Search Result

Results for "

FGFR1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (1) Akt (1) AMPK (2) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (16) Aurora Kinase (3) Autophagy (18) Bcl-2 Family (1) Bcr-Abl (6) c-Fms (8) c-Kit (23) c-Met/HGFR (3) Caspase (1) CDK (2) Cytochrome P450 (1) Discoidin Domain Receptor (1) Drug Metabolite (3) EGFR (6) Endogenous Metabolite (5) Ephrin Receptor (1) ERK (1) FGFR (160) FLT3 (8) HDAC (1) IGF-1R (1) Insulin Receptor (1) IRAK (1) Isotope-Labeled Compounds (9) Itk (1) LIM Kinase (LIMK) (1) MAP3K (1) MAP4K (1) MELK (1) Mitosis (1) Necroptosis (1) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) PDGFR (51) Peptide-Drug Conjugates (PDCs) (1) PROTAC Linkers (1) PROTACs (3) Pyroptosis (1) Raf (3) Reactive Oxygen Species (1) Reference Standards (1) RET (9) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (4) Src (15) Syk (1) TGF-β Receptor (1) TNF Receptor (1) Trk Receptor (2) ULK (1) VEGFR (68) Wee1 (1)
By Research Areas:	Cancer (166) Cardiovascular Disease (5) Infection (1) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

182

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156019

FGFR1 inhibitor-10	FGFR	Cancer
FGFR1 inhibitor-10 (Compound 4i) is an *FGFR1* inhibitor (IC₅₀: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect ^[1].

HY-169669

FGFR1 inhibitor-17	FGFR	Cancer
FGFR1 inhibitor-17 (Compound 92) is a potent *FGFR1* inhibitor. FGFR1 inhibitor-17 is promising for research of cancers ^[1].

HY-149488

FGFR1 inhibitor-9	FGFR	Cancer
FGFR1 inhibitor-9 (Compound 7) is an *FGFR1* inhibitor (IC₅₀s: 0.85 nM). FGFR1 inhibitor-9 binds to the ATP-binding pocket of FGFR1. FGFR1 inhibitor-9 has anticancer activity ^[1].

HY-149487

FGFR1 inhibitor-8	FGFR	Cancer
FGFR1 inhibitor-8 (Compound 9) is a *FGFR1* inhibitor (IC₅₀s: 0.5 nM). FGFR1 inhibitor-8 binds to the ATP-binding pocket of FGFR1. FGFR1 inhibitor-8 has anticancer activity ^[1].

HY-169710

FGFR1 inhibitor-16	FGFR	Cancer
FGFR1 inhibitor-16 (Compound 89) is an *FGFR1* inhibitor. FGFR1 inhibitor-16 exhibits an inhibitory rate of 53.00% against *FGFR1* at a concentration of 50 μM and 24.95% at 10 μM. FGFR1 inhibitor-16 can be used in the study of cancer ^[1].

HY-172618

FGFR1 inhibitor-18	FGFR	Cancer
FGFR1 inhibitor-18 (compound 16) is a potent *FGFR1* inhibitor with an IC₅₀ value of 1.31 nM. FGFR1 inhibitor-18 can occupy within the ATP-binding pocket of the target FGFR1 ^[1].

HY-W261325

FGFR1 inhibitor-15	FGFR	Cancer
FGFR1 inhibitor-15 (Compound 23) is an *FGFR1* inhibitor with an IC₅₀ of 27 μM. FGFR1 inhibitor-15 can be used in the study of cancer ^[1].

HY-143272

FGFR1 inhibitor-6	FGFR	Cancer
FGFR1 inhibitor-6 is a potent *FGFR1* inhibitor with an IC₅₀ value of 16.31 nM. FGFR1 inhibitor-6 shows cytotoxic activities. FGFR1 inhibitor-6 induces apoptosis and cell cycle arrest at pre-G1 and G2/M phase ^[1].

HY-W801893

FGFR1 inhibitor-13	FGFR	Cancer
FGFR1 inhibitor-13 (compound 1) is an FGFR1 inhibitor with an IC₅₀ of 4.2 μM ^[1].

HY-139376

FGFR1 inhibitor-2	FGFR	Cancer
FGFR1 inhibitor-2 is a *FGFR1* inhibitor (IC₅₀ is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer ^[1].

HY-169623

FGFR1 inhibitor-14	FGFR	Cancer
FGFR1 inhibitor-14 (compound 28) is a *FGFR1* inhibitor, which can be used in anti-cancer research ^[1].

HY-158098

FGFR1 inhibitor-11	FGFR	Metabolic Disease
FGFR1 inhibitor-11 (compound 5g) binds to *FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1* inhibitor-11 has oral bioactivity ^[1].

HY-149486

FGFR1 inhibitor 7	FGFR	Cancer
FGFR1 inhibitor 7 (compound 5) is an inhibitor of FGFR1 Tyrosine Kinase with IC₅₀ value of 0.33 nM. FGFR1 inhibitor 7 shows broad-spectrum cytotoxicity agasinst human cancer cell lines, and inhibits MOLT3 cells with IC₅₀ of 2.1 μM ^[1].

HY-RS04911

FGFR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) FGFR	Others
FGFR1 Human Pre-designed siRNA Set A contains three designed siRNAs for FGFR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FGFR1 Human Pre-designed siRNA Set A FGFR1 Human Pre-designed siRNA Set A

HY-RS04912

Fgfr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) FGFR	Others
Fgfr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgfr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgfr1 Mouse Pre-designed siRNA Set A Fgfr1 Mouse Pre-designed siRNA Set A

HY-RS04913

Fgfr1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) FGFR	Others
Fgfr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgfr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgfr1 Rat Pre-designed siRNA Set A Fgfr1 Rat Pre-designed siRNA Set A

HY-149512

FGFR1/VEGFR2-IN-1	FGFR VEGFR	Cancer
FGFR1/VEGFR2-IN-1 (compound 2b) is an *FGFR1/VEGFR2* inhibitor. FGFR1/VEGFR2-IN-1 can be used for cancer research ^[1].

HY-168597

FGFR1/VEGFR2-IN-3	FGFR Apoptosis VEGFR	Cancer
FGFR1/VEGFR2-IN-3 (Compound 8m) is a dual inhibitor of *FGFR1/VEGFR2. FGFR1*/VEGFR2-IN-3 exhibits anti-proliferative and anti-migratory activities against cancer cells, and is capable of inducing cell apoptosis ^[1].

HY-161995

FGFR1/VEGFR2-IN-2	Apoptosis Necroptosis FGFR VEGFR PDGFR	Cancer
FGFR1/VEGFR2-IN-2 (compound 6l) is a *VEGFR2/FGFR1* dual inhibitor. The IC₅₀ values for VEGFR2 and *FGFR1* are 0.025 µM and 0.026 µM respectively, and for EGFR and PDGFR-β, the IC₅₀ values are 0.106 µM and 0.077 µM. FGFR1/VEGFR2-IN-2 showes significant anti-cancer activity (GI=60.38%) on NCI-60 cell line, with an IC₅₀ of 8.51 µM in T-47D cell line and anti-migration. FGFR1/VEGFR2-IN-2 acts to arrest cells in the G1 phase and promote apoptosis and necrosis; the IC₅₀ for MCF-7 cell line exceeds 100 µM, and the IC₅₀ for MDA-MB-231 is 69.17 µM, non-toxic to normal cells ^[1].

HY-114311

FGFR1/DDR2 inhibitor 1 1 Publications Verification	FGFR Discoidin Domain Receptor	Cancer
FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC₅₀ values of 31.1 nM and 3.2 nM, respectively. Antitumor activity ^[1].

HY-RS04914

FGFR1OP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FGFR1OP2 Human Pre-designed siRNA Set A contains three designed siRNAs for FGFR1OP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FGFR1OP2 Human Pre-designed siRNA Set A FGFR1OP2 Human Pre-designed siRNA Set A

HY-170869

*PROTAC FGFR1* degrader-1**	PROTACs FGFR	Cancer
PROTAC FGFR1 degrader-1 (compound S2H) is a PROTAC degrader targeting FGFR1, with IC₅₀=26.81 nM and DC₅₀=39.78 nM in KG1a cells. PROTAC FGFR1 degrader-1 is composed of CRBN-type E3 ligase ligand (blue part) Pomalidomide (HY-10984), target protein ligand (red part) FGFR1 ligand-1 (HY-170871), and PROTAC linker (black part) 9-Bromononanoic acid (HY-W007587), in which the E3 ligase ligand and linker form a conjugate E3 Ligase Ligand-linker Conjugate 164 (HY-170870) ^[1].

HY-P990415

*Anti-FGFR1/CD331 Antibody*	FGFR	Inflammation/Immunology
The Anti-FGFR1/CD331 Antibody is a humanized antibody expressed in CHO cells, targeting *FGFR1/CD331. The Anti-FGFR1/CD331 Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-FGFR1*/CD331 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-W007587

9-Bromononanoic acid	PROTAC Linkers	Cancer
9-Bromononanoic acid is a PROTAC linker. 9-Bromononanoic acid can be used in synthesis PROTAC FGFR1 degrader-1 (HY-170869) ^[1].

HY-136605

DGY-06-116 2 Publications Verification	Src	Cancer
DGY-06-116 is an irreversible covalent, selective Src inhibitor with an IC₅₀ of 3nM. DGY-06-116 inhibits FGFR1 with an IC₅₀ of 8340 nM ^[1].

HY-101544

ARQ 069	FGFR	Cancer
ARQ 069, an analog of ARQ 523, inhibits *FGFR* in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases (IC₅₀s of 0.84 μM and 1.23 μM, respectively). ARQ 069 inhibits FGFR1/FGFR2 autophosphorylation (IC₅₀s of 2.8 and 1.9 μM, respectively) through a mechanism in a non-ATP competitive dependent manner ^[1].

HY-N0060

Ferulic acid 5+ Cited Publications Coniferic acid	FGFR Endogenous Metabolite	Cancer
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-N0060A

Ferulic acid sodium 5+ Cited Publications Coniferic acid sodium	FGFR Endogenous Metabolite Reactive Oxygen Species	Cardiovascular Disease Cancer
Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-15813

FIIN-1 FGFR irreversible inhibitor-1	FGFR	Cancer
FIIN-1 is a potent, irreversible, selective *FGFR* inhibitor. FIIN-1 binds to *FGFR1/2/3/4* and *Flt1/4* with K_ds of 2.8/6.9/5.4/120 nM and 32/120 nM respectively. The biochemical IC₅₀s of FIIN-1 are 9.2, 6.2, 11.9, and 189 nM against FGFR1/2/3/4, respectively ^[1].

HY-172921

FGFR-IN-18	FGFR	Cancer
FGFR-IN-18 (Compound KF7) is a lysine-targeting *FGFR* covalent inhibitor, with IC₅₀s of: 1.1 nM for FGFR2, 1.3 nM for FGFR1, 31.5 nM for FGFR4. FGFR-IN-18 also has affinity for FGFR3 (inhibition rate of 52% at 10 nM). FGFR-IN-18 covalently modifies Lys485 (an reactive site of FGFRs) .

HY-162153

CYY292	FGFR	Cancer
CYY292 is an *FGFR1* inhibitor that specifically targets the FGFR1/AKT/Snail pathway in GBM cells. CYY292 dose-dependently inhibits cancer cell proliferation, epithelial-mesenchymal transition, stemness, invasion, and migration in vitro ^[1].

HY-P990964

Efimosfermin alfa	FGFR	Inflammation/Immunology
HY-P990964 is an *FGFR1*-targeting human antibody ^[1].

HY-10321

PD173074 15+ Cited Publications	FGFR VEGFR Apoptosis	Cancer
PD173074 is a potent *FGFR1* inhibitor with an IC₅₀ of 25 nM and also inhibits VEGFR2 with an IC₅₀ of 100-200 nM, showing 1000-fold selectivity for FGFR1 over PDGFR and c-Src.

HY-16135A

CEP-11981 tosylate ESK981 tosylate; BOL 303213X tosylate	VEGFR FGFR	Others Cancer
CEP-11981 (tosylate) (ESK981 (tosylate), BOL 303213X (tosylate)) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, *VEGFR1-3* and *FGFR1*, and has potential anti-tumor and anti-angiogenic effects ^[1].

HY-16135

CEP-11981 ESK981; BOL 303213X	VEGFR FGFR	Cancer
CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, *VEGFR1-3* and *FGFR1*, and has potential anti-tumor and anti-angiogenic effects ^[1].

HY-12047

Ponatinib 35+ Cited Publications AP24534	Bcr-Abl PDGFR VEGFR FGFR Src Autophagy	Cancer
Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC₅₀s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, *FGFR1, and Src*, respectively ^[1].

HY-N0060S1

Ferulic acid-13C3	Isotope-Labeled Compounds FGFR Endogenous Metabolite	Cancer
Ferulic acid- ¹³C₃ is the ¹³C-labeled Ferulic acid. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

HY-N0060R

Ferulic acid (Standard)	FGFR Endogenous Metabolite	Cancer
Ferulic acid (Standard) is the analytical standard of Ferulic acid. This product is intended for research and analytical applications. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

HY-108766

Ponatinib hydrochloride 35+ Cited Publications AP24534 hydrochloride	Bcr-Abl FGFR PDGFR VEGFR Src Autophagy	Infection Cancer
Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC₅₀s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, *FGFR1, and Src*, respectively ^[1].

HY-123134

FIIN-4	FGFR	Cancer
FIIN-4 is a first-in-class, orally active and covalent *FGFR* inhibitor with IC₅₀s of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FIIN-4 can inhibit metastatic tumor growth.

HY-101466A

E7090 succinate	FGFR	Cancer
E7090 succinate is an orally available, selective and potent inhibitor of **FGFR1, FGFR2 and FGFR3 tyrosine kinase activities, with IC₅₀** values of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/2/3/4, respectively ^[1].

HY-101296

PD-166866 5+ Cited Publications	FGFR Autophagy	Cancer
PD166866 is a selective *FGFR1* tyrosine kinase inhibitor with an IC₅₀ of 52.4 nM.

HY-N7715

Ferulic acid acyl-β-D-glucoside Ferulic acid glucoside	Drug Metabolite	Others
Ferulic acid acyl-β-D-glucoside is a metabolite of Ferulic Acid (HY-N0060) ^[1]. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively .

HY-118203

SU4984	FGFR PDGFR Insulin Receptor	Cancer
SU4984 is a protein tyrosine kinase inhibitor, with an IC₅₀ of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer ^[1] .

HY-10517A

(Z)-Orantinib (Z)-SU6668; (Z)-TSU-68	VEGFR PDGFR FGFR	Cancer
(Z)-Orantinib ((Z)-SU6668) is a potent, selective, orally active and ATP competitive inhibitor of *Flk‐1/KDR, PDGFRβ, and FGFR1, with IC₅₀*s of 2.1, 0.008, and 1.2 µM, respectively. (Z)-Orantinib is a potent antiangiogenic and antitumor agent that induces regression of established tumors ^[1] .

HY-10321R

PD173074 (Standard)	FGFR VEGFR Apoptosis	Cancer
PD173074 (Standard) is the analytical standard of PD173074. This product is intended for research and analytical applications. PD173074 is a potent FGFR1 inhibitor with an IC50 of 25 nM and also inhibits VEGFR2 with an IC50 of 100-200 nM, showing 1000-fold selectivity for FGFR1 over PDGFR and c-Src.

HY-12047S

Ponatinib-d8 AP24534-d₈	Bcr-Abl PDGFR VEGFR FGFR Src Autophagy	Cancer
Ponatinib-d₈ is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

HY-101768

PRN1371 1 Publications Verification	FGFR c-Fms	Cancer
PRN1371 is a highly selective and potent *FGFR1-4* and *CSF1R* inhibitor with IC₅₀s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, FGFR2, FGFR3, FGFR4 and CSF1R, respectively ^[1].

HY-P10870

Pep1-DNP conjugate 9	Peptide-Drug Conjugates (PDCs) FGFR Apoptosis	Cancer
Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to *FGFR1* with K_D of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models ^[1].

HY-15599

SSR128129E 1 Publications Verification SSR	FGFR	Cancer
SSR128129E is an orally available and allosteric *FGFR* inhibitor with an IC₅₀ of 1.9 μM for FGFR1.

Cat. No.	Product Name	Type

HY-10407G

SU 5402 (GMP)	Fluorescent Dye
SU 5402 (GMP) is SU 5402 (HY-10407) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC₅₀ of 20 nM, 30 nM, and 510 nM for VEGFR2, *FGFR1, and PDGFRβ*, respectively ^[1].

Cat. No.	Product Name	Type

HY-10407G

SU 5402 (GMP)	Biochemical Assay Reagents
SU 5402 (GMP) is SU 5402 (HY-10407) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC₅₀ of 20 nM, 30 nM, and 510 nM for VEGFR2, *FGFR1, and PDGFRβ*, respectively ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P10870

Pep1-DNP conjugate 9	Peptide-Drug Conjugates (PDCs) FGFR Apoptosis	Cancer
Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to *FGFR1* with K_D of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P99614

Fazpilodemab BFKB8488A; RG-7992; RO-7040551	FGFR	Metabolic Disease
Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD) ^[1].

HY-P990415

*Anti-FGFR1/CD331 Antibody*	FGFR	Inflammation/Immunology
The Anti-FGFR1/CD331 Antibody is a humanized antibody expressed in CHO cells, targeting *FGFR1/CD331. The Anti-FGFR1/CD331 Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-FGFR1*/CD331 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990964

Efimosfermin alfa	FGFR	Inflammation/Immunology
HY-P990964 is an *FGFR1*-targeting human antibody ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0060

Ferulic acid 5+ Cited Publications Coniferic acid	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols other families Simple Phenylpropanols Sunscreen Phenols Phenylpropanoids Cosmetic Research Disease Research Fields Cancer	FGFR Endogenous Metabolite
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-N0060A

Ferulic acid sodium 5+ Cited Publications Coniferic acid sodium	Structural Classification Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Endogenous metabolite Disease Research Fields Cancer	FGFR Endogenous Metabolite Reactive Oxygen Species
Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for *FGFR1* and *FGFR2*, respectively.

HY-N7715

Ferulic acid acyl-β-D-glucoside Ferulic acid glucoside	Monophenols Classification of Application Fields Simple Phenylpropanols Source classification Other Diseases Rosaceae Phenols Phenylpropanoids Plants Aruncus sylvester Kostel. Disease Research Fields	Drug Metabolite
Ferulic acid acyl-β-D-glucoside is a metabolite of Ferulic Acid (HY-N0060) ^[1]. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively .

HY-N0060R

Ferulic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols other families Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Endogenous metabolite	FGFR Endogenous Metabolite
Ferulic acid (Standard) is the analytical standard of Ferulic acid. This product is intended for research and analytical applications. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

HY-W011873R

Palmitoleic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Pazopanib (Hydrochloride) (Standard) is the analytical standard of Pazopanib (Hydrochloride). This product is intended for research and analytical applications. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

Recombinant Proteins Recommended:

Species:	Human (14) Rhesus Macaque (2) Mouse (2)
Tag:	His (12) Avi (5) GST (1) Fc (6) Flag (1)
Source:	HEK293 (16) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75765

	FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 1; FGFR-1; FGF R1b; FGFR1 beta	Human	HEK293
	FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293 , with C-hFc labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc), has molecular weight of 76-106 kDa.

HY-P77659

	FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) FGF R1a; FGFR1 alpha	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P75768

	FGFR-1 Protein, Mouse (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Mouse	HEK293
	The FGFR-1 protein is a tyrosine-protein kinase receptor for fibroblast growth factors that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77660

	FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) FGF R1a; FGFR1 alpha	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P75770

	FGFR-1 Protein, Rhesus Macaque (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Rhesus Macaque	HEK293
	FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR-1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived FGFR-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P73055

	FGFR-1 beta Protein, Human (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; CEK; FGFBR, FLG	Human	HEK293
	FGFR-1 beta Protein, Human (HEK293, His) is the recombinant human-derived FGFR-1 beta protein, expressed by HEK293 , with C-His labeled tag.

HY-P75766

	FGFR-1 beta (IIIb) Protein, Human (HEK293, His) Fibroblast growth factor receptor 1; FGFR-1; FGF R1b; FGFR1 beta	Human	HEK293
	FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293 , with C-His labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, His), has molecular weight of 45-60 kDa.

HY-P702758

	FGFR-1 alpha Protein, Human (Biotinylated, sf9, Flag, Avi) FGF R1a; FGFR1 alpha	Human	Sf9 insect cells
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha Protein, Human (Biotinylated, sf9, Flag, Avi) is the recombinant human-derived FGFR-1 alpha, expressed by Sf9 insect cells , with Avi, Flag labeled tag.

HY-P75767

	FGFR-1 Protein, Mouse (HEK293, Fc) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Mouse	HEK293
	The FGFR-1 protein is a tyrosine-protein kinase receptor for fibroblast growth factors that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75769

	FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; HBGFR	Rhesus Macaque	HEK293
	FGFR-1 protein is a tyrosine-protein kinase that acts as a cell surface receptor for fibroblast growth factor and plays a critical role in the complex regulation of embryonic development, cell proliferation, differentiation, and migration. FGFR-1 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73054

	FGFR-1 beta Protein, Human (HEK293, His-Fc) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; CEK; FGFBR, FLG	Human	HEK293
	FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta Protein, Human (HEK293, His-Fc) is the recombinant human-derived FGFR-1 beta protein, expressed by HEK293 , with C-8*His, C-hFc labeled tag.

HY-P76927

	FGFR1OP Protein, Human (sf9, His-GST) Centrosomal protein 43; FGFR1 oncogene partner; CEP43; FOP	Human	Sf9 insect cells
	FGFR1OP is critical for microtubule dynamics, anchoring microtubules at centrosomes, which is critical for cell organization. It plays an integral role in cilia formation and helps control the complex process of cilia formation. FGFR1OP Protein, Human (sf9, His-GST) is the recombinant human-derived FGFR1OP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P700720

	FGFR-1 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) FGFR-1; BFGFR; bFGF-R-1; FLT-2; N-sam; CD331;	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 beta, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P700436

	FGFR-1 beta Protein, Human (HEK293, hFc) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; FLT-2; CD331; CEK; FGFBR, FLG	Human	HEK293
	FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta Protein, Human (HEK293, hFc) is the recombinant human-derived FGFR-1 beta protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77654

	FGFR-1 beta (IIIc) Protein, Human (HEK293, His-Avi) Fibroblast growth factor receptor 1; FGFR-1; BFGFR; bFGF-R-1; FLT-2; CD331;	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 beta (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 beta, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P700635

	FGFR-1 alpha Protein, Human (HEK293, C-His) rHuFGFR-1α, Fc Chimera; BFGFR; CD331; FLT-2	Human	HEK293
	FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha Protein, Human (HEK293, C-His) is the recombinant human-derived FGFR-1 alpha protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P75763

	FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc) Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha	Human	HEK293
	FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293 , with C-hFc labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc), has molecular weight of ~113.3 kDa.

HY-P75764

	FGFR-1 alpha (IIIb) Protein, Human (HEK293, His) Fibroblast growth factor receptor 2; FGFR-2; FGF R2a; FGFR2 alpha	Human	HEK293
	FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293 , with C-His, C-10*His labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His), has molecular weight of 60-90 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-N0060S1

Ferulic acid-13C3
Ferulic acid- ¹³C₃ is the ¹³C-labeled Ferulic acid. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

HY-12047S

Ponatinib-d8
Ponatinib-d₈ is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

HY-13311S

Infigratinib-d3
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the *FGFR* family, with IC₅₀ values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for *FGFR1, FGFR2, FGFR3, and FGFR4*, respectively ^[1].

HY-10981S

Lenvatinib-d4
Lenvatinib-d₄ is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities ^[1] .

HY-10208S

Pazopanib-d6
Pazopanib-d₆ is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

HY-12009S

Pazopanib-13C,d3 hydrochloride
Pazopanib- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Pazopanib hydrochloride ^[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC₅₀ of 10, 30, 47, 84, 74, 140 and 146 nM, respectively .

HY-W758126

(R)-Brivanib alaninate-d4
(R)-Brivanib alaninate-d₄ is the deuterium-labeled Brivanib (alaninate) (HY-10336). Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC₅₀ of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ ^[1].

HY-10981S1

Lenvatinib-d5
Lenvatinib-d₅ is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities ^[1] .

HY-50905S

Dovitinib-d8
Dovitinib-d₈ is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively ^[1] .

HY-10981S2

Lenvatinib-15N,d4
Lenvatinib- ¹⁵N,d₄ is ¹⁵N and deuterated labeled Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits *VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET*, shows potent antitumor activities ^[1] .

HY-W705479

Pazopanib-d3 hydrochloride
Pazopanib-d₃ (hydrochloride) (GW786034-d₃ (hydrochloride)) is deuterium labeled Pazopanib (Hydrochloride). Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of *VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms* with an IC₅₀ of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

HY-10208S1

Pazopanib-13C,d3
Pazopanib- ¹³C,d₃ is the deuterium and ¹³C labeled Pazopanib ^[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC₅₀s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively .

HY-10208S2

Pazopanib-d3
Pazopanib-d₃ (GW786034-d₃) is deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of *VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms* with IC₅₀s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively ^[1].

HY-W754878

Pemigatinib-d6
Pemigatinib-d₆ (INCB054828-d₆) is deuterium labeled Pemigatinib. Pemigatinib (INCB054828) is an orally active, selective *FGFR* inhibitor with IC₅₀s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma ^[1] .

HY-151903S

FGFR2/3-IN-1
FGFR2/3-IN-1 is a potent and selective FGFR2 and FGFR3 (FGFR) inhibitor with IC₅₀s of 1 nM and 0.5 nM, respectively. FGFR2/3-IN-1 displays >40-fold selectivity over FGFR1/FGFR4 and other kinome. FGFR2/3-IN-1 also inhibits FGFR3 V555L and V555M mutants with IC₅₀s of 2.7 nM and 6.1 nM, respectively ^[1].

HY-50904S

Nintedanib-d3
Nintedanib-d₃ is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

HY-50904S2

Nintedanib-d8
Nintedanib-d₈ is deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

HY-50904S1

Nintedanib-13C,d3
Nintedanib- ¹³C,d₃ is the ¹³C- and deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80395

	FGFR1 Antibody (YA441)	WB, ICC/IF	Human
	FGFR1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 100,140 kDa, targeting to FGFR1. It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P80396

	FGFR1 Oncogene Partner Antibody (YA440)	WB, IHC-P	Human, Mouse, Rat
	FGFR1 Oncogene Partner Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43 kDa, targeting to FGFR1 Oncogene Partner. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P84060

	FGFR1 Antibody (YA3757) CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR	WB, ELISA	Human