MC-Val-D-Cit-PAB-PNP

Cat. No.: HY-147021: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

MC-Val-D-Cit-PAB-PNP is a cleavable peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). MC-Val-D-Cit-PAB-PNP contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to antitumor compounds.

For research use only. We do not sell to patients.

MC-Val-D-Cit-PAB-PNP Chemical Structure

CAS No. : 1350456-66-4

Size	Price	Stock
25 mg		Ask For Quote & Lead Time
50 mg		Ask For Quote & Lead Time
100 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of MC-Val-D-Cit-PAB-PNP:

MC-D-Val-Cit-PAB-PNP Get quote

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View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
Customer Review

Description

IC₅₀ & Target

Protease Cleavable Linker

Molecular Weight

737.76

Formula

C₃₅H₄₃N₇O₁₁

CAS No.

1350456-66-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(C=C1)=CC=C1COC(OC(C=C2)=CC=C2[N+]([O-])=O)=O)[C@@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN(C3=O)C(C=C3)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (135.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3555 mL	6.7773 mL	13.5545 mL
5 mM	0.2711 mL	1.3555 mL	2.7109 mL
10 mM	0.1355 mL	0.6777 mL	1.3555 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.05%

Select Batch:

Data Sheet (244 KB) SDS (251 KB)

COA (252 KB) HNMR (309 KB) RP-HPLC (247 KB) MS (70 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3555 mL	6.7773 mL	13.5545 mL	33.8864 mL
	5 mM	0.2711 mL	1.3555 mL	2.7109 mL	6.7773 mL
	10 mM	0.1355 mL	0.6777 mL	1.3555 mL	3.3886 mL
	15 mM	0.0904 mL	0.4518 mL	0.9036 mL	2.2591 mL
	20 mM	0.0678 mL	0.3389 mL	0.6777 mL	1.6943 mL
	25 mM	0.0542 mL	0.2711 mL	0.5422 mL	1.3555 mL
	30 mM	0.0452 mL	0.2259 mL	0.4518 mL	1.1295 mL
	40 mM	0.0339 mL	0.1694 mL	0.3389 mL	0.8472 mL
	50 mM	0.0271 mL	0.1355 mL	0.2711 mL	0.6777 mL
	60 mM	0.0226 mL	0.1130 mL	0.2259 mL	0.5648 mL
	80 mM	0.0169 mL	0.0847 mL	0.1694 mL	0.4236 mL
	100 mM	0.0136 mL	0.0678 mL	0.1355 mL	0.3389 mL