2. Protein Tyrosine Kinase/RTK Autophagy
  3. Bcr-Abl FGFR PDGFR VEGFR Src Autophagy
  4. Ponatinib hydrochloride (Standard)

Ponatinib hydrochloride (Standard) 

Cat. No.: HY-108766R Purity: ≥98%
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Ponatinib (hydrochloride) (Standard) is the analytical standard of Ponatinib (hydrochloride). This product is intended for research and analytical applications. Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

For research use only. We do not sell to patients.

Ponatinib hydrochloride (Standard) Chemical Structure

Ponatinib hydrochloride (Standard) Chemical Structure

CAS No. : 1114544-31-8

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Description

Ponatinib (hydrochloride) (Standard) is the analytical standard of Ponatinib (hydrochloride). This product is intended for research and analytical applications. Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

Molecular Weight

569.02

Formula

C29H28ClF3N6O
CAS No.
SMILES

O=C(C1=CC=C(C)C(C#CC2=CN=C3C=CC=NN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4.Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Ponatinib hydrochloride (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ponatinib hydrochloride (Standard)1114544-31-8Bcr-AblFGFRPDGFRVEGFRSrcAutophagyFibroblast growth factor receptorPlatelet-derived growth factor receptorVascular endothelial growth factor receptororally activemulti-targetedkinaseAblPDGFRαVEGFR2FGFR1Inhibitorinhibitorinhibit

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