Search Result
Results for "
carboxylated
" in MedChemExpress (MCE) Product Catalog:
30
Biochemical Assay Reagents
10
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-131256A
-
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
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Cetirizine Impurity C dihydrochloride is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist [1] [2] .
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-
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- HY-W005963
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NO Synthase
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Inflammation/Immunology
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Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid that can found in the stems of Mahonia fortune. Methyl 5-hydroxypyridine-2-carboxylate exhibits NO inhibitory effects in vitro .
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-
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- HY-W454945S
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N-Boc-piperazine-d8
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Isotope-Labeled Compounds
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Others
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tert-Butyl piperazine-1-carboxylate-2,2,3,3,5,5,6,6-d8 is the deuterium labeled tert-Butyl piperazine-1-carboxylate .
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- HY-E70124B
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- HY-E70124A
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-
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- HY-E70124C
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-
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- HY-131256
-
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
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Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist [1] [2] .
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- HY-149676
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Glycosidase
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Metabolic Disease
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α-Glucosidase-IN-42 (Compound 26) is a 9-O-berberrubine carboxylate derivative. α-Glucosidase-IN-42 has potent α-glucosidase inhibitory activities with an IC50 value in the range of 1.61 μM. α-Glucosidase-IN-42 can be used for the research of antidiabetic .
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- HY-169477
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Biochemical Assay Reagents
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Cancer
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PAMAM Dendrimer G0.5 Carboxylate sodium is a polyamidoamine (PAMAM) dendrimer with carboxylate termini. PAMAM Dendrimer G0.5 Carboxylate sodium conjugated with DACHPt is cytotoxic to A2780 ovarian cancer cells, MCF-7 breast cancer cells, Caco-2 colon cancer cells and BJ fibroblasts with IC50 values of 0.03, 1.6, 0.18 and 3 µM, respectively .
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- HY-W125425
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HIV
METTL3
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Infection
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Methyl piperazine-2-carboxylate (compound 4) is a potent METTL3/METTL14/WTAP activator. Methyl piperazine-2-carboxylate increases HIV-1 p24 virion production. Methyl piperazine-2-carboxylate increases the N6-adenosine methylation level in the viral RNA genome .
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-
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- HY-W454729S
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4-Hydroxypiperidine-3,3,4,5,5-d5-N-t-BOC
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Isotope-Labeled Compounds
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Others
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tert-Butyl 4-hydroxypiperidine-1-carboxylate-3,3,4,5,5-d5 is the deuterium labeled tert-Butyl 4-hydroxypiperidine-1-carboxylate .
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-
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- HY-33615
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ADC Linker
PROTAC Linkers
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Cancer
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Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
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- HY-W064677
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Others
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Others
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Methyl 5-hydroxy-1H-indole-3-carboxylate is a marine natural product with isocitrate lyase inhibitory activity. Methyl 5-hydroxy-1H-indole-3-carboxylate is found in Hyrtios erectus. Methyl 5-hydroxy-1H-indole-3-carboxylate can be used to study its interaction with specific biological targets .
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- HY-W052600
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ADC Linker
PROTAC Linkers
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Cancer
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Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
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- HY-W003696
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Tert-butyl 5-bromo-1,3-dihydro-2H-isoindole-2- carboxylate
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PROTAC Linkers
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Cancer
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tert-Butyl 5-bromoisoindoline-2-carboxylate is a PROTAC Linker. tert-Butyl 5-bromoisoindoline-2-carboxylate can be used in synthesis PTOTAC HSD17B13 degrader 1 (HY-159651) .
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- HY-79635
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Bacterial
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Infection
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Methyl indole-3-carboxylate is a natural product isolated from Sorangium cellulosum strain Soce895. Methyl indole-3-carboxylate shows a weak activity against the Gram-positive Nocardia sp with a MIC value of 33.33 μg/mL .
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- HY-W003793
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Others
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Cancer
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Ethyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with anti-tumor activity. Ethyl 6-bromo-1H-indole-3-carboxylate was isolated from the sponge Iotrochota purpurea collected in Indonesia. The structure of Ethyl 6-bromo-1H-indole-3-carboxylate was confirmed by spectroscopic methods and accurate mass measurements .
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- HY-32208S
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Isotope-Labeled Compounds
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Others
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tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate-d4 is the deuterium labeled tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate[1].
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- HY-W007997R
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3-Amino-4-ethoxycarbonylpyrazole (Standard)
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Biochemical Assay Reagents
Reference Standards
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Others
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Ethyl 3-amino-1H-pyrazole-4-carboxylate (Standard) is the analytical standard of Ethyl 3-amino-1H-pyrazole-4-carboxylate (HY-W007997). This product is intended for research and analytical applications. Ethyl 3-amino-1H-pyrazole-4-carboxylate (3-Amino-4-ethoxycarbonylpyrazole) is a pyrazole organic compound containing an amino group and an ethoxycarbonyl group. Ethyl 3-amino-1H-pyrazole-4-carboxylate can be used as a ligand in the synthesis of metal coordination compounds .
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- HY-159557
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-
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- HY-W003995
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-
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- HY-40151
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ADC Linker
PROTAC Linkers
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Cancer
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Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1
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- HY-169047
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PAMAM G1.5 carboxylate sodium
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SARS-CoV
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Infection
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PAMAM dendrimer G1.5 carboxylate (PAMAM G1.5 carboxylate) sodium is a polyanionic dendrimers comprising the terminal groups sodium carboxylate. PAMAM dendrimer G1.5 carboxylate shows antiviral activity with the MERS‐CoV plaque inhibition assay, with the inhibition rate of 40.5% .
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- HY-W019226
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ADC Linker
PROTAC Linkers
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Cancer
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Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
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- HY-117020
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Drug Intermediate
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Others
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Methyl (S)-(-)-N-Z-aziridine-2-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
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- HY-138354
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PROTAC Linkers
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Cancer
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Pyrroline-5-carboxylate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-200615
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-
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- HY-W016232
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-
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- HY-137494
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GABA Receptor
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Neurological Disease
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Ethyl β-carboline-3-carboxylate (fl-CCE) is a ligand and short-acting antagonist of benzodiazepine receptors. Ethyl β-carboline-3-carboxylate did not affect cerebellar cGMP levels when used alone, but when taken together with Diazepam, it significantly inhibited the cGMP levels that were upregulated by Diazepam .
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- HY-W043311
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Pyrimidine-4-carboxylicacidmethylester
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Drug Intermediate
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Others
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Methyl pyrimidine-4-carboxylate (Pyrimidine-4-carboxylicacidmethylester) is a synthetic intermediate useful for pharmaceutical synthesis.
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- HY-N3288
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Others
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Others
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Methylcarbazole-3-carboxylate is a carbazole alkaloid can be isolated from the peel of Clausena lansium (Lour.) Skeels .
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- HY-W052289
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Endogenous Metabolite
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Cancer
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Methyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with antitumor activity. Methyl 6-bromo-1H-indole-3-carboxylate showed growth inhibition against Staphylococcus epidermidis, exhibiting weak or moderate minimum inhibitory concentrations (MICs) .
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- HY-W098127S
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Isotope-Labeled Compounds
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Others
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Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate-d2 is the deuterium labeled Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate .
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- HY-W278906
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Drug Intermediate
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Others
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Ethyl 2-(3-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
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-
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- HY-W002603
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Biochemical Assay Reagents
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Others
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Benzyl piperazine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-78337
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Biochemical Assay Reagents
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Others
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Methyl pyrimidine-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-69111
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Biochemical Assay Reagents
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Others
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Ethyl oxazole-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-30756
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PROTAC Linkers
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Others
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tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is a PROTAC linker. tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is the linker of PROTAC ER Degrader-12 (HY-160264) and PROTAC AR Degrader-9 (HY-170332) .
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- HY-W007997
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3-Amino-4-ethoxycarbonylpyrazole
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Biochemical Assay Reagents
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Others
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Ethyl 3-amino-1H-pyrazole-4-carboxylate (3-Amino-4-ethoxycarbonylpyrazole) is a pyrazole organic compound containing an amino group and an ethoxycarbonyl group. Ethyl 3-amino-1H-pyrazole-4-carboxylate can be used as a ligand in the synthesis of metal coordination compounds .
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- HY-W045268
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Drug Intermediate
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Others
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Ethyl-2-amino-4-phenyl thiophene-3-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
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- HY-CE00480
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- HY-W012071
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Biochemical Assay Reagents
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Others
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(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002625
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Biochemical Assay Reagents
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Others
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Ethyl 2-bromothiazole-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W329522
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Drug Intermediate
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Others
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Ethyl-2-(2-pyridyl)-4-(bromomethyl)-Thiazole-5-Carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
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- HY-50301
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Biochemical Assay Reagents
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Others
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Ethyl 2-aminothiazole-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002874
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Biochemical Assay Reagents
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Others
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Methyl 3-aminopyridine-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-34497
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Biochemical Assay Reagents
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Others
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Ethyl 3-trifluoromethylpyrazole-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-138354A
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Biochemical Assay Reagents
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Others
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Pyrroline-5-carboxylate sodium participates in amino acid metabolism in organisms and is an intermediate product of proline biosynthesis and catabolism. During pathogen infection and abiotic stress
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- HY-W713923
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-
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- HY-40146
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N-Boc-3-azetidinone
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Biochemical Assay Reagents
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Others
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tert-Butyl 3-oxoazetidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W008201
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Biochemical Assay Reagents
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Others
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tert-Butyl 3-formylpyrrolidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W003177
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Biochemical Assay Reagents
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Others
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tert-Butyl 4-iodopiperidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W003140
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Biochemical Assay Reagents
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Others
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tert-Butyl 3-hydroxypyrrolidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W088558
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Drug Intermediate
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Others
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Benzyl (1R,3R)-3-hydroxycyclopentane-1-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
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- HY-120021
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Drug Intermediate
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Others
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tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis..
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- HY-W012802
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Biochemical Assay Reagents
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Others
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Methyl 1H-pyrrole-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W016739
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Biochemical Assay Reagents
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Others
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Methyl 1H-indole-6-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-69260
-
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PROTAC Linkers
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Cancer
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tert-Butyl 4-formylpiperidine-1-carboxylate is the linker of PROTAC BRM/BRG1 degrader-3 (HY-168251) .
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- HY-76366
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Biochemical Assay Reagents
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Others
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(S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W003321
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Biochemical Assay Reagents
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Others
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(S)-tert-Butyl 5-oxopyrrolidine-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-N9156
-
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Others
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Others
|
Methyl 1,6-dihydroxy-3-methylxanthone-8-carboxylate is a Xanthones product that can be isolated from the roots of Polygala tenuifolia Willd .
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- HY-42448
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- HY-W002386
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Biochemical Assay Reagents
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Others
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Ethyl 2-amino-4-methylthiazole-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W006646
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-
- HY-34027
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Biochemical Assay Reagents
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Others
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Ethyl 5-methyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002128
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Biochemical Assay Reagents
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Others
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Ethyl 5-bromo-1H-indole-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-76558
-
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Biochemical Assay Reagents
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Others
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Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W007392
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Methyl 4-bromopyrrole-2-carboxylate
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Biochemical Assay Reagents
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Others
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Methyl 4-bromo-1H-pyrrole-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002351
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Biochemical Assay Reagents
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Others
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Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W007685
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Biochemical Assay Reagents
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Others
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Methyl 1H-1,2,4-triazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W087433
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-
- HY-W140616
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Drug Intermediate
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Others
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Ethyl 4'-hydroxy-[1,1'-biphenyl]-4-carboxylate is a 4-O-sulfamoyl-4-biphenyl based compound and can be used for synthesis of other compounds .
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- HY-126271
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DNA/RNA Synthesis
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Cancer
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PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC50 of 8.8 µM. PYCR1-IN-1 has anticancer effects .
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- HY-149929
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Beta-lactamase
Bacterial
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Infection
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EBL-3183, an indole-2-carboxylate, is a potent metallo-β-lactamase (MBL) inhibitor. EBL-3183 is reversibly binding, non-covalent, competitive NDM-1 inhibitor with a pIC50 of 7.7 .
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- HY-W776820
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OXYL-1-NHS
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Biochemical Assay Reagents
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Others
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1-Oxyl-2,2,5,5-tetramethylpyrroline-3-carboxylate NHS ester (OXYL-1-NHS) is an active acylating agent that can be used to spin label proteins and aminoacylated RNA species .
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- HY-W140284S
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Isotope-Labeled Compounds
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Others
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6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate-d8 (hydrochloride) is the deuterium labeled 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride .
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- HY-100924
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GABA Receptor
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Neurological Disease
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β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [ 3H]flunitrazepam and ethyl (3-[ 3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM. β-CCB exhibits proconvulsant and anxiogenic effects .
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- HY-172063
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- HY-Y0949
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Methyl furan-2-carboxylate
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Endogenous Metabolite
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Others
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Methyl 2-furoate (Methyl furan-2-carboxylate) is a building block in chemical synthesis. A flavoring agent in food. Found in cranberries, guava fruits, raisins and other fruits. Also present in baked potato, roasted filberts, roasted peanut, tomatoes, coffee, cocoa, okra, etc.
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- HY-N10590
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Deacetylalpinoside
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Others
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Others
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Arborescosidic acid (Deacetylalpinoside) is a carboxylated iridoid glucoside, that can be isolated from Veronica beccabunga (brooklime) .
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- HY-15992
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VEGFR
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Cancer
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BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.
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- HY-W009757
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Lipoxygenase
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Others
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Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate is an active compound, and can be used in the synthesis of 2-phenylthiomethyl-indole derivatives, 2-phenylthiomethyl-indole derivative is a 5-lipoxygenase (5-LO) inhibitor .
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- HY-W345492
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1-(Cyclohexylmethyl)-1H-indole-3-carboxylic Acid Methyl Ester
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Cannabinoid Receptor
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Neurological Disease
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Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate (1-(Cyclohexylmethyl)-1H-indole-3-carboxylic Acid Methyl Ester) is an analog of BB-22 that lacks the quinoline group. BB-22 is an analog of cannabinoid .
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- HY-W006635
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Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate
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PROTAC Linkers
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Cancer
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Bpin-Cyclohexene-COOEt (Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate) is a PROTAC linker belonging to the PEG class. Bpin-Cyclohexene-COOEt can be used to synthesize PROTAC molecules .
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- HY-401257
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Biochemical Assay Reagents
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Others
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Methyl (1S,3R)-2-(2-iodoacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate is a biological molecule.
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-
- HY-132186
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HIV
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Infection
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Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor Abacavir (HY-17423) .
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-
- HY-79880
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1,1'-Carbonyldiimidazole
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Biochemical Assay Reagents
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Others
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N,N'-Carbonyldiimidazole is a highly reactive carboxylating agent. N,N'-Carbonyldiimidazole can be used as a coupling reagent .
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- HY-N9721
-
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Others
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Others
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Methyl 8-hydroxy-3-(2-methoxy-2-oxoethyl)-6-methyl-9-oxo-9H-furo[3,4-b]chromene-1-carboxylate is a Phenols product that can be isolated from the roots of Polygala fallax .
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- HY-152372
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Nucleoside Antimetabolite/Analog
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Others
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Methyl 6-amino-9-β-D-ribofuranosyl-9H-purine-2-carboxylate is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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-
- HY-W158160
-
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Bacterial
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Infection
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AGS1286 (sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate) is an organosulfur compound that serves as a model for investigating the impact of sulfur-containing compounds on enzymatic activities and metabolic pathways. Additionally, it has been employed to explore the regulatory effects of these compounds on bacterial growth and gene expression.
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- HY-139428
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Drug Metabolite
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Others
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Hydroxydehydro Nifedipine Carboxylate is an inactive metabolite formed by the oxidative biotransformation of Nifedipine (HY-B0284) in the human body .
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-
- HY-124049
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Drug Intermediate
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Others
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Ethyl 4-methyl-2-(2-thienyl)-thiazole-5 carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.
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-
- HY-172625
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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VH 101-amide-piperidine-Pip-alkyne is an E3 Ligase Ligand-Linker Conjugates that can be used to synthesize PROTAC degrader. The linker part of VH 101-amide-piperidine-Pip-alkyne is tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and the VHL-type E3 ubiquitinase ligand is VH 101, acid (HY-47070) .
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-
- HY-32291
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(S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester
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Fungal
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Others
|
Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity .
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-
- HY-131579
-
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Drug Metabolite
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Inflammation/Immunology
|
Deschloro Cetirizine Dihydrochloride is a Cetirizine impurity. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist.
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-
- HY-W394551
-
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Biochemical Assay Reagents
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Others
|
Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a small pyrrolidone molecule which features two bromine atoms and a methyl ester. The unsaturated dibromo motif is a covalent ligand for thiol groups, and may be used to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time. The methyl ester can be saponified to link this molecule to amines to form larger structures.
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- HY-D2318
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Fluorescent Dye
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Others
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Flipper-TR 5 is a Flipper probe that contains a terminal carboxylate for retention on the plasma membrane. Flipper-TR 5 can selectively label the plasma membrane and exhibits excellent mechanosensitivity, negligible cytotoxicity, and manageable phototoxicity .
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- HY-12966
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-
- HY-15992S
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Isotope-Labeled Compounds
VEGFR
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Cancer
|
BIBF 1202- 13C,d3 is the 13C- and deuterium labeled BIBF 1202. BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.
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-
- HY-101884A
-
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Biochemical Assay Reagents
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Neurological Disease
|
Biotinylated-D-lysine TFA is a conjugate of L-biotin and D-lysine, where the carboxylate of L-biotin is coupled with the ϵ-amine of D-lysine via a secondary amide bond. Biotinylated-D-lysine TFA is an isomer of the neuroanatomical tracer Biocyte.
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-
- HY-W099276
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Biochemical Assay Reagents
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Others
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Ethyl (2R,4R)-4-methylpiperidine-2-carboxylate-Arg(NO2) hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-17042A
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P071
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
Cancer
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Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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-
- HY-17042
-
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
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Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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- HY-W127452
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Biochemical Assay Reagents
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Others
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Undecylenate SodiumIt is an organic compound belonging to the class of carboxylates. It is formed by the reaction of undecylenic acid and sodium hydroxide. Undecylenate SodiumIt has a variety of applications in the cosmetic and personal care industries, especially as an antifungal agent in products such as face creams, lotions and shampoos. In addition, it can be used as a preservative in various formulations.
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- HY-170340
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PROTACs
Estrogen Receptor/ERR
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Cancer
|
PROTAC ER Degrader-14 (compound 86) is a PTORAC-type Estrogen Receptor/ERR degrader, which is composed of E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide (HY-168055), PROTAC Linker (black part) N-Boc-piperazine (HY-30105) and target protein ligand (red part) ER ligand-6 (HY-170341). Among them, E3 ligase + Linker constitute tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate (HY-W998234) .
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-
- HY-159651
-
|
PROTACs
17β-HSD
|
Cancer
|
PTOTAC HSD17B13 degrader 1 (compound 1) is a PROTAC targeting 17β-HSD 13 (HSD17B13). PTOTAC HSD17B13 degrader 1 is composed of PROTAC target protein ligand HSD17B13 degrader 2 (HY-159662) (red part), PROTAC Linker tert-Butyl 5-bromoisoindoline-2-carboxylate (HY-W003696) (black part) and E3 ubiquitin ligase ligand E3 ligase Ligand 31 (HY-159660) (blue part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 114 (HY-159661) [1] .
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-
- HY-P2831
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CESs
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Endogenous Metabolite
|
Metabolic Disease
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Esterase, pig liver (CESs), namely carboxylate hydrolases, are widely distributed in nature, commonly found in mammalian liver, and often used in biochemical research. Esterase catalyzes the hydrolysis of a variety of endogenous and exogenous substrates, including esters, thioesters, carbamates, and amides, hydrolyzing carboxylic acid esters to the corresponding alcohols and carboxylic acids .
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- HY-17042AS
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Isotope-Labeled Compounds
Histamine Receptor
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Inflammation/Immunology
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Cetirizine-d4 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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- HY-D1643
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Biochemical Assay Reagents
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Others
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5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca 2+. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand .
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- HY-17042S1
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Histamine Receptor
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Inflammation/Immunology
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Cetirizine-d8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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-
- HY-17042AS1
-
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Isotope-Labeled Compounds
Histamine Receptor
|
Inflammation/Immunology
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Cetirizine-d8 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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-
- HY-17042S
-
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Histamine Receptor
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Inflammation/Immunology
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Cetirizine-d4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
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-
- HY-101884
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(+)-Biocytin
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Endogenous Metabolite
|
Neurological Disease
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Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the -amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays .
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- HY-17042R
-
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
Cancer
|
Cetirizine (Standard) is the analytical standard of Cetirizine. This product is intended for research and analytical applications. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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-
- HY-17042AR
-
|
Histamine Receptor
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Inflammation/Immunology
Endocrinology
Cancer
|
Cetirizine (dihydrochloride) (Standard) is the analytical standard of Cetirizine (dihydrochloride). This product is intended for research and analytical applications. Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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-
- HY-101884R
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(+)-Biocytin (Standard)
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Reference Standards
Endogenous Metabolite
|
Neurological Disease
|
Biocytin (Standard) is the analytical standard of Biocytin. This product is intended for research and analytical applications. Biocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the -amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays[1][2].
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-
- HY-132994
-
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Biochemical Assay Reagents
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Others
|
TVD-0003510 is a carboxamide derivative, and involves in synthesis of (2-((6-(2-aminopyrimidine-5-carboxamido)-8-methoxy-3,4-dihydro-2H-pyrimido[1,2-c]quinazolin-9-yl)oxy)ethyl)piperazine-l-carboxylate (C51), as a part of tert-butyl2-(4-hydroxyphenyl)acetate .
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-
- HY-107767
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DC 81
|
Antibiotic
Apoptosis
DNA/RNA Synthesis
|
Cancer
|
Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct .
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-
- HY-114402
-
|
PROTACs
Androgen Receptor
|
Cancer
|
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study the treatment of castration-resistant prostate cancer (mCRPC) .
ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624), a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and a VHL-type E3 ubiquitinase ligand (blue part) VH 101, acid (HY-47070); among them, the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyne (HY-172625).
|
-
- HY-162816
-
|
PROTACs
MAP4K
|
Cancer
|
PROTAC HPK1 Degrader-3 (compound C3) is an orally effective PROTAC targeting HPK1 (DC50=21.26 nM). HPK1 is a negative regulator of T cell receptors, which can lead to T cell dysfunction after abnormal activation. PROTAC HPK1 Degrader-3 can inhibit SLP76 and NF-κB signaling pathways and inhibit MAPK signal transduction, and has anticancer activity and immune activation. PROTAC HPK1 Degrader-3 has a certain oral bioavailability and can be combined with PD-L1 antibody therapy to achieve a tumor growth inhibition rate of 65.58%. PROTAC HPK1 Degrader-3 is composed of E3 ligase ligand Thalidomide (HY-14658; blue part), PROTAC linker tert-Butyl 3-oxoazetidine-1-carboxylate (HY-40146; black part), and target protein ligand HPK1-IN-51 (HY-162842; red part); the activity control of the target protein ligand can be HPK1 ligand 1 (HY-162841) [1] .
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-
- HY-W018746
-
EDTA disodium
Maximum Cited Publications
10 Publications Verification
Ethylenediaminetetraacetic acid disodium
|
Biochemical Assay Reagents
|
Others
|
EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
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-
- HY-W250143
-
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Biochemical Assay Reagents
|
Others
|
Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.
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- HY-W018746R
-
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Biochemical Assay Reagents
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Others
|
EDTA (disodium) (Standard) is the analytical standard of EDTA (disodium). This product is intended for research and analytical applications. EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
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-
- HY-W157376
-
|
Bacterial
Antibiotic
Drug Intermediate
|
Infection
Cancer
|
PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems .
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-
Cat. No. |
Product Name |
Type |
-
- HY-W250143
-
|
Dyes
|
Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.
|
-
- HY-D2318
-
|
Fluorescent Dyes/Probes
|
Flipper-TR 5 is a Flipper probe that contains a terminal carboxylate for retention on the plasma membrane. Flipper-TR 5 can selectively label the plasma membrane and exhibits excellent mechanosensitivity, negligible cytotoxicity, and manageable phototoxicity .
|
Cat. No. |
Product Name |
Type |
-
- HY-W003995
-
-
- HY-W002603
-
|
Biochemical Assay Reagents
|
Benzyl piperazine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-78337
-
|
Biochemical Assay Reagents
|
Methyl pyrimidine-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-69111
-
|
Biochemical Assay Reagents
|
Ethyl oxazole-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007997
-
3-Amino-4-ethoxycarbonylpyrazole
|
Biochemical Assay Reagents
|
Ethyl 3-amino-1H-pyrazole-4-carboxylate (3-Amino-4-ethoxycarbonylpyrazole) is a pyrazole organic compound containing an amino group and an ethoxycarbonyl group. Ethyl 3-amino-1H-pyrazole-4-carboxylate can be used as a ligand in the synthesis of metal coordination compounds .
|
-
- HY-W012071
-
|
Biochemical Assay Reagents
|
(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002625
-
|
Biochemical Assay Reagents
|
Ethyl 2-bromothiazole-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-50301
-
|
Biochemical Assay Reagents
|
Ethyl 2-aminothiazole-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002874
-
|
Biochemical Assay Reagents
|
Methyl 3-aminopyridine-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007997R
-
3-Amino-4-ethoxycarbonylpyrazole (Standard)
|
Biochemical Assay Reagents
|
Ethyl 3-amino-1H-pyrazole-4-carboxylate (Standard) is the analytical standard of Ethyl 3-amino-1H-pyrazole-4-carboxylate (HY-W007997). This product is intended for research and analytical applications. Ethyl 3-amino-1H-pyrazole-4-carboxylate (3-Amino-4-ethoxycarbonylpyrazole) is a pyrazole organic compound containing an amino group and an ethoxycarbonyl group. Ethyl 3-amino-1H-pyrazole-4-carboxylate can be used as a ligand in the synthesis of metal coordination compounds .
|
-
- HY-34497
-
|
Gene Sequencing and Synthesis
|
Ethyl 3-trifluoromethylpyrazole-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W713923
-
|
Indicators
|
Methyl 9-maleinimido-8-methoxy-6,7-benzocumarin-3-carboxylate is a kind of biochemical reagent.
|
-
- HY-40146
-
N-Boc-3-azetidinone
|
Biochemical Assay Reagents
|
tert-Butyl 3-oxoazetidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W008201
-
|
Biochemical Assay Reagents
|
tert-Butyl 3-formylpyrrolidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W003177
-
|
Biochemical Assay Reagents
|
tert-Butyl 4-iodopiperidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W003140
-
|
Biochemical Assay Reagents
|
tert-Butyl 3-hydroxypyrrolidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W012802
-
|
Biochemical Assay Reagents
|
Methyl 1H-pyrrole-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W016739
-
|
Biochemical Assay Reagents
|
Methyl 1H-indole-6-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-76366
-
|
Biochemical Assay Reagents
|
(S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W003321
-
|
Biochemical Assay Reagents
|
(S)-tert-Butyl 5-oxopyrrolidine-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002386
-
|
Biochemical Assay Reagents
|
Ethyl 2-amino-4-methylthiazole-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-34027
-
|
Biochemical Assay Reagents
|
Ethyl 5-methyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002128
-
|
Biochemical Assay Reagents
|
Ethyl 5-bromo-1H-indole-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-76558
-
|
Biochemical Assay Reagents
|
Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007392
-
Methyl 4-bromopyrrole-2-carboxylate
|
Biochemical Assay Reagents
|
Methyl 4-bromo-1H-pyrrole-2-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002351
-
|
Biochemical Assay Reagents
|
Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007685
-
|
Biochemical Assay Reagents
|
Methyl 1H-1,2,4-triazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127452
-
|
Drug Delivery
|
Undecylenate SodiumIt is an organic compound belonging to the class of carboxylates. It is formed by the reaction of undecylenic acid and sodium hydroxide. Undecylenate SodiumIt has a variety of applications in the cosmetic and personal care industries, especially as an antifungal agent in products such as face creams, lotions and shampoos. In addition, it can be used as a preservative in various formulations.
|
-
- HY-W018746
-
Ethylenediaminetetraacetic acid disodium
|
Chelators
|
EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
|
-
- HY-W018746R
-
|
Chelators
|
EDTA (disodium) (Standard) is the analytical standard of EDTA (disodium). This product is intended for research and analytical applications. EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
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Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-42448
-
-
- HY-P4557
-
|
Peptides
|
Others
|
H-Phe-Leu-Glu-Glu-Leu-OH is a synthetic pentapeptide, which can be used as the substrate of vitamin K dependent carboxylase, and a glutamyl residue in the generated product is carboxylated .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W454945S
-
|
tert-Butyl piperazine-1-carboxylate-2,2,3,3,5,5,6,6-d8 is the deuterium labeled tert-Butyl piperazine-1-carboxylate .
|
-
-
- HY-15992S
-
|
BIBF 1202- 13C,d3 is the 13C- and deuterium labeled BIBF 1202. BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.
|
-
-
- HY-17042S1
-
|
Cetirizine-d8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
|
-
-
- HY-17042S
-
|
Cetirizine-d4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
|
-
-
- HY-W454729S
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tert-Butyl 4-hydroxypiperidine-1-carboxylate-3,3,4,5,5-d5 is the deuterium labeled tert-Butyl 4-hydroxypiperidine-1-carboxylate .
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- HY-32208S
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tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate-d4 is the deuterium labeled tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate[1].
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- HY-W098127S
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Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate-d2 is the deuterium labeled Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate .
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- HY-W140284S
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6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate-d8 (hydrochloride) is the deuterium labeled 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride .
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- HY-17042AS
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Cetirizine-d4 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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- HY-17042AS1
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Cetirizine-d8 (dihydrochloride) is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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Product Name |
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Classification |
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- HY-126271
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Alkynes
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PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC50 of 8.8 µM. PYCR1-IN-1 has anticancer effects .
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- HY-114402
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PROTAC Synthesis
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ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study the treatment of castration-resistant prostate cancer (mCRPC) .
ARD-69 is composed of a target protein ligand (pink part) AR antagonist 14 (HY-172624), a PROTAC linker (black part) tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and a VHL-type E3 ubiquitinase ligand (blue part) VH 101, acid (HY-47070); among them, the VHL ligand and the linker can form a conjugate VH 101-amide-piperidine-Pip-alkyne (HY-172625).
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Cat. No. |
Product Name |
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Classification |
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- HY-152372
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Nucleosides and their Analogs
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Methyl 6-amino-9-β-D-ribofuranosyl-9H-purine-2-carboxylate is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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