Fmoc-Asn-Pro-Val-PABC-PNP

Cat. No.: HY-144628: FAQs
Data Sheet Handling Instructions Technical Support

Fmoc-Asn-Pro-Val-PABC-PNP (compound 6) is a potent ADC Linker.

For research use only. We do not sell to patients.

Fmoc-Asn-Pro-Val-PABC-PNP Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-Asn-Pro-Val-PABC-PNP (compound 6) is a potent ADC Linker^[1].

Molecular Weight

820.84

Formula

C₄₃H₄₄N₆O₁₁

CAS No.

2893871-64-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC1=CC=C(C=C1)NC([C@@H](NC([C@H]2N(CCC2)C([C@@H](NC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O)CC(N)=O)=O)=O)C(C)C)=O)OC6=CC=C(C=C6)[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (121.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2183 mL	6.0913 mL	12.1826 mL
5 mM	0.2437 mL	1.2183 mL	2.4365 mL
10 mM	0.1218 mL	0.6091 mL	1.2183 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mohamed Amar IA, et al. Dual intra- and extracellular release of monomethyl auristatin E from a neutrophil elastase-sensitive antibody-drug conjugate. Eur J Med Chem. 2022 Feb 5;229:114063. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2183 mL	6.0913 mL	12.1826 mL	30.4566 mL
	5 mM	0.2437 mL	1.2183 mL	2.4365 mL	6.0913 mL
	10 mM	0.1218 mL	0.6091 mL	1.2183 mL	3.0457 mL
	15 mM	0.0812 mL	0.4061 mL	0.8122 mL	2.0304 mL
	20 mM	0.0609 mL	0.3046 mL	0.6091 mL	1.5228 mL
	25 mM	0.0487 mL	0.2437 mL	0.4873 mL	1.2183 mL
	30 mM	0.0406 mL	0.2030 mL	0.4061 mL	1.0152 mL
	40 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.7614 mL
	50 mM	0.0244 mL	0.1218 mL	0.2437 mL	0.6091 mL
	60 mM	0.0203 mL	0.1015 mL	0.2030 mL	0.5076 mL
	80 mM	0.0152 mL	0.0761 mL	0.1523 mL	0.3807 mL
	100 mM	0.0122 mL	0.0609 mL	0.1218 mL	0.3046 mL