IWP L6  (Synonyms: Porcn Inhibitor III)

IWP L6 (GMP) (Porcn Inhibitor III (GMP)) is IWP L6 (HY-15825) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC₅₀ of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish^[1].

IWP L6 (Porcn Inhibitor III) (GMP) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP L6 (GMP) inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IWP L6 (Porcn Inhibitor III) (GMP) is stable in human plasma over 24 h, it is rapidly metabolized in rat plasma (t_1/2 = 190 min), murine plasma (t_1/2 = 2 min), and the murine liver S9 fractions (t_1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP L6 (GMP) is highly active in zebrafish. IWP L6 exhibits more potent activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

472.58

C₂₅H₂₀N₄O₂S₂

1427782-89-5

O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang X, et al. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56(6):2700-4.  [Content Brief]