2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Immunology/Inflammation
  3. Formyl Peptide Receptor (FPR) Calcium Channel Interleukin Related NO Synthase
  4. FPR2 agonist 5

FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056)-induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases.

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FPR2 agonist 5

FPR2 agonist 5 Chemical Structure

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FPR2 agonist 5 Related Antibodies

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Description

FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056)-induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases[1].

In Vitro

FPR2 agonist 5 (Compound (S)-9a) (1 μM, 1 h pretreatment) mitigates LDH release and NO production in LPS-induced mouse primary microglial cells[1].
FPR2 agonist 5 (1 μM, 1 h pretreatment) decreases LPS-induced increases in IL-1β, IL-6, IL-33, and IL-10 levels in mouse primary microglial cells[1].
FPR2 agonist 5 induces Ca2+ mobilization with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FPR2 agonist 5 Related Antibodies

ELISA Assay[1]

Cell Line: Mouse primary microglial cells
Concentration: 1 μM
Incubation Time: 1 h pretreatment
Result: Decreased LPS-induced increases in IL-1β, IL-6, IL-33, and IL-10 levels in mouse primary microglial cells.
Molecular Weight

453.47

Formula

C26H20FN5O2
SMILES

N#CC1=CC=C(C[C@H](NC2=NN=C(C3=CC=C(F)C=C3)O2)C(N4CCC5=C4C=CC=C5)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FPR2 agonist 5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPR2 agonist 5Formyl Peptide Receptor (FPR)Calcium ChannelInterleukin RelatedNO SynthaseCa2+ channelsCa channelsILNitric oxide synthasesNOSneuroinflammatory-related diseasesFPR2LDH releaseNO productionInhibitorinhibitorinhibit

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