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Results for "

Sting activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	STING (73) Akt (1) AMPK (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (4) Autophagy (2) Bacterial (3) Biochemical Assay Reagents (1) CD28 (1) CXCR (1) DNA/RNA Synthesis (1) EGFR (1) Endogenous Metabolite (12) Ferroptosis (1) Glutathione Peroxidase (1) HSV (1) IFNAR (7) Influenza Virus (2) Interleukin Related (4) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) Liposome (1) Mitochondrial Metabolism (1) Molecular Glues (1) PARP (2) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (1) PROTACs (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) SARS-CoV (1) TNF Receptor (2)
By Research Areas:	Cancer (40) Cardiovascular Disease (6) Infection (21) Inflammation/Immunology (50)
Click Chemistry:	DBCO (1) Alkynes (1)
Oligonucleotides:	Cationic Lipids (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: STING

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162465

BDW568	STING	Infection Inflammation/Immunology Cancer
BDW568 is a *STING* agonist that can selectively activate the human STING ^A230 allele. BDW568 can be used to activate STING ^A230-engineered macrophages in macrophage-based immunotherapy .

HY-151970

STING-IN-4	STING	Inflammation/Immunology
STING-IN-4 (Compound 1) is a *STING* inhibitor that inhibits STING expression and hence reducing activation of STING and nuclear factor-κB (NF-κB) signaling. STING-IN-4 shows anti-inflammatory activity and can be used for the research of sepsis .

HY-147010

STING agonist-12 1 Publications Verification	STING	Inflammation/Immunology
STING agonist-12 (Compound 53) is a potent, orally active human *STING* activator with an EC₅₀ of 185 nM .

HY-144329

STING agonist-11	STING	Inflammation/Immunology Cancer
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of *STING* with EC₅₀ of 18 nM. Activation of STING is a highly promising approach in immunotherapy .

HY-144328

STING agonist-10	STING	Inflammation/Immunology Cancer
STING agonist-10 (Compound 91) is a potent small molecule cyclic urea activator of *STING* with the EC₅₀ of 2600 nM. Activation of STING is a highly promising approach in immunotherapy .

HY-176541

diABZI-Mal	STING	Inflammation/Immunology Cancer
diABZI-Mal is a *STING* agonist. diABZI-Mal activates *cGAS-STING* pathway to induce cytokine production such as interferon-type I. diABZI-Mal promotes maturation of DC cells and efficiently induces CD8 ⁺ T immune reaction. diABZI-Mal inhibits tumor growth .

HY-173316

STING-IN-12	STING	Inflammation/Immunology
STING-IN-12 (compound Y2) is an inhibitor of *STING. STING-IN-12 inhibits IFNβ gene expression (IC₅₀=0.75μM) induced by SR717. STING-IN-12 inhibits STING* pathway activation induced by the STING agonist SR717 in THP1 cells and MSA-2-induced STING pathway activation in vivo in mice .

HY-152960

STING agonist-27	STING	Infection
STING agonist-27 (CF509) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains .

HY-152962

STING agonist-29	STING	Infection
STING agonist-29 (CF511) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, exhibits activity against SARS-CoV series strains .

HY-139179

STING agonist-14	STING	Infection Cancer
STING agonist-14 (compound 12b) is a potent *STING* agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections .

HY-173399

hSTING activator-1	STING Interleukin Related IFNAR	Inflammation/Immunology Cancer
hSTING activator-1 (Compound 68) is a *STING* agonist. hSTING activator-1 can effectively activate multiple human STING variants (R232, H232, HAQ) with EC₅₀ values of 56 nM, 89 nM and 51 nM, respectively. hSTING activator-1 activates the type I interferon pathway by directly binding to STING protein and stabilizing its conformation, promoting downstream IRF3 phosphorylation and cytokine release. hSTING activator-1 inhibits fibrosarcoma tumor growth and has potential in cancer research .

HY-176126

STING agonist-42	STING	Inflammation/Immunology
STING agonist-42 (compound 8a) is a potent *STING* agonist. STING agonist-42 activates STING in THP1 and RAW 264.7 cells with EC₅₀s of 0.06 and 14.15 μM, respectively .

HY-173326

STING-IN-14	STING	Inflammation/Immunology
STING-IN-14 is an inhibitor of *STING* (IC₅₀: 0.6 nM). STING-IN-14 inhibits the activation of the IRF pathway in THP1-Dual ^TM cells. STING-IN-14 can be used in autoimmune diseases research .

HY-138683

STING-IN-3 2 Publications Verification	STING	Inflammation/Immunology
STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING .

HY-148606

STING modulator-3	STING	Cancer
STING modulator-3 is a *STING* inhibitor. STING modulator-3 inhibits R232 STING with an K_i value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells .

HY-145010

SN-011 5+ Cited Publications	STING	Inflammation/Immunology
SN-011 is a potent and selective mouse and human *STING* inhibitor, with an IC₅₀ of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease .

HY-143321

STING agonist-13	STING	Cancer
STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate *STING* downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .

HY-149267

STING agonist-30	STING SARS-CoV	Infection
STING agonist-30 is a potent *STING* agonist. STING agonist-30 exhibits STING-dependent immune activation. STING agonist-30 has extensive inhibitory effects on various viruses, including the herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) .

HY-175210

STING-IN-16	STING Interleukin Related IFNAR Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology
STING-IN-16 is a *STING* inhibitor with IC₅₀ values of 44 nM (human) and 32 nM (mice) for cellular *STING* inhibition. STING-IN-16 effectively inhibits the activation of the *STING* axis in both human and murine cells. STING-IN-16 can restore renal mitochondrial function, suppress reactive oxygen species (ROS) production, and reduce cell apoptosis. STING-IN-16 shows robust anti-inflammatory efiicacy in vivo. STING-IN-16 can be used for the study of autoimmune and autoinflammatory diseases .

HY-172671

STING agonist-43	STING	Cancer
STING agonist-43 (Compound 67) is a selective *STING* agonist (EC₅₀: 20.53 μM). STING agonist-43 selectively amplifies cGAMP-dependent STING pathway activation by modulating STING oligomerization. B16.F10 has antitumor activity in a mouse melanoma model. STING agonist-43 can be used for the study of cancer immunity .

HY-174136

STING Degrader-2	STING	Inflammation/Immunology
STING Degrader-2 (Compound SI-43) is a *STING* inhibitor and mutant-specific degrader. STING Degrader-2 can effectively inhibit cGAMP-induced STING activation and significantly reduce the release of IFN-β and CXCL-10. It inhibits the activity of STING by binding to two pockets of the STING dimer and induces proteasome-independent degradation of mutants STING S154 and STING M155 (DC₅₀ values are 0.31 and 0.76 μM, respectively). STING Degrader-2 can be used to study STING-related autoimmune diseases .

HY-168803

BDW-OH	STING	Cancer
BDW-OH is an active metabolite of BDW568 (HY-162465 ). BDW568 is a STING agonist that can selectively activate the human STING ^A230 allele.

HY-152961

STING agonist-28	STING	Infection
STING agonist-28 (CF510) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152957

STING agonist-24	STING	Infection
STING agonist-24 (CF504) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152959

STING agonist-26	STING	Infection Cancer
STING agonist-26 (CF508) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152956

STING agonist-23	STING	Infection Cancer
STING agonist-23 (CF502) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-152958

STING agonist-25	STING	Infection
STING agonist-25 (CF505) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-176257

STING agonist-44	STING	Cancer
STING agonist-44 (Compound 4) is a potent and selective *STING* agonist with an EC₅₀ value of 5.68 for IRF induction in THP1 cells and 2.212 μM in RAW cells. STING agonist-44 activates the STING pathway, inducing the production of type I interferons and pro-inflammatory cytokines (e.g., CXCL10, TNFα). STING agonist-44 is promising for research of cancers .

HY-152955

STING agonist-22	STING	Infection Inflammation/Immunology
STING agonist-22 (CF501) is a potent non-nucleotide *STING* agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research .

HY-175166

BMS-025	STING	Inflammation/Immunology
BMS-025 is a orthosteric *STING* agonist. BMS-025 can induces chemical shift of STING M271 residue, further activating STING IFN signaling. BMS-025 can be used for monogenic autoinflammatory disease like SAVI disease research .

HY-123963

C-178 5+ Cited Publications	STING	Inflammation/Immunology
C-178 is a potent and selective covalent inhibitor of *STING. C-178 binds to Cys91 and suppresses the STING* responses elicited by distinct bona fide activators in mouse but not human .

HY-112906

C-176 Maximum Cited Publications 80 Publications Verification	STING	Inflammation/Immunology
C-176 is a selective and blood-brain barrier permeable *STING* inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of *STING* .

HY-162133

MSA-2-Pt	STING	Cancer
MSA-2-Pt is an orally active *STING* agonist that has good cell membrane permeability. MSA-2-Pt can induce cell death by Pt, which may release damaged DNA to activate the cGAS-STING pathway. Besides, MSA-2-Pt can activate the STING pathway directly by MSA-2. MSA-2-Pt can be used for the research of cancer .

HY-168034

diABZI-4	STING	Infection Inflammation/Immunology
diABZI-4 is an oral active *STING* agonist with broad-spectrum antiviral activity. diABZI-4 induces the production of pro-inflammatory cytokines and lymphocyte activation by activating *STING, thereby inhibiting the replication of influenza A virus (IAV), SARS-CoV-2, and human rhinovirus (HRV), with an EC₅₀* range of 11.8-199 nM .

HY-157214

NVS-STG2	STING Molecular Glues	Cancer
NVS-STG2 is a molecular glue that targets *STINGactivates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING* by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models .

HY-173404

VB-85247	STING Interleukin Related IFNAR TNF Receptor CXCR	Inflammation/Immunology Cancer
VB-85247 is a *STING* agonist. VB-85247 induces upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as maturation and activation of dendritic cells by activating the STING pathway. VB-85247 can achieve regression of intrabladder tumors and can be used in bladder cancer research .

HY-169225

PDIC-NN PDIC-NS free base	STING Apoptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
PDIC-NN (PDIC-NS free base) is a *STING* activator with anticancer activity. PDIC-NN promotes the content and biostability of endogenous cyclic dinucleotides (CDNs). PDIC-NN triggers ROS burst and causes serious damage to mitochondria. PDIC-NN induces cell apoptosis and inhibits DNA replication. PDIC-NN activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response .

HY-162874

diABZI-V/C-DBCO	STING	Inflammation/Immunology Cancer
diABZI-V/C-DBCO (Compound 3) is a potent *STING* agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate *STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC₅₀* values for diABZI-V/C-DBCO and diABZI-amine in activating *STING* in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC₅₀ values are 7.7 and 0.17 μM, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research .

HY-169225A

PDIC-NN dimethanesulfonate PDIC-NS	STING Apoptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
PDIC-NN dimethanesulfonate (PDIC-NS) is a *STING* activator with anticancer activity. PDIC-NN dimethanesulfonate promotes the content and biostability of endogenous cyclic dinucleotides (CDNs). PDIC-NN dimethanesulfonate triggers ROS burst and causes serious damage to mitochondria. PDIC-NN dimethanesulfonate induces cell apoptosis and inhibits DNA replication. PDIC-NN dimethanesulfonate activates cGAS-STING signaling pathway, enhances the immunogenicity of tumor cells and activates a robust innate immune response .

HY-160406

SNX281	STING IFNAR	Cancer
SNX281 is a systemically active non-CDN STING agonist that binds to the *STING* protein. SNX281 promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. SNX281 activates STING and leads to the production of type I IFNs and proinflammarory cytokines, ultimately stimulating the infilatration of immune cells into the tumor microenvironment. SNX281 enhances anti-tumor immunity, potentially overcoming resistance to checkpoint inhibitors in some cancer. SNX281 can be used in the research for anti-tumor immunity .

HY-130116A

IACS-8779 disodium	STING	Cancer
IACS-8779 disodium is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. IACS-8779 disodium shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma .

HY-164919

Calotatug ginistinag XMT-2056	Antibody-Drug Conjugates (ADCs) EGFR STING	Inflammation/Immunology Cancer
Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate targeting HER2, with an effective payload connected via a linker (LP, HY-148067) to a *STING* agonist (STING agonist-20, HY-148068), and has potential immune activation and anticancer activity .

HY-155100

BI 7446	STING	Inflammation/Immunology Cancer
BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research .

HY-148029

Dazostinag disodium TAK-676	STING	Cancer
Dazostinag disodium (TAK-676) is an agonist of *STING, triggering the activation* of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity .

HY-12885A

2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt 60+ Cited Publications ADU-S100 disodium salt; MIW815 disodium salt; ML RR-S2 CDA disodium salt	STING	Inflammation/Immunology Cancer
2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).

HY-10964

Vadimezan 50+ Cited Publications DMXAA; ASA-404	STING IFNAR Influenza Virus	Infection Cancer
Vadimezan (DMXAA), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.

HY-12212

Omaveloxolone 15+ Cited Publications RTA 408	Keap1-Nrf2 STING Apoptosis	Inflammation/Immunology Cancer
Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.

HY-175167

diABZI-i	STING	Inflammation/Immunology
diABZI-i is a orthosteric *STING* inhibitor. diABZI-i significantly inhibits cGAMP-induced IFNβ in PBMCs with an IC₅₀ of 49 nM. diABZI-i also activates V155M SAVI constitutive signaling in STING V155M THP-1 cells model with potent agonism (EC₅₀: 17 nM). diABZI-i can be used for monogenic autoinflammatory disease like SAVI disease research .

HY-12885

2’3’-c-di-AM(PS)2 (Rp,Rp) 60+ Cited Publications ADU-S100; MIW815; ML RR-S2 CDA	STING	Inflammation/Immunology Cancer
2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .

HY-12512

cGAMP 15+ Cited Publications Cyclic GMP-AMP; 3',3'-cGAMP	STING	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

Cat. No.	Product Name

HY-L031

Small Molecule Immuno-Oncology Compound Library

672 compounds

Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines.

MCE Small Molecule Immuno-Oncology Compound Library offers 672 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

Cat. No.	Product Name	Type

HY-148488

A18-Iso5-2DC18	Drug Delivery
A18-Iso5-2DC18 (Compound A18) is a cyclic lipidoid. A18-Iso5-2DC18 partially activates *STING*. A18-Iso5-2DC18 promotes mRNA protein expression and induces a strong immune response. A18-Iso5-2DC18 can be used in melanoma research .

Cat. No.	Product Name	Target	Research Area

HY-P990181

Anti-Mouse myeloperoxidase/MPO Antibody (6G4)	Glutathione Peroxidase STING	Inflammation/Immunology
Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is an anti-mouse myeloperoxidase/MPO IgG2c monoclonal antibody. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) can activate the cGAS/STING pathway. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) induces acute and chronic kidney injury in mice. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is often used in the construction of inflammation conditions models such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-110385

cGAMP disodium Maximum Cited Publications 16 Publications Verification Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates* a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-110385A

cGAMP diammonium Maximum Cited Publications 16 Publications Verification Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING), which activates* a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-12326A

c-di-AMP disodium 4 Publications Verification Cyclic diadenylate disodium; Cyclic-di-AMP disodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) sodium is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326B

c-di-AMP diammonium 4 Publications Verification Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP diammonium is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-113469R

Cyclic GMP (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	STING Endogenous Metabolite Reference Standards
Cyclic GMP (Standard) is the analytical standard of Cyclic GMP. This product is intended for research and analytical applications. Cyclic GMP is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I_Ca, and regulate myocardial contractility. The derivative of Cyclic GMP, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases.

HY-113469A

Cyclic GMP sodium 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Endogenous Metabolite
Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I_Ca, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases .

HY-113469

Cyclic GMP 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	STING Endogenous Metabolite
Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I_Ca, and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-113469AR

Cyclic GMP sodium (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	STING Endogenous Metabolite
Cyclic GMP (sodium) (Standard) is the analytical standard of Cyclic GMP (sodium). This product is intended for research and analytical applications. Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases .

Cat. No.	Product Name	Chemical Structure

HY-W654000

Cyclic GMP-13C,15N2
Cyclic GMP- ¹³C, ¹⁵N₂ is ¹³C and ¹⁵N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .

HY-W767865

Cyclic GMP sodium-13C5

Cyclic GMP sodium- ¹³C₅ is the ¹³C-labeled Cyclic GMP sodium (HY-113469A). Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases .

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