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Results for "

278

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (1) Calcium Channel (1) CD28 (1) CDK (1) COX (1) Dengue Virus (1) DNA/RNA Synthesis (2) Drug Isomer (1) DYRK (1) E1/E2/E3 Enzyme (1) Flavivirus (1) Fluorescent Dye (1) Fungal (1) Histone Methyltransferase (2) HIV (4) Isotope-Labeled Compounds (4) MMP (2) NAMPT (1) Nuclear Hormone Receptor 4A/NR4A (2) Parasite (1) PD-1/PD-L1 (2) PI3K (3) Prostaglandin Receptor (1) PROTACs (1) Ras (1) Reference Standards (3) Reverse Transcriptase (4) SARS-CoV (2) Sirtuin (1) Transmembrane Glycoprotein (1) VEGFR (1) VSV (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (6) Metabolic Disease (2)

By Targets:

Apoptosis (1)

Bacterial (1)

Calcium Channel (1)

CD28 (1)

CDK (1)

COX (1)

Dengue Virus (1)

DNA/RNA Synthesis (2)

Drug Isomer (1)

DYRK (1)

E1/E2/E3 Enzyme (1)

Flavivirus (1)

Fluorescent Dye (1)

Fungal (1)

Histone Methyltransferase (2)

HIV (4)

Isotope-Labeled Compounds (4)

MMP (2)

NAMPT (1)

Nuclear Hormone Receptor 4A/NR4A (2)

Parasite (1)

PD-1/PD-L1 (2)

PI3K (3)

Prostaglandin Receptor (1)

PROTACs (1)

Ras (1)

Reference Standards (3)

Reverse Transcriptase (4)

SARS-CoV (2)

Sirtuin (1)

Transmembrane Glycoprotein (1)

VEGFR (1)

VSV (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (1)

Infection (8)

Inflammation/Immunology (6)

Metabolic Disease (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W025074

BML-278	Sirtuin Histone Methyltransferase	Cancer
BML-278 is a SIRT1 activator (EC₁₅₀: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts .

HY-13963

ZCL278 2 Publications Verification	Flavivirus Dengue Virus VSV Ras	Cancer
ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with K_d of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.

HY-P99363

Feladilimab Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609	Transmembrane Glycoprotein	Cancer
Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) is humanized IgG4 anti-ICOS agonist monoclonal antibody. Feladilimab binds to ICOS-expressing T cells. Feladilimab has the potential for the research of cancer .

HY-10574A

Rilpivirine hydrochloride 5+ Cited Publications TMC-278 hydrochloride; TMC278 hydrochloride; TMC 278 hydrochloride	SARS-CoV MMP	Infection
Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .

HY-176144

Antibacterial agent 278	Bacterial	Infection
Antibacterial agent 278 (compound B1) is an antibacterial agent. Antibacterial agent 278 exhibites potent activity against Gram-positive bacteria .

HY-D0594

Disperse Red 278	Fluorescent Dye
Disperse Red 278 is a red dye derived from anthraquinone. It is used in plastics, textiles and cosmetics.

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	CD28	Others
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse/rat/monkey/human ICOS/CD278.

HY-157075S

(Z)-Rilpivirine-d4 R278474-d₄; TMC278-d₄; DB08864-d₄	Isotope-Labeled Compounds	Others
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

HY-10574AR

Rilpivirine hydrochloride (Standard) TMC-278 hydrochloride (Standard); TMC278 hydrochloride (Standard); TMC 278 hydrochloride (Standard)	Reference Standards SARS-CoV MMP	Infection
Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .

HY-P99679

Izuralimab	PD-1/PD-L1	Inflammation/Immunology Cancer
Izuralimab is a bispecific IgG1 antibody targeting inducible T-cell costimulator (ICOS/CD278) and PD-1 .

HY-166899S

1,3-Dibromo-2,7,8-trichlorodibenzofuran-13C12	Isotope-Labeled Compounds	Others
1,3-Dibromo-2,7,8-trichlorodibenzofuran- ¹³C₁₂ is ¹³C labeled 1,3-Dibromo-2,7,8-trichlorodibenzofuran .

HY-W715187S

3-Bromo-2,7,8-trichloro dibenzofuran-13C12	Isotope-Labeled Compounds	Others
3-Bromo-2,7,8-trichloro dibenzofuran- ¹³C₁₂ is ¹³C labeled 3-Bromo-2,7,8-trichlorodibenzo[b,d]furan .

HY-162742

PROTAC SMARCA2 degrader-16	PROTACs	Cancer
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC₅₀ <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-158706

SAE-IN-2	E1/E2/E3 Enzyme	Cancer
SAE-IN-2 (compound 6) is a potent inhibitor of sumo activating enzume (SAE), with the IC₅₀ of 27.8 nM .

HY-136499

DI-82	DNA/RNA Synthesis	Cancer
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀ ^app of 27.8 nM and K_i ^app of 9.2 nM. DI-82 has antitumor activity .

HY-10574

Rilpivirine 5+ Cited Publications R278474; TMC278; DB08864	HIV Reverse Transcriptase	Infection
Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-N2148

Cytosporone B Maximum Cited Publications 11 Publications Verification Csn-B; Dothiorelone G	Nuclear Hormone Receptor 4A/NR4A	Cancer
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC₅₀ of 0.278 nM.

HY-135827A

Roginolisib hemifumarate MSC2360844 hemifumarate; IOA-244 hemifumarate	PI3K	Inflammation/Immunology Cancer
Roginolisib (MSC2360844) hemifumarate is a potent, orally active and selective PI3Kδ inhibitor, with an IC₅₀ of 145 nM. Roginolisib hemifumarate shows highly selective against a panel of 278 additional kinases .

HY-135827

Roginolisib MSC2360844; IOA-244	PI3K	Inflammation/Immunology Cancer
Roginolisib (MSC2360844; IOA-244) is a potent, orally active and selective PI3Kδ inhibitor, with an IC₅₀ of 145 nM. Roginolisib shows highly selective against a panel of 278 additional kinases .

HY-163500

NAMPT activator-8	NAMPT	Cancer
NAMPT activator-8 (Compound 278) is an activator for nicotinamide phosphoribosyltransferase (NAMPT), with EC₅₀ < 0.5 μM. NAMPT activator-8 activates NAMPT in cells U2OS with cellular EC₅₀ of < 0.5 μM .

HY-10574R

Rilpivirine (Standard) R278474 (Standard); TMC278 (Standard); DB08864 (Standard)	Reference Standards HIV Reverse Transcriptase	Infection
Rilpivirine (Standard) is the analytical standard of Rilpivirine. This product is intended for research and analytical applications. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-167642

(Z)-Rilpivirine (Z)-R278474; (Z)-TMC278; (Z)-DB08864	Drug Isomer HIV Reverse Transcriptase	Infection
(Z)-Rilpivirine ((Z)-R278474) is the (Z)-isomer of Rilpivirine (HY-10574). Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It exhibits potent antiviral activity against both wild-type HIV (EC₅₀ = 0.4 nM) and mutant strains (EC₅₀ = 0.1-2.0 nM) .

HY-N2148R

Cytosporone B (Standard) Csn-B (Standard); Dothiorelone G (Standard)	Nuclear Hormone Receptor 4A/NR4A Reference Standards	Cancer
Cytosporone B (Standard) is the analytical standard of Cytosporone B. This product is intended for research and analytical applications. Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.

HY-153057

PRMT5-IN-46	Histone Methyltransferase	Metabolic Disease Cancer
PRMT5-IN-46 (compound 278) inhibits PRMT5 with IC₅₀s of 1-10 μM. PRMT5 is a methyltransferase which is associated with specific genetic alterations. PRMT5-IN-46 can be used for research of proliferative diseases, metabolic disorders, and blood diseases .

HY-129851

NTP42	Prostaglandin Receptor	Cardiovascular Disease
NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC₅₀ of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca ²⁺] mobilization following stimulation of cells with the alternative TP agonist U46619 . NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH) .

HY-172112

VEGFR-2-IN-64	VEGFR Apoptosis	Cancer
VEGFR-2-IN-64 (Compound 28) is the inhibitor for VEGFR2 with IC₅₀ of 27.8 nM. VEGFR-2-IN-64 inhibits the proliferation of cancer cell A549, T-47D and Caco-2, exhibits anti-migration and anti-cloning activities in cell T-47D, induces apoptosis in T-47D .

HY-Y1667

2,6-Dibromophenol 1 Publications Verification	Calcium Channel Fungal Parasite	Metabolic Disease
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca ²⁺ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC₅₀ of 2.78 mg/L for Daphnia magna and a 96 h EC₅₀ of 9.90 mg/L for algae (Scenedesmus quadricauda) .

HY-144258

PD-1/PD-L1-IN-14	PD-1/PD-L1	Inflammation/Immunology Cancer
PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC₅₀ of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1 .

HY-155723

Leucettinib-92	CDK DYRK	Others
Leucettinib-92 (compound 92) is an inhibitor of DYRK/CLK kinase, The IC₅₀s are 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), respectively. 1.0 μM (DYRK3), 0.52 μM (DYRK4), 2.78 μM (GSK3) .

HY-147912

COX-2/PI3K-IN-2	PI3K COX	Inflammation/Immunology Cancer
COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC₅₀ value of 2.78 nM. COX-2/PI3K-IN-2 is a selective COX-2 inhibitor with K_i value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties .

HY-173338

MSRV-IN-1	DNA/RNA Synthesis	Infection
MSRV-IN-1 (Compound M3) is an inhibitor targeting aquatic rhabdoviruses (such as MSRV, SVCV and IHNV). Its IC₅₀ values for inhibiting MSRV, SVCV and IHNV are 0.92 μM, 2.92 μM and 2.78 μM respectively. MSRV-IN-1 does not act directly on the virions but rather inhibits viral replication by altering the cell cycle arrest state in the S phase induced by the virus and disrupting the viral replication environment. When administered intraperitoneally at a dose of 20 mg/kg, MSRV-IN-1 can significantly increase the survival rate of largemouth bass infected with MSRV by 35.98% and reduce the viral loads in the liver, spleen and kidney. MSRV-IN-1 can be used in the research of diseases related to rhabdoviruses in aquaculture .

HY-10574S1

Rilpivirine-13C6 R278474-¹³C₆; TMC278-¹³C₆; DB08864-¹³C₆	Isotope-Labeled Compounds HIV Reverse Transcriptase	Infection
Rilpivirine- ¹³C₆ (R278474- ¹³C₆) is ¹³C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

Cat. No.	Product Name

HY-L189

Amino Acid Metabolism Compound Library	278 compounds
Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases. MCE designs a unique collection of 278 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.

Amino Acid Metabolism Compound Library

278 compounds

Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases.

MCE designs a unique collection of 278 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.

Cat. No.	Product Name	Type

HY-D0594

Disperse Red 278	Dyes
Disperse Red 278 is a red dye derived from anthraquinone. It is used in plastics, textiles and cosmetics.

Cat. No.	Product Name	Target	Research Area

HY-P5427

EAC3I	Peptides	Others
EAC3I is a biological active peptide. (The autocamtide-3 derived inhibitory peptide (EAC3I) sequence (KKALHRQEAVDAL) mimics the autoinhibitory region of the CaMKII regulatory domain (residues 278–290) and acts by competitively binding to the catalytic site.)

Cat. No.	Product Name	Target	Research Area

HY-P99363

Feladilimab Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609	Transmembrane Glycoprotein	Cancer
Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) is humanized IgG4 anti-ICOS agonist monoclonal antibody. Feladilimab binds to ICOS-expressing T cells. Feladilimab has the potential for the research of cancer .

HY-P990628

MEDI-570	Inhibitory Antibodies	Inflammation/Immunology
MEDI-570 is a humanized antibody expressed in CHO that targets *ICOS/CD278*. MEDI-570 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for MEDI-570 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990236

Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)	CD28	Others
Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse/rat/monkey/human ICOS/CD278.

HY-P99679

Izuralimab	PD-1/PD-L1	Inflammation/Immunology Cancer
Izuralimab is a bispecific IgG1 antibody targeting inducible T-cell costimulator (ICOS/CD278) and PD-1 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2148

Cytosporone B 10+ Cited Publications Csn-B; Dothiorelone G	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Nuclear Hormone Receptor 4A/NR4A
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC₅₀ of 0.278 nM.

HY-Y1667

2,6-Dibromophenol 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Marine natural products Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Calcium Channel Fungal Parasite
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca ²⁺ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC₅₀ of 2.78 mg/L for Daphnia magna and a 96 h EC₅₀ of 9.90 mg/L for algae (Scenedesmus quadricauda) .

HY-N2148R

Cytosporone B (Standard) Csn-B (Standard); Dothiorelone G (Standard)	Structural Classification Natural Products Microorganisms Source classification Phenols Polyphenols	Nuclear Hormone Receptor 4A/NR4A Reference Standards
Cytosporone B (Standard) is the analytical standard of Cytosporone B. This product is intended for research and analytical applications. Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.

Species:	Human (4) Virus (1) Rhesus Macaque (2) Mouse (5) Rat (2)
Tag:	His (7) Avi (3) Fc (8)
Source:	HEK293 (14)

Cat. No.	Compare	Product Name	Species	Source

HY-P72618

	ICOS Protein, Human (HEK293, Fc) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Human	HEK293
	ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (HEK293, Fc) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72619

	ICOS Protein, Mouse (HEK293, His) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (HEK293, His) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74868

	ICOS Protein, Rat (HEK293, Fc) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Rat	HEK293
	ICOS is a key protein for T cell function and can significantly enhance various T cell responses to foreign antigens. It plays a crucial role in promoting T cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promoting efficient secretion of B cell antibodies. ICOS Protein, Rat (HEK293, Fc) is the recombinant rat-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78673

	ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) ICOS; CD278; AILIM; Inducible T-cell costimulator	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag and C137S, C138S mutation.

HY-P78307

	ICOS Protein, Mouse (HEK293, Fc) AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76396

	ICOS Protein, Human (HEK293, His-Fc) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Human	HEK293
	ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (HEK293, His-Fc) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P76397

	ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P75819

	ICOS Protein, Rhesus Macaque (Biotinylated, HEK293, Fc-Avi) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Rhesus Macaque	HEK293
	ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus Macaque (Biotinylated, HEK293, Fc-Avi) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P78306

	ICOS Protein, Mouse (C137S, C138S, HEK293, His) AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850	Mouse	HEK293
	ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (C137S, C138S, HEK293, His) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-His labeled tag and C137S, C138S mutation.

HY-P78546

	ICOS Protein, Human (C136S, C137S, HEK293, His) AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850	Human	HEK293
	ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (C136S, C137S, HEK293, His) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-His labeled tag.

HY-P704668

	ICOS Protein, Rat (C137S, C138S, HEK293, His) Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS	Rat	HEK293
	ICOS is a key protein for T cell function and can significantly enhance various T cell responses to foreign antigens. It plays a crucial role in promoting T cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promoting efficient secretion of B cell antibodies. ICOS Protein, Rat (C137S, C138S, HEK293, His) is the recombinant rat-derived ICOS protein, expressed by HEK293, with C-His labeled tag.

HY-P78864

	ICOS Protein, Human (Biotinylated, C136S, C137S, HEK293, His-Avi ) ICOS; CD278; AILIM; Inducible T-cell costimulator	Human	HEK293
	ICOS proteins enhance T cell responses to foreign antigens, promote proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and help B cells secrete antibodies. ICOS Protein, Human (Biotinylated, C136S, C137S, HEK293, His-Avi ) is the recombinant human-derived ICOS protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P70187

	ICOS Protein, Rhesus macaque (HEK293,Fc) rRhInducible T-cell costimulator/ICOS, Fc ; Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS	Rhesus Macaque	HEK293
	ICOS proteins play a critical role in enhancing all basic T cell responses to foreign antigens. It promotes cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promotes effective B cell antibody secretion. ICOS Protein, Rhesus macaque (HEK293,Fc) is the recombinant Rhesus Macaque-derived ICOS protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74185

	*E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His)* Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His Tag); HCV-1a E2 Protein	Virus	HEK293
	E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293, with C-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-157075S

(Z)-Rilpivirine-d4
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

HY-166899S

1,3-Dibromo-2,7,8-trichlorodibenzofuran-13C12
1,3-Dibromo-2,7,8-trichlorodibenzofuran- ¹³C₁₂ is ¹³C labeled 1,3-Dibromo-2,7,8-trichlorodibenzofuran .

HY-W715187S

3-Bromo-2,7,8-trichloro dibenzofuran-13C12
3-Bromo-2,7,8-trichloro dibenzofuran- ¹³C₁₂ is ¹³C labeled 3-Bromo-2,7,8-trichlorodibenzo[b,d]furan .

HY-10574S1

Rilpivirine-13C6

Rilpivirine- ¹³C₆ (R278474- ¹³C₆) is ¹³C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80235

	Myosin Light Chain 2 Antibody (YA278)	WB, IHC-P, IP	Human, Mouse, Rat
	Myosin Light Chain 2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 19 kDa, targeting to Myosin Light Chain 2. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P84984

	ICOS Antibody (YA4676) ICOS; AILIM; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278; CD278 nanobody; ICOS nanobody;	ELISA	Human
	ICOS Antibody (YA4676) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CD278/ICOS. It can be applicated for ELISA assays, in the background of human.

HY-P81467

	ICOS Antibody (YA1212) ICOS; AILIM; CD278; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule	IHC-P	Human
	ICOS Antibody (YA1212) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1212), targeting ICOS. ICOS Antibody (YA1212) can be used for IHC-P experiment in human background.

HY-P86912

	ICOS Antibody (YA6605) Activation inducible lymphocyte immunomediatory molecule antibody; Activation-inducible lymphocyte immunomediatory molecule antibody; AILIM antibody; CD278 antibody; CD278 antigen antibody; CD28-related Protein-1 antibody; CRP1 antibody; CVID1 antibody; ICOS antibody; ICOS_HUMAN antibody; Activation inducible lymphocyte immunomediatory molecule antibody; Activation-inducible lymphocyte immunomediatory molecule antibody; AILIM antibody; CD278 antibody; CD278 antigen antibody; CD28-related Protein-1 antibody; CRP1 antibody; CVID1 antibody; ICOS antibody; ICOS_HUMAN antibody; Inducible costimulator antibody; Inducible T cell co stimulator antibody; Inducible T-cell costimulator antibody; MGC39850 antibody	WB	Mouse, Rat