2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-150252A
    ATIC-IN-1 acetate
    		Inhibitor 99.96%
    ATIC-IN-1 (compound 14) acetate is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM, whcich catalyzes de novo purine biosynthesis. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity via reduction in cell numbers and cell division rates.
    ATIC-IN-1 acetate
  • HY-Y1069
    (S)-Malic acid
    		99.62%
    (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
    (S)-Malic acid
  • HY-N1420
    Rhamnose
    		98.0%
    Rhamnose (L-Rhamnose ) is an orally active deoxysugar. Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas.
    Rhamnose
  • HY-113130
    Eicosadienoic acid
    		99.87%
    Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues.
    Eicosadienoic acid
  • HY-113227
    Oxoadipic acid
    		99.86%
    Oxoadipic acid is a key metabolite of the essential amino acids tryptophan and lysine.
    Oxoadipic acid
  • HY-126050
    (R)-Pantetheine
    		99.72%
    (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity.
    (R)-Pantetheine
  • HY-18569S
    3-Indoleacetic acid-d5
    		99.84%
    3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates.
    3-Indoleacetic acid-d<sub>5</sub>
  • HY-113493
    4-Pyridoxic acid
    		99.82%
    4-Pyridoxic acid is an endogenous substrate of renal organic anion transporters (OAT1/3) and a catabolite of vitamin B6. 4-Pyridoxic acid is excreted through OAT1/3-mediated tubular active secretion, which can reflect OAT1/3 activity. Elevated plasma concentrations of 4-Pyridoxic acid are associated with decreased OAT1/3 activity in chronic kidney disease (CKD) and can be used as a biomarker to reflect the severity of knee osteoarthritis (KOA) and lumbar spondylosis (LS).
    4-Pyridoxic acid
  • HY-W127758
    Alginic acid
    Alginic acid is a natural polysaccharide, which has been widely concerned and applied due to its excellent water solubility, film formation, biodegradability and biocompatibility. Alginic acid induces oxidative stress-mediated hormone secretion disorder, apoptosis and autophagy in mouse granulosa cells and ovaries. Alginic acid has an inhibitory effect on histamine release. Anti-anaphylactic and anti-inflammatory properties.
    Alginic acid
  • HY-122942
    Moracin M
    		98.99%
    Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity.
    Moracin M
  • HY-15129
    O-Phospho-L-serine
    		99.90%
    O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
    O-Phospho-L-serine
  • HY-W012980
    Isovaleric acid
    		≥98.0%
    Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders.
    Isovaleric acid
  • HY-N0486S1
    L-Leucine-13C
    		99.4%
    L-Leucine-13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-<sup>13</sup>C
  • HY-E70013
    Lichenase, Microorganism
    Lichenase, Microorganism (endo-1,3:1,4-β-D-Glucanase) is a specific, endo-(1-3),(1-4)-β-D-glucan 4-glucanohydrolase. Lichenase, Microorganism solubilizes β-glucans from cereal grains and gives gluco-oligosaccharides (GOS). Lichenase, Microorganism can be used in the degradation of polysaccharides in the cell walls.
    Lichenase, Microorganism
  • HY-N0466
    Rebaudioside A
    		98.0%
    Rebaudioside A is a steviol glycoside with high sweetness potency and is a potent α-glucosidase inhibitor with an IC50 value of 35.01 ug/mL. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells via inhibition of ATP-sensitive K+-channels.
    Rebaudioside A
  • HY-W001080
    3,4-Dihydroxybenzeneacetic acid
    		99.90%
    3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
    3,4-Dihydroxybenzeneacetic acid
  • HY-Y0313
    p-Hydroxybenzaldehyde
    		99.99%
    p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
    p-Hydroxybenzaldehyde
  • HY-N0390S8
    L-Glutamine-15N2
    		99.10%
    L-Glutamine-15N2 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
    L-Glutamine-<sup>15</sup>N<sub>2</sub>
  • HY-P2890
    Laccase, Microorganisms
    Laccase, Microorganisms (Denilite IIS) is a multi-copper oxidase (MCOs), which widely exists in microorganisms, plants and fungi, and can catalyze the oxidation of one electron of various phenolic compounds. Laccase can promote the oxidative coupling of single lignin, which plays an important role in the formation and biodegradation of lignin, and also has the potential to cross-link food polymers.
    Laccase, Microorganisms
  • HY-129380
    Fructosyl-lysine
    Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection.
    Fructosyl-lysine
Cat. No. Product Name / Synonyms Application Reactivity