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Isoforms Recommended:	HSP90

Results for "

Hsp90

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (173) Cardiovascular Disease (3) Endocrinology (3) Infection (26) Inflammation/Immunology (21) Metabolic Disease (7) Neurological Disease (11)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (3) siRNAs (9)

211

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
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Isotope-Labeled Compounds

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W107935

Hsp90-IN-37	HSP	Cancer
Hsp90-IN-37 (Z-2) is a heat shock protein 90 (Hsp90) inhibitor that inhibits Hsp90 enzymatic activity by 69%. Hsp90-IN-37 has antitumor activity .

HY-149891

HSP90-IN-23	HSP	Cancer
HSP90-IN-23 (Comp 12-1) is an inhibitor of heat shock protein 90(HSP90) with an IC₅₀ of 9 nM. HSP90-IN-23 induces apoptosis of tumor cells and arrests the tumor cell cycle in G0/G1 phase. HSP90-IN-23 can be used for cancer research .

HY-148215A

Hsp90-IN-17 hydrochloride	HSP	Cancer
Hsp90-IN-17 (Example 5) hydrochloride is an *HSP90* inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases .

HY-153588

HSP90-IN-22	HSP	Cancer
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC₅₀ values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.

HY-144724

HSP90-IN-10	HSP Apoptosis	Cancer
HSP90-IN-10 (Compound 16s) is a potent inhibitor of *HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC₅₀* value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis .

HY-171755

Hsp90-IN-40	HSP	Cancer
Hsp90-IN-40 (Compound 15b) is a heat shock protein 90 (Hsp90) C-terminal inhibitor. Hsp90-IN-40 exhibits antiproliferative activity against SKBr3 and MCF-7 breast cancer cells (IC₅₀ of 2.57 µM and 2.43 µM, respectively). Hsp90-IN-40 inhibits cancer cell growth by inhibiting the Hsp90 C-terminal function, leading to Hsp90-dependent protein degradation. Hsp90-IN-40 can be used in breast cancer research .

HY-146325

HSP90-IN-11	HSP	Cancer
HSP90-IN-11 (Compound 12c) is a potent inhibitor of *HSP90. HSP90-IN-11 displays potent HSP90α inhibition comparable to AUY-922 (Luminespib). HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP90*-IN-11 induces significant accumulation of a sub-G1 phase population .

HY-170895

Hsp90-IN-38	HSP Na+/K+ ATPase	Cancer
Hsp90-IN-38 (compound 20m) is a HSP90 (heat shock protein) inhibitor. Hsp90-IN-38 exhibits strong *HSP90* binding affinity with a K_d of 87 nM. Hsp90-IN-38 inhibits ATPase with an IC₅₀ of 0.13 μM. Hsp90-IN-38 inhibits HCT116, MCF-7, SKBr3, K562 and A549 cells with IC₅₀s of 0.187, 0.072, 0.105, 0.403 and 031 μM, respectively .

HY-148215

Hsp90-IN-17	HSP	Cancer
Hsp90-IN-17 (Example 5) is an *HSP90* inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases .

HY-151137

HSP90/mTOR-IN-1	mTOR HSP Apoptosis Autophagy	Cancer
HSP90/mTOR-IN-1 is a potent and orally active *Hsp90* and mTOR inhibitor with IC₅₀ values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer .

HY-162900

HSP90-IN-32	HSP	Cancer
HSP90-IN-32 is a *Hsp90* C-terminal inhibitor that displays anti-proliferative activities against SKMel173, SKMel103, SKMel19 and A375 cells with IC₅₀ values of 1.01 μM, 0.782 μM, 0.607 μM and 1.413 μM , respectively. HSP90-IN-32 is promising for research of anti-cancer agents .

HY-167827

Hsp90-IN-34	HSP	Cancer
Hsp90-IN-34 (compound HAM-1) is a compound that inhibits the Aha1-Hsp90 chaperone complex with a high affinity for *Hsp90/Aha1* (K_Dapp=23.5 µM). Hsp90-IN-34 modulates the ATPase activity of *Hsp90* by affecting the interaction between *Hsp90* and Aha1 .

HY-170326

HSP90-IN-35	Ligands for Target Protein for PROTAC HSP	Cancer
Hsp90-in-35 (Compound 379) is an inhibitor of *Hsp90. The IC₅₀* of HSP90-IN-35 for Her2 is between 0.05 and 0.5 μM. HSP90-IN-35 has antitumor activity. HSP90-IN-35 can be used to synthesize PROTAC (HY-153881) .

HY-152028

HSP90-IN-19	HSP	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-19 is an effective *heat shock protein 90 (Hsp90)* inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-152027

HSP90-IN-18	HSP Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
HSP90-IN-18 is an effective *heat shock protein 90 (Hsp90)* inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation .

HY-149531

HSP90-IN-25	HSP	Cancer
HSP90-IN-25 (compound 4a) is an HSP90 inhibitor that specifically inhibits the ATPase activity of HSP90 .

HY-150655

Hsp90-IN-15	HSP	Cancer
Hsp90-IN-15 is an *Hsp90* inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of *Hsp90* in Hela cell .

HY-147974

HSP90-IN-14	HSP Influenza Virus	Infection
HSP90-IN-14 (compound 4) is a potent *Hsp90* (heat shock protein 90) inhibitor, with a K_d of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC₅₀ values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively .

HY-113574

HSP90-IN-29	HSP	Cancer
HSP90-IN-29 (Compound 13), a benzoxazole derivative, is a potent and selective *HSP-90* inhibitor with an IC₅₀ value of 30 nM. HSP90-IN-29 has antitumor activity .

HY-148963

HSP90-IN-20	HSP	Cancer
HSP90-IN-20 (compound 78p) is a potent *HSP90* inhibitor with an IC₅₀ of ≤10 μM. HSP90-IN-20 has the potential for cancers research .

HY-156779

HSP90-IN-27	HSP	Cancer
HSP90-IN-27 (compound 19) is an *HSP90* inhibitor .

HY-145814

HSP90-IN-9	HSP Fungal	Infection
HSP90-IN-9 is a potent and selective *HSP90* inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2) .

HY-170910

Hsp90-IN-39	HSP	Cancer
Hsp90-IN-39 (Compound 16t) is a *HSP90* inhibitor with notable selectivity for the *HSP90α* isoform. Hsp90-IN-39 demonstrates significant antiproliferative activity in various cancer cell lines, including MCF-7, HCT116, SKBr3, K562, and A549. Hsp90-IN-39 holds potential for cancer research .

HY-168205

HSP90-IN-33	HSP Apoptosis	Cancer
HSP90-IN-33 (compound 24e) is a potent *Hsp90* inhibitor with K_d values of ≥200, 7.3 µM for Hsp90α, Hsp90β, respectively. HSP90-IN-33 induces apoptosis and cell cycle arrest at G0/G1 phase. HSP90-IN-33 decreases the protein expression of ERα, CDK4 and Akt .

HY-161427

HSP90-IN-30	HSP HIF/HIF Prolyl-Hydroxylase	Cancer
HSP90-IN-30 (compound 3e) inhibits *HSP90* chaperone activity. HSP90-IN-30 inhibits the activity of HIF-1 transcriptional under hypoxia with an IC₅₀ value of 2.16 μM .

HY-146228

HSP90-IN-13	HSP Apoptosis Topoisomerase EGFR VEGFR	Cancer
HSP90-IN-13 (compound 5k) is a highly potent *HSP90* pan inhibitor with an IC₅₀ value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway .

HY-170328

Hsp90-IN-36	HSP	Cancer
Hsp90-IN-36 (compound 5) is a *Hsp90* inhibitor with anticancer activity (MCF-7, IC₅₀=14.74 μM) .

HY-144650

Hsp90-Cdc37-IN-3	Apoptosis HSP	Cancer
Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol−imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits *Hsp90−Cdc37* by covalent-binding, and induces apoptosis .

HY-111414

Hsp90-Cdc37-IN-1	HSP	Cancer
Hsp90-Cdc37-IN-1 is an *Hsp90-Cdc37* interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC₅₀ of 140 nM.

HY-153547

HSP90-IN-21	Parasite	Infection Inflammation/Immunology
HSP90-IN-21 (5e) is an antiplasmodial agent, with IC₅₀ values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2 strains), cytotoxicity of human liver hepatocellular carcinoma cell line (HepG2), respectively .

HY-169098

HSP90/LSD1-IN-1	HSP Histone Demethylase	Cancer
HSP90/LSD1-IN-1 (compound 6) is a *HSP90/LSD1* dual inhibitor. HSP90/LSD1-IN-1 inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI₅₀ values of 0.24 and 0.30 μM, respectively .

HY-161833

HSP90-IN-31	Interleukin Related TNF Receptor	Inflammation/Immunology
HSP90-IN-31 (compound Be01) causes reduction of CD80 and CD86 expression on dendritic cells (DCs). HSP90-IN-31 decreases the production of pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β) in BMDC and peritoneal macrophages stimulated by LPS (HY-D1056). Under the delayed-type hypersensitivity (DTH) mice model, HSP90-IN-31 reduces ear swelling and pro-inflammatory cytokines in the spleen .

HY-130624

Hsp90-Cdc37-IN-2	HSP Apoptosis	Cancer
Hsp90-Cdc37-IN-2 (Compound 41) is an inhibitor for the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (Cdc37). Hsp90-Cdc37-IN-2 inhibits the proliferation of cancer cell A549, MCF-7, HOS and HepG2 with IC₅₀ of 0.41-0.94 μM. Hsp90-Cdc37-IN-2 decreases the mitochondrial membrane potential, induces apoptosis, and arrest cell cycle at G0/G1 phase in A549 .

HY-147747

HSP90-IN-12	HSP	Cancer
Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of *hsp90* related proteins in cells and inhibited *hsp90* mediated protein refolding of luciferase in vitro.

HY-173337

HSP90α-IN-1	HSP Interleukin Related	Cancer
HSP90α-IN-1 is a *HSP90α* inhibitor (IC₅₀ = 111 nM) that exhibits senolytic activity across various cellular senescence models. HSP90α-IN-1 is related to the xanthinic family. HSP90α-IN-1 is involved in research on combating age-related inflammaging and diseases, including cancer, and possibly extend a healthy lifespan .

HY-RS06419

HSP90B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90B1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90B1 Human Pre-designed siRNA Set A HSP90B1 Human Pre-designed siRNA Set A

HY-RS18017

Hsp90ab1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90ab1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsp90ab1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90ab1 Mouse Pre-designed siRNA Set A Hsp90ab1 Mouse Pre-designed siRNA Set A

HY-RS06416

Hsp90aa1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90aa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsp90aa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90aa1 Mouse Pre-designed siRNA Set A Hsp90aa1 Mouse Pre-designed siRNA Set A

HY-RS27757

Hsp90b1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsp90b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90b1 Rat Pre-designed siRNA Set A Hsp90b1 Rat Pre-designed siRNA Set A

HY-RS06415

HSP90AA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90AA1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90AA1 Human Pre-designed siRNA Set A HSP90AA1 Human Pre-designed siRNA Set A

HY-RS24490

Hsp90ab1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90ab1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsp90ab1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90ab1 Rat Pre-designed siRNA Set A Hsp90ab1 Rat Pre-designed siRNA Set A

HY-RS21240

Hsp90b1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsp90b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90b1 Mouse Pre-designed siRNA Set A Hsp90b1 Mouse Pre-designed siRNA Set A

HY-RS06418

HSP90AB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90AB1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90AB1 Human Pre-designed siRNA Set A HSP90AB1 Human Pre-designed siRNA Set A

HY-RS06417

Hsp90aa1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90aa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsp90aa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90aa1 Rat Pre-designed siRNA Set A Hsp90aa1 Rat Pre-designed siRNA Set A

HY-115997

*PROTAC HSP90* degrader BP3**	PROTACs HSP	Cancer
PROTAC HSP90 degrader BP3 is a potent and selective degradation of *HSP90* in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain degradation effect on *HSP90* protein in MCF-7 cells (DC₅₀=0.99 μM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell . PROTAC HSP90 degrader BP3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151337

*Aha1/Hsp90-IN-1*	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology
Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC₅₀ of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation .

HY-146212

*HDAC/HSP90-IN-4*	HDAC HSP	Cancer
These compounds have strong hdac and *hsp90* inhibitory activities. Compound 20 (HDAC ic₅₀   =   194   nm; Hsp90 α < b> Ic₅₀ =   153   nm) and compound 26 ((HDAC ic₅₀=   360   nm; Hsp90 α < b> Ic₅₀   =   77   nm) shows the strongest HDAC and HSP90 α Inhibitory activity. Both compounds can induce *hsp90* expression and down regulate *hsp90* client proteins, which play an important role in regulating the survival and invasion of cancer cells.

HY-170816

*CYP51/Hsp90-IN-1*	HSP Cytochrome P450 Fungal	Infection
CYP51/Hsp90-IN-1 (Compound MM4) is a dual *CYP51/Hsp90* inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candida albicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis .

HY-163288

*EZH2/HSP90-IN-29*	Histone Methyltransferase HSP Apoptosis	Cancer
EZH2/HSP90-IN-29 is a dual inhibitor for EZH2 and *HSP90, with IC₅₀s of 6.29 nM and 60.1 nM, for EZH2 and HSP90, respectively. EZH2/HSP90-IN-29 increases apoptosis/necrosis-related gene expression, induces cell cycle arrest at M phase and inhibits reactive oxygen species (ROS) catabolism pathway. EZH2/HSP90*-IN-29 is able to cross the blood-brain-barrier (BBB) .

HY-150774

*HDAC6/HSP90-IN-2*	HDAC HSP Apoptosis	Cancer
HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and *Hsp90, with IC₅₀s of 105.7 and 61 nM, respectively. HDAC6/HSP90*-IN-2 can be used for the research of cancer .

Cat. No.	Product Name	Type

HY-133705

Geldanamycin-FITC	Fluorescent Dyes/Probes
Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90 (Ex/Em = 488/515 nm) .

HY-122878

HS-131	Fluorescent Dyes/Probes
HS-131, a near infrared dye tethered *Hsp90* inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers .

Cat. No.	Product Name	Target	Research Area

HY-P1750A

Shepherdin (79-87) (TFA)	HSP Survivin	Cancer
Shepherdin (79-87) TFA is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity .

HY-P1750

Shepherdin (79-87)	HSP Survivin	Cancer
Shepherdin (79-87) is amino acids 79 to 87 fragment of Shepherdin. Shepherdin is a peptidomimetic antagonist of the complex between Hsp90 and Survivin. Anticancer activity .

HY-P10757

DTX-P7	Peptide-Drug Conjugates (PDCs) Apoptosis HSP Eukaryotic Initiation Factor (eIF) PERK	Cancer
DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90 .

Cat. No.	Product Name	Target	Research Area

HY-P9962

Efungumab	Fungal	Infection
Efungumab is a monoclonal antibody with antifungal activity. Efungumab binds to HSP 90, preventing a conformational change needed for fungal viability. Efungumab can be used for research on invasive candidiasis (IC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119906

Conglobatin FW-04-806	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HSP Apoptosis
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active *Hsp90* inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-107577

Gedunin	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	HSP
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent *Hsp90* inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research .

HY-N3417

Kongensin A 1 Publications Verification	Classification of Application Fields Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Croton kongensis Gagnep.	HSP RIP kinase Apoptosis Necroptosis
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent *HSP90* inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications .

HY-N0754

Eupalinolide A	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Inflammation/Immunology	HSP
Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90 .

HY-15230

Geldanamycin Maximum Cited Publications 28 Publications Verification	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Inflammation/Immunology Disease Research Fields	HSP Bacterial Influenza Virus Antibiotic
Geldanamycin is a *Hsp90* inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

HY-N14780

Pochonin D (+)-Pochonin D	Structural Classification Natural Products Microorganisms Source classification	HSP Interleukin Related Enterovirus
Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affecting the homeostasis, folding, and assembly processes of viral proteins, reducing the replication ability of the virus. Pochonin D reduces the infiltration of inflammatory cells and the secretion of inflammatory cytokines such as TNF-α and IL-1β, alleviating the inflammatory response. Pochonin D is promising for research of Human rhinoviruses (HRV) infections and cancers .

HY-N1455

Falcarinol Panaxynol; Carotatoxin	Structural Classification Natural Products Classification of Application Fields Ambrosia psilostachya DC. Source classification Umbelliferae Plants Disease Research Fields Cancer	HSP Apoptosis
Falcarinol (Panaxynol) is a natural, orally active *Hsp90* inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis . Falcarinol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N15154

Tasiamide B	Structural Classification Natural Products Marine algae Marine natural products Source classification	Cathepsin HSP
Tasiamide B is a Cathepsin D inhibitor, which is a linear peptide found in the marine cyanobacteria Symploca sp.. Tasiamide B is proved as a good template for the development of aspartic proteases inhibitors. Tasiamide B is effective against skin cancer by strongly interacting with the target protein *HSP90* .

HY-N10393

Vibsanin A	Structural Classification Natural Products Classification of Application Fields Viburnaceae Source classification Viburnum awabuki K. Koch Plants Disease Research Fields Cancer	PKC HSP
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a *HSP90* inhibitor .

HY-15230R

Geldanamycin (Standard)	Quinones Structural Classification Microorganisms Source classification Benzene Quinones	HSP Bacterial Influenza Virus Antibiotic
Geldanamycin (Standard) is the analytical standard of Geldanamycin. This product is intended for research and analytical applications. Geldanamycin is a *Hsp90* inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

HY-N10502

Colletofragarone A2	Other Terpenoids Structural Classification Microorganisms Terpenoids	MDM-2/p53 HSP
Colletofragarone A2 can be be isolated from the fungus Colletotrichum sp. (13S020). Colletofragarone A2 inhibits mutant p53 and *HSP90* with anti-cancer activity. Colletofragarone A2 promotes degradation and aggregation of mutant p53 and suppressing tumor growth in vivo .

HY-B0425A

Novobiocin sodium 5+ Cited Publications Albamycin sodium; Cathomycin sodium	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Cancer	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-108486

Herbimycin A	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-N1986

Cucurbitacin D	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Trichosanthes kirilowii Maxim. Plants Disease Research Fields Cancer	HSP Apoptosis
Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between *Hsp90* and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

HY-13425

Deguelin 5+ Cited Publications (-)-Deguelin; (-)-cis-Deguelin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Isoflavanones Source classification Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Akt Autophagy Apoptosis
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N1986R

Cucurbitacin D (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Trichosanthes kirilowii Maxim. Plants	HSP Apoptosis
Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

HY-N6769

Radicicol 3 Publications Verification Monorden	Structural Classification Antifungal Classification of Application Fields Marine natural products Source classification Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Marine microorganism Disease Research Fields	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of *Hsp90* with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

HY-N1934

Dihydroberberine	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Potassium Channel HSP
Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy .

HY-N1934R

Dihydroberberine (Standard)	Alkaloids Structural Classification other families Source classification Plants Isoquinoline Alkaloids	Potassium Channel HSP
Dihydroberberine (Standard) is the analytical standard of Dihydroberberine. This product is intended for research and analytical applications. Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy .

HY-B1434

7-Aminocephalosporanic acid 1 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a *HSP90β* inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

Species:	Human (9) Mouse (2)
Tag:	His (7) SUMO (1) Tag Free (2) Strep (2) Avi (2) GST (3)
Source:	Sf9 insect cells (7) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P72238

	HSP90AA1 Protein, Human (His-SUMO) 1 Publications Verification Heat shock 86 kDa; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein Hsp 90 alpha ; Heat shock protein Hsp 90 beta; Heat shock protein Hsp 90-alpha; HS90A_HUMAN; Hsp 84; Hsp 86; Hsp 90; Hsp86; Hsp90A; Hsp90AA1; Hsp90AB1; Hsp90B; HspC1; HspC2; HspCAL1 ; HspCAL4; Renal carcinoma antigen NY-REN-38	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P703226

	HSP90B1 Protein, Human (His, Strep) GRP94; HspC4; TRA1	Human	E. coli
	HSP90B1 Protein, Human (His, Strep) is the recombinant human-derived HSP90B1, expressed by E. coli , with Strep, His labeled tag. ,

HY-P75364

	CDC37 Protein, Human (sf9, GST) Hsp90 co-chaperone Cdc37; CDC37; CDC37A	Human	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds multiple kinases and promotes their interaction with the Hsp90 complex, resulting in stability and enhanced activity. CDC37 Protein, Human (sf9, GST) is the recombinant human-derived CDC37 protein, expressed by Sf9 insect cells , with C-GST labeled tag.

HY-P703570

	HSP90 Protein, Human (Biotinylated, Avi) Hsp90B; HspC2; HspC3; HspCB	Human	E. coli
	HSP90 Protein, Human (Biotinylated, Avi) is the recombinant human-derived HSP90, expressed by E. coli , with Avi labeled tag. ,

HY-P704104

	HSP90AA1 Protein, Human (sf9, His) Hsp90AA1; Hsp90A; HspCAHeat shock protein Hsp 90-alpha	Human	Sf9 insect cells

HY-P72051

	HSP90AA1 Protein, Sus scrofa (Sf9, His) Hsp90AA1; Hsp90A; HspCAHeat shock protein Hsp 90-alpha	Others	Sf9 insect cells
	HSP90AA1 is a molecular chaperone that regulates target proteins involved in cell cycle control and signal transduction. It interacts with co-chaperones to regulate substrate recognition and chaperone function. HHSP90AA1 Protein, Sus scrofa (Sf9, His) is the recombinant HSP90AA1 protein, expressed by Sf9 insect cells , with N-6*His labeled tag.

HY-P703571

	HSP90b Protein, Human (Sf9) Hsp90B; HspC2; HspC3; HspCB	Human	Sf9 insect cells
	HSP90b Protein, Human (Sf9) is the recombinant human-derived HSP90b, expressed by Sf9 insect cells , with tag Free labeled tag.

HY-P703572

	HSP90b Protein, Human (Sf9, His, Strep) Hsp90B; HspC2; HspC3; HspCB	Human	Sf9 insect cells
	HSP90b Protein, Human (Sf9, His, Strep) is the recombinant human-derived HSP90b, expressed by Sf9 insect cells , with Strep, His labeled tag.

HY-P703083

	HSP90AA1 Protein, Human (His, Avi) Heat shock protein Hsp 90-alpha; Heat shock 86 kDa (Hsp 86; Hsp86); Heat shock protein family C member 1; Lipopolysaccharide-associated protein 2 (LAP-2; LPS-associated protein 2); Renal carcinoma antigen NY-REN-38; Hsp90A, HspC1, HspCA	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His, Avi) is the recombinant human-derived HSP90AA1, expressed by E. coli , with C-Avi, C-6*His labeled tag. ,

HY-P75363

	CDC37 Protein, Mouse (sf9) Hsp90 co-chaperone Cdc37; CDC37; CDC37A	Mouse	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with tag free and with residual Gly-Pro in N-terminal (not related to functional changes).

HY-P75362

	CDC37 Protein, Mouse (sf9, His-GST) Hsp90 co-chaperone Cdc37; CDC37; CDC37A	Mouse	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P71537

	TRAP1 Protein, Human (GST) Heat shock protein 75kDa; Heat shock protein 75kDa, mitochondrial; Hsp 75; Hsp75; Hsp90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein	Human	E. coli
	As a chaperone with ATPase activity, TRAP1 protein plays a crucial role in protecting mitochondrial function and polarization, especially downstream of PINK1 and mitochondrial complex I. TRAP1 acts as a negative regulator of mitochondrial respiration, affecting the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1 Protein, Human (GST) is the recombinant human-derived TRAP1 protein, expressed by E. coli , with N-GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-13757AS

Tamoxifen-d5
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity .

HY-13757S

Tamoxifen-d3 hydrochloride

Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen . Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80187

	Hsp90 beta Antibody (YA355)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Hsp90 beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to Hsp90 beta. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80714

	Hsp90 alpha/beta Antibody (YA356) Hsp90AA1; Hsp90A; HspC1; HspCA; Heat shock protein Hsp 90-alpha; Heat shock 86 kDa; Hsp 86; Hsp86; Renal carcinoma antigen NY-REN-38; Hsp90AB1; Hsp90B; HspC2; HspCB; Heat shock protein Hsp 90-beta; Hsp 90; Heat shock 84 kDa; Hsp 84; Hsp84	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Hsp90 alpha/beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 85 kDa, targeting to Hsp90 alpha/beta. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P83386

	p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3131), targeting p23, with a predicted molecular weight of 19 kDa (observed band size: 23 kDa). p23 Antibody (YA3131) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82880

	Hsp75 Antibody (YA2625) Hsp75; Hsp90L; Trap1	WB, IHC-P, ICC/IF	Human
	Hsp75 Antibody (YA2625) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2625), targeting Hsp75, with a predicted molecular weight of 80 kDa (observed band size: 75 kDa). Hsp75 Antibody (YA2625) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P82774

	GRP94 Antibody (YA2519) Endoplasmin; GRP-94; gp96 homolog; Hsp90B1; GRP 94; TRA1	WB, IHC-P, ICC/IF	Human, Mouse
	GRP94 Antibody (YA2519) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2519), targeting GRP94, with a predicted molecular weight of 92 kDa (observed band size: 92 kDa). GRP94 Antibody (YA2519) can be used for WB, IHC-P, ICC/IF experiment in human, mouse background.

HY-P83995

	HSP90AA1 Antibody (YA3692) HspN; LAP2; Hsp86; HspC1; HspCA; Hsp89; Hsp90; Hsp89A; Hsp90A; Hsp90N; HspCAL1; HspCAL4	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey

HY-P84003

	HSP90AB1 Antibody (YA3700) HspC2; HspCB; D6S182; Hsp90B; FLJ26984; Hsp90-BETA	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey