Aquaporin 4 Antibody (YA3204)

Cat. No.: HY-P83459: Data Sheet User Guide for Antibodies
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Aquaporin 4 Antibody (YA3204) is a non-conjugated IgG antibody, targeting Aquaporin 4. Aquaporin 4 Antibody (YA3204) can be used for IHC-P experiment in human, rat background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 5 - 6 weeks 4 - 5 weeks 4 - 5 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 5 - 6 weeks 4 - 5 weeks 4 - 5 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 5 - 6 weeks 4 - 5 weeks 4 - 5 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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Aquaporin 4 Antibody (YA3204) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	Aquaporin 4 Antibody (YA3204) is a non-conjugated IgG antibody, targeting Aquaporin 4. Aquaporin 4 Antibody (YA3204) can be used for IHC-P experiment in human, rat background.
Background	AQP4, a water-specific channel, is instrumental in maintaining brain water homeostasis and facilitating glymphatic solute transport. It plays a crucial role in regulating the exchange of water across the blood-brain interface, influencing cerebrospinal fluid influx into the brain cortex and parenchyma through paravascular spaces surrounding penetrating arteries. Additionally, AQP4 is essential for the proper drainage of interstitial fluid along paravenous pathways, contributing to the normal clearance of solutes, including soluble beta-amyloid peptides derived from APP, from the brain interstitial fluid. While redundant in urinary water homeostasis and concentrating ability, AQP4 forms homotetramers, with the tetramers capable of organizing into oligomeric arrays of varying sizes in membranes. This oligomerization can facilitate cell-cell adhesion through interactions between AQP4 arrays in adjacent cells. AQP4 is also part of a complex involving MLC1, TRPV4, HEPACAM, and ATP1B1, highlighting its role within a larger molecular network.
Gene ID	361 [NCBI]
SwissProt ID	P55087
Synonyms	AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4
Molecular Weight	Predicted band size: 35 kDa; Observed band size: 35 kDa
Purity	Affinity Chromatography
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Cell Biology
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Rat
Dilution Ratio	IHC: 1/50-1/100
Application	IHC-P
Appearance	Liquid
Formulation	Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human AQP4
Database	Entrez Gene: 361 Human ; 11829 Mouse ; 25293 Rat SwissProt: P55087 Human ; P55088 Mouse ; P47863 Rat OMIM: 620448 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

Aquaporin 4 Antibody (YA3204) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Aquaporin 4 Antibody (YA3204)

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Aquaporin 4 Antibody (YA3204) Related Classifications

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