Search Result
Results for "
succinate dehydrogenase (SDH)
" in MedChemExpress (MCE) Product Catalog:
3
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-119976
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Fungal
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Infection
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Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor .
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- HY-170974
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Fungal
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Infection
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SDH-IN-20 (compound A19) is an antifungal agent. SDH-IN-20 against Verticillium dahlia, R. solani with EC50s of less than 3.0 μg/mL, 2.87 μg/mL. SDH-IN-20 exerts its highly antifungal effects by acting as an effective succinate dehydrogenase (SDH) inhibitor with an IC50 of 29.33 μM. SDH-IN-20 adversely impacts the integrity of cell membranes and mycelial morphologies of R. solani .
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- HY-162776
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- HY-178346
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Fungal
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Infection
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SDH-IN-33 (Compound I-9) is a succinate dehydrogenase inhibitor. SDH-IN-33 exhibits excellent fungicidal activity with an EC50 of 0.07 μg/mL. SDH-IN-33 inhibits R. solani succinate dehydrogenase (RsSDH) with an IC50 0.35 μg/mL. SDH-IN-33 can be used for the study of fungal infection .
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- HY-149601
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Fungal
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Infection
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SDH-IN-8 (compound G40) is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 27 nM for porcine SDH. SDH-IN-8 has fungicidal properties .
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- HY-149600
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Fungal
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Infection
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SDH-IN-7 (compound G28) is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 26 nM for porcine SDH. SDH-IN-7 has fungicidal properties .
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- HY-149653
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Fungal
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Infection
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SDH-IN-10 is a potent succinate dehydrogenase inhibitor (SDHI) with antifungal effects .
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- HY-N7114
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Antibiotic
Bacterial
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Infection
Metabolic Disease
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Chloramphenicol succinate is a proagent of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate also is an antibiotic. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity .
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- HY-155700
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Fungal
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Infection
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SDH-IN-6 (compound 6i) is a potent succinate dehydrogenase (SDH) inhibitor. SDH-IN-6 has antifungal activity against Valsa mali with an EC50 value of 1.77 mg/L .
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- HY-178177
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Fungal
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Infection
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SDH-IN-31 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.11 μM. SDH-IN-31 exhibits anti-fungal activity. SDH-IN-31 can be used for the research of infection, such as infection, such as rice sheath blight .
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- HY-172362
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Succinate Dehydrogenase
Fungal
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Infection
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SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC50 of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC50 of 0.5 mg/L .
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- HY-163890
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Succinate Dehydrogenase
Parasite
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Infection
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Succinate dehydrogenase-IN-2 (Compound 12x) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 1.22 mg/L. Succinate dehydrogenase-IN-2 exhibits antifungal activity, that inhibits S. sclerotiorum, V. mali, G. graminis, R. solani and B. cinerea with EC50 of 0.52-3.42 mg/L .
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- HY-156270
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Bacterial
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Infection
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SDH-IN-9 (compound Ip) is a potent inhibitor of Succinate Dehydrogenase. SDH-IN-9 shows fungicidal activity against Fusarium graminearum Schw with the EC50 of 0.93 μg/mL .
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- HY-155004
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Antibiotic
Fungal
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Infection
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SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 7.2 μg/mL. SDH-IN-3 exhibits excellent antifungal activities against Nigrospora oryzae with an EC50 of 1.9 μg/mL. SDH-IN-3 can be used for anti-infection research .
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- HY-158321
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Fungal
Succinate Dehydrogenase
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Infection
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SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC50=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death .
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- HY-157459
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Fungal
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Infection
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SDH-IN-11 (compound A7) is a SDH inhibitor, and shows inhibitory effect on nematode feeding, reproductive ability, and egg hatching. SDH-IN-11 promotes the oxidative stress of nematodes and causes intestinal damage to nematodes. SDH-IN-11 inhibits the activity of succinate dehydrogenase (SDH) in nematodes .
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- HY-139983
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Fungal
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Infection
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SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against S. sclerotiorum (EC50 of 0.14 mg/L) .
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- HY-161504
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Fungal
Succinate Dehydrogenase
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Infection
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SDH-IN-14 (Compound Z2) is an inhibitor of succinate dehydrogenase (SDH). SDH-IN-14 has antifungal activity (EC50=2.7 μg/mL) against B.cinerea. SDH-IN-14 acts by disrupting the integrity of the cell wall and cell membrane .
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- HY-N7114A
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Bacterial
Antibiotic
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Infection
Metabolic Disease
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Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity. Chloramphenicol succinate acts as a prodrug, being converted to active chloramphenicol by esterases while it is circulating in the body .
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- HY-159486
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Succinate Dehydrogenase
Fungal
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Infection
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SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 of 0.48 and 1.4 mg/L .
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- HY-162648
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Fungal
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Infection
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Succinate dehydrogenase-IN-1 (Compound 34) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 0.94 μM and a KD of 22.4 μM. Succinate dehydrogenase-IN-1 exhibits antifungal activity against Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea, with EC50 of 0.04 μM, 1.13 μM, 1.61 μM and 1.21 μM, respectively .
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- HY-149323
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Fungal
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Infection
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SDH-IN-4 (compound B6) is a selective inhibitor against succinate dehydrogenase (SDH) with an IC50 value of 0.28 μg/mL. SDH-IN-4 has highly efficient and broad-spectrum antifungal activity, against R. solani with an EC50 value of 0.23 μg/mL .
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- HY-172810
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Succinate Dehydrogenase
Fungal
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Infection
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Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L) .
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- HY-119976R
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Fungal
Reference Standards
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Infection
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Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor .
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- HY-172363
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Succinate Dehydrogenase
Fungal
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Infection
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Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC50 of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC50s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC50 > 12.5 μg/mL) .
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- HY-149876
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Fungal
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Infection
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SDH-IN-5 (compound 7d) is a potent succinate dehydrogenase (SDH) inhibitor, with an IC50 of 3.293 μM. SDH-IN-5 is also exhibits antifungal activity, with an EC50 of 0.046 μg/mL against R. solani. SDH-IN-5 could significantly inhibit the growth of R. solani in rice leaves with excellent protective and curative efficacies .
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- HY-120183
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Fungal
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Infection
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Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities .
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- HY-106371
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Antibiotic
Fungal
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Infection
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Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi .
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- HY-D0007
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Tetrazolium blue
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Fluorescent Dye
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Others
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Blue Tetrazolium (Tetrazolium blue), as a blue dye for microbial research, can be reduced into blue tetrazolium formazan (BTF). Blue Tetrazolium can be used to determine the activity of succinate dehydrogenase (SDH) in yeast strains, which has been reduced as a substrate. Use DMSO to extract BTF from cells, and test absorption spectrum of BTF. The BTF shows a wide wavelength range of 480-600 nm with maximal absorbance seen at 540 nm. Blue Tetrazolium, combines with succinate dehydrogenase (SDH) .
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- HY-N7114AR
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Reference Standards
Bacterial
Antibiotic
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Infection
Metabolic Disease
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Chloramphenicol succinate (sodium) (Standard) is the analytical standard of Chloramphenicol succinate (sodium). This product is intended for research and analytical applications. Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity. Chloramphenicol succinate acts as a prodrug, being converted to active chloramphenicol by esterases while it is circulating in the body .
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- HY-178196
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Fungal
MMP
Apoptosis
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Infection
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SDH-IN-32 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 2.74 μM. SDH-IN-32 exhibits excellent antifungal activity. SDH-IN-32 can destroy the cell membrane structure and increase the permeability of the cell membrane. SDH-IN-32 can decrease the mitochondrial membrane potential (MMP), thereby inducing cell apoptosis and inhibiting the normal growth of mycelia. SDH-IN-32 can be used for the research of infection .
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- HY-Y1787R
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Apoptosis
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Neurological Disease
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Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .
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- HY-Y1787
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Apoptosis
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Neurological Disease
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Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .
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- HY-162500
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Fungal
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Infection
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Antifungal agent 99 (Compound E1) is a fungal succinate dehydrogenase (SDH) inhibitor. Antifungal agent 99 reduces mycelial density and significantly increase the mitochondrial number in mycelia cytoplasm .
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- HY-148921
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Fungal
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Infection
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SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-168470
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Fungal
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Infection
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Antifungal agent 125 (compound 4H) is a potent inhibitor of succinate dehydrogenase (SDH), with the IC50 of 3.59 μg/mL. Antifungal agent 125 exhibits fungicidal activity against Alternaria alternata .
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- HY-163284
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Succinate Dehydrogenase
Fungal
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Infection
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SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC50s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants .
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- HY-159481
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Succinate Dehydrogenase
Fungal
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Infection
Inflammation/Immunology
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SDH-IN-17 (compound C32), a hydrazide-containing flavonol derivative, is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 8.42 μM. SDH-IN-17 can occupy the active site and form strong interactions with the key residues of SDH. SDH-IN-17 exhibits antifungal activity against Rhizoctonia solani (EC50=0.170 μg/mL). SDH-IN-17 disrupts the normal growth of hyphae by affecting the structural integrity of the cell membrane and cellular respiration. SDH-IN-17 has the potential for plant disease control research .
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- HY-173264
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Parasite
Insecticide
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Infection
|
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SDH-IN-24 (Compound 51) is an inhibitor of succinate dehydrogenase (SDH). The LC50 against the second-stage juveniles of Bursaphelenchus xylophilus (B. xylophilus) is 6.9 mg/L, and the IC50 for SDH is 15.0 μM. SDH-IN-24 exerts its nematicidal activity by inhibiting the activity of SDH to interfere with the energy metabolism of nematodes. Meanwhile, it inhibits the motility, feeding, and reproduction of nematodes, induces oxidative stress, reduces the protein content of nematodes, and impairs their antioxidant capacity. SDH-IN-24 can be used in the research related to anti-nematode fields .
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- HY-174831
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Fungal
Succinate Dehydrogenase
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Infection
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SDH-IN-28 is a succinate dehydrogenase inhibitor with an IC50 value of 2.65 mg/L. SDH-IN-28 demonstrates broad-spectrum fungicidal efficacy, with EC50 values of 0.21 (Valsa mali), 0.95 (Botrytis cinerea), 0.64 (Rhizoctonia solani), 1.33 (Fusarium graminearum), and 0.66 mg/L (Gaeumannomyces graminis). SDH-IN-28 effectively prevents V. mali infection in apples .
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- HY-176413
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Fungal
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Infection
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SDH-IN-27 (Compound Q18) is a succinate dehydrogenase inhibitor (SDHI) (IC50: 9.7 mg/L). SDH-IN-27 induces mycelial morphology changes and lipid peroxidation, and exhibits antifungal activity against C. camelliae (EC50: 6.0 mg/L). SDH-IN-27 is an ergosterol biosynthesis inhibitor (EBI) that binds to the active site of CYP51, ultimately leading to cell death of pathogenic fungi .
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- HY-172777
-
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Succinate Dehydrogenase
Fungal
Reactive Oxygen Species (ROS)
MMP
|
Infection
|
|
SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control .
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- HY-162559
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Fungal
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Infection
|
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SDH-IN-16 (compound 5aa) is a potent inhibitor of Succinate Dehydrogenase, with the IC50 of 1.62 μM. SDH-IN-16 displays a broad spectrum of antifungal activity against F. graminearum, B. cinerea, S. sclerotiorum, and R. solani, with the corresponding EC50 values of 0.12, 4.48, 0.33, and 0.15 μg/mL, respectively .
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- HY-172804
-
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Succinate Dehydrogenase
Fungal
Apoptosis
|
Infection
|
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SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-26 exhibits significant inhibitory activity against multiple phytopathogenic fungi, such as Rhizoctonia solani and Botrytis cinerea, with an EC50 value of 0.270 μg/mL against Rhizoctonia solani. SDH-IN-26 damages the integrity of the fungal cell membrane, increases membrane permeability, disrupts cell structure, and reduces the number of mitochondria, thus affecting the normal growth of mycelia. SDH-IN-26 leads to a decrease in mitochondrial membrane potential, and induces cell apoptosis. SDH-IN-26 is promising for research of plant diseases caused by fungi .
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- HY-162458
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Fungal
|
Infection
Inflammation/Immunology
|
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Antifungal agent 100 (compound 3i) exhibits significant antifungal effects against S. sclerotiorum with an EC50 value of 0.33 mg/L. Antifungal agent 100 displays an IC50 of 0.63 mg/mL against the Succinate dehydrogenase (SDH) of S. sclerotiorum .
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- HY-178050
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Fungal
Succinate Dehydrogenase
|
Infection
|
|
SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research .
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- HY-175722
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Fungal
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Infection
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JSZ16 is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 30.3 μM. JSZ16 has potent broad-spectrum fungicidal activity, such as Sclerotinia sclerotiorum, Botrytis cinerea and Colletotrichum fragariae, with an EC50 of 4.4 mg/L for Sclerotinia sclerotiorum. JSZ16 influences the cell membrane permeability of pathogenic fungi. JSZ16 can be used for the development of fungicide .
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- HY-178051
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Succinate Dehydrogenase
Fungal
|
Infection
|
|
Antifungal agent 135 (Compound C2), an antifungal agent, is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.99 μM. Antifungal agent 135 has potent antifungal activities against Valsa mali, Sclerotinia sclerotiorum and Phytophthora capsici with EC50s of 0.280, 1.11 and 0.130 mg/L, respectively. Antifungal agent 135 shows protective and curative activities against P. capsici and V. mali by effectively disrupting hyphal structural integrity and inhibiting mycelial growth .
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- HY-113298
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Methylmaleic acid
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NOD-like Receptor (NLR)
Keap1-Nrf2
Reactive Oxygen Species (ROS)
|
Cardiovascular Disease
Inflammation/Immunology
|
|
Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .
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- HY-113298R
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Methylmaleic acid (Standard)
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Reference Standards
NOD-like Receptor (NLR)
Keap1-Nrf2
Reactive Oxygen Species (ROS)
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Cardiovascular Disease
Inflammation/Immunology
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Citraconic acid (Methylmaleic acid) (Standard) is the analytical standard of Citraconic acid (HY-113298). This product is intended for research and analytical applications. Citraconic acid is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .
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| Cat. No. |
Product Name |
Type |
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- HY-119976
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|
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Microbial Culture
|
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Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor .
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- HY-D0007
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Tetrazolium blue
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Indicators
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|
Blue Tetrazolium (Tetrazolium blue), as a blue dye for microbial research, can be reduced into blue tetrazolium formazan (BTF). Blue Tetrazolium can be used to determine the activity of succinate dehydrogenase (SDH) in yeast strains, which has been reduced as a substrate. Use DMSO to extract BTF from cells, and test absorption spectrum of BTF. The BTF shows a wide wavelength range of 480-600 nm with maximal absorbance seen at 540 nm. Blue Tetrazolium, combines with succinate dehydrogenase (SDH) .
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- HY-119976R
-
|
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Microbial Culture
|
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Boscalid (Standard) is the analytical standard of Boscalid. This product is intended for research and analytical applications. Boscalid is an anti-fungal agent. Boscalid is a succinate dehydrogenase (SDH) inhibitor .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-N7114A
-
-
-
- HY-Y1787
-
-
-
- HY-113298
-
-
-
- HY-N7114
-
-
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- HY-120183
-
|
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Natural Products
Microorganisms
Source classification
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Fungal
|
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Harzianopyridone is a compound that can be isolated from Trichoderma harzianum. Harzianopyridone is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 80 nM. Harzianopyridone has antifungal, antibacterial, and herbicidal activities .
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- HY-N7114AR
-
|
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Microorganisms
Antibiotics
Source classification
Antibacterial
Disease Research
Other Antibiotics
|
Reference Standards
Bacterial
Antibiotic
|
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Chloramphenicol succinate (sodium) (Standard) is the analytical standard of Chloramphenicol succinate (sodium). This product is intended for research and analytical applications. Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with Haemotoxicity. Chloramphenicol succinate sodium is a proagent of Chloramphenicol, with haemotoxicity. Chloramphenicol succinate is a competitive substrate and inhibitor of succinate dehydrogenase (SDH) that is the possible reason for its toxicity. Chloramphenicol succinate acts as a prodrug, being converted to active chloramphenicol by esterases while it is circulating in the body .
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-
- HY-Y1787R
-
-
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- HY-113298R
-
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Methylmaleic acid (Standard)
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Microorganisms
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
|
Reference Standards
NOD-like Receptor (NLR)
Keap1-Nrf2
Reactive Oxygen Species (ROS)
|
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Citraconic acid (Methylmaleic acid) (Standard) is the analytical standard of Citraconic acid (HY-113298). This product is intended for research and analytical applications. Citraconic acid is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .
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Alkynes
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SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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