2. Others Protein Tyrosine Kinase/RTK
  3. VEGFR Isotope-Labeled Compounds
  4. BIBF 1202-d3

BIBF 1202-d3 is the deuterium labeled BIBF 1202 (HY-15992). BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.

For research use only. We do not sell to patients.

BIBF 1202-d<sub>3</sub> Chemical Structure

BIBF 1202-d3 Chemical Structure

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BIBF 1202-d3 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

BIBF 1202-d3 is the deuterium labeled BIBF 1202 (HY-15992). BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BIBF 1202-d3 Related Antibodies
Molecular Weight

528.62

Formula

C30H28D3N5O4
Unlabeled CAS
SMILES

O=C1NC2=CC(C(O)=O)=CC=C2/C1=C(NC3=CC=C(C=C3)N(C(CN4CCN(CC4)C([2H])([2H])[2H])=O)C)\C5=CC=CC=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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BIBF 1202-d3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIBF 1202-d3VEGFRIsotope-Labeled CompoundsVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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