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-N0571

Purpurin	Quinones Structural Classification Anthraquinones Source classification Rubiaceae Phenols Polyphenols Plants Rubia cordifolia L.	Fungal Bacterial Antibiotic
Purpurin is a natural anthraquinone compound from Rubia cordifolia L.. Purpurin has antidepressant-like effects .

HY-118620

Nortriptyline 2 Publications Verification Desmethylamitriptyline; Desitriptilina	Alkaloids Neurological Disease Classification of Application Fields Centaurea bracteata Scop. Other Alkaloids Labiatae Source classification Plants Disease Research Fields Cancer	Autophagy Drug Metabolite Apoptosis
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects . N

HY-N6076

Tenuifoliside A	Triterpenes Structural Classification Monophenols Terpenoids Source classification Polygalaceae Phenols Plants Polygala tenuifolia Willd.	ERK
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells .

HY-N0705

Curculigoside 5+ Cited Publications	Curculigo orchioides Gaertn. Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Plants Amaryllidaceae Disease Research Fields Cancer	JAK STAT NF-κB
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-N4161

Euparin	Monophenols Source classification Phenols Plants Compositae Guilandina minax (Hance) G. P. Lewis	Reactive Oxygen Species (ROS)
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-N3204

Neoechinulin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Indole Alkaloids	Apoptosis
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-N2439

Methyl isoeugenol	Natural Products other families Neurological Disease Classification of Application Fields Source classification Plants Pteris semipinnata L. Sp. Disease Research Fields	Others
Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active .

HY-N13088

Hyperidione D	Structural Classification Natural Products Hypericum perforatum Linn. Guttiferae Source classification Plants	Others
Hyperidione D is apotent antidepressant agent. Hyperidione D shows neuroprotective effects .

HY-N0571R

Purpurin (Standard)	Quinones Structural Classification Anthraquinones Source classification Rubiaceae Phenols Polyphenols Plants Rubia cordifolia L.	Fungal Bacterial Antibiotic
Purpurin (Standard) is the analytical standard of Purpurin. This product is intended for research and analytical applications. Purpurin is a natural anthraquinone compound from Rubia cordifolia L.. Purpurin has antidepressant-like effects .

HY-N0765

Isoliquiritin 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Chalcones Flavonoids Leguminosae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Fungal
Isoliquiritin, isolated from Licorice Root, inhibits angiogenesis and tube formation. Isoliquiritin also exhibits antidepressant-like, anti-oxidative, anti-Inflammatory effects and antifungal activity .

HY-N0705R

Curculigoside (Standard)	Curculigo orchioides Gaertn. Structural Classification Monophenols Source classification Phenols Plants Amaryllidaceae	JAK STAT NF-κB
Curculigoside (Standard) is the analytical standard of Curculigoside. This product is intended for research and analytical applications. Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-N0008

Orcinol glucoside	Curculigo orchioides Gaertn. Structural Classification Monophenols Source classification Phenols Plants Amaryllidaceae	Wnt
Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway .

HY-118620R

Nortriptyline (Standard) Desmethylamitriptyline (Standard); Desitriptilina (Standard)	Alkaloids Centaurea bracteata Scop. Other Alkaloids Labiatae Source classification Plants	Reference Standards Autophagy Drug Metabolite Apoptosis
Nortriptyline (Standard) is the analytical standard of Nortriptyline. This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects . N

HY-N6947

Lutein 4 Publications Verification Xanthophyll	Structural Classification Classification of Application Fields Source classification Whitening Agent Food Research Microorganisms Animals Terpenoids Pigments Diterpenoids Cosmetic Research Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health . Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS) . Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active .

HY-N2055

Kaempferol 3-O-sophoroside	Panax ginseng C. A. Meyer Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Araliaceae	Toll-like Receptor (TLR) NF-κB TNF Receptor AMPK
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases .

HY-N0765R

Isoliquiritin (Standard)	Structural Classification Chalcones Flavonoids Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Fungal
Isoliquiritin (Standard) is the analytical standard of Isoliquiritin. This product is intended for research and analytical applications. Isoliquiritin, isolated from Licorice Root, inhibits angiogenesis and tube formation. Isoliquiritin also exhibits antidepressant-like, anti-oxidative, anti-Inflammatory effects and antifungal activity .

HY-N8303

Gardenin A	Structural Classification Flavonoids Flavones Source classification Rutaceae Plants Citrus reticulata Blanco	ERK PAK
Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects .

HY-N2439R

Methyl isoeugenol (Standard)	Natural Products other families Source classification Plants Pteris semipinnata L. Sp.	Others
Methyl isoeugenol (Standard) is the analytical standard of Methyl isoeugenol. This product is intended for research and analytical applications. Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active .

HY-128743R

12-Hydroxydodecanoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Methyl isoeugenol (Standard) is the analytical standard of Methyl isoeugenol. This product is intended for research and analytical applications. Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active .

HY-N0008R

Orcinol glucoside (Standard)	Curculigo orchioides Gaertn. Structural Classification Monophenols Source classification Phenols Plants Amaryllidaceae	Wnt
Orcinol glucoside (Standard) is the analytical standard of Orcinol glucoside. This product is intended for research and analytical applications. Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway .

HY-B0617A

S-Adenosyl-L-methionine tosylate 10+ Cited Publications S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine (S-Adenosyl methionine) tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine tosylate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine tosylate has the potential for, cancer, liver disease and osteoarthritis research .

HY-B0617

S-Adenosyl-L-methionine S-Adenosyl methionine; Ademetionine; AdoMet	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-Y0511

N,N-Dimethylglycine 1 Publications Verification Dimethylglycine; DMG; N-Methylsarcosine	Structural Classification Microorganisms Other disease Classification of Application Fields Source classification Disease markers Other Diseases Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite iGluR Amino Acid Derivatives
N,N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine has antidepressant-like and surfactant effects .

HY-14614D

S-Adenosyl-L-methionine iodide 10+ Cited Publications S-Adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine (S-Adenosyl methionine) iodide is an orally active methyl group donor. S-Adenosyl-L-methionine iodide is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine iodide also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine iodide has the potential for, cancer, liver disease and osteoarthritis research .

HY-N7085

Citropten 5,7-Dimethoxycoumarin; Limettin	Structural Classification Natural Products Classification of Application Fields Rutaceae Plants Disease Research Fields Citrus medica Linn. var. sarcodactylis (Noot.) Swingle Cancer	JNK p38 MAPK ERK
Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .

HY-N6962

α-Spinasterol	Structural Classification Natural Products Plants Caryophyllaceae Melandrium firmum (S. et Z . ) Rohrb.	TRP Channel COX Bacterial
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( TRPV1), and it's also an inhibitor of COX-1 and COX-2, with IC₅₀ values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice .

HY-121793

Roemerine (-)-Roemerine	Structural Classification Aporphine Alkaloids Classification of Application Fields Fibraurea recisa Pierre Source classification Plants Menispermaceae Nymphaeaceae Alkaloids Nelumbo nucifera Gaertn. Isoquinoline Alkaloids Disease Research Fields Cancer	Endogenous Metabolite 5-HT Receptor mGluR iGluR Bacterial Antibiotic
Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases .

HY-N7085R

Citropten (Standard)	Structural Classification Natural Products Rutaceae Plants Citrus medica Linn. var. sarcodactylis (Noot.) Swingle	ERK JNK p38 MAPK
Citropten (Standard) is the analytical standard of Citropten. This product is intended for research and analytical applications. Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .

HY-B0617B

S-Adenosyl-L-methionine (1,4-butanedisulfonate) S-Adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research .

HY-W017770

S-Adenosyl-L-methionine disulfate tosylate 10+ Cited Publications Ademetionine disulfate tosylate; S-Adenosyl methionine disulfate tosylate; AdoMet disulfate tosylate	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine (Ademetionine) disulfate tosylate is the disulfate tosylate form of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine disulfate tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine disulfate tosylate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine disulfate tosylate has the potential for, cancer, liver disease and osteoarthritis research .

HY-Y0511R

N,N-Dimethylglycine (Standard) Dimethylglycine (Standard); DMG (Standard); N-Methylsarcosine (Standard)	Structural Classification Microorganisms Other disease Source classification Disease markers Amino acids Endogenous metabolite	Endogenous Metabolite iGluR Amino Acid Derivatives
N,N-Dimethylglycine (Dimethylglycine) (Standard) is the analytical standard of N,N-Dimethylglycine (HY-Y0511). This product is intended for research and analytical applications. N,N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine has antidepressant-like and surfactant effects.

HY-B0617AR

S-Adenosyl-L-methionine tosylate (Standard) S-Adenosyl methionine tosylate (Standard); Ademetionine tosylate (Standard); AdoMet tosylate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine tosylate (Standard) (S-Adenosyl methionine tosylate (Standard)) is the analytical standard of S-Adenosyl-L-methionine tosylate (HY-B0617A). This product is intended for research and analytical applications. S-Adenosyl-L-methionine (S-Adenosyl methionine) tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine tosylate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine tosylate has the potential for, cancer, liver disease and osteoarthritis research .

HY-N0507

Rosavin	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	TNF Receptor Interleukin Related
Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .

HY-N0507R

Rosavin (Standard)	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	TNF Receptor Interleukin Related
Rosavin (Standard) is the analytical standard of Rosavin. This product is intended for research and analytical applications. Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis .

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-101392A

Harmane hydrochloride	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Rauwolfia canescens	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-B0765

Dehydroepiandrosterone sulfate sodium 5 Publications Verification DHEA sulfate sodium; Prasterone sulfate sodium	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	GABA Receptor Sigma Receptor iGluR PPAR NF-κB
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium salt has both non-competitive antagonist activity of GABA_A receptor and agonist activity of σ₁ receptor. Dehydroepiandrosterone sulfate sodium salt can partially penetrate the blood-brain barrier, inhibit GABA_A receptor-mediated chloride influx, enhance NMDA receptor activity through σ₁ receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium salt participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium salt may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .

HY-113416

Dehydroepiandrosterone sulfate 5 Publications Verification DHEA sulfate; Prasterone sulfate	Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	GABA Receptor Sigma Receptor iGluR PPAR NF-κB
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABA_A receptor and agonist activity of σ₁ receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABA_A receptor-mediated chloride influx, enhance NMDA receptor activity through σ₁ receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .

HY-113416R

Dehydroepiandrosterone sulfate (Standard) DHEA sulfate (Standard); Prasterone sulfate (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards GABA Receptor Sigma Receptor iGluR PPAR NF-κB
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) (Standard) is the analytical standard of Dehydroepiandrosterone sulfate (HY-113416). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABA_A receptor and agonist activity of σ₁ receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABA_A receptor-mediated chloride influx, enhance NMDA receptor activity through σ₁ receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .

HY-B0765R

Dehydroepiandrosterone sulfate sodium (Standard) DHEA sulfate sodium (Standard); Prasterone sulfate sodium (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	GABA Receptor Sigma Receptor iGluR PPAR NF-κB
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt (Standard) is the analytical standard of Dehydroepiandrosterone sulfate sodium salt (HY-B0765). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABA_A receptor and agonist activity of σ₁ receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABA_A receptor-mediated chloride influx, enhance NMDA receptor activity through σ₁ receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .

Cat. No.	Product Name	Chemical Structure

HY-B0031S1

Quetiapine-d4 hemifumarate
Quetiapine-d₄ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects .

HY-17412S1

Minocycline-d6 sulfate

Minocycline-d₆ sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-W654013

Minocycline-d7

Minocycline-d₇ is deuterium labeled Minocycline. Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-B0031S

Quetiapine-d4 fumarate
Quetiapine-d₄ (fumarate) is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects .

HY-90003S

Tianeptine-d12
Tianeptine-d12 is a deuterated analog of Tianeptine. Tianeptine is an antidepressant with oral activity and neurochemical properties. Tianeptine has neuroprotective effects against hypoxia in tissue culture and against the deleterious effects of cytokines in the cortex and white matter, but not against NMDA receptor-mediated excitotoxicity .

HY-176436S

GW-117
GW-117 is a 5-HT2C receptor antagonist and a melatonin (MT1/MT2) receptor agonist. GW-117 shows antidepressant-like and anxiolytic-like effects .

HY-113739S1

Desmethylcitalopram-d4 hydrochloride
Desmethylcitalopram-d₄ hydrochloride is deuterated labeled Desmethylcitalopram hydrochloride (HY-113739). Desmethylcitalopram (DCIT) hydrochloride is the active metabolite of Citalopram (HY-121203). Desmethylcitalopram has antidepressant effects. Desmethylcitalopram also inhibits cytochrome P450-2D6, -2C19 with IC₅₀s of 39.5 and 53.5 μM .

HY-17412S

Minocycline-d6 hydrochloride

Minocycline-d₆ hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412AS

Minocycline-d6

Minocycline-d₆ is deuterium labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-B0982S

Pindolol-d7
Pindolol-d₇ (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is the antagonist for 5-HT 1A (K_i=33 nM) and 5-HT 1B. Pindolol is the antagonist for β1/β2-adrenergic receptor. Pindolol exhibits anti-anxiety and antidepressant effects .

HY-B1490AS1

Imipramine-d4

Imipramine-d₄ is deuterium labeled Imipramine. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490AS

Imipramine-d6

Imipramine-d₆ is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490S1

Imipramine-d3 hydrochloride

Imipramine-d₃ (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B1490S

Imipramine-d4 hydrochloride

Imipramine-d₄ (hydrochloride) is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .

HY-B1490AS3

Imipramine-d4-1

Imipramine-d4-1 is the deuterium labeled Imipramine (HY-W010179). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-W001158S1

N,N-Dimethylglycine-d3 hydrochloride

N,N-Dimethylglycine-d₃ (Dimethylglycine-d₃) hydrochloride is the deuterium labeled N,N-Dimethylglycine hydrochloride (HY-W001158). N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects .

HY-150964S

S-Adenosyl-L-methionine-d3 methylbenzenesulfonate

2 Publications Verification

S-Adenosyl-L-methionine-d₃ (S-Adenosyl methionine-d₃) methylbenzenesulfonate is the deuterium labeled S-Adenosyl-L-methionine methylbenzenesulfonate . S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-B0617S2

S-Adenosyl-L-methionine-13C dihydrochloride

S-Adenosyl-L-methionine- ¹³C (S-Adenosyl methionine- ¹³C) dihydrochloride is the ¹³C labeled S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-B1110S

Nomifensine-d3 maleate

Nomifensine-d₃ ((±)-Nomifensine-d₃) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-W001158S

N,N-Dimethylglycine-d6 hydrochloride

N,N-Dimethylglycine-d₆ (Dimethylglycine-d₆) hydrochloride is the deuterium labeled N,N-Dimethylglycine hydrochloride (HY-W001158). N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects .

HY-B0617S

S-Adenosyl-L-methionine-d3

S-Adenosyl-L-methionine-d₃ (S-Adenosyl methionine-d₃) is the deuterated product of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-111124

Paroxetine-d2

Paroxetine-d₂ (CTP 347) is a deuterium labeled Paroxetine (HY-122272). Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-B0031S2

Quetiapine-d8 fumarate

Quetiapine-d₈ (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-122272S

Paroxetine-d4

Paroxetine-d₄ (BRL29060-d₄) is deuterium labeled Paroxetine. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

HY-B0031S3

Quetiapine-d8 hemifumarate

Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-B0031S5

Quetiapine-d4-1 fumarate

Quetiapine-d₄-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-B0031S4

Quetiapine hemifumarate-d8

Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate . Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-14544AS

Quetiapine-d4 hydrochloride

Quetiapine-d₄ (hydrochloride) (ICI204636-d₄ (hydrochloride)) is deuterium labeled Quetiapine. Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-113416AS

Dehydroepiandrosterone sulfate-d6 sodium dihydrate

Dehydroepiandrosterone sulfate sodium dihydrate-d₆ sodium dihydrate is the deuterium labeled Dehydroepiandrosterone sulfate sodium dihydrate. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium dihydrate is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium dihydrate has both non-competitive antagonist activity of GABA_A receptor and agonist activity of σ₁ receptor. Dehydroepiandrosterone sulfate sodium dihydrate can partially penetrate the blood-brain barrier, inhibit GABA_A receptor-mediated chloride influx, enhance NMDA receptor activity through σ₁ receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium dihydrate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium dihydrate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .

HY-141921S

Dehydroepiandrosterone sulfate sodium-d6

Dehydroepiandrosterone sulfate sodium salt-d₆ (DHEA sulfate sodium salt-d₆; Prasterone sulfate sodium salt-d₆) is the deuterium labeled Dehydroepiandrosterone sulfate sodium salt (HY-B0765). Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium salt has both non-competitive antagonist activity of GABA_A receptor and agonist activity of σ₁ receptor. Dehydroepiandrosterone sulfate sodium salt can partially penetrate the blood-brain barrier, inhibit GABA_A receptor-mediated chloride influx, enhance NMDA receptor activity through σ₁ receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium salt participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium salt may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality .

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