Search Result

Results for "

developmental

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (1) Androgen Receptor (2) Antibiotic (2) Apelin Receptor (APJ) (2) Apoptosis (13) Aryl Hydrocarbon Receptor (3) ATP Synthase (1) Autophagy (2) Bacterial (4) Beta-lactamase (2) Biochemical Assay Reagents (4) Caspase (1) CDK (1) Cytochrome P450 (3) DNA/RNA Synthesis (5) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (2) Endogenous Metabolite (15) Estrogen Receptor/ERR (1) Fungal (10) Gli (1) Glycosidase (1) Hedgehog (1) Herbicide (5) HMG-CoA Reductase (HMGCR) (2) HSV (2) iGluR (2) Insecticide (1) Interleukin Related (1) Isotope-Labeled Compounds (9) JNK (2) Leukotriene Receptor (1) Ligands for E3 Ligase (1) mAChR (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) Mixed Lineage Kinase (2) Molecular Glues (1) Monoamine Oxidase (1) mRNA (1) Oxidative Phosphorylation (5) p38 MAPK (1) Parasite (6) Porcupine (2) Pregnane X Receptor (PXR) (2) Protoporphyrinogen IX oxidase (3) Reactive Oxygen Species (ROS) (19) Reference Standards (18) SARS-CoV (2) Smo (1) SOD (3) Sodium Channel (1) Taste Receptor (3) Transmembrane Glycoprotein (1) VEGFR (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (11) Endocrinology (13) Infection (20) Inflammation/Immunology (5) Metabolic Disease (21) Neurological Disease (16)
Oligonucleotides:	mRNA (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116483

MPX-007	iGluR	Neurological Disease
MPX-007 is a GluN2A antagonist (IC₅₀: 27 nM). MPX-007 is a tools to probe GluN2A physiology, and to study neuropsychiatric and developmental disorders .

HY-130221

(25S)-Δ7-Dafachronic acid Dafachronic acid A; Δ7-Dafachronic acid	Insecticide	Others
(25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans .

HY-W013058

Decabromodiphenyl ethane DBDPE; 1,2-Bis(perbromophenyl)ethane	Biochemical Assay Reagents	Neurological Disease Metabolic Disease
Decabromodiphenyl ethane (DBDPE; 1,2-Bis(perbromophenyl)ethane) is a brominated flame retardant. Decabromodiphenyl ethane can exhibit neurotoxicity, thyroid toxicity, reproductive developmental toxicity, hepatotoxicity, and oxidative stress in living organisms .

HY-148939

MPX-004	iGluR	Neurological Disease
MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC₅₀ of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research .

HY-N0179

Ecdysone 1 Publications Verification α-Ecdysone	Endogenous Metabolite Apoptosis	Metabolic Disease
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-W102684

N,N-Dicyclohexyl-2-benzothiazolesulfenamide	Biochemical Assay Reagents	Others
N,N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain, reproductive organ weight, and multiple reproductive and developmental indicators in rats.

HY-119896

Clethodim	Herbicide	Neurological Disease
Clethodim is a postemergence herbicide. Clethodim shows developmental toxicity and neurotoxicity in zebrafish embryos and larvae .

HY-106281

Bemfivastatin PPD 10558	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Metabolic Disease
Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor, also known as Statin. Bemfivastatin enhances the activity of liver extraction. Bemfivastatin exhibits little developmental toxicity effects in pregnant rats and rabbits via daily oral doses during organogenesis period. The no observed adverse effect level (NOAEL) are ≥320 mg/kg/day for rats developmental toxicity, 12.5 mg/kg/day for rabbits maternal toxicity, and 25 mg/kg/day for rabbits developmental toxicity, respectively. Bemfivastatin can be used for research on Statin-related hypercholesterolemic myalgia with inability to tolerate statins .

HY-B0761

(R,R)-Glycopyrrolate (R,R)-Glycopyrronium bromide; (R,R)-Glycopyrrolate bromide	mAChR	Neurological Disease
(R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) is an anticholinergic agent. (R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) has the ability to reduce the frequency of drooling in vivo with developmental disabilities .

HY-P2196

ELA-32(human)	Apelin Receptor (APJ)	Cardiovascular Disease
ELA-32 (human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor .

HY-21796

1-Methyl-3-phenylpropylamine 4-Phenylbutan-2-amine	Apelin Receptor (APJ)	Cardiovascular Disease
ELA-32(human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor .

HY-101000

Clazuril R62690	Parasite	Infection
Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle .

HY-N1738

2-Methoxystypandrone	Others	Others
2-Methoxystypandroneis a naphthoquinonethat can be found inPolygonum cuspidatum. 2-Methoxystypandrone showsantioxidantactivities. 2-Methoxystypandrone improves developmental competence of bovine embryos .

HY-B0847

Propiconazole 2 Publications Verification	Fungal Reactive Oxygen Species (ROS)	Infection
Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .

HY-132971

Thalidomide-piperazine hydrochloride	Molecular Glues Ligands for E3 Ligase Autophagy Apoptosis	Cancer
Thalidomide-piperazine hydrochloride has the potential for the research of leprosy and multiple myeloma. Thalidomide-piperazine hydrochloride used as a tool in developmental biology leads to important discoveries in the biochemical pathways of limb development .

HY-B0263

Thiabendazole 3 Publications Verification Tiabendazole; 2-(4-Thiazolyl)benzimidazole	Mitochondrial Metabolism Parasite CDK MDM-2/p53 Caspase VEGFR Interleukin Related	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling .

HY-119896R

Clethodim (Standard)	Herbicide Reference Standards	Neurological Disease
Clethodim (Standard) is the analytical standard of Clethodim. This product is intended for research and analytical applications. Clethodim is a postemergence herbicide. Clethodim shows developmental toxicity and neurotoxicity in zebrafish embryos and larvae .

HY-136355

Picoxystrobin	Fungal Reactive Oxygen Species (ROS) SOD	Infection Inflammation/Immunology
Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity .

HY-106281A

Bemfivastatin hemicalcium PPD 10558 hemicalcium	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Metabolic Disease
Bemfivastatin (PPD 10558) hemicalcium is an orally active lipid-lowering agent and HMG-CoA reductase inhibitor. Bemfivastatin hemicalcium enhances the activity of liver extracts. Bemfivastatin hemicalcium has no-observed adverse effect levels (NOAEL) with dosages of ≥320 mg/kg/d (rat developmental toxicity), ≥12.5 mg/kg/d (rabbit maternal toxicity), ≥25 mg/kg/d (rabbit developmental toxicity), respectively. Bemfivastatin hemicalcium can be used in the study of statin-related hypercholesterolemic myalgia in statin-intolerant patients.

HY-B0835S

Fenobucarb-d3	Isotope-Labeled Compounds Apoptosis	Neurological Disease
Fenobucarb-d₃ is the deuterium labeled Fenobucarb. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis .

HY-121423

Dimethachlor	Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease
Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .

HY-W088190

Dicyclohexyl ketone Cyclohexyl ketone	Drug Intermediate Biochemical Assay Reagents	Others
Dicyclohexyl ketone (Cyclohexyl ketone) is a toxic compound that causes toxic effects in rats at high doses, including death, decreased activity, staining of the fur on the lower body, reddening of the tears, and reproductive and developmental effects.

HY-B0835

Fenobucarb	Apoptosis	Cardiovascular Disease Neurological Disease
Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals .

HY-15825

IWP L6 3 Publications Verification Porcn Inhibitor III	Porcupine	Cancer
IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC₅₀ of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish .

HY-B1986R

p,p'-DDE (Standard) 4,4'-DDE (Standard); p,p'-Dichlorodiphenyldichloroethylene (Standard)	Reference Standards Androgen Receptor Drug Metabolite	Metabolic Disease Endocrinology
p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC₅₀ of 5 μM and a K_i of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women .

HY-101000R

Clazuril (Standard) R62690 (Standard)	Reference Standards Parasite	Infection
Clazuril (Standard) is the analytical standard of Clazuril. This product is intended for research and analytical applications. Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle .

HY-W011787

DPPD N,N′-Diphenyl-p-phenylenediamine	Reactive Oxygen Species (ROS)	Metabolic Disease
DPPD (N,N′-Diphenyl-p-phenylenediamine) is an orally active polymerization inhibitor and antioxidant with antioxidative activity. DPPD causes reproductive/developmental toxicity in rats. DPPD is widely used in rubber, oils, and feedstuffs, especially for tires in the rubber industry .

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage .

HY-B0847R

Propiconazole (Standard)	Reference Standards Fungal Reactive Oxygen Species (ROS)	Infection
Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .

HY-136355S

Picoxystrobin-d3	Isotope-Labeled Compounds Fungal Reactive Oxygen Species (ROS) SOD	Infection Inflammation/Immunology
Picoxystrobin-d₃ is the deuterium labeled Picoxystrobin (HY-136355). Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity .

HY-W774881

Thiabendazole-d6 Tiabendazole-d₆; 2-(4-Thiazolyl)benzimidazole-d₆	Isotope-Labeled Compounds	Others
Thiabendazole-d₆ is a deuterated labeled Thiabendazole (HY-B0263). Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling .

HY-B1111

Amitraz BTS-27419	Adrenergic Receptor Monoamine Oxidase Parasite	Infection Endocrinology
Amitraz is a non-systemic acaricide and insecticide with alpha-adrenergic agonist activity that interacts with octopamine receptors in the central nervous system and inhibits monoamine oxidase and prostaglandin synthesis .

HY-136355R

Picoxystrobin (Standard)	Reference Standards Fungal Reactive Oxygen Species (ROS) SOD	Infection Inflammation/Immunology
Picoxystrobin (Standard) is the analytical standard of Picoxystrobin (HY-136355). This product is intended for research and analytical applications. Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity .

HY-W762011

BDE 47	Apoptosis Reactive Oxygen Species (ROS) JNK Oxidative Phosphorylation	Neurological Disease Cancer
BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish .

HY-121423R

Dimethachlor (Standard)	Reference Standards Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease
Dimethachlor (Standard) is the analytical standard of Dimethachlor. This product is intended for research and analytical applications. Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .

HY-W720961

Dimethachlor-d6	Reactive Oxygen Species (ROS)	Metabolic Disease
Dimethachlor-d₆ is the deuterium labeled Dimethachlor (HY-121423). Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .

HY-E70800

Biotin-MLK2 Recombinant Human Active Protein Kinase	Mixed Lineage Kinase	Cancer
MLK2 is a kinase for phosphorylation of H3 at threonine 3 and is associated with the osmotic stress response. MLK2 is involved in multiple signaling pathways in the developmental process. Biotin-MLK2 Recombinant Human Active Protein Kinase is obtained by expressing MLK2 proteins and is biotinylated .

HY-B1134

Imazalil 1 Publications Verification Enilconazole	Pregnane X Receptor (PXR) Fungal	Infection
Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

HY-B0835R

Fenobucarb (Standard)	Reference Standards Apoptosis	Cardiovascular Disease Neurological Disease
Fenobucarb (Standard) is the analytical standard of Fenobucarb. This product is intended for research and analytical applications. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals .

HY-E70799

Biotin-MLK1 Recombinant Human Active Protein Kinase	Mixed Lineage Kinase	Cancer
MLK1 is a kinase for phosphorylation of H3 at threonine 3 and is associated with the osmotic stress response. MLK1 is involved in multiple signaling pathways in the developmental process. Biotin-MLK1 Recombinant Human Active Protein Kinase is obtained by expressing MLK1 proteins and is biotinylated .

HY-B1986

p,p'-DDE 1 Publications Verification 4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene	Androgen Receptor Drug Metabolite	Metabolic Disease Endocrinology
p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC₅₀ of 5 μM and a K_i of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women .

HY-W039454

2,4-Dichlorobenzyl alcohol	Bacterial SARS-CoV	Infection
2,4-Dichlorobenzyl alcohol is an orally active mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections. 2,4-Dichlorobenzyl alcohol exhibits prenatal developmental toxicity.2,4-Dichlorobenzyl alcohol can be used in the study of SARS-CoV .

HY-B0831

Buprofezin 2 Publications Verification	Oxidative Phosphorylation Reactive Oxygen Species (ROS)	Others
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .

HY-B1134A

Imazalil sulfate 1 Publications Verification Enilconazolel sulfate	Fungal Pregnane X Receptor (PXR)	Infection
Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

HY-119442

Quininib	Leukotriene Receptor	Cardiovascular Disease
Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist with IC₅₀s of 1.2 and 52 μM for CysLT₁R and CysLT₂R, respectively. Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye. Quininib can be used for the research of ocular neovascular pathologies and may complement current anti-VEGF biological agents .

HY-107408

SANT 2	Hedgehog Gli	Metabolic Disease Cancer
SANT 2 is a potent Hh-signaling pathway antagonist. SANT 2 interferes with the expression of Gli1. SANT 2 causes developmental delay in medaka embryos. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers .

HY-174590

Human LIN28A mRNA	mRNA	Cancer
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.

HY-B2010

Fomesafen	Herbicide Protoporphyrinogen IX oxidase Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Cancer
Fomesafen is an orally active herbicide. Fomesafen inhibits protoporphyrinogen oxidase (PPO). Fomesafen induces Apoptosis and increases ROS. Fomesafen exhibits developmental toxicity, immunotoxicity, and neurotoxicity. It induces precancerous lesions in the liver and hepaturoporphyria in mice. Fomesafen is used to control broadleaf weeds in soybean fields, rubber plantations, and orchards .

HY-108913

Nitrocefin 2 Publications Verification	Beta-lactamase Antibiotic Bacterial	Infection
Nitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic β-lactamase substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .

HY-B0831S

Buprofezin-d6	Oxidative Phosphorylation Reactive Oxygen Species (ROS)	Metabolic Disease
Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .

Cat. No.	Product Name

HY-L203

Methylation Compound Library

311 compounds

Methylation is an epigenetic modification mechanism that involves adding methyl groups to molecules such as DNA and histones, which can alter gene expression without changing the DNA sequence. This process is catalyzed by enzymes such as DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs), and can be reversed by demethylases. The balance of methylation and demethylation is crucial for maintaining cellular function and genomic stability. Abnormal regulation of methylation may lead to a variety of diseases, including cancer, neurological disorders, and developmental abnormalities. A deep understanding of the molecular mechanisms of methylation metabolism is essential for developing therapeutic strategies for diseases associated with methylation dysregulation.

MCE contains 311 compounds targeting methylation/demethylation enzymes, which is of significant value for studying the pathways of methylation metabolism and exploring their mechanisms of action in diseases.

HY-L047

Endocrinology Compound Library

1,035 compounds

The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function.

The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease.

MCE offers a unique collection of 1,035 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

HY-L020

Wnt/Hedgehog/Notch Compound Library

510 compounds

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 510 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

HY-L018

TGF-beta/Smad Compound Library

350 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 350 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L045

Oxygen Sensing Compound Library

3,391 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 3,391 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Type

HY-15825G

IWP L6 (GMP) Porcn Inhibitor III (GMP)	Fluorescent Dye
IWP L6 (GMP) (Porcn Inhibitor III (GMP)) is IWP L6 (HY-15825) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC₅₀ of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish .

Cat. No.	Product Name	Type

HY-B1024

DL-Panthenol

1 Publications Verification

DL-Pantothenol; DL-Pantothenyl alcohol

Biochemical Assay Reagents

DL-Panthenol (DL-Pantothenol) is a precursor of pantothenic acid. DL-Panthenol easily penetrates the skin and has effects of deep moisturizing, promoting wound healing and anti-inflammation. DL-Panthenol can also be used as a hair conditioner in cosmetics. DL-Panthenol has low acute toxicity, non-sensitizing property, and no significant genotoxicity or reproductive and developmental toxicity. DL-Panthenol can be applied to the research of cosmetics .

HY-15825G

IWP L6 (GMP) Porcn Inhibitor III (GMP)	Biochemical Assay Reagents
IWP L6 (GMP) (Porcn Inhibitor III (GMP)) is IWP L6 (HY-15825) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC₅₀ of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish .

Cat. No.	Product Name	Target	Research Area

HY-P2196

ELA-32(human)	Apelin Receptor (APJ)	Cardiovascular Disease
ELA-32 (human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor .

HY-P10495

GPR110 peptide agonist P12	Transmembrane Glycoprotein	Others Cancer
GPR110 peptide agonist P12 is a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 can be used in the study of developmental disorders and cancers related to GPR110 .

HY-P10495A

GPR110 peptide agonist P12 acetate	Peptides	Cancer
GPR110 peptide agonist P12 acetate is the acetate salt form of GPR110 peptide agonist P12 (HY-P10495). GPR110 peptide agonist P12 acetateis a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 acetate can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 acetate mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 acetate can be used in the study of developmental disorders and cancers related to GPR110 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0179

Ecdysone 1 Publications Verification α-Ecdysone	Structural Classification Animals Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Apoptosis
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-B1134

Imazalil 1 Publications Verification Enilconazole	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Pregnane X Receptor (PXR) Fungal
Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

HY-18260

Bisphenol A Maximum Cited Publications 9 Publications Verification	Structural Classification Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite p38 MAPK Akt Reactive Oxygen Species (ROS) Apoptosis
Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cancers, cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-18260R

Bisphenol A (Standard) Maximum Cited Publications 9 Publications Verification	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Reference Standards
Bisphenol A (Standard) is the analytical standard of Bisphenol A. This product is intended for research and analytical applications. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-W008091

5-Methylcytosine 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Endogenous Metabolite
5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma .

HY-W008091R

5-Methylcytosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Reference Standards DNA/RNA Synthesis Endogenous Metabolite
5-Methylcytosine (Standard) is the analytical standard of 5-Methylcytosine (HY-W008091). This product is intended for research and analytical applications. 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma .

HY-N0500

Mogroside III	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Food Research	Glycosidase Autophagy
Mogroside III is a triterpenoid glycoside. Mogroside III exhibits maltase inhibitory effect with an IC₅₀ value of 1.6 mM. Mogroside III enhances oocyte developmental potential by promoting autophagy in cumulus cells. Mogroside III, as the active ingredient of the low-polarity glycoside component (L-SGgly), L-SGgly can increase serum GLP-1 levels, improve insulin resistance, and reduce IL-6 levels, and has hypoglycemic, lipid-regulating and anti-inflammatory effects. Mogroside III can be used for the studies of type 2 diabetes mellitus (T2DM) and assisted reproductive technology .

HY-12316

20(S)-Hydroxycholesterol 2 Publications Verification 20α-Hydroxycholesterol	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC₅₀ of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .

HY-N1738

2-Methoxystypandrone	Quinones Structural Classification Polygonaceae Reynoutria japonica Houtt. Source classification Plants Naphthalene Quinones	Others
2-Methoxystypandroneis a naphthoquinonethat can be found inPolygonum cuspidatum. 2-Methoxystypandrone showsantioxidantactivities. 2-Methoxystypandrone improves developmental competence of bovine embryos .

HY-B1134R

Imazalil (Standard) Enilconazole (Standard)	Structural Classification Natural Products other families Source classification Plants	Reference Standards Fungal
Imazalil (Standard) is the analytical standard of Imazalil. This product is intended for research and analytical applications. Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

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HY-P703100

	CENPE Protein, Human Centromere-associated protein E; Centromere protein E; CENP-E; Kinesin-7; Kinesin-related protein CENPE; CENPE; Homo sapiens; Human; CENP-E; developmental protein; Motor protein	Human	E. coli
	CENPE Protein, Human is the recombinant human-derived CENPE, expressed by E. coli , with tag Free labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-18260S

Bisphenol A-d16

Bisphenol A-d₁₆ is the deuterium labeled Bisphenol A . Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-18260S1

Bisphenol A-d6

Bisphenol A-d₆ is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-18260S3

Bisphenol A-d8

Bisphenol A-d₈ is the deuterium labeled Bisphenol A . Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-B0835S

Fenobucarb-d3
Fenobucarb-d₃ is the deuterium labeled Fenobucarb. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis .

HY-136355S

Picoxystrobin-d3
Picoxystrobin-d₃ is the deuterium labeled Picoxystrobin (HY-136355). Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity .

HY-W774881

Thiabendazole-d6
Thiabendazole-d₆ is a deuterated labeled Thiabendazole (HY-B0263). Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling .

HY-W720961

Dimethachlor-d6
Dimethachlor-d₆ is the deuterium labeled Dimethachlor (HY-121423). Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .

HY-B0831S

Buprofezin-d6

Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .

HY-18260S5

Bisphenol A-d4-1

Bisphenol A-d₄-1 is the deuterium labeled Bisphenol A . Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-W778391

Bisphenol A-13C2

Bisphenol A- ¹³C₂ is ¹³C labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-18260S4

Bisphenol A-d4

Bisphenol A-d₄ is the deuterium labeled Bisphenol A . Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-18260S6

Bisphenol A-d14

Bisphenol A-d₁₄ is a deuterium labeled Bisphenol A (HY-18260). Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-B2010S

Fomesafen-d3

Fomesafen-d₃ is the deuterium-labeled Fomesafen (HY-B2010). Fomesafen is an orally active herbicide. Fomesafen inhibits protoporphyrinogen oxidase (PPO). Fomesafen induces Apoptosis and increases ROS. Fomesafen exhibits developmental toxicity, immunotoxicity, and neurotoxicity. It induces precancerous lesions in the liver and hepaturoporphyria in mice. Fomesafen is used to control broadleaf weeds in soybean fields, rubber plantations, and orchards .

HY-B0973S

Dibenzothiophene-d8

Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-W008091S

5-Methylcytosine-d4

5-Methylcytosine-d₄ is the deuterium labeled 5-Methylcytosine (HY-W008091). 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma .

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HY-P82703

	Fibulin 5 Antibody (YA2448) FBLN5; DANCE; Fibulin-5; FIBL-5; developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50	WB	Human, Mouse
	Fibulin 5 Antibody (YA2448) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fibulin 5.

HY-P85166

	Fibulin 5 Antibody (YA4858) FBLN5; DANCE; Fibulin-5; FIBL-5; developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50	WB, IHC-P, ICC/IF, ELISA	Human
	Fibulin 5 Antibody (YA4858) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Fibulin 5.

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Cat. No.	Product Name		Classification

HY-174590

Human LIN28A mRNA		mRNA
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.

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