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terminus

" in MedChemExpress (MCE) Product Catalog:

126

Inhibitors & Agonists

39

Biochemical Assay Reagents

63

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9

Inhibitory Antibodies

4

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1

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1

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1

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25

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2842

    Biochemical Assay Reagents Others Cancer
    Aminopeptidase catalyzes the cleavage of amino acids from the amino terminus of protein or peptide substrates .
    Aminopeptidase
  • HY-P3102

    GCGR Metabolic Disease
    GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice .
    GLP-1(32-36)amide
  • HY-18619
    YL-109
    2 Publications Verification

    Aryl Hydrocarbon Receptor Cancer
    YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness .
    YL-109
  • HY-P99963

    HS636

    PD-1/PD-L1 Cancer
    Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment .
    Sudubrilimab
  • HY-P1884

    Bacterial Infection
    LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host .
    LL-37, acetylated,amidated
  • HY-131800

    ATP Synthase Metabolic Disease
    3'-NH2-ATP, an ATP analogue, is a potent and competitive inhibitor of ATP, with a Ki of 2.3 μM. 3'-NH2-ATP can be used to synthesis of 3′-Amino-3′-deoxy transfer RNA by incorporation into the 3' terminus of tRNA-C-C .
    3'-NH2-ATP
  • HY-P3102A

    GCGR Metabolic Disease
    GLP-1(32-36)amide TFA, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide TFA could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice .
    GLP-1(32-36)amide TFA
  • HY-168781

    Drug Derivative Metabolic Disease
    Arachidoyl glycine is composed of a 0:0 fatty acid with glycine attached to its carboxyl terminus .
    Arachidoyl glycine
  • HY-N15079

    Bacterial Infection
    Arphamenine B is a Zn 2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B enhances the immune response and is used to characterize novel proteases .
    Arphamenine B
  • HY-P1493

    FPB,human

    Thrombin Inflammation/Immunology
    Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.
    Fibrinopeptide B, human
  • HY-136887

    Bacterial Infection
    Arphamenine B hemisulfate is a Zn 2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B hemisulfate is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B hemisulfate enhances the immune response and is used to characterize novel proteases .
    Arphamenine B hemisulfate
  • HY-E70368

    Biochemical Assay Reagents Others
    Collagenase G Recombinant is involved in the islet isolation process, and digests specific collagens from the N-terminus, especially Col-V .
    Collagenase G (Recombinant)
  • HY-171573

    AZddGTP

    Telomerase Others
    3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a Ki value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro .
    3′-Azido-2′,3′-dideoxy-GTP
  • HY-P1505

    Complement 3a (70-77)

    Complement System Inflammation/Immunology
    C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
    C3a (70-77)
  • HY-P2019

    Neuropeptide Y Receptor Neurological Disease
    Levitide is a neurohormone-like peptide, can be isolated from skin secretions of the South African frog Xenopus laevis. Levitide comes from preprolevitide, is 88 residues long and contains contains the levitide peptide at the C terminus (Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2) and the putative signal sequence at the N terminus .
    Levitide
  • HY-P1735

    Cytochrome P450 Inflammation/Immunology
    Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes .
    Moth Cytochrome C (MCC) (88-103)
  • HY-P10055

    PSMA-1

    PSMA Cancer
    PSMA-1 is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells. PSMA-1 is selected and polyarginine sequences R6 or R9 were added at the C terminus to generate the CTPs. FITC labeling of the peptide with an aminohexanoic acid (Ahx) linker at the N terminus produced FITC-PSMA-1,to track PSMA binding on PCa cells .
    PSMA targeting peptide
  • HY-16757
    Trofinetide
    1 Publications Verification

    NNZ-2566

    iGluR Neurological Disease
    Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.
    Trofinetide
  • HY-P5954

    Calcium Channel Others
    PLTX-II is a calcium channel blocker. PLTX-II has a 44-residue peptide containing ten Cys residues and an O-palmitoylated threonine amide at the carboxy-terminus .
    PLTX-II
  • HY-P991676

    Kallikrein Inflammation/Immunology
    Eflumenibep alfa is a Kallikrein 5 inhibitor with anti-inflammatory activity. Eflumenibep alfa is a fusion protein that combines human SPINK2 with the human IgG1 Fc fragment at the C-terminus .
    Eflumenibep alfa
  • HY-P3891

    Neurokinin Receptor Neurological Disease
    Substance P (4-11), the C-terminus fragment of Substance P (HY-P0201), is a Substance P agonist that shows highly selective for NK1 receptors .
    Substance P (4-11)
  • HY-P991680

    TNF Receptor Inflammation/Immunology
    Elipunercept is a fusion protein that combines human TNFRSF1B extracellular domain fragment (1-235) fused at the C-terminus to a human IgG1 Fc fragment. Elipunercept is an immunomodulator .
    Elipunercept
  • HY-160550

    Phosphatase Inflammation/Immunology
    DPM-1003 is a PTP1B conformational inhibitor that targets the non-catalytic, disordered segment at the C-terminus of the PTP1B protein, showing improvement in lung inflammation in mice .
    DPM-1003
  • HY-P991678

    Interleukin Related Inflammation/Immunology
    Efpixileukin alfa is a fusion protein that combines human IL-2 variant fused at the C-terminus to human immunoglobulin G1 (IgG1) Fc fragment. Efpixileukin alfa is an immunomodulator .
    Efpixileukin alfa
  • HY-P5007

    Biochemical Assay Reagents Cardiovascular Disease
    Copeptin (human) is a diagnostic and prognostic biomarker for cardiovascular disease (CVD). Copeptin (human) is also the carboxyl terminus of the arginine vasopressin (AVP) precursor peptide. Copeptin (human) can be used in the study of cardiovascular disease .
    Copeptin (human)
  • HY-174365D

    Biochemical Assay Reagents Others
    mPEG-NPC (MW 10000) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
    mPEG-NPC (MW 10000)
  • HY-P1505A
    C3a (70-77) TFA
    1 Publications Verification

    Complement 3a (70-77) TFA

    Complement System Inflammation/Immunology
    C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a .
    C3a (70-77) TFA
  • HY-174365B

    Biochemical Assay Reagents Others
    mPEG-NPC (MW 3400) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
    mPEG-NPC (MW 3400)
  • HY-174365H

    Biochemical Assay Reagents Others
    mPEG-NPC (MW 20000) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
    mPEG-NPC (MW:20000)
  • HY-174365E

    Biochemical Assay Reagents Others
    mPEG-NPC (MW 40000) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
    mPEG-NPC (MW 40000)
  • HY-174365

    Biochemical Assay Reagents Others
    mPEG-NPC (MW 1000) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
    mPEG-NPC (MW 1000)
  • HY-174365C

    Biochemical Assay Reagents Others
    mPEG-NPC (MW 5000) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
    mPEG-NPC (MW 5000)
  • HY-174365A

    Biochemical Assay Reagents Others
    mPEG-NPC (MW 2000) is an important PEG derivative whose reactive groups can be used to modify proteins, peptides or any other compounds with available amino groups at lysine residues or N-terminus .
    mPEG-NPC (MW 2000)
  • HY-157712

    Biochemical Assay Reagents Others
    08:0 PI(4,5)P2 ammonium is suitable for identifying its binding site at the transient receptor potential vanilloid 4 (TRPV 4 N) terminus .
    08:0 PI(4,5)P2 ammonium
  • HY-P3932

    Neurokinin Receptor Neurological Disease
    [Sar4] Substance P (4-11) is an analog of Substance P (4-11). Substance P (4-11), the C-terminus fragment of Substance P (HY-P0201), is a Substance P agonist .
    [Sar4] Substance P (4-11)
  • HY-107091

    DA-DKP

    Endogenous Metabolite Inflammation/Immunology
    Aspartyl-alanyl-diketopiperazine (DA-DKP) is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin and can modulate the inflammatory immune response through a molecular pathway implicated in T- lymphocyte anergy .
    Aspartyl-alanyl-diketopiperazine
  • HY-P99185

    Amyloid-β Neurological Disease
    Bapineuzumab is an anti-β-amyloid protein (APP) monoclonal antibody. Bapineuzumab is a humanized IgG1 that recognizes the N terminus of Aβ cleared plaques from the brains. Bapineuzumab can be used for the research of Alzheimer’s disease (AD) .
    Bapineuzumab
  • HY-44370

    ADC Linker Cancer
    (tert-Butoxycarbonyl)glycyl-glycyl-glycyl-glycyl-glycine is a protease cleavable ADC linker with a Boc group on the N terminus, and it is used for the development of antibody-drug conjugates (ADCs). The Boc group can be deprotected under mild acidic conditions to form the free amine.
    Boc-Gly-Gly-Gly-Gly-Gly
  • HY-19738

    Tau Protein Neurological Disease
    NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide ( 41GCWMLY 46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin .
    NQTrp
  • HY-140741
    DSPE-PEG-OH, MW 2000
    1 Publications Verification

    Liposome Cancer
    DSPE-PEG-OH, MW 2000 is a hydroxyl-terminated PEGylated phospholipid. The hydrophobic tail allows for the encapsulation and aggregation of other hydrophobic drugs, and the hydroxyl terminus is suitable for further reactions. DSPE-PEG-OH, MW 2000 can be used to prepare liposomes or lipid nanoparticles .
    DSPE-PEG-OH, MW 2000
  • HY-164166

    Biochemical Assay Reagents Others
    Fmoc-Sar-Sar-Sar-OH is a small molecule polypeptide composed of four sarcosine residues, in which the N-terminus of the peptide chain is protected by Fmoc. Fmoc-Sar-Sar-Sar-OH can be used for peptide synthesis or synthesis of drug-peptide ligand conjugates .
    Fmoc-Sar-Sar-Sar-OH
  • HY-W106311

    Biochemical Assay Reagents Others
    Fmoc-Val-Ala-OH is a reagent consisting of a Val-Ala dipeptide with an Fmoc protecting group on its N-terminus. Carboxylic acids can be reactive with alcohols or amines, while the Fmoc protecting group can be removed with piperidine to allow for coupling with carboxylic acids to form amides.
    Fmoc-Val-Ala-OH
  • HY-149872

    Biochemical Assay Reagents Others
    DCA-RMR1 is a cross-linker. DCA-RMR1 elicits facile bicyclization of native peptides via N-terminus Cys-Cys cross-linking. DCA-RMR1 derivatizes RMR1 with 1,3-dichloroacetone (DCA) .
    DCA-RMR1
  • HY-W015450

    Endogenous Metabolite Others
    D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase .
    D-Ala-D-Ala
  • HY-P2844

    DNA/RNA Synthesis Metabolic Disease
    Polynucleotide Kinase is a DNA repair enzyme. Polynucleotide Kinase possesses both a 5’-kinase activity that catalyzes the transfer of phosphate from ATP to a 5’-hydroxyl (OH) terminus and also a 3’-phosphatase activity that converts 3’-phosphate termini to 3’-OH termini .
    Polynucleotide kinase
  • HY-157508
    VCP Activator 1
    1 Publications Verification

    p97 Others
    VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail .
    VCP Activator 1
  • HY-P10909

    MBX 2109

    Thyroid Hormone Receptor Endocrinology
    Canvuparatide (MBX 2109) is a prodrug for parathyroid hormone (PTH) peptide that releases the bioactive PTH[1-32] peptide agonist that retains a fatty acylated lysine (Lys33) at the C-terminus, thereby extending the halflife of Canvuparatide. Canvuparatide can be used for the symptoms of hypoparathyroidism such as hypocalcemia and hyperphosphatemia .
    Canvuparatide
  • HY-E70566

    Ser/Thr Protease Others
    Protease (Fab Cleaving) is a serine protease expressed recombinantly in E.coli with a 6×His tag at the C-terminus. Protease (Fab Cleaving) specifically digests human IgG1 at a single site above the hinge, generating intact Fab and Fc fragments within two hours without reducing conditions.
    Protease (Fab Cleaving)
  • HY-34738

    3-(Boc-amino)-1-propanol

    Amino Acid Derivatives Others
    Boc-β-Ala-ol (3-(Boc-amino)-1-propanol) is an alanine derivative with a Boc protecting group at the N-terminus, which can be used to synthesize bioactive peptide mimics, such as Nα-Benzoyl-α-azaornithine phenyl ester, which has trypsin inhibitory activity .
    Boc-β-Ala-ol
  • HY-N15973

    Biochemical Assay Reagents Others
    DSPE PEG2k-OH ammonium is a hydroxyl-terminated PEGylated phospholipid. The hydrophobic tail allows for the encapsulation and aggregation of other hydrophobic drugs, and the hydroxyl terminus is suitable for further reactions. DSPE PEG2k-OH ammonium can be used to prepare liposomes or lipid nanoparticles .
    DSPE PEG2k-OH ammonium

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