2. Anti-infection
  3. SARS-CoV
  4. TPG-20A

TPG-20A is a SARS-CoV-2 main protease inhibitor with an IC50 of 27.8 nM. TPG-20A also inhibits MERS-CoV main protease. TPG-20A can be used for the research of infection, such as SARS-CoV-2.

For research use only. We do not sell to patients.

TPG-20A

TPG-20A Chemical Structure

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TPG-20A Related Antibodies

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Description

TPG-20A is a SARS-CoV-2 main protease inhibitor with an IC50 of 27.8 nM. TPG-20A also inhibits MERS-CoV main protease. TPG-20A can be used for the research of infection, such as SARS-CoV-2[1].

IC50 & Target[1]

SARS-CoV-2

27.8 nM (IC50)

In Vitro

TPG-20A (Compound 20a) shows EC50 values of 3.9 and 0.46 μM against SARS-CoV-2WK-521-exposed VeroE6 cells or SARS-CoV-2BQ.1.1-exposed HeLaACE2-TMPRSS2 cells[1].
TPG-20A shows CC50 values >100 μM against VeroE6 and HeLaACE2-TMPRSS2 cells[1].
TPG-20A shows IC50 values of 7.1 and 42.9 nM against SARS-CoV-2 Mpro and MERS-CoV Mpro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TPG-20A Related Antibodies
Molecular Weight

536.41

Formula

C24H27Cl2N5O5
SMILES

O=C(C(N1)=CC2=C1C=CC=C2OC)N[C@@H](CC(C)C)C(NN(C(C(Cl)Cl)=O)CC3=CC=CNC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TPG-20A Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPG-20ASARS-CoVSARS coronavirusSARS-CoV-2MERS-CoVinfectionVeroE6HeLaInhibitorinhibitorinhibit

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TPG-20A
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HY-178188
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