Boc-Val-Ala-PAB-PNP

Name: Boc-Val-Ala-PAB-PNP
Brand: MedChemExpress
SKU: HY-130932
Rating: 4.5 (1 reviews)

Cat. No.: HY-130932 Purity: ≥98.0%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Boc-Val-Ala-PAB-PNP Chemical Structure

CAS No. : 1884578-00-0

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

558.58

Formula

C₂₇H₃₄N₄O₉

CAS No.

1884578-00-0

Appearance

Solid

Color

White to off-white

SMILES

CC([C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(NC1=CC=C(C=C1)COC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)C)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 35 mg/mL (62.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7903 mL	8.9513 mL	17.9025 mL
5 mM	0.3581 mL	1.7903 mL	3.5805 mL
10 mM	0.1790 mL	0.8951 mL	1.7903 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (244 KB) HNMR (136 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7903 mL	8.9513 mL	17.9025 mL	44.7563 mL
	5 mM	0.3581 mL	1.7903 mL	3.5805 mL	8.9513 mL
	10 mM	0.1790 mL	0.8951 mL	1.7903 mL	4.4756 mL
	15 mM	0.1194 mL	0.5968 mL	1.1935 mL	2.9838 mL
	20 mM	0.0895 mL	0.4476 mL	0.8951 mL	2.2378 mL
	25 mM	0.0716 mL	0.3581 mL	0.7161 mL	1.7903 mL
	30 mM	0.0597 mL	0.2984 mL	0.5968 mL	1.4919 mL
	40 mM	0.0448 mL	0.2238 mL	0.4476 mL	1.1189 mL
	50 mM	0.0358 mL	0.1790 mL	0.3581 mL	0.8951 mL
	60 mM	0.0298 mL	0.1492 mL	0.2984 mL	0.7459 mL