Sox2 - SRY (sex determining region Y)-box 2 Gene

Mus musculus

Also known as lcc; ysb; Sox-2

Gene ID: 20674 | Gene type: protein coding

About Sox2

Summary

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). [provided by RefSeq, Sep 2015]

Sox2 Products(1)

mRNA	Protein	Name
NM_011443.4	NP_035573.3	transcription factor SOX-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8625802	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7628452	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22344693	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	21076177	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12665572	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	15863505	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	25901318	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	24268575	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15988017	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7590241	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7628452	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19328208	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Notch signaling pathway	IDA IDA: Inferred from direct assay	16631155	MGI
acts upstream of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	15781477	MGI
acts upstream of or within adenohypophysis development	IMP IMP: Inferred from mutant phenotype	16932809	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	9851841	MGI
acts upstream of or within cell fate commitment	IDA IDA: Inferred from direct assay	18374910	MGI
acts upstream of or within cell fate specification	IMP IMP: Inferred from mutant phenotype	12514105	MGI
acts upstream of or within cellular response to cadmium ion	IDA IDA: Inferred from direct assay	15219627	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	15240551	MGI
acts upstream of or within detection of mechanical stimulus involved in equilibrioception	IMP IMP: Inferred from mutant phenotype	15846349	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	15846349	MGI
acts upstream of or within diencephalon morphogenesis	IMP IMP: Inferred from mutant phenotype	15240551	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	17522155	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IDA IDA: Inferred from direct assay	18374910	MGI
acts upstream of or within forebrain neuron differentiation	IMP IMP: Inferred from mutant phenotype	15240551	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	17267691	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15846349	MGI
acts upstream of or within lens induction in camera-type eye	IGI IGI: Inferred from genetic interaction	17140559	MGI
acts upstream of or within lung alveolus development	IDA IDA: Inferred from direct assay	18374910	MGI
acts upstream of or within male genitalia development	IMP IMP: Inferred from mutant phenotype	16932809	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	15781477	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17875931	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	17507372	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	16631155	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15781477	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9649510	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15240551	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	16631155	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16651659	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	17015430	MGI
involved in neuronal stem cell population maintenance	IGI IGI: Inferred from genetic interaction	22198669	MGI
acts upstream of or within olfactory placode formation	IGI IGI: Inferred from genetic interaction	17140559	MGI
acts upstream of osteoblast differentiation	IDA IDA: Inferred from direct assay	15781477	MGI
acts upstream of or within pigment biosynthetic process	IMP IMP: Inferred from mutant phenotype	12036291	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	16631155	MGI
acts upstream of or within positive regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	18374910	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	15240551	MGI
acts upstream of or within positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16651659	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7628452	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26691508	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7590241	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15988017	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12665572	MGI
acts upstream of or within regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	22513373	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
acts upstream of or within response to retinoic acid	IDA IDA: Inferred from direct assay	18400104	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	16651659	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	12036291	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	16767105	MGI
acts upstream of or within stem cell differentiation	IDA IDA: Inferred from direct assay	20123909	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	23169531	MGI
acts upstream of or within tongue development	IMP IMP: Inferred from mutant phenotype	17015430	MGI
acts upstream of trophectodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	17507372	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in chromatin	IDA IDA: Inferred from direct assay	23798425	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9512512	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9512512	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	17507372	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor SOX-2

SRY-box containing gene 2

Sox2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sox2	Q60I23	Chd4	Mus musculus	Q6PDQ2	Anti Bait CoIP	21532573
Intra	Sox2	Q60I23	Chd4	Mus musculus	Q6PDQ2	Anti Tag CoIP	21532573
Intra	Sox2	Q60I23	Chd7	Mus musculus	A2AJK6	Anti Tag CoIP	21532573
Intra	Sox2	Q60I23	Chd7	Mus musculus	A2AJK6	Anti Bait CoIP	21532573

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12303	OAC1	Activator	99.56%	Unkown
HY-B1238	Pronethalol	Inhibitor	99.88%	Unkown
HY-18772	O4I2	Activator	99.30%	Unkown
HY-150082	CP681301	Inhibitor	99.18%	Unkown
HY-RS13591	SOX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-143443	DS17701585	Inhibitor	/	Unkown
HY-168885	ZSH-512		/	Unkown
HY-173076	HDAC11-IN-1	Inhibitor	/	Unkown
HY-B1238A	Pronethalol hydrochloride	Inhibitor	/	Unkown
HY-119666	Rooperol	Activator	/	Unkown
HY-RS16652	Sox2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23087	Sox2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox2	NCBI	NCBI:6657

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