2. Antibody-drug Conjugate/ADC Related Neuronal Signaling GPCR/G Protein
  3. Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor
  4. DOTA-NOC

DOTA-NOC  (Synonyms: DOTA-Nal3-octreotide)

Cat. No.: HY-P2112 Purity: 99.22%
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Handling Instructions Technical Support

DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging. DOTA-NOC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DOTA-NOC Chemical Structure

DOTA-NOC Chemical Structure

CAS No. : 619300-53-7

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Customer Review

Based on 1 publication(s) in Google Scholar

DOTA-NOC Related Antibodies

Top Publications Citing Use of Products

View All Radionuclide-Drug Conjugates (RDCs) Isoform Specific Products:

View All Isoforms
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

View All Somatostatin Receptor Isoform Specific Products:

View All Isoforms
SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging[1]. DOTA-NOC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

IC50 & Target

RDC Peptide

 

In Vitro

Affinity profiles (IC50(μM)) for human somatostatin receptor (SST) 1-5[1].

Compound hsst1 hsst2 hsst3 hsst4 hsst5
InIII-DOTA-NOC >10000 2.9 8 227 11.2
YIII-DOTA-NOC >10000 3.3 26 >10000 10.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-NOC Related Antibodies
Molecular Weight

1455.70

Formula

C69H94N14O17S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

DOTA-{d-Phe}-Cys-{Nal}-{d-Trp}-Lys-Thr-Cys-Thr-ol (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

DOTA-{d-Phe}-C-{Nal}-{d-Trp}-KTCT-ol (Disulfide bridge: Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (34.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6870 mL 3.4348 mL 6.8695 mL
5 mM 0.1374 mL 0.6870 mL 1.3739 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6870 mL 3.4348 mL 6.8695 mL 17.1739 mL
5 mM 0.1374 mL 0.6870 mL 1.3739 mL 3.4348 mL
10 mM 0.0687 mL 0.3435 mL 0.6870 mL 1.7174 mL
15 mM 0.0458 mL 0.2290 mL 0.4580 mL 1.1449 mL
20 mM 0.0343 mL 0.1717 mL 0.3435 mL 0.8587 mL
25 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6870 mL
30 mM 0.0229 mL 0.1145 mL 0.2290 mL 0.5725 mL
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DOTA-NOC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-NOC619300-53-7DOTA-Nal3-octreotideRadionuclide-Drug Conjugates (RDCs)Somatostatin ReceptorSSTRsSSTRRadiometalradiopeptidePETInhibitorinhibitorinhibit

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