Pnp - purine-nucleoside phosphorylase Gene

Mus musculus

Also known as Np; Np-1; Np-2; Pnp1

Gene ID: 18950 | Gene type: protein coding

About Pnp

Summary

Enables guanosine phosphorylase activity and purine-nucleoside phosphorylase activity. Involved in allantoin metabolic process and nucleobase-containing small molecule metabolic process. Acts upstream of or within several processes, including nucleobase-containing small molecule metabolic process; positive regulation of lymphocyte activation; and urate biosynthetic process. Located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study purine nucleoside phosphorylase deficiency. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Apr 2022]

Pnp Products(1)

mRNA	Protein	Name
NM_013632.4	NP_038660.1	purine nucleoside phosphorylase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanosine phosphorylase activity	IDA IDA: Inferred from direct assay	718989	MGI
enables purine-nucleoside phosphorylase activity	IDA IDA: Inferred from direct assay	109081	MGI
enables purine-nucleoside phosphorylase activity	IMP IMP: Inferred from mutant phenotype	1664183	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in AMP catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in AMP catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
involved in AMP salvage	IDA IDA: Inferred from direct assay	8064675	MGI
acts upstream of B cell differentiation	IMP IMP: Inferred from mutant phenotype	10859343	MGI
acts upstream of DNA repair	IMP IMP: Inferred from mutant phenotype	10859343	MGI
involved in GMP catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
involved in GMP catabolic process to guanine	IMP IMP: Inferred from mutant phenotype	11783524	MGI
involved in GMP salvage	IDA IDA: Inferred from direct assay	718989	MGI
acts upstream of or within GTP biosynthetic process	IMP IMP: Inferred from mutant phenotype	10859343	MGI
involved in IMP catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
involved in IMP salvage	IDA IDA: Inferred from direct assay	819300	MGI
acts upstream of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	10859343	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	9122228	MGI
involved in adenosine catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in adenosine catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
involved in allantoin metabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in allantoin metabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
acts upstream of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	9122228	MGI
involved in amide catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in amide catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
acts upstream of or within apoptotic mitochondrial changes	IMP IMP: Inferred from mutant phenotype	10859343	MGI
involved in dAMP catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
involved in dGMP catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
acts upstream of or within dGTP metabolic process	IMP IMP: Inferred from mutant phenotype	9122228	MGI
involved in deoxyadenosine catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
acts upstream of or within deoxyguanosine catabolic process	IMP IMP: Inferred from mutant phenotype	10859343	MGI
involved in deoxyguanosine catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
acts upstream of or within deoxyinosine catabolic process	IMP IMP: Inferred from mutant phenotype	10859343	MGI
involved in deoxyinosine catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
acts upstream of or within guanosine catabolic process	IMP IMP: Inferred from mutant phenotype	10859343	MGI
involved in inosine catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
acts upstream of or within inosine catabolic process	IMP IMP: Inferred from mutant phenotype	10859343	MGI
involved in inosine catabolic process	IMP IMP: Inferred from mutant phenotype	11783524	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	10859343	MGI
acts upstream of or within negative regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	10859343	MGI
acts upstream of or within positive regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	10859343	MGI
acts upstream of or within positive regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	10859343	MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	10859343	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	9122228	MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	9122228	MGI
acts upstream of or within purine nucleoside metabolic process	IDA IDA: Inferred from direct assay	109081	MGI
acts upstream of or within purine nucleoside metabolic process	IMP IMP: Inferred from mutant phenotype	1664183	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	10859343	MGI
acts upstream of or within urate biosynthetic process	IMP IMP: Inferred from mutant phenotype	16964310	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	109081	MGI
located in cytosol	IDA IDA: Inferred from direct assay	109081	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

purine nucleoside phosphorylase

inosine phosphorylase	inosine-guanosine phosphorylase
purine-nucleoside phosphorylase 1

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-16209	Forodesine hydrochloride	99.86%	Yes
HY-16210	Forodesine	99.88%	Yes
HY-W011727A	Pyridoxal 5'-phosphate monohydrate	≥98.0%	Unkown
HY-W011727	Pyridoxal 5'-phosphate hydrate	99.76%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19480	Ulodesine		99.00%	Phase 2
HY-106934A	Peldesine dihydrochloride	Inhibitor	99.63%	Phase 1
HY-106934	Peldesine	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (98)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-20336	Mc-Val-Cit-PABC-PNP		98.89%	Unkown
HY-41189	Fmoc-Val-Cit-PAB-PNP		98.99%	Unkown
HY-136329	β-D-glucuronide-pNP-carbonate		99.44%	Unkown
HY-130777A	AMP-PNP lithium hydrate		≥94.0%	Unkown
HY-W008638	2'-Deoxyinosine		99.83%	Unkown
HY-136136	Fmoc-Val-Ala-PAB-PNP		98.90%	Unkown
HY-141142	Boc-Val-Cit-PAB-PNP		99.55%	Unkown
HY-112835	Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside		99.42%	Unkown
HY-128933	AMP-PNP tetralithium	Inhibitor	≥97.0%	Unkown
HY-137827	4-Nitrophenyl β-D-Cellobioside		99.48%	Unkown
HY-140150	Azido-PEG3-Val-Cit-PAB-PNP		99.09%	Unkown
HY-136154	Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP		96.67%	Unkown
HY-P2724	Purine nucleoside phosphorylase, Microorganism		/	Unkown
HY-130937	DBCO-Val-Cit-PABC-PNP		96.54%	Unkown
HY-139362	Enpp-1-IN-2	Inhibitor	99.16%	Unkown
HY-148425	Mal-amide-PEG8-Val-Ala-PAB-PNP		99.60%	Unkown
HY-W039442	2′-Deoxy-2′-fluoroadenosine		99.71%	Unkown
HY-135975	MC-Val-Ala-PAB-PNP		99.51%	Unkown
HY-130932	Boc-Val-Ala-PAB-PNP		≥98.0%	Unkown
HY-140145	Mal-PEG4-Val-Cit-PAB-PNP		97.05%	Unkown
HY-W039911	4-Nitrophenyl α-D-galactopyranoside		98.70%	Unkown
HY-140147	Mal-amido-PEG2-Val-Cit-PAB-PNP		98.40%	Unkown
HY-147164	MC-Gly-Gly-Phe-Gly-PAB-PNP		98.75%	Unkown
HY-148461	Mal-VC-PAB-PNP		96.86%	Unkown
HY-114430	Fmoc-Phe-Lys(Boc)-PAB-PNP		98.67%	Unkown
HY-W011727S	Pyridoxal Phosphate-d3		98.01%	Unkown
HY-131156	Mal-PEG2-Val-Cit-PABA-PNP		96.82%	Unkown
HY-121106	9-Deazaguanine		99.18%	Unkown
HY-129350	Fmoc-Phe-Lys(Trt)-PAB-PNP		≥98.0%	Unkown
HY-147021	MC-Val-D-Cit-PAB-PNP		/	Unkown
HY-W008638R	2'-Deoxyinosine (Standard)		/	Unkown
HY-129352	Cbz-Phe-(Alloc)Lys-PAB-PNP		/	Unkown
HY-118047	CI 972 anhydrous	Inhibitor	/	Unkown
HY-129351	Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP		/	Unkown
HY-129353	Boc-Phe-(Alloc)Lys-PAB-PNP		/	Unkown
HY-129361	Fmoc-Ala-Ala-Asn-PABC-PNP		/	Unkown
HY-130777	AMP-PNP		/	Unkown
HY-134354	pNP-ADPr		/	Unkown
HY-134354A	pNP-ADPr disodium		99.93%	Unkown
HY-134420	p-Nitrophenyl α-L-fucoside		/	Unkown
HY-136100	TCO-PEG1-Val-Cit-PABC-PNP		/	Unkown
HY-136105	Azido-PEG1-Val-Cit-PABC-PNP		/	Unkown
HY-136108	Fmoc-Gly3-Val-Cit-PAB-PNP		/	Unkown
HY-139247	pNPS-DHA		/	Unkown
HY-139856	Mal-Ala-Ala-PAB-PNP		/	Unkown
HY-140144	Mal-PEG1-Val-Cit-PAB-PNP		98.41%	Unkown
HY-141145	OPSS-Val-Cit-PAB-PNP		/	Unkown
HY-144628	Fmoc-Asn-Pro-Val-PABC-PNP		/	Unkown
HY-147021A	MC-D-Val-Cit-PAB-PNP		/	Unkown
HY-148031	MC-Ala-Ala-Asn-PAB-PNP		/	Unkown
HY-148399	Mal-VC-PAB-PNP-CDN-A		/	Unkown
HY-153486	N3-VC-PAB-PNP		97.35%	Unkown
HY-158199	BCN-HS-PEG2-bis(PNP)		/	Unkown
HY-160703	DMBA-SIL-PNP		/	Unkown
HY-173161	Mc-d-Val-d-Cit-PAB-PNP		/	Unkown
HY-20336G	Mc-Val-Cit-PABC-PNP (GMP)		/	Unkown
HY-P2724A	Purine nucleoside phosphorylase, Bacillus sp.		/	Unkown
HY-RS10789	PNP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W145529	GalNAcβ(1-3)Galα(1-4)Galβ(1-4)Glc-β-pNP		/	Unkown
HY-W145534	GlcNAcβ(1-3)GalNAc-α-pNP		/	Unkown
HY-W145540	Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP		/	Unkown
HY-W145553	GalNAcβ(1-3)GlcNAc-β-pNP		/	Unkown
HY-W145556	Galβ(1-3)GlcNAcβ(1-3)Galβ(1-4)Glc-β-pNP		/	Unkown
HY-W145607	Galβ(1-3)GalNAc-β-pNP		/	Unkown
HY-W145622	Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP		/	Unkown
HY-W145631	GalNAcβ(1-4)GlcNAc-β-pNP		/	Unkown
HY-W357155	Gal1-β-3GlcNAc-β-PNP		/	Unkown
HY-W698379	Gal1-b-4GlcNAc-α-PNP		/	Unkown
HY-W698411	GlcNAc1-β-6GalNAc-α-PNP		/	Unkown
HY-W699180	Fuc1-α-2Gal1-β-3GlcNAc-β-PNP		/	Unkown
HY-W800847	Mal-Amide-PEG4-Val-Cit-PAB-PNP		/	Unkown
HY-137828	4-Nitrophenyl N,N′-diacetyl-β-D-chitobioside		/	Unkown
HY-137878	2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid		/	Unkown
HY-141153	Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP		/	Unkown
HY-151699	6-Azidohexanoyl-Val-Cit-PAB-PNP		/	Unkown
HY-151726	Azido-PEG(4)-Val-Cit-PAB-PNP		/	Unkown
HY-151740	4-Pentynoyl-Val-Ala-PAB-PNP		/	Unkown
HY-160790	β-Glu-PNP		/	Unkown
HY-172291	Mal-amide-PEG8-Val-Cit-PAB-PNP		/	Unkown
HY-20560	(Ac)Phe-Lys(Alloc)-PABC-PNP		/	Unkown
HY-W015996	4-Nitrophenyl-N-acetyl-α-D-galactosaminide		/	Unkown
HY-W190913	DBCO-PEG4-Val-Cit-PAB-PNP		/	Unkown
HY-W395122	Mal-PEG1-PNP-carbonate		/	Unkown
HY-W591286	Alkyne-Val-Cit-PAB-PNP		/	Unkown
HY-W591336	Alloc-Val-Ala-PAB-PNP		/	Unkown
HY-W591374	DBCO-PEG4-Val-Ala-PAB-PNP		/	Unkown
HY-W591439	Fmoc-Lys(Boc)-PAB-PNP		/	Unkown
HY-W591440	Fmoc-Cit-PAB-PNP		/	Unkown
HY-W591441	Fmoc-Ala-PAB-PNP		/	Unkown
HY-W800617	NH2-PEG1-Val-Cit-PAB-OH		/	Unkown
HY-W800618	NH2-PEG3-Val-Cit-PAB-OH		/	Unkown
HY-W800619	NH2-PEG4-Val-Cit-PAB-OH		/	Unkown
HY-W800620	NH2-PEG6-Val-Cit-PAB-OH		/	Unkown
HY-W800621	Fmoc-PEG2-Val-Cit-PAB-OH		/	Unkown
HY-W800622	Fmoc-PEG4-Val-Cit-PAB-OH		/	Unkown
HY-W800623	Fmoc-PEG6-Val-Cit-PAB-OH		/	Unkown
HY-W800624	Boc-PEG2-Val-Cit-PAB-OH		/	Unkown
HY-W800625	Boc-PEG4-Val-Cit-PAB-OH		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pnp	NCBI	NCBI:4860
Macaca fascicularis	Pnp	NCBI	NCBI:102146459
Rattus norvegicus	Pnp	NCBI	NCBI:290029

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