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Results for "

caspases-8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (48) Adrenergic Receptor (1) Akt (2) Antibiotic (1) Apoptosis (34) Autophagy (5) Bacterial (7) Bcl-2 Family (11) Biochemical Assay Reagents (2) CDK (4) Ceramidase (1) Chloride Channel (2) COX (2) Cytochrome P450 (1) EGFR (1) Endogenous Metabolite (9) ERK (1) FAK (1) Fluorescent Dye (4) Glutathione Peroxidase (2) HIF/HIF Prolyl-Hydroxylase (2) HIV (1) IAP (1) IFNAR (1) Integrin (3) Interleukin Related (4) Isotope-Labeled Compounds (1) JNK (3) Lactate Dehydrogenase (2) MDM-2/p53 (6) MMP (1) mTOR (2) MyD88 (2) NF-κB (3) NO Synthase (1) NOD-like Receptor (NLR) (1) p38 MAPK (5) Parasite (4) PARP (11) PDGFR (1) PTEN (2) Reactive Oxygen Species (ROS) (6) Reference Standards (6) SOD (5) Telomerase (1) TNF Receptor (3) VEGFR (1) β-catenin (1)
By Research Areas:	Cancer (47) Cardiovascular Disease (7) Infection (12) Inflammation/Immunology (23) Metabolic Disease (8) Neurological Disease (8)
Oligonucleotides:	Cholesterol (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120833

Ac-Ile-Glu-Thr-Asp-pNA	Caspase	Others
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .

HY-P2208

Z-IETD-AFC	Fluorescent Dye	Cancer
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Caspase	Others
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-P4222

IETD-CHO Caspase-8-IN-1	Caspase	Others
IETD-CHO (Caspase-8-IN-1) is a potent *caspase-8* inhibitor .

HY-P4222A

IETD-CHO TFA	Caspase	Others
IETD-CHO TFA (Caspase-8-IN-1) is a potent *caspase-8* inhibitor .

HY-P3362

Ac-IETD-AMC	Fluorescent Dye	Others
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

HY-P10454

(Z-IETD)2-Rh 110 (Z-Ile-Glu-Thr-Asp)2-R110	Caspase	Others
(Z-IETD)2-Rh 110 is a fluorescent substrate of *caspase-8* (λex= 488 nm, λem= 523 nm), which can be used to detect the activity of *caspase-8* and the process of apoptosis .

HY-P2620

Ac-LETD-AFC	Fluorescent Dye	Metabolic Disease Cancer
Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .

HY-P10001

Z-IETD-pNA Z-Ile-Glu-Thr-Asp-pNA	Caspase	Cancer
Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .

HY-P5830

Biotin-DEVD-CHO	Caspase	Others
Biotin-DEVD-CHO can be used for affinity labeling of *Caspase-8* following in vitro caspase cleavage .

HY-P1169A

Ac-IETD-AFC TFA	Caspase	Others
Ac-IETD-AFC TFA is a synthetic fluorogenic substrate that can be used to specifically detect caspase-8 activity. INDO 1 pentasodium is imbued with the fluorophore AFC (7-amino-4-trifluoromethylcoumarin). When caspase-8 recognizes and cleaves the amide bond following the IETD sequence in this substrate, AFC is released and emits fluorescence (Ex = ~400 nm; Em = ~505 nm) .

HY-P10149

Ac-IEPD-CHO	Caspase	Cancer
Ac-IEPD-CHO is a reversible granzyme B inhibitor with a K_i of 80 nM . Ac-IEPD-CHO is also a *caspase-8* inhibitor .

HY-P10322

Z-IETD-R110	Fluorescent Dye	Cancer
Z-IETD-R110 is a fluorescent substrate of *caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8* is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .

HY-138203

Z-LE(OMe)TD(OMe)-FMK	Caspase Apoptosis	Cancer
Z-LE(OMe)TD(OMe)-FMK is a selective *caspase-8* inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis .

HY-16591

Birinapant 35+ Cited Publications TL32711	IAP Apoptosis HIV	Cancer
Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with K_ds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.

HY-101297

Z-IETD-FMK Maximum Cited Publications 63 Publications Verification Z-IE(OMe)TD(OMe)-FMK	Caspase	Cancer
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable *caspase-8* inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .

HY-N0605

Ginsenoside Rh2 4 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2	Caspase Apoptosis Endogenous Metabolite	Cancer
Ginsenoside Rh2 (20(S)-Ginsenoside Rh2) induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-W750678

9-cis-Canthaxanthin	Apoptosis Caspase	Inflammation/Immunology
9-cis-Canthaxanthin is a carotenoid with pro-apoptotic activity in THP-1 macrophage cells. 9-cis-Canthaxanthin induces cell apoptosis by increasing *caspase-3* and *caspase-8* activity .

HY-N6777

Penicillic acid 1 Publications Verification	Caspase Bacterial Apoptosis Antibiotic	Infection Cancer
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .

HY-129440

N-(p-Coumaroyl) Serotonin	PDGFR ERK Caspase	Metabolic Disease Inflammation/Immunology
N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2 and *caspase-8* with antioxidant, anti-atherosclerotic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits glioblastoma cells (U251MG, T98G) with IC₅₀ of 48-81 μM, while the IC₅₀ for normal fibroblasts is 181-197 μM. N-(p-Coumaroyl) Serotonin inhibits PDGF signaling (reducing receptor phosphorylation), blocks Ca ²⁺ influx, and induces apoptosis (activating caspase-8). N-(p-Coumaroyl) Serotonin can improve atherosclerosis and aortic wall enlargement, and can also be used in the study of glioblastoma .

HY-N0605R

Ginsenoside Rh2 (Standard) 20(S)-Ginsenoside Rh2(Standard); 20(S)-Rh2(Standard)	Reference Standards Caspase Apoptosis Endogenous Metabolite	Cancer
Ginsenoside Rh2 (Standard) is the analytical standard of Ginsenoside Rh2. This product is intended for research and analytical applications. Ginsenoside Rh2 induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-113963

Ac-IETD-CHO	Apoptosis	Cancer
Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and *caspase-8*. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death .

HY-121320

Raptinal 5+ Cited Publications	Caspase Apoptosis	Cancer
Raptinal, a agent that directly activates *caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8* and caspase-9 .

HY-P5834

Boc-AEVD-CHO	Caspase Apoptosis	Inflammation/Immunology
Boc-AEVD-CHO is a *Caspase 8* inhibitor useful in the study of apoptosis and immune and inflammatory diseases .

HY-124134

AD-2646 LCL102	Ceramidase Caspase PARP	Cancer
AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC₅₀: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism .

HY-P10241

Ac-LEHD-CHO	Apoptosis Caspase	Cancer
Ac-LEHD-CHO is an inhibitor for *caspase* 8/9. Ac-LEHD-CHO prevents GalN/TNF-α-induced hepatotoxicity and hepatocyte apoptosis .

HY-168877

FMP	MDM-2/p53 Reactive Oxygen Species (ROS) Apoptosis Caspase PARP Bcl-2 Family	Cancer
FMP is a Platinum(IV) complexe. FMP significantly upregulates the expression of γ-H2AX and p53. FMP increases the production of ROS. FMP markedly upregulates the expressions of Apoptosis-related proteins (*DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax*). FMP shows antiproliferative activity against breast cancer .

HY-P3560

Edratide TV 4710	Apoptosis	Inflammation/Immunology
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .

HY-P10082

Ac-VETD-AMC	Caspase	Others
Ac-VETD-AMC is a synthetic peptide substrate for *caspase 8*. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .

HY-B0493

Niflumic acid 2 Publications Verification	Chloride Channel COX	Inflammation/Immunology Cancer
Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC₅₀ value of 100 nM. Niflumic acid induces apoptosis through *caspase-8/Bid/Bax* pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis ^[8].

HY-15091

Anisperimus LF-150195	Endogenous Metabolite	Neurological Disease
Anisperimus (LF-150195) is an immunosuppressant with the activity of enhancing activation-induced T cell death. Anisperimus enhances the sensitivity of T cells to anti-CD95 antibodies and other inducers by promoting the activation of caspase-8 and caspase-10 at the level of the death-inducing signaling complex (DISC). Anisperimus also promotes the development of Foxp3-expressing regulatory CD4 T cells, thereby preventing central nervous system autoimmunity .

HY-N2993

Polyporenic acid C	Apoptosis Caspase PARP Akt PTEN MDM-2/p53 JNK	Cancer
Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of *caspase-8* and *caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN* and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer .

HY-N0674A

Dehydrocorydaline chloride 35+ Cited Publications 13-Methylpalmatine chloride	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Cancer
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-W010155

Tryptophol Indole-3-ethanol	Endogenous Metabolite Apoptosis Caspase Bacterial	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of *caspase-8. Tryptophol inhibits Cunninghamella blakesleeana* biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy ^[8] .

HY-N0674B

Dehydrocorydaline (hydroxyl) 35+ Cited Publications 13-Methylpalmatine (hydroxyl)	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Inflammation/Immunology Cancer
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N0674

Dehydrocorydaline 35+ Cited Publications 13-Methylpalmatine	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Cancer
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-Y1881B

Copper sulfate pentahydrate, for cell culture, 98%	Biochemical Assay Reagents Reactive Oxygen Species (ROS) MyD88 SOD Caspase	Others
Copper sulfate pentahydrate, for cell culture, 98% is a biochemical reagent. Copper sulfate pentahydrate, for cell culture, 98% reduces the production of ROS and the expression levels of MyD88 as well as c-Rel genes. Copper sulfate pentahydrate, for cell culture, 98% decreases the activities of T-SOD, CAT, and GSH, increases the activities of *caspase-3, caspase-8, and caspase-9*. Copper sulfate pentahydrate, for cell culture, 98% is cytotoxic to various cells .

HY-N4238

Dehydrocorydaline nitrate 35+ Cited Publications 13-Methylpalmatine nitrate	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Cancer
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N6969A

Dicentrine hydrochloride	Adrenergic Receptor	Cancer
Dicentrine hydrochloride is a drug with anti-inflammatory and anti-cancer activity. Dicentrine hydrochloride exerts its effects by enhancing TNF-α-induced apoptosis in A549 lung adenocarcinoma cells. Dicentrine hydrochloride increases caspase-8, -9, -3 and poly(ADP-ribose) polymerase (PARP) activities. Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells. Dicentrine hydrochloride significantly inhibited the TNF-α-activated TAK1, p38, JNK and Akt signaling pathways, and reduced the transcriptional activities of NF-κB and AP-1 .

HY-N0905

Ginsenoside Rh4	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite	Cancer
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, *caspase 8, and caspase* 9. Ginsenoside Rh4 also induces autophagy.

HY-P10146

Ac-LETD-CHO	Caspase	Cancer
Ac-LETD-CHO is a caspases 8 inhibitor. Ac-LETD-CHO has specific inhibition to casp-8 with an IC₅₀ value of 6.71 nM. Ac-LETD-CHO can be used for the research of anticancer .

HY-W010155R

Tryptophol (Standard) Indole-3-ethanol (Standard)	Reference Standards Endogenous Metabolite Apoptosis Caspase Bacterial	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Tryptophol (Standard) (Indole-3-ethanol (Standard)) is an analytical standard of Tryptophol (HY-W010155). This product is intended for use in research and analytical applications.Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of *caspase-8. Tryptophol inhibits Cunninghamella blakesleeana* biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy.

HY-172623

EGFR/HER2-IN-17	EGFR Caspase Apoptosis Bcl-2 Family	Cancer
EGFR/HER2-IN-17 (Compound 7h) is a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). EGFR/HER2-IN-17 inhibits cancer cell proliferation. EGFR/HER2-IN-17 interacts with the binding pockets of EGFR and HER2, activating caspase-3 and caspase-8, and decreases the expression of Bcl-2, thereby inducing apoptosis. EGFR/HER2-IN-17 is promising for research of cancers .

HY-B0493R

Niflumic acid (Standard)	Reference Standards Chloride Channel COX	Inflammation/Immunology
Niflumic acid (Standard) is the analytical standard of Niflumic acid. This product is intended for research and analytical applications. Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC₅₀ value of 100 nM. Niflumic acid induces apoptosis through *caspase-8/Bid/Bax* pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis ^[8].

HY-N2993R

Polyporenic acid C (Standard)	Apoptosis Caspase PARP Akt PTEN MDM-2/p53 JNK	Cancer
Polyporenic acid C (Standard) is an analytical standard of Polyporenic acid C (HY-N2993). This product is intended for research and analytical applications. Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of *caspase-8* and *caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN* and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer .

HY-153161

CASP8-IN-1	Caspase Apoptosis	Cancer
CASP8-IN-1 (Compound 63-R) is a selective inhibitor for caspase 8 (CASP8), with an IC₅₀ of 0.7 μM. CASP8-IN-1 inhibits FasL-induced apoptosis in cell Jurkat .

HY-178099

Apoptosis inducer 45	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of *caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8* cleavage, subsequently initiating cleavage of *caspase-3* and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer .

HY-W750342

Tryptophol-d4 Indole-3-ethanol-d₄	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Caspase Bacterial	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Tryptophol-d₄ (Indole-3-ethanol-d₄) is the deuterium labeled Tryptophol (HY-W010155). Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy ^[8] .

HY-10531

ARRY-380 analog	Caspase	Infection Cancer
ARRY-380 analog (Compound PCM-0095494) is an ARRY-380 (HY-16069) analog. ARRY-380 analog activates *caspases* 3 and *caspases 8. ARRY-380 analog inhibits Salmonella* replication in cells .

HY-172393

TCF4/β-catenin-IN-1	β-catenin Apoptosis Caspase MDM-2/p53 Bcl-2 Family Cytochrome P450	Cancer
TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells .

Cat. No.	Product Name	Type

HY-P2208

Z-IETD-AFC	Fluorescent Dyes/Probes
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Fluorescent Dyes/Probes
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-P3362

Ac-IETD-AMC	Fluorescent Dyes/Probes
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

Cat. No.	Product Name	Type

HY-Y1881B

Copper sulfate pentahydrate, for cell culture, 98%

Buffer Reagents

Copper sulfate pentahydrate, for cell culture, 98% is a biochemical reagent. Copper sulfate pentahydrate, for cell culture, 98% reduces the production of ROS and the expression levels of MyD88 as well as c-Rel genes. Copper sulfate pentahydrate, for cell culture, 98% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, for cell culture, 98% is cytotoxic to various cells .

HY-Y1881A

Copper sulfate pentahydrate, 99.9%

Buffer Reagents

Copper sulfate pentahydrate, 99% is a biochemical reagent. Copper sulfate pentahydrate, 99% reduces the production of ROS and the expression levels of MyD88 as well as c-Rel genes. Copper sulfate pentahydrate, 99% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, 99% is cytotoxic to various cells. Copper sulfate pentahydrate, 99% has antioxidant activity. Copper sulfate pentahydrate, 99% can be used in the research of diabetes, Parkinson's disease and DMBA (HY-W011845)-induced tumors .

Cat. No.	Product Name	Target	Research Area

HY-120833

Ac-Ile-Glu-Thr-Asp-pNA	Caspase	Others
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .

HY-P2208

Z-IETD-AFC	Fluorescent Dye	Cancer
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Caspase	Others
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-P4222

IETD-CHO Caspase-8-IN-1	Caspase	Others
IETD-CHO (Caspase-8-IN-1) is a potent *caspase-8* inhibitor .

HY-P4222A

IETD-CHO TFA	Caspase	Others
IETD-CHO TFA (Caspase-8-IN-1) is a potent *caspase-8* inhibitor .

HY-P3362

Ac-IETD-AMC	Fluorescent Dye	Others
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

HY-P10454

(Z-IETD)2-Rh 110 (Z-Ile-Glu-Thr-Asp)2-R110	Caspase	Others
(Z-IETD)2-Rh 110 is a fluorescent substrate of *caspase-8* (λex= 488 nm, λem= 523 nm), which can be used to detect the activity of *caspase-8* and the process of apoptosis .

HY-P2620

Ac-LETD-AFC	Fluorescent Dye	Metabolic Disease Cancer
Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .

HY-P10001

Z-IETD-pNA Z-Ile-Glu-Thr-Asp-pNA	Caspase	Cancer
Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .

HY-P5830

Biotin-DEVD-CHO	Caspase	Others
Biotin-DEVD-CHO can be used for affinity labeling of *Caspase-8* following in vitro caspase cleavage .

HY-P1169A

Ac-IETD-AFC TFA	Caspase	Others
Ac-IETD-AFC TFA is a synthetic fluorogenic substrate that can be used to specifically detect caspase-8 activity. INDO 1 pentasodium is imbued with the fluorophore AFC (7-amino-4-trifluoromethylcoumarin). When caspase-8 recognizes and cleaves the amide bond following the IETD sequence in this substrate, AFC is released and emits fluorescence (Ex = ~400 nm; Em = ~505 nm) .

HY-P10149

Ac-IEPD-CHO	Caspase	Cancer
Ac-IEPD-CHO is a reversible granzyme B inhibitor with a K_i of 80 nM . Ac-IEPD-CHO is also a *caspase-8* inhibitor .

HY-P10322

Z-IETD-R110	Fluorescent Dye	Cancer
Z-IETD-R110 is a fluorescent substrate of *caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8* is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .

HY-138203

Z-LE(OMe)TD(OMe)-FMK	Caspase Apoptosis	Cancer
Z-LE(OMe)TD(OMe)-FMK is a selective *caspase-8* inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis .

HY-101297

Z-IETD-FMK Maximum Cited Publications 63 Publications Verification Z-IE(OMe)TD(OMe)-FMK	Caspase	Cancer
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable *caspase-8* inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .

HY-113963

Ac-IETD-CHO	Apoptosis	Cancer
Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and *caspase-8*. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death .

HY-P5834

Boc-AEVD-CHO	Caspase Apoptosis	Inflammation/Immunology
Boc-AEVD-CHO is a *Caspase 8* inhibitor useful in the study of apoptosis and immune and inflammatory diseases .

HY-P10241

Ac-LEHD-CHO	Apoptosis Caspase	Cancer
Ac-LEHD-CHO is an inhibitor for *caspase* 8/9. Ac-LEHD-CHO prevents GalN/TNF-α-induced hepatotoxicity and hepatocyte apoptosis .

HY-P3560

Edratide TV 4710	Apoptosis	Inflammation/Immunology
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .

HY-P10082

Ac-VETD-AMC	Caspase	Others
Ac-VETD-AMC is a synthetic peptide substrate for *caspase 8*. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .

HY-P10146

Ac-LETD-CHO	Caspase	Cancer
Ac-LETD-CHO is a caspases 8 inhibitor. Ac-LETD-CHO has specific inhibition to casp-8 with an IC₅₀ value of 6.71 nM. Ac-LETD-CHO can be used for the research of anticancer .

HY-12290

Arg-Gly-Asp-Ser 5+ Cited Publications RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-P3779

Amyloid 17-42 Aβ(17-42)	Apoptosis	Neurological Disease
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway .

HY-12290R

Arg-Gly-Asp-Ser (Standard)	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (Standard) is the analytical standard of Arg-Gly-Asp-Ser. This product is intended for research and analytical applications. Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-P11108

RP-182	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of *caspase 8, apoptosis*, and cell death. RP-182 is used in pancreatic cancer and melanoma research .

HY-P11298

d-T101 peptide	Caspase Apoptosis JNK p38 MAPK Interleukin Related IFNAR	Inflammation/Immunology Cancer
d-T101 peptide, a human hormone-peptide, is a T1/ST2 receptor ligand. d-T101 peptide binds to the T1/ST2 receptor and activates *caspases 8, 9 and 3 mediated apoptosis, together with activation of JNKinase* and p38 MAPKinase. d-T101 peptide also changes Golgi structural with function loss and downregulation of the endoplasmic reticulum (ER) stress repair mechanism. d-T101 peptide has immunostimulatory and anticancer activity, selectively induces apoptosis in proliferating cancer cells and increases IL-2 and IFN-γ expression as well as the recruitment of NK cells and M1 macrophages to the tumor site .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0605

Ginsenoside Rh2 4 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2	Panax ginseng C. A. Meyer Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Caspase Apoptosis Endogenous Metabolite
Ginsenoside Rh2 (20(S)-Ginsenoside Rh2) induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-N6777

Penicillic acid 1 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Caspase Bacterial Apoptosis Antibiotic
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .

HY-129440

N-(p-Coumaroyl) Serotonin	Classification of Application Fields Carthamus tinctorius L. Source classification Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	PDGFR ERK Caspase
N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2 and *caspase-8* with antioxidant, anti-atherosclerotic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits glioblastoma cells (U251MG, T98G) with IC₅₀ of 48-81 μM, while the IC₅₀ for normal fibroblasts is 181-197 μM. N-(p-Coumaroyl) Serotonin inhibits PDGF signaling (reducing receptor phosphorylation), blocks Ca ²⁺ influx, and induces apoptosis (activating caspase-8). N-(p-Coumaroyl) Serotonin can improve atherosclerosis and aortic wall enlargement, and can also be used in the study of glioblastoma .

HY-N2993

Polyporenic acid C	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Source classification Poria cocos Plants Disease Research Fields Cancer	Apoptosis Caspase PARP Akt PTEN MDM-2/p53 JNK
Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of *caspase-8* and *caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN* and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer .

HY-N0674A

Dehydrocorydaline chloride Maximum Cited Publications 40 Publications Verification 13-Methylpalmatine chloride	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-W010155

Tryptophol Indole-3-ethanol	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Caspase Bacterial
Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of *caspase-8. Tryptophol inhibits Cunninghamella blakesleeana* biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy ^[8] .

HY-N0674B

Dehydrocorydaline (hydroxyl) 35+ Cited Publications 13-Methylpalmatine (hydroxyl)	Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N0674

Dehydrocorydaline Maximum Cited Publications 40 Publications Verification 13-Methylpalmatine	Infection Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N4238

Dehydrocorydaline nitrate 35+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0605R

Ginsenoside Rh2 (Standard) 20(S)-Ginsenoside Rh2(Standard); 20(S)-Rh2(Standard)	Panax ginseng C. A. Meyer Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Reference Standards Caspase Apoptosis Endogenous Metabolite
Ginsenoside Rh2 (Standard) is the analytical standard of Ginsenoside Rh2. This product is intended for research and analytical applications. Ginsenoside Rh2 induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-N6969A

Dicentrine hydrochloride	Alkaloids Other Alkaloids Source classification Stephania epigaea Lo Plants Menispermaceae	Adrenergic Receptor
Dicentrine hydrochloride is a drug with anti-inflammatory and anti-cancer activity. Dicentrine hydrochloride exerts its effects by enhancing TNF-α-induced apoptosis in A549 lung adenocarcinoma cells. Dicentrine hydrochloride increases caspase-8, -9, -3 and poly(ADP-ribose) polymerase (PARP) activities. Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells. Dicentrine hydrochloride significantly inhibited the TNF-α-activated TAK1, p38, JNK and Akt signaling pathways, and reduced the transcriptional activities of NF-κB and AP-1 .

HY-N0905

Ginsenoside Rh4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, *caspase 8, and caspase* 9. Ginsenoside Rh4 also induces autophagy.

HY-W010155R

Tryptophol (Standard) Indole-3-ethanol (Standard)	Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite Apoptosis Caspase Bacterial
Tryptophol (Standard) (Indole-3-ethanol (Standard)) is an analytical standard of Tryptophol (HY-W010155). This product is intended for use in research and analytical applications.Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of *caspase-8. Tryptophol inhibits Cunninghamella blakesleeana* biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy.

HY-N2993R

Polyporenic acid C (Standard)	Triterpenes Terpenoids Polyporaceae Source classification Poria cocos Plants	Apoptosis Caspase PARP Akt PTEN MDM-2/p53 JNK
Polyporenic acid C (Standard) is an analytical standard of Polyporenic acid C (HY-N2993). This product is intended for research and analytical applications. Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of *caspase-8* and *caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN* and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer .

HY-W013579

(S)-(+)-Carvone D-Carvone	Classification of Application Fields Ketones, Aldehydes, Acids Gymnaster koraiensis Source classification Other Diseases Umbelliferae Plants Disease Research Fields	SOD Reactive Oxygen Species (ROS) Interleukin Related NOD-like Receptor (NLR) Caspase Apoptosis
(S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of *caspase*-8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis ^[8] .

HY-W013579R

(S)-(+)-Carvone (Standard) D-Carvone (Standard)	Ketones, Aldehydes, Acids Gymnaster koraiensis Source classification Umbelliferae Plants	Reference Standards Others
(S)-(+)-Carvone (Standard) is the analytical standard of (S)-(+)-Carvone. This product is intended for research and analytical applications. (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of *caspase*-8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis ^[8] .

HY-N0171

Beta-Sitosterol (purity>80%) 10+ Cited Publications	Cardiovascular Disease other families Classification of Application Fields Leguminosae Source classification Plants Endogenous metabolite Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Steroids	Apoptosis Endogenous Metabolite
Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating *caspase-3, caspase-8, and caspase-9, mediating PARP* inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[8] .

HY-N0171A

Beta-Sitosterol (purity>98%) 10+ Cited Publications β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)	Cardiovascular Disease Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating *caspase-3, caspase-8, and caspase-9, mediating PARP* inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[8] .

HY-N0171R

Beta-Sitosterol (Standard) 5+ Cited Publications β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))	Cardiovascular Disease other families Classification of Application Fields Leguminosae Source classification Plants Endogenous metabolite Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Steroids	Reference Standards Apoptosis Endogenous Metabolite
Beta-Sitosterol (Standard) is the analytical standard of Beta-Sitosterol. This product is intended for research and analytical applications. Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating *caspase-3, caspase-8, and caspase-9, mediating PARP* inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.

HY-N0171AR

Beta-Sitosterol (purity>98%) (Standard) β-Sitosterol (purity>98%) (Standard); 22,23-Dihydrostigmasterol (purity>98%) (Standard)	Leguminosae Glycine max (L.) merr Source classification Plants Steroids	Reference Standards Apoptosis Bacterial Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD
Beta-Sitosterol (purity>98%) (Standard) is an analytical standard for Beta-Sitosterol (purity>98%). Beta-Sitosterol (purity>98%) is intended for research and analytical applications. Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating *caspase-3, caspase-8, and caspase-9, mediating PARP* inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[8] .

Cat. No.	Product Name	Chemical Structure

HY-W750342

Tryptophol-d4

Tryptophol-d₄ (Indole-3-ethanol-d₄) is the deuterium labeled Tryptophol (HY-W010155). Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy ^[8] .

Cat. No.	Product Name		Classification

HY-N0171

Beta-Sitosterol (purity>80%) 10+ Cited Publications		Cholesterol
Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating *caspase-3, caspase-8, and caspase-9, mediating PARP* inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[8] .

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