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Results for "

IL-1 production

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (58) ADC Payload (1) AIM2 (1) Akt (3) AMPK (2) Amyloid-β (1) Antibiotic (5) Apoptosis (9) Autophagy (6) Bacterial (7) Bcl-2 Family (4) Calcium Channel (3) Caspase (7) Cathepsin (1) CD28 (1) Cholinesterase (ChE) (1) COX (7) DNA/RNA Synthesis (3) Drug Derivative (3) Drug Metabolite (2) EGFR (2) Endogenous Metabolite (2) ERK (2) FGFR (1) Formyl Peptide Receptor (FPR) (3) Glucocorticoid Receptor (1) GPR65 (1) HIV Protease (1) HSP (1) Isotope-Labeled Compounds (1) JAK (2) JNK (3) Keap1-Nrf2 (2) Lactate Dehydrogenase (2) Lipoxygenase (2) Molecular Glues (2) Monoamine Oxidase (2) mTOR (2) MyD88 (1) nAChR (2) NADPH Oxidase (1) NEKs (2) NF-κB (17) NO Synthase (13) NOD-like Receptor (NLR) (11) Notch (1) P2X Receptor (1) P2Y Receptor (1) p38 MAPK (10) Parasite (4) PARP (2) PGE synthase (1) Phosphodiesterase (PDE) (2) PI3K (1) PKA (2) PKC (2) Potassium Channel (1) PPAR (2) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (1) Proteasome (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (10) Reference Standards (8) Renin (2) SphK (1) STAT (2) STING (1) Tau Protein (1) TNF Receptor (19) Toll-like Receptor (TLR) (3) TRP Channel (1) VEGFR (2)
By Research Areas:	Cancer (20) Cardiovascular Disease (8) Endocrinology (4) Infection (10) Inflammation/Immunology (93) Metabolic Disease (5) Neurological Disease (14)
Click Chemistry:	Alkynes (2)

103

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1110

AF12198 4 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

HY-N0283

Diacerein 5 Publications Verification Diacerhein; Diacetylrhein	Interleukin Related Calcium Channel	Inflammation/Immunology
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of *IL-1* converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research .

HY-162734

BRD5075	Interleukin Related GPR65	Inflammation/Immunology
BRD5075 is a potent GPR65 activator. BRD5075 induces GPR65-dependent cAMP production. BRD5075 decreases the gene expression of IL-1, IL-2, TNF, and chemokine. BRD5075 has the potential for the research of multiple sclerosis and inflammatory bowel disease (IBD) .

HY-12511

SKF-86002 3 Publications Verification	p38 MAPK	Inflammation/Immunology
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-B1350A

Fusidic acid sodium salt 2 Publications Verification Sodium fusidate; SQ-16360	Bacterial Antibiotic Interleukin Related	Infection Inflammation/Immunology
Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins *IL-1* and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice .

HY-112349

SB 203580 sulfone	Drug Derivative Interleukin Related Lipoxygenase	Inflammation/Immunology
SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the *IL-1* production (IC₅₀ of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC₅₀ of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC₅₀ value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases .

HY-117921

DA-E 5090	Interleukin Related	Inflammation/Immunology
DA-E 5090 is an orally effective inhibitor of IL-1 production that can be converted into a pharmacologically active deacetylated form (DA-E5090) in vivo. In this study, the effects of DA-E5090 on IL-1 production in vitro were examined by LPS-stimulated human monocytes. The results showed that DA-E5090 could dose-dependently inhibit the production of IL-1α and IL-1β (1-10 μM) by LPS-stimulated human monocytes, as determined by LAF assay and ELISA. Northern blotting analysis showed that DA-E5090 inhibited the transcription of IL-1α and IL-1β mRNA.

HY-122767

Romurtide Muroctasin	Interleukin Related	Inflammation/Immunology
Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), *IL-1* and IL-6 in vitro .

HY-108641

SKF-86002 dihydrochloride	p38 MAPK	Inflammation/Immunology
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-12511R

SKF-86002 (Standard)	p38 MAPK	Inflammation/Immunology
SKF-86002 (Standard) is the analytical standard of SKF-86002. This product is intended for research and analytical applications. SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-136502

(E)-Aztreonam SQ-28429	Antibiotic Bacterial	Infection
(E)-Aztreonam (SQ-28429) is a monocyclic beta-lactam antibiotic. (E)-Aztreonam has the potential for the research of infections caused by gram-negative pathogens .

HY-N0281R

Daphnetin (Standard) 7,8-Dihydroxycoumarin (Standard)	Reference Standards EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite	Inflammation/Immunology Cancer
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-120152

SLP7111228	SphK	Inflammation/Immunology
SLP7111228 is a SphK1 inhibitor. SLP7111228 reduces LPS-induced TNFα and IL-1β production. SLP7111228 can be used in neuroinflammatory diseases research .

HY-147119

INX-SM-6	ADC Payload	Inflammation/Immunology
INX-SM-6 can be used for targeted delivery of anti-inflammatory agent. INX-SM-6 inhibits LPS-induced IL-1β production in human PBMCS .

HY-15509

Semapimod CNI-1493 free base; CPSI-2364	Interleukin Related TNF Receptor p38 MAPK	Inflammation/Immunology Cancer
Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, *IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod inhibits p38 MAPK* and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders .

HY-139414

Lysophosphatidylcholines 2 Publications Verification	Interleukin Related p38 MAPK ERK Apoptosis	Inflammation/Immunology
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of *IL-1β* and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis .

HY-131668

9-POHSA	Endogenous Metabolite	Inflammation/Immunology
9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-POHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression .

HY-122941

Viscidulin II	Interleukin Related	Inflammation/Immunology
Viscidulin II (FL6) is a flavone. Viscidulin II can be isolated from the root of Scutellaria baicalensis. Viscidulin II significantly suppresses P. acnes-induced IL-8 and IL-1β production in THP-1 cells .

HY-173591

T0080	Formyl Peptide Receptor (FPR) Apoptosis Reactive Oxygen Species (ROS) Interleukin Related	Cardiovascular Disease
T0080 is a FPR-1 antagonist. T0080 reduces the cell apoptosis, inhibits ROS production and pro-inflammatory cytokines (TNF-α and IL-1β) from plaque macrophages, which attenuates atherosclerotic progression in ApoE ^−/− mice .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-15509A

Semapimod tetrahydrochloride 4 Publications Verification CNI-1493; CPSI-2364 tetrahydrochloride	TNF Receptor Interleukin Related p38 MAPK	Inflammation/Immunology Cancer
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, *IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK* and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders .

HY-N15566

Theleganbanin D	Drug Derivative	Neurological Disease Inflammation/Immunology
Theleganbanin D is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin D inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin D is promising for research of neurodegenerative diseases .

HY-158111

NLRP3-IN-34	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC₅₀ is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis .

HY-P5890

YVAD-CHO	Interleukin Related Caspase	Neurological Disease Inflammation/Immunology
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (K_i: 0.76 nM). YVAD-CHO inhibits mature IL-1β production. YVAD-CHO partially delays motoneurone death in lesioned facial nerve mice .

HY-156060

NCI126224	Toll-like Receptor (TLR)	Inflammation/Immunology
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases .

HY-N15226

Butyrolactone Ia	NO Synthase Interleukin Related Autophagy	Inflammation/Immunology
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-N0722

Neochlorogenic acid 1 Publications Verification trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and *IL-1β. Neochlorogenic acid suppresses iNOS and COX-2* protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-115976

COX-2-IN-10	COX	Inflammation/Immunology
COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE₂ in concentration dependent manner (IC₅₀=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β .

HY-P5890A

YVAD-CHO TFA	Caspase Interleukin Related	Neurological Disease Inflammation/Immunology
YVAD-CHO TFA is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (K_i: 0.76 nM). YVAD-CHO TFA inhibits mature IL-1β production. YVAD-CHO TFA partially delays motoneurone death in lesioned facial nerve mice .

HY-19888

GSK-1482160	P2X Receptor	Inflammation/Immunology
GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases .

HY-172451

MC4762	NADPH Oxidase Monoamine Oxidase Reactive Oxygen Species (ROS) NO Synthase Interleukin Related	Inflammation/Immunology
MC4762 is an inhibitor of NOX2 and MAOB, with IC₅₀ values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, *IL-1β, and IL-6* .

HY-158155

CVN293	Potassium Channel NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
CVN293 is a selective and brain permeable potassium ion (K ⁺) channel KCNK13 inhibtor with IC₅₀s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia .

HY-149478

JT002	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
JT002 is an orally active and selective NLRP3 inflammasome assembly inhibitor. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice. JT002 can be used for the study of a variety of inflammatory diseases, such as Muckle-Wells syndrome (MWS) .

HY-18754

FR 167653 free base	p38 MAPK Autophagy	Endocrinology
FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo .

HY-N12042

Taxamairin B	TNF Receptor PI3K Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, *IL-1β* and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-15507

VGX-1027 1 Publications Verification GIT 27	Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events .

HY-131934

9-OAHSA	Endogenous Metabolite	Inflammation/Immunology
9-OAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-OAHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression. 9-OAHSA is also a protective molecule to prevent colon carcinoma cells from apoptotic cell death .

HY-N15307

Trigraecum	Interleukin Related TNF Receptor	Inflammation/Immunology
Trigraecum is a flavonoid compound found in Dracaena steudneri and Dalbergia cochinchinensis, exhibiting anti-inflammatory activity. It can inhibit the LPS (HY-D1056)-induced production of *IL-1β, IL-2, GM-CSF, and TNF-α* in human peripheral blood mononuclear cells. Trigraecum holds promise for research on inflammatory diseases .

HY-131945

CU-115 2 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
CU-115 is a potent TLR8 antagonist (IC₅₀=1.04 µM), and shows selective for TLR8 over TLR7 (IC₅₀=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells .

HY-18754A

FR 167653 FR 167653 sulfate	p38 MAPK Autophagy	Endocrinology
FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo .

HY-159669

Stercobilin hydrochloride (mixture of isomers)	HIV Protease	Infection Inflammation/Immunology
Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and *IL-1β*. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .

HY-168091

YM-I-26	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
YM-I-26 is a selective NLRP3 inflammasome inhibitor. YM-I-26 enhances the phagocytosis of β-amyloid protein by mouse microglial BV2 cells and inhibits the production of *IL-1β* and IL-10. YM-I-26 can be used to study the immunomodulatory activity associated with inflammation .

HY-N8371

Shizukaol B	NO Synthase COX Interleukin Related TNF Receptor	Inflammation/Immunology
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and **IL-1β expression .**

HY-N15564

Theleganbanin B	Drug Derivative	Neurological Disease Inflammation/Immunology
Theleganbanin B is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin B inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin B inhibits the phosphorylation of JAK2/STAT3. Theleganbanin B is promising for research of neurodegenerative diseases .

HY-N0936R

Coixol (Standard) 6-Methoxy-2-benzoxazolinone (Standard); 6-MBOA (Standard)	Others	Inflammation/Immunology
Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level .

HY-134353B

ADP-β-S trilithium Adenosine 5'-β-thiodiphosphate (trILithium)	P2Y Receptor NF-κB	Inflammation/Immunology
ADP-β-S trilithium is the trilithium salt form of ADP-β-S (HY-134353). ADP-β-S trilithium is the activator for P2Y12 receptor, which upregulates levels of IL-1βand IL-6 production in microglial cells, promotes the phosphorylation and nuclear translocation of NF-κB, and enhances the activation of the NLRP3 inflammasome .

HY-173144

AChE-IN-85	Cholinesterase (ChE) Reactive Oxygen Species (ROS) Interleukin Related Lactate Dehydrogenase Amyloid-β	Neurological Disease Inflammation/Immunology
AChE-IN-85 (Compound 7k) is an AChE inhibitor with an IC₅₀ of 0.083 μM. AChE-IN-85 can inhibit the release of NO, the production of TNF-α and *IL-1β, the levels of LDH* and ROS, as well as the aggregation of Aβ42. AChE-IN-85 has anti-inflammatory and neuroprotective effects and can be used in the research of diseases such as Alzheimer's disease .

HY-N0722R

Neochlorogenic acid (Standard) trans-5-O-Caffeoylquinic acid (Standard)	Reference Standards NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid (Standard) is the analytical standard of Neochlorogenic acid. This product is intended for research and analytical applications. Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-137007

SMA-12b	Interleukin Related	Others Inflammation/Immunology
SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine *IL-1β* associated with inflammatory bodies and inhibites the production of *IL-1β* through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases .

Cat. No.	Product Name

HY-L156

Autoimmune Disease Compound Library

753 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 753 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Cat. No.	Product Name	Type

HY-139414

Lysophosphatidylcholines 2 Publications Verification	Cell Assay Reagents
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of *IL-1β* and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis .

HY-159669

Stercobilin hydrochloride (mixture of isomers)

Cell Assay Reagents

Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .

Cat. No.	Product Name	Target	Research Area

HY-P1110

AF12198 4 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

HY-P1117

MMK1	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .

HY-122767

Romurtide Muroctasin	Interleukin Related	Inflammation/Immunology
Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), *IL-1* and IL-6 in vitro .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-P5890

YVAD-CHO	Interleukin Related Caspase	Neurological Disease Inflammation/Immunology
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (K_i: 0.76 nM). YVAD-CHO inhibits mature IL-1β production. YVAD-CHO partially delays motoneurone death in lesioned facial nerve mice .

HY-P5890A

YVAD-CHO TFA	Caspase Interleukin Related	Neurological Disease Inflammation/Immunology
YVAD-CHO TFA is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (K_i: 0.76 nM). YVAD-CHO TFA inhibits mature IL-1β production. YVAD-CHO TFA partially delays motoneurone death in lesioned facial nerve mice .

HY-P1117A

MMK1 TFA	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .

Cat. No.	Product Name	Target	Research Area

HY-P99111

Golimumab CNTO-148	TNF Receptor Apoptosis Interleukin Related Caspase	Inflammation/Immunology Cancer
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research .

HY-P99555

Tomaralimab OPN-305	Toll-like Receptor (TLR) MyD88 NOD-like Receptor (NLR) Tau Protein Interleukin Related	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Tomaralimab (OPN-305) is a humanized anti-TLR2 IgG4 monoclonal antibody. Tomaralimab inhibits TLR2, MyD88, NLRP3, and reduces pro-inflammatory cytokine (IL-1β, IL-6, IL-8) production. Tomaralimab reduces tau pathology. Tomaralimab improves cognition, atopic dermatitis. Tomaralimab has anticancer effects on pancreatic ductal adenocarcinoma. Tomaralimab is being studied in myelodysplastic syndrome (MDS), atopic dermatitis, pancreatic ductal adenocarcinoma, Alzheimer's disease, and myocardial ischemia/reperfusion injury .

HY-P990252

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)	Notch Interleukin Related NF-κB VEGFR FGFR NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors *(IL-1β, iNOS, IL-6)* levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0283

Diacerein 5 Publications Verification Diacerhein; Diacetylrhein	Rumex crispus Linn. Quinones Structural Classification Classification of Application Fields Anthraquinones Polygonaceae Source classification Plants Inflammation/Immunology Disease Research Fields	Interleukin Related Calcium Channel
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of *IL-1* converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research .

HY-B1350A

Fusidic acid sodium salt 2 Publications Verification Sodium fusidate; SQ-16360	Infection Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields Cancer	Bacterial Antibiotic Interleukin Related
Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins *IL-1* and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice .

HY-122941

Viscidulin II	Structural Classification Flavonoids Flavones Labiatae Source classification Plants Medicago truncatula Gaertn.	Interleukin Related
Viscidulin II (FL6) is a flavone. Viscidulin II can be isolated from the root of Scutellaria baicalensis. Viscidulin II significantly suppresses P. acnes-induced IL-8 and IL-1β production in THP-1 cells .

HY-N3552

Catalposide	Other Terpenoids Structural Classification Catalpa ovata G. Don Monophenols Classification of Application Fields Terpenoids Source classification Phenols Bignoniaceae Plants Inflammation/Immunology Disease Research Fields	NF-κB
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-N0722

Neochlorogenic acid 1 Publications Verification trans-5-O-Caffeoylquinic acid	Structural Classification Caprifoliaceae Classification of Application Fields Simple Phenylpropanols Lonicera japonica Thunb. Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	NF-κB Interleukin Related TNF Receptor COX
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and *IL-1β. Neochlorogenic acid suppresses iNOS and COX-2* protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N0281R

Daphnetin (Standard) 7,8-Dihydroxycoumarin (Standard)	Structural Classification Daphne Thymelaeaceae Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants	Reference Standards EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N15566

Theleganbanin D	Structural Classification Microorganisms Source classification Phenols Polyphenols	Drug Derivative
Theleganbanin D is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin D inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin D is promising for research of neurodegenerative diseases .

HY-N15226

Butyrolactone Ia	Structural Classification Microorganisms Source classification Phenols	NO Synthase Interleukin Related Autophagy
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-N12042

Taxamairin B	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus wallichiana var. mairei (Lemee & H. Léveillé) L. K. Fu & Nan Li	TNF Receptor PI3K Reactive Oxygen Species (ROS) Interleukin Related
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, *IL-1β* and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-N15307

Trigraecum	Dalbergia cochinchinensis Structural Classification Flavonoids Flavonones Papilionaceae Source classification Plants	Interleukin Related TNF Receptor
Trigraecum is a flavonoid compound found in Dracaena steudneri and Dalbergia cochinchinensis, exhibiting anti-inflammatory activity. It can inhibit the LPS (HY-D1056)-induced production of *IL-1β, IL-2, GM-CSF, and TNF-α* in human peripheral blood mononuclear cells. Trigraecum holds promise for research on inflammatory diseases .

HY-N8371

Shizukaol B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants Chloranthus henryi Hemsl.	NO Synthase COX Interleukin Related TNF Receptor
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and **IL-1β expression .**

HY-N15564

Theleganbanin B	Structural Classification Microorganisms Source classification Phenols Polyphenols	Drug Derivative
Theleganbanin B is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin B inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin B inhibits the phosphorylation of JAK2/STAT3. Theleganbanin B is promising for research of neurodegenerative diseases .

HY-N0936R

Coixol (Standard) 6-Methoxy-2-benzoxazolinone (Standard); 6-MBOA (Standard)	Structural Classification Ketones, Aldehydes, Acids Gramineae Marine natural products Source classification Coix lacryma-jobi Linn. Plants	Others
Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level .

HY-N0722R

Neochlorogenic acid (Standard) trans-5-O-Caffeoylquinic acid (Standard)	Structural Classification Caprifoliaceae Simple Phenylpropanols Lonicera japonica Thunb. Source classification Phenols Polyphenols Phenylpropanoids Plants	Reference Standards NF-κB Interleukin Related TNF Receptor COX
Neochlorogenic acid (Standard) is the analytical standard of Neochlorogenic acid. This product is intended for research and analytical applications. Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N15570

2-O-Methylatromentin	Structural Classification Microorganisms Source classification Phenols Polyphenols	Interleukin Related TNF Receptor
2-O-Methylatromentin is an anti-neuroinflammatory agent. 2-O-Methylatromentin shows inhibitory activity on the production of pro-inflammatory cytokines TNF-α, IL-6 and *IL-1β* in Lipopolysaccharides (HY-D1056) (LPS) -induced BV-2 microglial cells. 2-O-Methylatromentin can be used for the study of neuroinflammatory related diseases .

HY-N1326

Santamarine Santamarin; Balchanin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Magnoliaceae Plants Inflammation/Immunology Disease Research Fields Magnolia grandiflora L.	Keap1-Nrf2
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities .

HY-N2115

Araloside A 1 Publications Verification Chikusetsusaponin IV	Cardiovascular Disease Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Renin Apoptosis Bcl-2 Family Interleukin Related
Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC₅₀ of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .

HY-N2115R

Araloside A (Standard) Chikusetsusaponin IV (Standard)	Triterpenes Structural Classification other families Terpenoids Source classification Plants Araliaceae	Reference Standards Renin Apoptosis Bcl-2 Family Interleukin Related
Araloside A (Standard) (Chikusetsusaponin IV (Standard)), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A (Standard) shows low-renin-inhibitory activity with an IC₅₀ of 77.4 μM. Araloside A (Standard) can inhibit cell proliferation and induce apoptosis. Araloside A (Standard) suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A (Standard) can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis .

HY-N6636

Valencene 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Cyperaceae Cyperus rotundus L. Plants Inflammation/Immunology Disease Research Fields	NF-κB Interleukin Related
Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model .

HY-N0890

Tubeimoside I 4 Publications Verification Tubeimoside-1; Lobatoside-H	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields Cancer	HSP NF-κB p38 MAPK Akt Autophagy Interleukin Related VEGFR
Tubeimoside I is an orally active HSPD1 inhibitor. Tubeimoside I inhibits NF-κB, MAPK, as well as regulates eNOS-VEGF. Tubeimoside I induces cytoprotective Autophagy via an Akt-mediated pathway. Tubeimoside I inhibits proinflammatory cytokine (IL-6 and *IL-1β) production*. Tubeimoside I exhibits anti-inflammatory activities. Tubeimoside I promotes angiogenesis and improves sepsis symptoms. Tubeimoside I is used in the research of inflammatory diseases, various cancers, sepsis and ischemic diseases .

HY-N6636R

Valencene (Standard)	Structural Classification Classification of Application Fields Terpenoids Source classification Cyperaceae Cyperus rotundus L. Plants Inflammation/Immunology Disease Research Fields	Reference Standards NF-κB Interleukin Related
Valencene (Standard) is the analytical standard of Valencene. This product is intended for research and analytical applications. Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model .

HY-N0890R

Tubeimoside I (Standard) Tubeimoside-1 (Standard); Lobatoside-H (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet	Reference Standards Apoptosis
Tubeimoside I (Standard) is the analytical standard of Tubeimoside I. This product is intended for research and analytical applications. Tubeimoside I is an orally active HSPD1 inhibitor. Tubeimoside I inhibits NF-κB, MAPK, as well as regulates eNOS-VEGF. Tubeimoside I induces cytoprotective Autophagy via an Akt-mediated pathway. Tubeimoside I inhibits proinflammatory cytokine (IL-6 and *IL-1β) production*. Tubeimoside I exhibits anti-inflammatory activities. Tubeimoside I promotes angiogenesis and improves sepsis symptoms. Tubeimoside I is used in the research of inflammatory diseases, various cancers, sepsis and ischemic diseases .

HY-N0281

Daphnetin 5 Publications Verification 7,8-Dihydroxycoumarin	Structural Classification Daphne Classification of Application Fields Thymelaeaceae Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N2434

[10]-Shogaol 3 Publications Verification	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Zingiberaceae Cancer	COX Interleukin Related NF-κB Parasite
[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC₅₀ value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis .

HY-N9541

Chaetoglobosin Vb	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Others
Chaetoglobosin Vb is a novel cytotoxic alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb can inhibit oxidative stress induced by LPS stimulation, reduce the production of reactive oxygen species and increase the expression of the antioxidant enzyme superoxide dismutase (SOD). Chaetoglobosin Vb significantly reduced the gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) induced by LPS, and alleviated the production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Chaetoglobosin Vb exerts its biological activity through the TLR4-mediated MyD88-dependent signaling pathway and the TRIF-dependent signaling pathway, which is specifically manifested by inhibiting the phosphorylation of p38, ERK, and JNK MAPK and the translocation of NF-κB p65 subunit to the nucleus. Chaetoglobosin Vb showed no cytotoxic effect in the concentration range of 25-100 μM and promoted SOD enzyme activity and phosphorylation of p38, ERK1/2 and JNK in a dose-dependent manner .

HY-N2481

Oroxylin A-7-O-glucuronide Oroxyloside; Oroxylin A-7-O-β-D-glucuronide	Structural Classification Monophenols Flavonoids Neurological Disease Classification of Application Fields Flavones Labiatae Source classification Phenols Plants Medicago truncatula Gaertn. Disease Research Fields	Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related
Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

HY-N2434R

[10]-Shogaol (Standard)	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	Reference Standards COX Interleukin Related NF-κB Parasite
-Shogaol (Standard) is the analytical standard of -Shogaol (HY-N2434). This product is intended for research and analytical applications. [10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC₅₀ value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis .

HY-N2481R

Oroxylin A-7-O-glucuronide (Standard) Oroxyloside (Standard); Oroxylin A-7-O-β-D-glucuronide (Standard)	Structural Classification Monophenols Flavonoids Flavones Labiatae Source classification Phenols Plants Medicago truncatula Gaertn.	Reference Standards Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related
Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities .

Cat. No.	Product Name	Chemical Structure

HY-B0506S1

Nadifloxacin-d5

Nadifloxacin-d₅ (OPC7251-d₅) is deuterium labeled Nadifloxacin (HY-B0506). Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .

Cat. No.	Product Name		Classification

HY-130252

YQ128 1 Publications Verification		Alkynes
YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC₅₀ of 0.30 μM. YQ128 significantly and selectively suppresses the production of *IL-1β*, but not TNF-α, and it can cross the BBB to reach the CNS. YQ128 has anti-inflammatory activity . YQ128 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.