Search Result

Results for "

278

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Arenavirus (1) Bacterial (1) Calcium Channel (2) CDK (1) COX (1) Dengue Virus (1) DNA/RNA Synthesis (2) Drug Isomer (1) DYRK (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Fluorescent Dye (1) Fungal (2) Histone Methyltransferase (2) HIV (4) Isotope-Labeled Compounds (5) MMP (2) NAMPT (1) Nuclear Hormone Receptor 4A/NR4A (2) Parasite (2) PD-1/PD-L1 (2) PI3K (3) Prostaglandin Receptor (1) PROTACs (2) Ras (1) Reference Standards (3) Reverse Transcriptase (4) SARS-CoV (3) Sirtuin (1) Tau Protein (1) Transmembrane Glycoprotein (2) VEGFR (1) VSV (1) α-synuclein (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (1) Infection (12) Inflammation/Immunology (7) Metabolic Disease (4) Neurological Disease (2)

By Targets:

Apoptosis (1)

Arenavirus (1)

Bacterial (1)

Calcium Channel (2)

CDK (1)

COX (1)

Dengue Virus (1)

DNA/RNA Synthesis (2)

Drug Isomer (1)

DYRK (1)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (1)

Fluorescent Dye (1)

Fungal (2)

Histone Methyltransferase (2)

HIV (4)

Isotope-Labeled Compounds (5)

MMP (2)

NAMPT (1)

Nuclear Hormone Receptor 4A/NR4A (2)

Parasite (2)

PD-1/PD-L1 (2)

PI3K (3)

Prostaglandin Receptor (1)

PROTACs (2)

Ras (1)

Reference Standards (3)

Reverse Transcriptase (4)

SARS-CoV (3)

Sirtuin (1)

Tau Protein (1)

Transmembrane Glycoprotein (2)

VEGFR (1)

VSV (1)

α-synuclein (1)

By Research Areas:

Cancer (19)

Cardiovascular Disease (1)

Infection (12)

Inflammation/Immunology (7)

Metabolic Disease (4)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W025074

BML-278	Sirtuin Histone Methyltransferase	Cancer
BML-278 is a SIRT1 activator (EC₁₅₀: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts .

HY-13963

ZCL278 3 Publications Verification	Ras Dengue Virus VSV Arenavirus	Infection Neurological Disease Metabolic Disease Cancer
ZCL278 is a selective Cdc42 inhibitor with K_ds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 is able to disrupt the Cdc42-ITSN interaction as well as GTP/GDP binding. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used for the studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC) .

HY-P99363

Feladilimab Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609	Transmembrane Glycoprotein	Cancer
Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) is humanized IgG4 anti-ICOS agonist monoclonal antibody. Feladilimab binds to ICOS-expressing T cells. Feladilimab has the potential for the research of cancer .

HY-10574A

Rilpivirine hydrochloride 5+ Cited Publications TMC-278 hydrochloride; TMC278 hydrochloride; TMC 278 hydrochloride	SARS-CoV MMP	Infection
Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .

HY-176144

Antibacterial agent 278	Bacterial	Infection
Antibacterial agent 278 (compound B1) is an antibacterial agent. Antibacterial agent 278 exhibites potent activity against Gram-positive bacteria .

HY-175598

Anticancer agent 278	Others	Cancer
Anticancer agent 278 (Compound 5e) is an anticancer agent. Anticancer agent 278 has potent toxicity and inhibitory activities against cancer cells with IC₅₀s of 4.02  μM, 6.02  μM and 6.11 μM for A549, HeLa and HCT116, respectively. Anticancer agent 278 can be used for cancers like human lung, cervical and colorectal cancer research .

HY-13963S

ZCL278-13C	Isotope-Labeled Compounds Endogenous Metabolite	Infection Cancer
ZCL278- ¹³C is ¹³C-labeled ZCL278 (HY-13963). ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with K_d of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.

HY-D0594

Disperse Red 278	Fluorescent Dye
Disperse Red 278 is a red dye derived from anthraquinone. It is used in plastics, textiles and cosmetics.

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human *ICOS/CD278* IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .

HY-157075S

(Z)-Rilpivirine-d4 R278474-d₄; TMC278-d₄; DB08864-d₄	Isotope-Labeled Compounds	Others
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

HY-10574AR

Rilpivirine hydrochloride (Standard) TMC-278 hydrochloride (Standard); TMC278 hydrochloride (Standard); TMC 278 hydrochloride (Standard)	Reference Standards SARS-CoV MMP	Infection
Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .

HY-P99679

Izuralimab	PD-1/PD-L1	Inflammation/Immunology Cancer
Izuralimab is a bispecific IgG1 antibody targeting inducible T-cell costimulator (ICOS/CD278) and PD-1 .

HY-166899S

1,3-Dibromo-2,7,8-trichlorodibenzofuran-13C12	Isotope-Labeled Compounds	Others
1,3-Dibromo-2,7,8-trichlorodibenzofuran- ¹³C₁₂ is ¹³C labeled 1,3-Dibromo-2,7,8-trichlorodibenzofuran .

HY-W715187S

3-Bromo-2,7,8-trichloro dibenzofuran-13C12	Isotope-Labeled Compounds	Others
3-Bromo-2,7,8-trichloro dibenzofuran- ¹³C₁₂ is ¹³C labeled 3-Bromo-2,7,8-trichlorodibenzo[b,d]furan .

HY-162742

PROTAC SMARCA2 degrader-16	PROTACs	Cancer
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-158706

SAE-IN-2	E1/E2/E3 Enzyme	Cancer
SAE-IN-2 (compound 6) is a potent inhibitor of sumo activating enzume (SAE), with the IC₅₀ of 27.8 nM .

HY-136499

DI-82	DNA/RNA Synthesis	Cancer
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀ ^app of 27.8 nM and K_i ^app of 9.2 nM. DI-82 has antitumor activity .

HY-10574

Rilpivirine 5+ Cited Publications R278474; TMC278; DB08864	HIV Reverse Transcriptase	Infection
Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-N2148

Cytosporone B Maximum Cited Publications 14 Publications Verification Csn-B; Dothiorelone G	Nuclear Hormone Receptor 4A/NR4A	Cancer
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC₅₀ of 0.278 nM.

HY-135827A

Roginolisib hemifumarate MSC2360844 hemifumarate; IOA-244 hemifumarate	PI3K	Inflammation/Immunology Cancer
Roginolisib (MSC2360844) hemifumarate is a potent, orally active and selective PI3Kδ inhibitor, with an IC₅₀ of 145 nM. Roginolisib hemifumarate shows highly selective against a panel of 278 additional kinases .

HY-135827

Roginolisib MSC2360844; IOA-244	PI3K	Inflammation/Immunology Cancer
Roginolisib (MSC2360844; IOA-244) is a potent, orally active and selective PI3Kδ inhibitor, with an IC₅₀ of 145 nM. Roginolisib shows highly selective against a panel of 278 additional kinases .

HY-163500

NAMPT activator-8	NAMPT	Cancer
NAMPT activator-8 (Compound 278) is an activator for nicotinamide phosphoribosyltransferase (NAMPT), with EC₅₀ < 0.5 μM. NAMPT activator-8 activates NAMPT in cells U2OS with cellular EC₅₀ of < 0.5 μM .

HY-10574R

Rilpivirine (Standard) R278474 (Standard); TMC278 (Standard); DB08864 (Standard)	Reference Standards HIV Reverse Transcriptase	Infection
Rilpivirine (Standard) is the analytical standard of Rilpivirine. This product is intended for research and analytical applications. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-167642

(Z)-Rilpivirine (Z)-R278474; (Z)-TMC278; (Z)-DB08864	Drug Isomer HIV Reverse Transcriptase	Infection
(Z)-Rilpivirine ((Z)-R278474) is the (Z)-isomer of Rilpivirine (HY-10574). Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It exhibits potent antiviral activity against both wild-type HIV (EC₅₀ = 0.4 nM) and mutant strains (EC₅₀ = 0.1-2.0 nM) .

HY-N2148R

Cytosporone B (Standard) Csn-B (Standard); Dothiorelone G (Standard)	Nuclear Hormone Receptor 4A/NR4A Reference Standards	Cancer
Cytosporone B (Standard) is the analytical standard of Cytosporone B. This product is intended for research and analytical applications. Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.

HY-178188

TPG-20A	SARS-CoV	Infection
TPG-20A is a SARS-CoV-2 main protease inhibitor with an IC₅₀ of 27.8 nM. TPG-20A also inhibits MERS-CoV main protease. TPG-20A can be used for the research of infection, such as SARS-CoV-2 .

HY-153057

PRMT5-IN-46	Histone Methyltransferase	Metabolic Disease Cancer
PRMT5-IN-46 (compound 278) inhibits PRMT5 with IC₅₀s of 1-10 μM. PRMT5 is a methyltransferase which is associated with specific genetic alterations. PRMT5-IN-46 can be used for research of proliferative diseases, metabolic disorders, and blood diseases .

HY-129851

NTP42	Prostaglandin Receptor	Cardiovascular Disease
NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC₅₀ of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca ²⁺] mobilization following stimulation of cells with the alternative TP agonist U46619 . NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH) .

HY-172112

VEGFR-2-IN-64	VEGFR Apoptosis	Cancer
VEGFR-2-IN-64 (Compound 28) is the inhibitor for VEGFR2 with IC₅₀ of 27.8 nM. VEGFR-2-IN-64 inhibits the proliferation of cancer cell A549, T-47D and Caco-2, exhibits anti-migration and anti-cloning activities in cell T-47D, induces apoptosis in T-47D .

HY-Y1667

2,6-Dibromophenol 1 Publications Verification	Calcium Channel Fungal Parasite	Metabolic Disease
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca ²⁺ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC₅₀ of 2.78 mg/L for Daphnia magna and a 96 h EC₅₀ of 9.90 mg/L for algae (Scenedesmus quadricauda) .

HY-Y1667R

2,6-Dibromophenol (Standard)	Calcium Channel Fungal Parasite	Metabolic Disease
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda) .

HY-144258

PD-1/PD-L1-IN-14	PD-1/PD-L1	Inflammation/Immunology Cancer
PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC₅₀ of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1 .

HY-155723

Leucettinib-92	CDK DYRK	Others
Leucettinib-92 (compound 92) is an inhibitor of DYRK/CLK kinase, The IC₅₀s are 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), respectively. 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3) .

HY-147912

COX-2/PI3K-IN-2	PI3K COX	Inflammation/Immunology Cancer
COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC₅₀ value of 2.78 nM. COX-2/PI3K-IN-2 is a selective COX-2 inhibitor with K_i value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties .

HY-173338

MSRV-IN-1	DNA/RNA Synthesis	Infection
MSRV-IN-1 (Compound M3) is an inhibitor targeting aquatic rhabdoviruses (such as MSRV, SVCV and IHNV). Its IC₅₀ values for inhibiting MSRV, SVCV and IHNV are 0.92 μM, 2.92 μM and 2.78 μM respectively. MSRV-IN-1 does not act directly on the virions but rather inhibits viral replication by altering the cell cycle arrest state in the S phase induced by the virus and disrupting the viral replication environment. When administered intraperitoneally at a dose of 20 mg/kg, MSRV-IN-1 can significantly increase the survival rate of largemouth bass infected with MSRV by 35.98% and reduce the viral loads in the liver, spleen and kidney. MSRV-IN-1 can be used in the research of diseases related to rhabdoviruses in aquaculture .

HY-157839

PROTAC α-Synuclein/Tau degrader 1	PROTACs α-synuclein Tau Protein	Neurological Disease
PROTAC α-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of α-synuclein (α-Syn) and tau, with DC₅₀ of 1.57 μM and 4.09 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 binds to α-Syn and tau PFF, with K_Ds of 0.47 and 2.78 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC α-Synuclein/Tau degrader 6 can be used for the study of Parkinson’s disease (PD) (Pink: α-Synuclein/Tau ligand (HY-151035); Blue: CRBN ligase ligand (HY-14658); Black: Linker (HY-128803)) .

HY-10574S1

Rilpivirine-13C6 R278474-¹³C₆; TMC278-¹³C₆; DB08864-¹³C₆	Isotope-Labeled Compounds HIV Reverse Transcriptase	Infection
Rilpivirine- ¹³C₆ (R278474- ¹³C₆) is ¹³C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

Cat. No.	Product Name

HY-L213

Anti-Cancer Approved Drug Library	278 compounds
The anti-cancer drug library meticulously collects all drugs approved by FDA and other major national drug regulatory authorities for cancer treatment. These drugs cover a variety of cancer types, including but not limited to lung cancer, breast cancer, colorectal cancer, leukemia, and other common cancers. The library includes a wide range of drugs, from classic chemotherapeutic agents to cutting-edge targeted therapies and immunotherapies. It contains various types of drug compounds with different mechanisms of action. There are cytotoxic drugs that directly kill cancer cells, as well as drugs that work by modulating the tumor microenvironment, inhibiting tumor angiogenesis, and activating the immune system. This diversity provides researchers with a broad range of perspectives and options for intervention strategies. This library can be used for basic research on cancer treatment, exploring new targets and new mechanisms of drug action; Conducting drug reuse research to look for potential therapeutic effects of existing drugs on other cancer types or diseases; Or conducting research into combination drugs to optimize cancer treatment. MCE has collected 278 small-molecule compounds with cancer indications, which are good tools for drug repurposing.

Anti-Cancer Approved Drug Library

278 compounds

The anti-cancer drug library meticulously collects all drugs approved by FDA and other major national drug regulatory authorities for cancer treatment. These drugs cover a variety of cancer types, including but not limited to lung cancer, breast cancer, colorectal cancer, leukemia, and other common cancers. The library includes a wide range of drugs, from classic chemotherapeutic agents to cutting-edge targeted therapies and immunotherapies. It contains various types of drug compounds with different mechanisms of action. There are cytotoxic drugs that directly kill cancer cells, as well as drugs that work by modulating the tumor microenvironment, inhibiting tumor angiogenesis, and activating the immune system. This diversity provides researchers with a broad range of perspectives and options for intervention strategies.

This library can be used for basic research on cancer treatment, exploring new targets and new mechanisms of drug action; Conducting drug reuse research to look for potential therapeutic effects of existing drugs on other cancer types or diseases; Or conducting research into combination drugs to optimize cancer treatment.

MCE has collected 278 small-molecule compounds with cancer indications, which are good tools for drug repurposing.

Cat. No.	Product Name	Type

HY-D0594

Disperse Red 278	Dyes
Disperse Red 278 is a red dye derived from anthraquinone. It is used in plastics, textiles and cosmetics.

Cat. No.	Product Name	Target	Research Area

HY-P5427

EAC3I	Peptides	Others
EAC3I is a biological active peptide. (The autocamtide-3 derived inhibitory peptide (EAC3I) sequence (KKALHRQEAVDAL) mimics the autoinhibitory region of the CaMKII regulatory domain (residues 278–290) and acts by competitively binding to the catalytic site.)

Cat. No.	Product Name	Target	Research Area

HY-P99363

Feladilimab Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609	Transmembrane Glycoprotein	Cancer
Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) is humanized IgG4 anti-ICOS agonist monoclonal antibody. Feladilimab binds to ICOS-expressing T cells. Feladilimab has the potential for the research of cancer .

HY-P99679

Izuralimab	PD-1/PD-L1	Inflammation/Immunology Cancer
Izuralimab is a bispecific IgG1 antibody targeting inducible T-cell costimulator (ICOS/CD278) and PD-1 .

HY-P990628

MEDI-570	Inhibitory Antibodies	Inflammation/Immunology
MEDI-570 is a humanized antibody expressed in CHO that targets *ICOS/CD278*. MEDI-570 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for MEDI-570 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	Transmembrane Glycoprotein	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human *ICOS/CD278* IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2148

Cytosporone B 10+ Cited Publications Csn-B; Dothiorelone G	Natural Products Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Nuclear Hormone Receptor 4A/NR4A
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC₅₀ of 0.278 nM.

HY-Y1667

2,6-Dibromophenol 1 Publications Verification	Monophenols Classification of Application Fields Marine natural products Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Calcium Channel Fungal Parasite
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca ²⁺ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC₅₀ of 2.78 mg/L for Daphnia magna and a 96 h EC₅₀ of 9.90 mg/L for algae (Scenedesmus quadricauda) .

HY-N2148R

Cytosporone B (Standard) Csn-B (Standard); Dothiorelone G (Standard)	Natural Products Microorganisms Source classification Phenols Polyphenols	Nuclear Hormone Receptor 4A/NR4A Reference Standards
Cytosporone B (Standard) is the analytical standard of Cytosporone B. This product is intended for research and analytical applications. Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.

HY-Y1667R

2,6-Dibromophenol (Standard)	Monophenols Marine natural products Source classification Phenols Endogenous metabolite	Calcium Channel Fungal Parasite
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda) .

Species:	Human (6) Virus (1) Rhesus Macaque (2) Mouse (5) Rat (2)
Tag:	His (8) Tag Free (1) Avi (3) Fc (8)
Source:	HEK293 (14) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P72618

	ICOS Protein, Human (HEK293, Fc) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Human	HEK293
	ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (HEK293, Fc) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72619

	ICOS Protein, Mouse (HEK293, His) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (HEK293, His) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74868

	ICOS Protein, Rat (HEK293, Fc) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Rat	HEK293
	ICOS is a key protein for T cell function and can significantly enhance various T cell responses to foreign antigens. It plays a crucial role in promoting T cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promoting efficient secretion of B cell antibodies. ICOS Protein, Rat (HEK293, Fc) is the recombinant rat-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78673

	ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) ICOS; CD278; AILIM; Inducible T-cell costimulator	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag and C137S, C138S mutation.

HY-P78307

	ICOS Protein, Mouse (HEK293, Fc) AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76396

	ICOS Protein, Human (HEK293, His-Fc) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Human	HEK293
	ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (HEK293, His-Fc) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P76397

	ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P75819

	ICOS Protein, Rhesus Macaque (Biotinylated, HEK293, Fc-Avi) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Rhesus Macaque	HEK293
	ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus Macaque (Biotinylated, HEK293, Fc-Avi) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P78306

	ICOS Protein, Mouse (C137S, C138S, HEK293, His) AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (C137S, C138S, HEK293, His) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-His labeled tag and C137S, C138S mutation.

HY-P78546

	ICOS Protein, Human (C136S, C137S, HEK293, His) AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850	Human	HEK293
	ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (C136S, C137S, HEK293, His) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-His labeled tag.

HY-P704668

	ICOS Protein, Rat (C137S, C138S, HEK293, His) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Rat	HEK293
	ICOS is a key protein for T cell function and can significantly enhance various T cell responses to foreign antigens. It plays a crucial role in promoting T cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promoting efficient secretion of B cell antibodies. ICOS Protein, Rat (C137S, C138S, HEK293, His) is the recombinant rat-derived ICOS protein, expressed by HEK293, with C-His labeled tag.

HY-P78864

	ICOS Protein, Human (Biotinylated, C136S, C137S, HEK293, His-Avi ) ICOS; CD278; AILIM; Inducible T-cell costimulator	Human	HEK293
	ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (Biotinylated, C136S, C137S, HEK293, His-Avi ) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P701981

	MCD Protein, Human (E58A, K59A, E278A, E279A, K280A) MLYCD; Malonyl-CoA decarboxylase; mitochondrial; MCD	Human	E. coli
	MCD proteins catalyze the conversion of malonyl-CoA to acetyl-CoA, ensuring that only methylmalonyl-CoA serves as a substrate for fatty acid synthase, producing fatty acids with multiple methyl side chains. MCD Protein, Human (E58A, K59A, E278A, E279A, K280A) is the recombinant human-derived MCD protein, expressed by E. coli , with tag free.

HY-P701982

	MCD Protein, Human (E58A, K59A, E278A, E279A, K280A, His) MLYCD; Malonyl-CoA decarboxylase; mitochondrial; MCD	Human	E. coli
	MCD proteins catalyze the conversion of malonyl-CoA to acetyl-CoA, ensuring that only methylmalonyl-CoA serves as a substrate for fatty acid synthase, producing fatty acids with multiple methyl side chains. MCD Protein, Human (E58A, K59A, E278A, E279A, K280A, His) is the recombinant human-derived MCD protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70187

	ICOS Protein, Rhesus Macaque (HEK293, Fc) rRhInducible T-cell costimulator/ICOS, Fc ; Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS	Rhesus Macaque	HEK293
	ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74185

	*E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His)* Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His Tag); HCV-1a E2 Protein	Virus	HEK293
	E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293, with C-His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-13963S

ZCL278-13C
ZCL278- ¹³C is ¹³C-labeled ZCL278 (HY-13963). ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with K_d of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.

HY-157075S

(Z)-Rilpivirine-d4
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

HY-166899S

1,3-Dibromo-2,7,8-trichlorodibenzofuran-13C12
1,3-Dibromo-2,7,8-trichlorodibenzofuran- ¹³C₁₂ is ¹³C labeled 1,3-Dibromo-2,7,8-trichlorodibenzofuran .

HY-W715187S

3-Bromo-2,7,8-trichloro dibenzofuran-13C12
3-Bromo-2,7,8-trichloro dibenzofuran- ¹³C₁₂ is ¹³C labeled 3-Bromo-2,7,8-trichlorodibenzo[b,d]furan .

HY-10574S1

Rilpivirine-13C6

Rilpivirine- ¹³C₆ (R278474- ¹³C₆) is ¹³C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80235

	Myosin Light Chain 2 Antibody (YA278)	WB, IHC-P, IP	Human, Mouse, Rat
	Myosin Light Chain 2 Antibody (YA278) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin Light Chain 2.

HY-P86912

	ICOS Antibody (YA6605) Activation inducible lymphocyte immunomediatory molecule antibody; Activation-inducible lymphocyte immunomediatory molecule antibody; AILIM antibody; CD278 antibody; CD278 antigen antibody; CD28-related Protein-1 antibody; CRP1 antibody; CVID1 antibody; ICOS antibody; ICOS_HUMAN antibody; Activation inducible lymphocyte immunomediatory molecule antibody; Activation-inducible lymphocyte immunomediatory molecule antibody; AILIM antibody; CD278 antibody; CD278 antigen antibody; CD28-related Protein-1 antibody; CRP1 antibody; CVID1 antibody; ICOS antibody; ICOS_HUMAN antibody; Inducible costimulator antibody; Inducible T cell co stimulator antibody; Inducible T-cell costimulator antibody; MGC39850 antibody;	WB	Mouse, Rat
	ICOS Antibody (YA6605) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICOS.

HY-P84984

	ICOS Antibody (YA4676) ICOS; AILIM; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278; CD278 nanobody; ICOS nanobody;	ELISA	Human
	ICOS Antibody (YA4676) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ICOS.

HY-P81467

	ICOS Antibody (YA1212) ICOS; AILIM; CD278; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule	IHC-P	Human
	ICOS Antibody (YA1212) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICOS.