Search Result

Results for "

high-affinity ligand

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PD-1/PD-L1 (1) 5-HT Receptor (4) Adenosine Receptor (1) Adrenergic Receptor (3) Amylin Receptor (1) Amyloid-β (2) Antifolate (1) Apoptosis (2) Aryl Hydrocarbon Receptor (1) Aurora Kinase (1) Autophagy (1) Biochemical Assay Reagents (2) c-Fms (1) Cannabinoid Receptor (2) CCR (1) CXCR (1) Cytochrome P450 (1) Dopamine Receptor (5) Endogenous Metabolite (4) Epigenetic Reader Domain (3) Estrogen Receptor/ERR (3) FAP (1) Ferroptosis (5) FKBP (1) Fluorescent Dye (2) Folate Receptor (FR) (1) GABA Receptor (5) GnRH Receptor (2) Histamine Receptor (1) Histone Acetyltransferase (1) HSP (1) IGF-1R (1) iGluR (1) Imidazoline Receptor (4) Influenza Virus (1) Isotope-Labeled Compounds (1) Ligands for E3 Ligase (2) Ligands for Target Protein for PROTAC (2) LXR (1) mAChR (1) Mitochondrial Metabolism (1) Monoamine Oxidase (1) nAChR (2) Neuropeptide Y Receptor (3) PCSK9 (2) Peptide-Drug Conjugates (PDCs) (1) PPAR (7) Prostaglandin Receptor (1) PROTACs (1) Radionuclide-Drug Conjugates (RDCs) (1) Reference Standards (2) Sigma Receptor (3) Sodium Channel (1) Somatostatin Receptor (1) Tau Protein (1) Tie (1) TNF Receptor (3) TRP Channel (1) TSPO (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (2) Endocrinology (3) Infection (1) Inflammation/Immunology (15) Metabolic Disease (10) Neurological Disease (37)

By Targets:

PD-1/PD-L1 (1)

5-HT Receptor (4)

Adenosine Receptor (1)

Adrenergic Receptor (3)

Amylin Receptor (1)

Amyloid-β (2)

Antifolate (1)

Apoptosis (2)

Aryl Hydrocarbon Receptor (1)

Aurora Kinase (1)

Autophagy (1)

Biochemical Assay Reagents (2)

c-Fms (1)

Cannabinoid Receptor (2)

CCR (1)

CXCR (1)

Cytochrome P450 (1)

Dopamine Receptor (5)

Endogenous Metabolite (4)

Epigenetic Reader Domain (3)

Estrogen Receptor/ERR (3)

FAP (1)

Ferroptosis (5)

FKBP (1)

Fluorescent Dye (2)

Folate Receptor (FR) (1)

GABA Receptor (5)

GnRH Receptor (2)

Histamine Receptor (1)

Histone Acetyltransferase (1)

HSP (1)

IGF-1R (1)

iGluR (1)

Imidazoline Receptor (4)

Influenza Virus (1)

Isotope-Labeled Compounds (1)

Ligands for E3 Ligase (2)

Ligands for Target Protein for PROTAC (2)

LXR (1)

mAChR (1)

Mitochondrial Metabolism (1)

Monoamine Oxidase (1)

nAChR (2)

Neuropeptide Y Receptor (3)

PCSK9 (2)

Peptide-Drug Conjugates (PDCs) (1)

PPAR (7)

Prostaglandin Receptor (1)

PROTACs (1)

Radionuclide-Drug Conjugates (RDCs) (1)

Reference Standards (2)

Sigma Receptor (3)

Sodium Channel (1)

Somatostatin Receptor (1)

Tau Protein (1)

Tie (1)

TNF Receptor (3)

TRP Channel (1)

TSPO (1)

By Research Areas:

Cancer (26)

Cardiovascular Disease (2)

Endocrinology (3)

Infection (1)

Inflammation/Immunology (15)

Metabolic Disease (10)

Neurological Disease (37)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates MARK HMG Family PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1840

Galanin Receptor Ligand M35	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively .

HY-112210

Shield-1 5 Publications Verification Shld1	FKBP	Others
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) .

HY-P5964A

K1 peptide TFA	GABA Receptor	Neurological Disease
K1 peptide TFA is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP) .

HY-154844

FAP Ligand 1	Biochemical Assay Reagents	Cancer
FAP Ligand 1 (FL), a high-affinity FAP small-molecule ligand, is used to target attached drugs to FAP-expressing fibroblasts and can be used in radiation imaging studies of targeted cancers .

HY-P1840A

Galanin Receptor Ligand M35 TFA	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively .

HY-P5964

K1 peptide	GABA Receptor	Neurological Disease
K1 peptide is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP) .

HY-P5054

Galanin (1-13)-Neuropeptide Y (25-36) amide	Neuropeptide Y Receptor	Neurological Disease
Galanin (1-13)-Neuropeptide Y (25-36) amide is a high-affinity ligand for galanin receptors, and galanin itself .

HY-162553

GNE7599	Ligands for E3 Ligase	Cancer
GNE7599 is a high-affinity and orally active von Hippel-Lindau (VHL) ligand with a K_d of 540 pM. GNE7599 can be connected to the ligand for protein by a linker to form PROTACs .

HY-155698

Mz438	Fluorescent Dye CXCR	Others
Mz438 is high-affinity and selective fluorescent CXCR2 ligand. Mz438 is a small-molecule-based fluorescent probe targeting the IABS of CXCR2 .

HY-121738

TC AC 28	Epigenetic Reader Domain	Cancer
TC AC 28 is a high-affinity BET bromodomain ligand with K_d values of 40, 800 nM for Brd2(2), Brd2(1), respectively .

HY-P1887

p5 Ligand for Dnak and DnaJ	HSP	Infection
p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ is a high-affinity ligand for DnaK and DnaJ .

HY-114306

EC0489	Antifolate	Cancer
EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor . Small molecule-agent conjugate (SMDC) .

HY-117379

CHIR-2279	Adrenergic Receptor	Others
CHIR-2279 is a high-affinity ligand (K_i=5 nM) for the α₁-adrenergic receptor and can be further studied as a drug lead compound .

HY-170789

H1R ligand-1	Histamine Receptor	Neurological Disease
H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). H1R ligand-1 can be used as a scaffold to design and synthesize a set of derivatives to explore H1R binding kinetics .

HY-101310

SYM 2081	iGluR	Neurological Disease
SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [ ³H]-kainate binding with an IC₅₀ of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively .

HY-168440

Aurora-A ligand 1	Ligands for Target Protein for PROTAC Aurora Kinase	Cancer
Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (K_d) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma .

HY-149933

AM841	Cannabinoid Receptor	Neurological Disease
AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility .

HY-P2112

DOTA-NOC DOTA-Nal3-octreotide	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Others
DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging . DOTA-NOC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-D1643

5,5'-Dinitro BAPTA AM	Biochemical Assay Reagents	Others
5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca ²⁺. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand .

HY-W020790

Sialyl-Lewis X sLeX	Endogenous Metabolite	Inflammation/Immunology
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity *ligand* for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

HY-100982

(E) -4-Hydroxycrotonic acid trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA	GABA Receptor	Neurological Disease
(E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a k_i value of 1.1 μM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with k_i values ranging from 0.023 to 0.075 μM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models .

HY-100583

(-)-(S)-Equol 1 Publications Verification	Estrogen Receptor/ERR Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
(-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a K_i of 0.73 nM.

HY-D2413

BODIPY FL VH032 BODIPY FL PEG4-VH032	Fluorescent Dye	Others
BODIPY FL VH032 is a high-affinity VHL fluorescent probe with a K_d value of 3.01 nM. BODIPY FL VH032 consists of von Hippel-Lindau (VHL) ligand VH032 (HY-120217) and BODIPY FL (HY-43520). BODIPY FL VH032 can be used for time-resolved fluorescence resonance energy transfer (TR-FRET) detection for high-throughput identification and characterization of VHL ligands with maximum excitation emission wavelength: 504/520 nm .

HY-101301A

RS 45041-190 hydrochloride	Imidazoline Receptor	Neurological Disease
RS 45041-190 hydrochloride is a high-affinity ligand for I2 imidazoline receptors, with the pK_is of 8.66, 9.37, 9.32, and 8.85 in rat, rabbit, dog and baboon kidney, respectively. RS 45041-190 hydrochloride shows moderate potency for the inhibition of monoamine oxidase A in vitro (pIC₅₀= 6.12), but had much lower potency for monoamine oxidase B (pIC₅₀ = 4.47) .

HY-133486

GABAA receptor agent 1	GABA Receptor	Neurological Disease
GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity .

HY-145938

OncoFAP	FAP	Cancer
OncoFAP is an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential.

HY-103223

Phortress NSC 710305	Cytochrome P450	Cancer
Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1 .

HY-122612

SB-258585	5-HT Receptor	Neurological Disease
SB-258585 is a selective ligand with high affinity for the 5-HT₆ receptor, with a pK_i value of 8.53 .

HY-100930

L-693403 maleate	Sigma Receptor	Neurological Disease
L-693403 maleate is a high affinity and selective *σ ligand*. L-693403 maleate has the potential for physiological disease research .

HY-112429

HJB97 2 Publications Verification	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Cancer
HJB97 is a high-affinity BET inhibitor with K_i values of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), and 1.0 nM (BRD4 BD2) . HJB97 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC BET degraders with antitumor activity . HJB97 can be used for the synthesis of BETd-260 (HY-101519).

HY-172563

BTR2000	Ligands for E3 Ligase	Others
BTR2000, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity. BTR2000 can be used as a ligand for E3 ligase for the synthesis of BTR2004 (HY-172562) .

HY-136280

Panamesine EMD 57445	Sigma Receptor	Neurological Disease
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC₅₀ 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent .

HY-100583R

(-)-(S)-Equol (Standard)	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
(-)-(S)-Equol (Standard) is the analytical standard of (-)-(S)-Equol. This product is intended for research and analytical applications. (-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM.

HY-D1027

Dansylcadaverine 5+ Cited Publications Monodansyl cadaverine	Autophagy	Others
Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands .

HY-P99188

Carlumab 1 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (*chemokine ligand* 2*) antibody with high affinity*. Carlumab can be used in cancer research, particularly in prostate cancer .

HY-115953

Dopamine D3 receptor ligand-1	Dopamine Receptor	Neurological Disease
Dopamine D₃ receptor ligand is a potent, selective and high affinity ligand for Dopamine D₃ receptor with 89-fold selective for D₃ over D₂ (D₃ K_i= 8 nM, D₂ K_i= 715 nM) .

HY-B1033

Metergoline 1 Publications Verification	5-HT Receptor Dopamine Receptor Sodium Channel	Neurological Disease
Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pK_is of 8.64, 8.75 and 8.75 for 5-HT_2A, 5-HT_2B and 5-HT_2C, respectively. Metergoline is a high-affinity ligand for the h5-HT₇ receptor, with a K_i of 16 nM. Metergoline is also a reversible neural Na ⁺ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation .

HY-P1464

Amylin, amide, rat Amylin (rat)	Amylin Receptor	Metabolic Disease
Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.

HY-U00180

KF21213	Adenosine Receptor	Neurological Disease
KF21213 is a highly selective ligand for mapping CNS adenosine A_2A receptors. KF21213 shows a high affinity for the adenosine A_2A receptors (K_i=3.0 nM).

HY-P99307

Namilumab AMG-203; Anti-Human CSF2 Recombinant Antibody	c-Fms	Inflammation/Immunology
Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis .

HY-139516

AZD4694 Precursor AZ13040214; NAV4614	Amyloid-β	Others
AZD4694 Precursor (AZ13040214) is the precursor of [ ¹⁸F] AZD4694 for the synthesis of [ ¹⁸F] AZD4694, an amyloid-β imaging ligand with high affinity for amyloid-β plaques .

HY-120842

RLH-033	mAChR	Neurological Disease
RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [ ³H](+)-pentazocine with a K_i of 50 pM .

HY-118438

10-Cl-BBQ	Aryl Hydrocarbon Receptor	Inflammation/Immunology
10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations .

HY-P99036

Nesvacumab	Tie	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1 .

HY-N0927

(-)-Isocorypalmine Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine	Dopamine Receptor	Others
(-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a dopamine receptor ligand . Recombinant CYP719A21 displays strict substrate specificity and high affinity (K_m=4.63 ± 0.71 μM) for (-)-Isocorypalmine .

HY-170994

I2-IRs ligand-1	Imidazoline Receptor	Neurological Disease Inflammation/Immunology
I2-IRs ligand-1 (Compound 12d) is an orally active and BBB-penetrable compound. I2-IRs ligand-1 has a high affinity for imidazoline I₂ receptors (I₂-IRs) (pK_i: 9.98). I2-IRs ligand-1 can improve cognitive impairment in senescent mice and exhibits analgesic, anti-inflammatory, and neuroprotective activities. I2-IRs ligand-1 can be used for the research of Alzheimer's disease and related pain disorders .

HY-13956S

Pioglitazone-d4 U 72107-d₄	PPAR Ferroptosis	Metabolic Disease Cancer
Pioglitazone-d₄ is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC₅₀ of 0.93 and 0.99 μM for human and mouse PPARγ, respectively .

HY-173291

Tau ligand-1	Tau Protein	Neurological Disease
Tau ligand-1 (Compound 75) is a ligand for aggregated tau protein that can penetrate the blood-brain barrier . In tissues from patients with Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 exhibits high affinity for aggregated tau protein, with equilibrium dissociation constant (K_D) values ranging from 1 to 3.8 nM . Tau ligand-1 can serve as a potential positron emission tomography (PET) tracer and holds promise for application in positron emission tomography imaging studies of tau-related diseases in the central nervous system .

HY-13956C

(R)-Pioglitazone (R)-U 72107	PPAR	Neurological Disease
(R)-Pioglitazone ((+)-pioglitazone) is the R enantiomer of Pioglitazone (HY-13956). (R)-Pioglitazone is an orally active and selective peroxisome proliferator-activated receptor (PPARγ) agonist with high affinity binding to the PPARγ ligand-binding domain. (R)-Pioglitazone can be used for the research of Alzheimer's disease .

HY-115462

PGN-9856	Prostaglandin Receptor	Inflammation/Immunology
PGN-9856 is a selective and high affinity (pK_i ≥ 8.3) ligand at EP2 receptor. PGN-9856 is a potetn and non-prostanoid EP2 receptor agonist (pEC₅₀ ≥ 8.5). PGN-9856 shows anti-inflammatory and anti-glaucoma activities .

Cat. No.	Product Name	Type

HY-D1027

Dansylcadaverine 5+ Cited Publications Monodansyl cadaverine	Fluorescent Dyes/Probes
Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands .

HY-D2413

BODIPY FL VH032

BODIPY FL PEG4-VH032

Fluorescent Dyes/Probes

BODIPY FL VH032 is a high-affinity VHL fluorescent probe with a K_d value of 3.01 nM. BODIPY FL VH032 consists of von Hippel-Lindau (VHL) ligand VH032 (HY-120217) and BODIPY FL (HY-43520). BODIPY FL VH032 can be used for time-resolved fluorescence resonance energy transfer (TR-FRET) detection for high-throughput identification and characterization of VHL ligands with maximum excitation emission wavelength: 504/520 nm .

Cat. No.	Product Name	Target	Research Area

HY-P1840

Galanin Receptor Ligand M35	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively .

HY-P5964A

K1 peptide TFA	GABA Receptor	Neurological Disease
K1 peptide TFA is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP) .

HY-P2112

DOTA-NOC DOTA-Nal3-octreotide	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Others
DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging . DOTA-NOC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P2288A

WL47 TFA 2 Publications Verification	Peptides	Cancer
WL47 TFA, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of CAV1 oligomers. WL47 TFA shows selectivity for CAV1 over BSA, casein and HEWL. WL47 TFA is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function .

HY-P1464

Amylin, amide, rat Amylin (rat)	Amylin Receptor	Metabolic Disease
Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.

HY-P1840A

Galanin Receptor Ligand M35 TFA	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively .

HY-P5964

K1 peptide	GABA Receptor	Neurological Disease
K1 peptide is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP) .

HY-P5054

Galanin (1-13)-Neuropeptide Y (25-36) amide	Neuropeptide Y Receptor	Neurological Disease
Galanin (1-13)-Neuropeptide Y (25-36) amide is a high-affinity ligand for galanin receptors, and galanin itself .

HY-P1887

p5 Ligand for Dnak and DnaJ	HSP	Infection
p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ is a high-affinity ligand for DnaK and DnaJ .

HY-P2288

WL47	Peptides	Cancer
WL47, a high-affinity cavolin-1 (CAV1) ligand (K_d=23 nM), is a potent disrupter of CAV1 oligomers. WL47 shows selectivity for CAV1 over BSA, casein and HEWL. WL47 is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function .

HY-P1530

Prolactin Releasing Peptide (12-31), human	Peptides	Neurological Disease
Prolactin Releasing Peptide (12-31), human is a fragment of the prolactin releasing peptide (PrRP). Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin.

HY-P10332

WL 47 dimer	Peptides	Others
WL 47 dimer (ligand 1) is a caveolin-1 (CAV-1) ligand with high affinity, selectivity and oligomer dissociation activity. WL 47 dimer simultaneously occupies two binding sites of CAV-1, inducing the dissociation of oligomers. WL 47 dimer has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. WL 47 dimer can be used to permit targeted study of CAV-1 function .

HY-P1520

Prolactin Releasing Peptide (1-31), human	GnRH Receptor	Neurological Disease
Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. Prolactin Releasing Peptide (1-31) binds to GPR10 for human and rats with K_i values of 1.03 nM and 0.33 nM, respectively. Prolactin Releasing Peptide (1-31) can be used for the research of the hypothalamo-pituitary axis .

HY-P1520A

Prolactin Releasing Peptide (1-31), human acetate	GnRH Receptor	Neurological Disease
Prolactin Releasing Peptide (1-31), human (acetate) is a high affinity GPR10 ligand that causes the release of the prolactin. Prolactin Releasing Peptide (1-31) binds to GPR10 for human and rats with K_i values of 1.03 nM and 0.33 nM, respectively. Prolactin Releasing Peptide (1-31) can be used for the research of the hypothalamo-pituitary axis .

HY-P10762

CBP-1008 LDC 10B	Peptide-Drug Conjugates (PDCs) Folate Receptor (FR) TRP Channel	Cancer
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folate receptor α (FRα) and TRPV6. CBP-1008 binds to FRα with high affinity and TRPV6 with low affinity. CBP-1008 has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma) .

Cat. No.	Product Name	Target	Research Area

HY-P99188

Carlumab 1 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (*chemokine ligand* 2*) antibody with high affinity*. Carlumab can be used in cancer research, particularly in prostate cancer .

HY-P99307

Namilumab AMG-203; Anti-Human CSF2 Recombinant Antibody	c-Fms	Inflammation/Immunology
Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis .

HY-P99036

Nesvacumab	Tie	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1 .

HY-P99763

Ociperlimab BGB-A1217	Inhibitory Antibodies	Cancer
Ociperlimab is a humanized IgG1 anti-TIGIT antibody. Ociperlimab binds to the extracellular domain of human TIGIT with high affinity (K_D = 0.135 nM). Ociperlimab blocks the interaction between TIGIT and its ligands PVR or PVR-L2. Ociperlimab can be used in research of cancer .

HY-P99257

Bleselumab ASKP 1240	TNF Receptor	Inflammation/Immunology
Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (K_d: 0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection .

HY-P99345

Dostarlimab TSR-042	PD-1/PD-L1	Cancer
Dostarlimab (TSR-042) is a humanized anti-PD-1 monoclonal antibody. Dostarlimab binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC₅₀s of 1.8 and 1.5 nM, respectively .

HY-P99189

Cixutumumab IMC-A12; NSC742460	IGF-1R	Cancer
Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W020790

Sialyl-Lewis X sLeX	Structural Classification Polysaccharides Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity *ligand* for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

HY-100583

(-)-(S)-Equol 1 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavanols Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Estrogen Receptor/ERR Endogenous Metabolite
(-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a K_i of 0.73 nM.

HY-N0927

(-)-Isocorypalmine Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine	Alkaloids Structural Classification Monophenols other families Classification of Application Fields Source classification Other Diseases Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Dopamine Receptor
(-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a dopamine receptor ligand . Recombinant CYP719A21 displays strict substrate specificity and high affinity (K_m=4.63 ± 0.71 μM) for (-)-Isocorypalmine .

HY-N0443

N-Methylcytisine 1 Publications Verification Caulophylline	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Source classification Pyridine Alkaloids Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology	nAChR
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (K_d = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia .

HY-100583R

(-)-(S)-Equol (Standard)	Structural Classification Flavonoids Flavanols Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Estrogen Receptor/ERR Endogenous Metabolite
(-)-(S)-Equol (Standard) is the analytical standard of (-)-(S)-Equol. This product is intended for research and analytical applications. (-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM.

HY-N0443R

N-Methylcytisine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Leguminosae Source classification Pyridine Alkaloids Sophora flavescens Aiton Plants	nAChR
N-Methylcytisine (Standard) is the analytical standard of N-Methylcytisine. This product is intended for research and analytical applications. N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia .

HY-13956R

Pioglitazone (Standard)	Human Gut Microbiota Metabolites Source classification Endogenous metabolite	PPAR Ferroptosis
Pioglitazone (Standard) is the analytical standard of Pioglitazone. This product is intended for research and analytical applications. Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC₅₀ of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research .

Cat. No.	Product Name	Chemical Structure

HY-13956S

Pioglitazone-d4
Pioglitazone-d₄ is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC₅₀ of 0.93 and 0.99 μM for human and mouse PPARγ, respectively .

HY-13956S1

Pioglitazone-d4 (alkyl)
Pioglitazone-d₄ (alkyl) (U 72107-d₄ (alkyl)) is the deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC₅₀ of 0.93 and 0.99 μM for human and mouse PPARγ, respectively .

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