Aquaporin

By Targets:	Aquaporin (9) Apoptosis (1) Liposome (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) PROTAC Linkers (2) Pyroptosis (1) Reference Standards (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Phospholipids (1)

Targets Recommended: Aquaporin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W008574A

TGN-020 sodium Maximum Cited Publications 17 Publications Verification	PROTAC Linkers	Inflammation/Immunology Cancer
TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

HY-W008574

TGN-020 Maximum Cited Publications 17 Publications Verification	PROTAC Linkers	Inflammation/Immunology Cancer
TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

HY-115460

AER-271 1 Publications Verification	Aquaporin	Cardiovascular Disease Neurological Disease
AER-271, a phosphonate proagent derivative of AER-270, is an *aquaporin-4* (AQP4) inhibitor for the research of acute ischemic stroke .

HY-W176557

TGN-073	Aquaporin	Neurological Disease
TGN-073 is a facilitator of aquaporin-4 (AQP4), an astroglial water channel. TGN-073 reveals an increase of up to 41% in glymphatic transport in rat brain .

HY-126073

DFP00173 4 Publications Verification	Aquaporin	Inflammation/Immunology Cancer
DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC₅₀ of ～0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9 .

HY-126074

Z433927330 1 Publications Verification	Aquaporin	Others
Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC₅₀s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively .

HY-P10937

AQP4 (205-215)	Aquaporin	Inflammation/Immunology
AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .

HY-P10937A

AQP4 (205-215) TFA	Aquaporin	Inflammation/Immunology
AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .

HY-N6016R

Bacopaside II (Standard)	Reference Standards Apoptosis Aquaporin	Cancer
Bacopaside II (Standard) is the analytical standard of Bacopaside II. This product is intended for research and analytical applications. Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis .

HY-142980

Dioleoylphosphatidylglycerol DOPG	Liposome	Inflammation/Immunology
Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .

HY-157979

AQP3-IN-1	Aquaporin	Cancer
AQP3-IN-1 (compounds 3) is an AQP3 inhibitor with a IC₅₀ value of 8.91 μM. AQP3-IN-1 inhibits cell proliferation of melanoma cells .

HY-161834

RG100204	Pyroptosis Aquaporin NOD-like Receptor (NLR) p38 MAPK	Infection Metabolic Disease Inflammation/Immunology
RG100204 is a selective, orally available inhibitor of the aquaporin AQP9. RG100204 directly inhibits AQP9 channel function, preventing the transmembrane transport of water, glycerol, and H ²O ². RG100204 reduces the activation of the NLRP3 inflammasome and p38 MAPK signaling pathways, thereby alleviating inflammation and pyroptosis. RG100204 reduces multi-organ dysfunction in a mouse sepsis model and shows glucose-regulating effects in diabetic db/db mice .

Cat. No.	Product Name	Type

HY-142980

Dioleoylphosphatidylglycerol DOPG	Drug Delivery
Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .

Cat. No.	Product Name	Target	Research Area

HY-P5513

Aquaporin-2 (254-267), pSER261, human	Peptides	Others
Aquaporin-2 (254-267), pSER261, human is a biological active peptide. (This peptide is a fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser261. Protein phosphorylation plays a key role in vasopressin signaling in renal-collecting duct. Phosphorylation at several AQP2 residues including Ser256 and Ser261, is altered in response to vasopressin. It is possible that both sites are involved in vasopressin-dependent AQP2 trafficking.)

HY-P10937

AQP4 (205-215)	Aquaporin	Inflammation/Immunology
AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .

HY-P10937A

AQP4 (205-215) TFA	Aquaporin	Inflammation/Immunology
AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6016R

Bacopaside II (Standard)	Triterpenes Structural Classification Terpenoids Source classification Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst.	Reference Standards Apoptosis Aquaporin
Bacopaside II (Standard) is the analytical standard of Bacopaside II. This product is intended for research and analytical applications. Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis .

Species:	Human (4) Mouse (2)
Tag:	His (4) SUMO (2) Tag Free (1) GST (1)
Source:	E. coli Cell-free (2) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P72086

	AQP1 Protein, Human (GST) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; Aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; ; Aquaporin 1 Colton blood group; ; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO;	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (GST) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P72087

	AQP4 Protein, Human (His-SUMO) AQP 4; AQP-4; AQP4; AQP4_HUMAN; Aquaporin type 4; Aquaporin-4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; Mercurial-insensitive water channel; MGC22454; MIWC; WCH 4; WCH4	Human	E. coli
	The AQP4 protein forms water-specific channels and is involved in brain water balance and solute transport. AQP4 Protein, Human (His-SUMO) is the recombinant human-derived AQP4 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P72087A

	AQP4 Protein, Human (His) AQP 4; AQP-4; AQP4; AQP4_HUMAN; Aquaporin type 4; Aquaporin-4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; Mercurial-insensitive water channel; MGC22454; MIWC; WCH 4; WCH4	Human	E. coli
	The AQP4 protein forms water-specific channels and is involved in brain water balance and solute transport. AQP4 Protein, Human (His) is the recombinant human-derived AQP4, expressed by E. coli, with N-6His labeled tag. The total length of AQP4 Protein, Human (His) is 71 a.a.*.

HY-P702215

	AQP4 Protein, Mouse (Cell-Free) Aquaporin-4; Mercurial-insensitive water channel; MIWC; WCH4	Mouse	E. coli Cell-free
	The AQP4 protein forms water-specific channels that are critical for brain water homeostasis and lymphoid solute transport. It regulates water exchange at the blood-brain interface, promoting the influx of cerebrospinal fluid into the brain and the drainage of interstitial fluid. AQP4 Protein, Mouse (Cell-Free) is the recombinant mouse-derived AQP4 protein, expressed by E. coli Cell-free , with tag free.

HY-P702216

	AQP4 Protein, Mouse (Cell-Free, His) Aquaporin-4; Mercurial-insensitive water channel; MIWC; WCH4	Mouse	E. coli Cell-free
	The AQP4 protein forms water-specific channels that are critical for brain water homeostasis and lymphoid solute transport. It regulates water exchange at the blood-brain interface, promoting the influx of cerebrospinal fluid into the brain and the drainage of interstitial fluid. AQP4 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived AQP4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P72085

	AQP1 Protein, Human (His-SUMO) AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; Aquaporin 1 channel-forming integral protein; 28kDa; CO blood group; Aquaporin 1 Colton blood group; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; Water channel protein CHIP 29; Water channel protein CHIP29; Water channel protein for red blood cells and kidney proximal tubule	Human	E. coli
	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (His-SUMO) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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HY-P81136

	Aquaporin 5 Antibody 1 Publications Verification Aquaporin 5; AQP5; AQP 5; AQP-5; AQP5_HUMAN; Aquaporin-5.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
	Aquaporin 5 Antibody is an unconjugated, approximately 29 kDa, rabbit-derived, anti-Aquaporin 5 polyclonal antibody. Aquaporin 5 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: dog, pig, cow, horse, sheep background without labeling.

HY-P83459A

	Aquaporin 4 Antibody Aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.	WB, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
	Aquaporin 4 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Aquaporin 4, with a predicted molecular weight of 36 kDa (observed band size: 34 kDa). Aquaporin 4 Antibody can be used for WB, IHC-P, IHC-F, FC, ICC/IF experiments in human, mouse, rat, pig, cow, rabbit, sheep backgrounds.

HY-P81400

	Aquaporin 3 Antibody (YA1145) Aquaporin 3; AQP-3; Aquaglyceroporin-3; AQP3	IHC-P	Human
	Aquaporin 3 Antibody (YA1145) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1145), targeting Aquaporin 3. Aquaporin 3 Antibody (YA1145) can be used for IHC-P experiment in human background.

HY-P86785

	Aquaporin 5 Antibody (YA6478) AQP 5 antibody; AQP-5 antibody; AQP5 antibody; AQP5_HUMAN antibody; Aquaporin 5 antibody; Aquaporin-5 antibody	WB, IHC-P, IF-Tissue	Human

HY-P82397

	Aquaporin 2 Antibody (YA2142) AQP-CD; WCH-CD	WB, IHC-P, IP	Human
	Aquaporin 2 Antibody (YA2142) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2142), targeting Aquaporin 2, with a predicted molecular weight of 29 kDa (observed band size: 37 kDa). Aquaporin 2 Antibody (YA2142) can be used for WB, IHC-P, IP experiment in human background.

HY-P83459

	Aquaporin 4 Antibody (YA3204) AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4	IHC-P	Human, Rat
	Aquaporin 4 Antibody (YA3204) is a non-conjugated IgG antibody, targeting Aquaporin 4. Aquaporin 4 Antibody (YA3204) can be used for IHC-P experiment in human, rat background.

HY-P81404

	Aquaporin 1 Antibody (YA1149) AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule	IHC-P	Human
	Aquaporin 1 Antibody (YA1149) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1149), targeting Aquaporin 1. Aquaporin 1 Antibody (YA1149) can be used for IHC-P experiment in human background.

HY-P85657

	AQP4 Antibody (YA5349) AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	AQP4 Antibody (YA5349) is a mouse-derived and non-conjugated monoclonal antibody, targeting to AQP4. It can be applicated for WB, IHC-P, ICC/IF assays, in the background of human, mouse, rat.

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HY-142980

Dioleoylphosphatidylglycerol DOPG		Phospholipids
Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .

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Aquaporin

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