Search Result

Results for "

myeloperoxidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) Adenosine Receptor (1) Apoptosis (3) Bacterial (3) Cathepsin (2) CFTR (3) Chloride Channel (3) COX (3) Cytochrome P450 (1) Dipeptidyl Peptidase (2) DNA/RNA Synthesis (1) Elastase (3) Endogenous Metabolite (4) Fluorescent Dye (1) Glutathione Peroxidase (24) Glycosidase (3) Interleukin Related (2) Isotope-Labeled Compounds (3) Microtubule/Tubulin (1) NO Synthase (3) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (1) Pantetheinase (1) Phosphatase (1) Potassium Channel (1) Reactive Oxygen Species (1) TGF-β Receptor (1) TNF Receptor (5) VAP-1 (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (9) Infection (3) Inflammation/Immunology (31) Metabolic Disease (3) Neurological Disease (5)

By Targets:

Adenosine Kinase (1)

Adenosine Receptor (1)

Apoptosis (3)

Bacterial (3)

Cathepsin (2)

CFTR (3)

Chloride Channel (3)

COX (3)

Cytochrome P450 (1)

Dipeptidyl Peptidase (2)

DNA/RNA Synthesis (1)

Elastase (3)

Endogenous Metabolite (4)

Fluorescent Dye (1)

Glutathione Peroxidase (24)

Glycosidase (3)

Interleukin Related (2)

Isotope-Labeled Compounds (3)

Microtubule/Tubulin (1)

NO Synthase (3)

Nuclear Factor of activated T Cells (NFAT) (1)

p38 MAPK (1)

Pantetheinase (1)

Phosphatase (1)

Potassium Channel (1)

Reactive Oxygen Species (1)

TGF-β Receptor (1)

TNF Receptor (5)

VAP-1 (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (9)

Infection (3)

Inflammation/Immunology (31)

Metabolic Disease (3)

Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145197

MPO-IN-3	Glutathione Peroxidase	Cardiovascular Disease
MPO-IN-3 is a potent myeloperoxidase (MPO) inhibitor (WO2013068875A1, example 191). Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the peroxidase superfamily .

HY-114360A

Taurohyodeoxycholic acid sodium 1 Publications Verification	Interleukin Related TNF Receptor	Inflammation/Immunology
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-139915

MPO-IN-1	Glutathione Peroxidase	Inflammation/Immunology
MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase (MPO). MPO-IN-1 has IC₅₀s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation .

HY-105017

Evodenoson ATL 313; DE 112	Adenosine Receptor	Infection Inflammation/Immunology
Evodenoson is a selective agonist of the A_2A adenosine receptor. Evodenoson’s primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile toxin A. Evodenoson’s protective effect is achieved by reducing myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α) .

HY-145581

Mitiperstat AZD4831	Glutathione Peroxidase Cytochrome P450	Cardiovascular Disease Inflammation/Immunology
Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC₅₀s of 1.5 nM and 0.69 μM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC₅₀ of 6 μM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease .

HY-125859A

Myeloperoxidase, human white blood cells MPO	Bacterial	Inflammation/Immunology
Myeloperoxidase, human white blood cells (MPO) is a peroxidase. In Myeloperoxidase, human white blood cells mediate oxidative stress by promoting the production of reactive oxygen species (ROS) and active nitrogen (RNS), regulating the polarization and inflammation-related signaling pathways of microglia and neutrophils. Myeloperoxidase, human white blood cells has antibacterial activity .

HY-P990812

*Anti-Mouse myeloperoxidase/MPO Antibody (6D1)*	Glutathione Peroxidase	Others
Anti-Mouse myeloperoxidase/MPO Antibody (6D1) is a kind of mouse IgG2b kappa in vivo mouse antibody, targeting to MPO. The recommend isotype control of Anti-Mouse myeloperoxidase/MPO Antibody (6D1): Mouse IgG2b kappa, Isotype Control (HY-P99982).

HY-171183

AB8939	Microtubule/Tubulin Apoptosis	Cancer
AB8939 is an effective small moleculeMicrotubule/Tubulin polymerization inhibitor with anti-tumor activity (it inhibits tumor cell proliferation with an IC₅₀ of less than 10 nM). AB8939 can effectively evade resistance mechanisms mediated by things like P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis in cells .

HY-168002

MPO-IN-8	Others	Inflammation/Immunology
MPO-IN-8 is an orally active myeloperoxidase (MPO) inhibitor. MPO-IN-8 can inhibit the generation of hypochlorous acid in neutrophils and the release of extracellular traps (NETosis). In mice with gouty arthritis, MPO-IN-8 can reduce swelling, lower peroxidase activity, and decrease IL-1β levels .

HY-163332

MPO-IN-6	Glycosidase Dipeptidyl Peptidase Glutathione Peroxidase	Cardiovascular Disease
MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC₅₀s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent .

HY-147691

MPO-IN-5	Glutathione Peroxidase Potassium Channel	Inflammation/Immunology
MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC₅₀ values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (k_inact/K_i) of 23000 M ⁻¹s ⁻¹ .

HY-N4288

4-Methylesculetin 1 Publications Verification	Glutathione Peroxidase Cathepsin Phosphatase	Inflammation/Immunology Cancer
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits *myeloperoxidase* activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .

HY-116005

A-286501	Adenosine Kinase	Neurological Disease Inflammation/Immunology
A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC₅₀ value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents .

HY-163335

MPO-IN-7	Glutathione Peroxidase Dipeptidyl Peptidase Glycosidase	Cardiovascular Disease Inflammation/Immunology
MPO-IN-7 (compound MDC) is a *myeloperoxidase* inhibitor with the IC₅₀ values of 41 μM, 25 μM and 4.5 μM towards α-Glucosidase, dipeptidyl peptidase-4 and myeloperoxidase, respectively. MPO-IN-7 shows antioxidant and anti-inflammatory activity in vitro .

HY-19321

PF-06282999	Glutathione Peroxidase	Cardiovascular Disease
PF-06282999 is a potent and selective *myeloperoxidase* inhibitor which is potential useful for the treatment of cardiovascular diseases.

HY-111341

AZD5904 Maximum Cited Publications 13 Publications Verification	Glutathione Peroxidase	Neurological Disease
AZD5904 is a selective and irreversible inhibitor of human *Myeloperoxidase* (MPO) with an IC₅₀ of 140 nM and has similar potency in mouse and rat.

HY-17646

Verdiperstat 3 Publications Verification AZD3241	Glutathione Peroxidase	Neurological Disease
Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC₅₀ of 630 nM, and can be used in the research of neurodegenerative brain disorders.

HY-W041171

3-Chloro-L-tyrosine 3-Chlorotyrosine	Endogenous Metabolite	Others
3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

HY-115486

MPO-IN-28 1 Publications Verification	Glutathione Peroxidase	Cardiovascular Disease
MPO-IN-28 is a selective myeloperoxidase (MPO) inhibitor with an IC₅₀ of 44 nM. MPO-IN-28 can effectively inhibit MPO-mediated low-density lipoprotein oxidation with an IC₅₀ of 90 nM .

HY-N11552

Sorbifolin	Glutathione Peroxidase	Inflammation/Immunology
Sorbifolin, a flavone glucoside, can be isolated from the Pterogyne nitens. Sorbifolin has myeloperoxidase inhibitory and radical scavenging activities. Sorbifolin is also a MPO inhibitor with an IC₅₀ value of 19.2 nM .

HY-146651

MPO-IN-4	Glutathione Peroxidase	Cardiovascular Disease Inflammation/Immunology
MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC₅₀0 of 25 nM. MPO-IN-4 has no effect on methyl guanine methyl transferase (MGMT) .

HY-116188

HX1	Others	Inflammation/Immunology
HX1 is a potent reversible myeloperoxidase (MPO) inhibitor with an IC₅₀ value of 50 nM. HX1 is bound within the active site cavity above the heme and blocks the substrate channel. HX1 is promising for research of inflammatory diseases .

HY-159986

X-17	Pantetheinase	Cancer
X-17 is a Vanin-1 Inhibitor with potent anti-inflammatory and antioxidant activities. X-17 repressrs the inflammatory factor expressions and myeloperoxidase activity, elevats the colonic glutathione reserve, and restors the intestinal barrier .

HY-109094

Mosedipimod EC-18	Others	Inflammation/Immunology
Mosedipimod is a monoacetyldiaglyceride that can be isolated from Cervus nippon Temminck. Mosedipimod is an orally active Toll-Like Receptor signaling inhibitor. Mosedipimod attenuates airway infammation by reducing myeloperoxidase expression in lung tissue. Mosedipimod is used in chronic obstructive pulmonary disease research .

HY-132132

Neutrophil elastase inhibitor 3	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC₅₀ of 80.8 nM for NE release .

HY-148226

20-5,14-HEDGE	Others	Cardiovascular Disease
20-5,14-HEDGE is a 20-HETE analog. 20-5,14-HEDGE protects against lung ischemic reperfusion injury in rats .

HY-W041171S

3-Chloro-L-tyrosine-13C6	Endogenous Metabolite	Others
3-Chloro-L-tyrosine- ¹³C₆ is the ¹³C labeled 3-Chloro-L-tyrosine[1]. 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima[2].

HY-114360AS1

Taurohyodeoxycholic acid-d4 sodium	Isotope-Labeled Compounds TNF Receptor Interleukin Related	Inflammation/Immunology
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-D0169A

Phenol Red sodium salt 1 Publications Verification Phenolsulfonephthalein sodium salt	Fluorescent Dye Glutathione Peroxidase	Others
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of *myeloperoxidase*. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

HY-B0880

4-Aminobenzohydrazide 1 Publications Verification p-Aminobenzohydrazide; p-Aminobenzoic acid hydrazide	Glutathione Peroxidase	Neurological Disease
4-Aminobenzohydrazide (p-Aminobenzohydrazide) is an irreversible myeloperoxidase (MPO) inhibitor (IC₅₀=0.3 μM) that induces oxidative stress burst in neutrophils (ROS IC₅₀=43.6 μM). 4-Aminobenzohydrazide has been used in subacute stroke research .

HY-P10868

Pegtarazimod RLS-0071	Reactive Oxygen Species	Inflammation/Immunology
Pegtarazimod (RLS-0071) is an inhibitor for Complement system via classical and lectin pathways. Pegtarazimod inhibits *myeloperoxidase* (MPO), reduces ROS generation. Pegtarazimod reduces the formation of neutrophil extracellular traps (NETs). Pegtarazimod exhibits anti-inflammatory activity and can be used in research of acute graft-versus-host disease .

HY-147693

COX-1/2-IN-3	COX	Inflammation/Immunology
COX-1/2-IN-3 (Compound 7a) is a COX-1 and COX-2 inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity .

HY-B0679

Lubiprostone 1 Publications Verification RU-0211; SPI-0211	Chloride Channel CFTR Glutathione Peroxidase NO Synthase TNF Receptor	Metabolic Disease
Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-N6937

(R,R)-Secoisolariciresinol diglucoside (R,R)-SDG; (R,R)-LGM2605	Others	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N0656

Usnic acid 1 Publications Verification	Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis	Infection Inflammation/Immunology Cancer
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .

HY-147692

COX-2-IN-14	COX	Inflammation/Immunology
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice .

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Endogenous Metabolite Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces *myeloperoxidase* activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-138896

(9E,11E)-9-Nitro-9,11-octadecadienoic acid 9E,11E-9-Nitro CLA	Endogenous Metabolite	Others
(9E,11E)-9-Nitro-9,11-octadecadienoic acid (9E,11E-9-Nitro CLA) is a nitro-fatty acid, It is formed by exposure of 9Z, 11E-CLA to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite .

HY-126758

Ludartin	Apoptosis Glutathione Peroxidase	Inflammation/Immunology
Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury .

HY-146584

Cathepsin C-IN-5	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .

HY-15652A

Freselestat quarterhydrate ONO-6818 quarterhydrate; ONO-PO-736 quarterhydrate	Elastase	Inflammation/Immunology
Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a K_i of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat quarterhydrate has a potent anti-inflammatory activity .

HY-15652

Freselestat ONO-6818; ONO-PO-736	Elastase	Inflammation/Immunology
Freselestat (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a K_i of 12.2 nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat has a potent anti-inflammatory activity .

HY-125039

N-Acetyl lysyltyrosylcysteine amide 2 Publications Verification	Glutathione Peroxidase	Cardiovascular Disease Neurological Disease
N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation .

HY-B0679R

Lubiprostone (Standard) RU-0211 (Standard); SPI-0211 (Standard)	Chloride Channel CFTR Glutathione Peroxidase NO Synthase TNF Receptor	Metabolic Disease
Lubiprostone (Standard) is the analytical standard of Lubiprostone. This product is intended for research and analytical applications. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-B0679S

Lubiprostone-d7 RU-0211-d₇; SPI-0211-d₇	Isotope-Labeled Compounds Chloride Channel CFTR Glutathione Peroxidase NO Synthase TNF Receptor	Metabolic Disease
Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-173596

SNT-8370	VAP-1 Glutathione Peroxidase	Inflammation/Immunology
SNT-8370 is an orally active inhibitor of VAP-1 (IC₅₀: 10 nM) and myeloperoxidase (MPO) (IC₅₀: 17 nM), with >100-1000 fold more potency for VAP-1 and MPO versus other mammalian (per)oxidases. SNT-8370 inhibits MPO-mediated LDL lipid peroxidation. SNT-8370 inhibits leukocyte infiltration in lung injury models of acute inflammation. SNT-8370 is an anti-inflammatory agent, and can be used for research of inflammatory disorders .

HY-N6937R

(R,R)-Secoisolariciresinol diglucoside (Standard)	Others	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside (Standard) is the analytical standard of (R,R)-Secoisolariciresinol diglucoside. This product is intended for research and analytical applications. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N6937S1

(R,R)-Secoisolariciresinol diglucoside-d6 (R,R)-SDG-d₆; (R,R)-LGM2605-d₆	Isotope-Labeled Compounds	Inflammation/Immunology
(R,R)-Secoisolariciresinol diglucoside-d₆ is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Glycosidase	Inflammation/Immunology
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

HY-103388

NCX 466	COX TGF-β Receptor Glutathione Peroxidase	Inflammation/Immunology
NCX 466 is an orally active COX-1 and COX-2 inhibitor that exhibits anti-inflammatory and analgesic effects. Additionally, NCX 466 acts as a NO donor, exerting anti-inflammatory and antioxidant effects by improving microcirculation. NCX 466 significantly reduces the levels of transforming growth factor-β (TGF-β) and oxidative stress markers (such as thiobarbituric acid reactive substances (TBARS) and 8-hydroxy-2'-deoxyguanosine (8-OHdG)), and it decreases leukocyte recruitment during inflammation by reducing myeloperoxidase (MPO) activity, thereby preventing bleomycin (HY-108345)-induced pulmonary fibrosis in mice .

Cat. No.	Product Name	Type

HY-D0169A

Phenol Red sodium salt 1 Publications Verification Phenolsulfonephthalein sodium salt	Dyes
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat P2X1R. Phenol Red sodium salt enhances the halogenating activity of *myeloperoxidase*. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction .

Cat. No.	Product Name	Type

HY-114360A

Taurohyodeoxycholic acid sodium 1 Publications Verification	Biochemical Assay Reagents
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

Cat. No.	Product Name	Target	Research Area

HY-P10868

Pegtarazimod RLS-0071	Reactive Oxygen Species	Inflammation/Immunology
Pegtarazimod (RLS-0071) is an inhibitor for Complement system via classical and lectin pathways. Pegtarazimod inhibits *myeloperoxidase* (MPO), reduces ROS generation. Pegtarazimod reduces the formation of neutrophil extracellular traps (NETs). Pegtarazimod exhibits anti-inflammatory activity and can be used in research of acute graft-versus-host disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4288

4-Methylesculetin 1 Publications Verification	Structural Classification Nicotiana tabacum L. Classification of Application Fields Source classification Coumarins Phenols Polyphenols Phenylpropanoids Solanaceae Plants Disease Research Fields Cancer	Glutathione Peroxidase Cathepsin Phosphatase
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits *myeloperoxidase* activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .

HY-W041171

3-Chloro-L-tyrosine 3-Chlorotyrosine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

HY-N11552

Sorbifolin	Pterogyne nitens Tul. Leguminosae Source classification Plants	Glutathione Peroxidase
Sorbifolin, a flavone glucoside, can be isolated from the Pterogyne nitens. Sorbifolin has myeloperoxidase inhibitory and radical scavenging activities. Sorbifolin is also a MPO inhibitor with an IC₅₀ value of 19.2 nM .

HY-N6937

(R,R)-Secoisolariciresinol diglucoside (R,R)-SDG; (R,R)-LGM2605	Structural Classification Linum usitatissimum Linn. Classification of Application Fields Linaceae Source classification Lignans Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N0656

Usnic acid 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Plants Infection Usnea diffracta Vain. Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Usneaceae	Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Endogenous Metabolite Glutathione Peroxidase Bacterial
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces *myeloperoxidase* activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-126758

Ludartin	Source classification Artemisia sieversiana Ehrhart ex Willd. Plants Compositae	Apoptosis Glutathione Peroxidase
Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury .

HY-N6937R

(R,R)-Secoisolariciresinol diglucoside (Standard)	Structural Classification Linum usitatissimum Linn. Linaceae Source classification Lignans Phenylpropanoids Plants	Others
(R,R)-Secoisolariciresinol diglucoside (Standard) is the analytical standard of (R,R)-Secoisolariciresinol diglucoside. This product is intended for research and analytical applications. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Glycosidase
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70255

	Myeloperoxidase/MPO Protein, Human (HEK293, His) rHumyeloperoxidase/MPO, His; myeloperoxidase; MPO	Human	HEK293
	The myeloperoxidase (MPO) protein is an important component of polymorphonuclear leukocytes and is critical for bactericidal activity in a variety of organisms. Upon leukocyte stimulation, MPO catalyzes the production of hypohalous acids (mainly hypochlorous acid), thereby enhancing bactericidal activity. Myeloperoxidase/MPO Protein, Human (HEK293, His) is the recombinant human-derived Myeloperoxidase/MPO protein, expressed by HEK293 , with C-His labeled tag.

HY-P70282

	Myeloperoxidase/MPO Protein, Mouse (HEK293, His) 1 Publications Verification rMumyeloperoxidase/MPO, His; myeloperoxidase; MPO	Mouse	HEK293
	Myeloperoxidase (MPO) protein, integral to polymorphonuclear leukocytes' host defense system, catalyzes the production of hypohalous acids, notably hypochlorous acid, enhancing microbicidal activity.Beyond antimicrobial functions, MPO mediates the proteolytic cleavage of alpha-1-microglobulin, yielding t-alpha-1-microglobulin.This processed form inhibits low-density lipoprotein particle oxidation, contributing to vascular damage limitation.Myeloperoxidase/MPO Protein, Mouse (HEK293, His) is the recombinant mouse-derived Myeloperoxidase/MPO protein, expressed by HEK293 , with C-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W041171S

3-Chloro-L-tyrosine-13C6
3-Chloro-L-tyrosine- ¹³C₆ is the ¹³C labeled 3-Chloro-L-tyrosine[1]. 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima[2].

HY-114360AS1

Taurohyodeoxycholic acid-d4 sodium
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-B0679S

Lubiprostone-d7

Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-N6937S1

(R,R)-Secoisolariciresinol diglucoside-d6

(R,R)-Secoisolariciresinol diglucoside-d₆ is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81219

	MPO Antibody myeloperoxidase; MPO; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.	ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
	MPO Antibody is an unconjugated, approximately 84 kDa, rabbit-derived, anti-MPO polyclonal antibody. MPO Antibody can be used for: ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, dog, horse, rabbit, guinea pig background without labeling.

HY-P81219A

	MPO Antibody(YA3392) myeloperoxidase; MPO; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	MPO Antibody is an unconjugated, approximately 84 kDa, mouse-derived, anti-MPO monoclonal antibody. MPO Antibody can be used for: WB, IHC-P, IF-Cell, IF-Tissue expriments in human, mouse, rat background without labeling.

HY-P83736

	MPO Antibody (YA3466) myeloperoxidase; MPO; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	MPO Antibody is an unconjugated, approximately 84 kDa, mouse-derived, anti-MPO monoclonal antibody. MPO Antibody can be used for: WB, IHC-P, FC, IF-Cell, IF-Tissue expriments in human, mouse, rat background without labeling.