Search Result
Results for "
anti-diabetic research
" in MedChemExpress (MCE) Product Catalog:
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P10959
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- HY-B0104R
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Glimperide (Standard); HOE-490 (Standard)
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Amyloid-β
Reference Standards
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Metabolic Disease
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Glimepiride (Standard) is the analytical standard of Glimepiride. This product is intended for research and analytical applications. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
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- HY-N13759
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Aldose Reductase
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Metabolic Disease
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Mumeose K is the inhibitor for aldose reductase with an IC50 of 27 μM. Mumeose K exhibits potential anti-diabetic activity, and can be used in research about diabetes-related complication .
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- HY-P10959A
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- HY-N15585
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Others
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Metabolic Disease
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Fomentariol is a natural compound found in the fungus Fomes fomentarius. Fomentariol has major biological activities such as anti-diabetic and antioxidant. Fomentariol can be used in the research of anti-diabetic or natural active ingredients .
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- HY-N13144
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Others
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Metabolic Disease
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Entagenic acid, a glycoside ligand, can be derived from Entada phaseoloides seeds. Entagenic acid is used in anti-diabetic research .
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- HY-P11233
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GLP Receptor
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Metabolic Disease
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Acmopatide (Compound E-153) is a dual-acting GIP/GLP-1 receptor agonist. Acmopatide is used in anti-diabetic research .
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- HY-16397AR
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Phenethylbiguanide hydrochloride (Standard)
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Reference Standards
AMPK
Autophagy
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Cancer
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Phenformin (hydrochloride) (Standard) is the analytical standard of Phenformin (hydrochloride). This product is intended for research and analytical applications. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.
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- HY-P10952
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- HY-N8438R
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Methyl lignocerate (Standard)
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Reference Standards
Others
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Metabolic Disease
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Methyl tetracosanoate (Standard) is the analytical standard of Methyl tetracosanoate. This product is intended for research and analytical applications. Methyl tetracosanoate (Methyl lignocerate) is a fatty acid methyl ester with anti-diabetic activity .
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- HY-N0184R
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Glycyrrhizin (Standard)
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Reference Standards
Virus Protease
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Metabolic Disease
Cancer
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Glycyrrhizic acid (Standard) is the analytical standard of Glycyrrhizic acid. This product is intended for research and analytical applications. Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
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- HY-111317
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Sirtuin
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Metabolic Disease
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SIRT1 activator 3 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. SIRT1 activator 3 has the potential for anti-obesity or anti-diabetic researches .
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- HY-N0628R
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Lespedin (Standard); Lespenephryl (Standard)
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Reference Standards
Insulin Receptor
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Metabolic Disease
Endocrinology
Cancer
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Kaempferitrin (Standard) is the analytical standard of Kaempferitrin. This product is intended for research and analytical applications. Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.
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- HY-155030
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Glycosidase
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Metabolic Disease
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α-Glucosidase-IN-25 (Compound (R)-8k) is a competitive inhibitor of α-glucosidase, with an IC50 of 1.19μM and can be used for anti-diabetic research .
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- HY-N0009R
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Reference Standards
Amyloid-β
Influenza Virus
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Neurological Disease
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Geniposide (Standard) is the analytical standard of Geniposide. This product is intended for research and analytical applications. Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
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- HY-B0813R
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UT-15C (Standard)
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Reference Standards
Prostaglandin Receptor
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Endocrinology
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Geniposide (Standard) is the analytical standard of Geniposide. This product is intended for research and analytical applications. Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
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- HY-106328R
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- HY-N2555R
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- HY-N2302R
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- HY-N7096R
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CTZ sodium (Standard)
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Reference Standards
Bacterial
Antibiotic
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Infection
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Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
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- HY-101399R
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γ-Glutamylphenylalanine (Standard)
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Reference Standards
Endogenous Metabolite
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Others
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Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
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- HY-N1425R
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Reference Standards
Others
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Metabolic Disease
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Tiliroside (Standard) is the analytical standard of Tiliroside. This product is intended for research and analytical applications. Tiliroside, a glycosidic flavonoid, possesses anti-diabetic activities. Tiliroside is a noncompetitive inhibitor of α-amylase with a Ki value of 84.2 μM. Tiliroside inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract .
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- HY-N6948R
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- HY-152158
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Glycosidase
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Metabolic Disease
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α-Glucosidase-IN-22 (compound 7i), a benzimidazole, is a potent α-glucosidase inhibitor with an IC50 of 0.64 μM. α-Glucosidase-IN-22 is a potent anti-diabetic agent and has the potential for type 2 diabetes mellitus (T2DM) research .
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- HY-W013075R
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Rutoside trihydrate (Standard); Quercetin 3-O-rutinoside trihydrate (Standard)
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Reference Standards
Amyloid-β
Autophagy
Apoptosis
Endogenous Metabolite
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Neurological Disease
Cancer
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Rutin (trihydrate) (Standard) is the analytical standard of Rutin (trihydrate). This product is intended for research and analytical applications. Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .
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- HY-N2534
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- HY-N0502
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Reactive Oxygen Species (ROS)
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Metabolic Disease
Cancer
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Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .
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- HY-B0254
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CP 28720; K 4024
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Potassium Channel
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Metabolic Disease
Cancer
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Glipizide (CP 2872; K 4024)?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium?(KATP) channels among β cells of pancreatic islets of Langerhans .
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- HY-100618R
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- HY-N2486R
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Reference Standards
Fatty Acid Synthase (FASN)
Apoptosis
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Cancer
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Desoxyrhaponticin (Standard) is the analytical standard of Desoxyrhaponticin. This product is intended for research and analytical applications. Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects .
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- HY-N6257R
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- HY-120912R
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- HY-N2534R
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- HY-N4103
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PARP
Endogenous Metabolite
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Metabolic Disease
Cancer
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Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .
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- HY-N1504R
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Reference Standards
PAI-1
Potassium Channel
ERK
JNK
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Metabolic Disease
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Loureirin B (Standard) is the analytical standard of Loureirin B. This product is intended for research and analytical applications. Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
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- HY-N0393R
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Reference Standards
PPAR
Reactive Oxygen Species (ROS)
Bacterial
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Infection
Inflammation/Immunology
Cancer
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Glabridin (Standard) is the analytical standard of Glabridin. This product is intended for research and analytical applications. Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
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- HY-B0254R
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CP 28720 (Standard); K 4024 (Standard)
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Reference Standards
Potassium Channel
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Metabolic Disease
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Glipizide (Standard) is the analytical standard of Glipizide. This product is intended for research and analytical applications. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans .
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- HY-P10341
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GCGR
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Metabolic Disease
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ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .
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- HY-N0502R
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Reactive Oxygen Species (ROS)
Reference Standards
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Metabolic Disease
Cancer
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Mogroside V (Standard) is the analytical standard of Mogroside V. This product is intended for research and analytical applications. Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .
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- HY-B0254S
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Isotope-Labeled Compounds
Potassium Channel
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Metabolic Disease
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Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024)?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium?(KATP) channels among β cells of pancreatic islets of Langerhans .
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- HY-174319
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Amylases
Glycosidase
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Metabolic Disease
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α-Amylase/α-Glucosidase-IN-20 (Compound 6b) is a dual inhibitor of α-Amylase and α-Glucosidase with IC50s of 414.57 and 924.15 μM for α-Amylase and α-Glucosidase, respectively. α-Amylase/α-Glucosidase-IN-20 shows a potent anti-diabetic activity, promising for diabetes research .
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- HY-N4103R
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Reference Standards
PARP
Endogenous Metabolite
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Metabolic Disease
Cancer
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Fucosterol (Standard) is the analytical standard of Fucosterol. This product is intended for research and analytical applications. Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .
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- HY-101292
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PPAR
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Metabolic Disease
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FK614 is an orally active, non-thiazolidinedione (TZD) type, and selective PPARγ modulator (SPPARM). FK614 functions as a PPARγ agonist with potent anti-diabetic activity in vivo. FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 can be used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes .
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- HY-N0692R
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Gomisin-A (Standard); TJN-101 (Standard); Wuweizi alcohol-B (Standard)
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Reference Standards
Reactive Oxygen Species (ROS)
Cytochrome P450
Autophagy
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Cancer
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Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
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- HY-N2393R
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- HY-N0828R
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Reference Standards
Autophagy
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Inflammation/Immunology
Cancer
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Pterostilbene (Standard) is the analytical standard of Pterostilbene. This product is intended for research and analytical applications. Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .
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- HY-N3841R
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epsilon-Viniferin (Standard)
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Reference Standards
Cytochrome P450
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
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ε-Viniferin (Standard) is the analytical standard of ε-Viniferin. This product is intended for research and analytical applications. ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity .
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- HY-N0367R
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(E)-Anethole (Standard)
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Reference Standards
Endogenous Metabolite
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Cardiovascular Disease
Metabolic Disease
Endocrinology
Cancer
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Trans-Anethole (Standard) is the analytical standard of Trans-Anethole. This product is intended for research and analytical applications. Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor .
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- HY-162578
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PPAR
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Metabolic Disease
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PPARα/γ agonist 4 (Compound (S)-7) is an orally active dual potent agonist of PPARα and PPARγ, with EC50 values of 0.061 μM and 1.42 μM respectively. PPARα/γ agonist 4 acts through an insulin-independent mechanism and exhibits mitochondrial pyruvate carrier inhibition and anti-diabetic properties. PPARα/γ agonist 4 is expected to be used in research for dyslipidemic type 2 diabetes .
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- HY-N2447R
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Reference Standards
AMPK
Apoptosis
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Metabolic Disease
Cancer
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Amarogentin (Standard) is the analytical standard of Amarogentin. This product is intended for research and analytical applications. Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .
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- HY-P3206
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Thymulin; Thymic factor
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ERK
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Neurological Disease
Inflammation/Immunology
Endocrinology
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Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .
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- HY-B0920R
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U-17835 (Standard)
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Reference Standards
Potassium Channel
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Metabolic Disease
Endocrinology
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Tolazamide (U-17835) (Standard) is the analytical standard of Tolazamide. This product is intended for research and analytical applications. Tolazamide is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC50 = 4.2 µM in HEK293 cells transfected with the human receptor). Tolazamide has anti-diabetic properties. Tolazamide can lower blood glucose in sulfonylurea class. Tolazamide decreases insulin dose while continuing to maintain adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA .
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- HY-161429
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Amylases
Glycosidase
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Metabolic Disease
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Antidiabetic agent 5 (compound S1) is a antidiabetic agent. Antidiabetic agent 5 inhibits the activity of α-glucosidase and α-amylase with IC50 values of 3.91，8.89 μM，respectively. Antidiabetic agent 5 decreases sugar levels. Antidiabetic agent 5 has the potential for the research of type-II diabetes .
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- HY-Y0790
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p-Isopropylbenzaldehyde
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α-synuclein
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Infection
Neurological Disease
Inflammation/Immunology
Cancer
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Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .
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- HY-B1890R
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rel-Cianidanol (Standard); rel-Catechuic acid (Standard)
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Reference Standards
COX
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Infection
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
Cancer
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(±)-Catechin (Standard) is the analytical standard of (±)-Catechin. This product is intended for research and analytical applications. (±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .
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- HY-170943
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AMPK
GLUT
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Metabolic Disease
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Antidiabetic agent 7 (Compound 5m) is hyperglycemic inhibitor. Antidiabetic agent 7 exhibits promising potency to stimulate GLUT4 translocation in skeletal muscle cells via activating AMPK-dependent pathway. Antidiabetic agent 7 reduces blood glucose levels. Antidiabetic agent 7 shows favorable pharmacokinetic properties. Antidiabetic agent 7 is potential to be used for anti-hyperglycemic research .
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- HY-N0755R
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Reference Standards
Insulin Receptor
GLUT
NF-κB
p38 MAPK
Autophagy
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Metabolic Disease
Endocrinology
Cancer
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Rhoifolin (Standard) is the analytical standard of Rhoifolin. This product is intended for research and analytical applications. Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .
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- HY-P3206A
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Thymulin acetate; Thymic factor acetate
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ERK
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Neurological Disease
Inflammation/Immunology
Endocrinology
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Serum thymic factor acetate (Thymulin acetate) is the acetate salt form of Serum thymic factor (HY-P3206). Serum thymic factor acetate is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor acetate stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor acetate protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor acetate exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor acetate can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .
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- HY-N7204
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Monoamine Oxidase
Dopamine β-hydroxylase
Apoptosis
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Neurological Disease
Inflammation/Immunology
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4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .
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- HY-16278R
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Acyltransferase
BCRP
OAT
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Infection
Metabolic Disease
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Pradigastat (Standard) is the analytical standard of Pradigastat. This product is intended for research and analytical applications. Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .
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- HY-N4226R
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Reference Standards
AP-1
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Inflammation/Immunology
Cancer
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1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Standard) is the analytical standard of 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid. This product is intended for research and analytical applications. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function[1].
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- HY-P11271
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- HY-P11237
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GCGR
Insulin Receptor
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Metabolic Disease
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Enicepatide is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Enicepatide can be studied in antidiabetic research .
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- HY-15516R
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SGLT
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Metabolic Disease
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Sotagliflozin (Standard) is the analytical standard of Sotagliflozin. This product is intended for research and analytical applications. Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.
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- HY-P11270
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BG128
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Insulin Receptor
GLP Receptor
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Metabolic Disease
|
|
Relsipatide (BG128) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Enicepatide can be studied in antidiabetic research .
|
-
- HY-17451R
-
|
|
Reference Standards
Potassium Channel
|
Metabolic Disease
|
|
Glibornuride (Standard) is the analytical standard of Glibornuride. This product is intended for research and analytical applications. Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75 . Antidiabetic agent .
|
-
- HY-110065
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
SER-601 is a potent and selective peripheral cannabinoid (CB2) receptor agonist with a Ki of 6.3 nM. SER-601 has analgesic and antidiabetic properties and can be used for relevant research .
|
-
- HY-Y0790R
-
|
p-Isopropylbenzaldehyde (Standard)
|
α-synuclein
Reference Standards
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Cuminaldehyde Standard is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL) and α-glucosidase (IC50=0.5 mg/mL). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .
|
-
- HY-N0073R
-
-
- HY-P1482R
-
|
Mating Factor α (Standard)
|
Sex Pheromone
Reference Standards
|
Endocrinology
|
|
Sarsasapogenin (Standard) is the analytical standard of Sarsasapogenin. This product is intended for research and analytical applications. Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.
|
-
- HY-W041324R
-
|
|
Drug Intermediate
Reference Standards
|
Infection
|
|
Glimepiride sulfonamide (Standard) is the analytical standard of Glimepiride sulfonamide. This product is intended for research and analytical applications. Glimepiride sulfonamide is a intermediate, and can be used to synthesize Glimepiride (HY-B0104) (antidiabetic agent) .
|
-
- HY-15097R
-
|
Cannabiscetin (Standard)
|
Reference Standards
Apoptosis
Autophagy
Endogenous Metabolite
|
Cancer
|
|
Myricetin (Standard) is the analytical standard of Myricetin. This product is intended for research and analytical applications. Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.
|
-
- HY-N12354
-
|
|
Phosphatase
|
Metabolic Disease
|
|
Stevisaliosides D (Compound 5) can be isolated from Stevia serrata roots. Stevisaliosides D inhibits PTP1B (IC50: 31.8 μM). Stevisalioside D can be used for antidiabetic research .
|
-
- HY-B0401A
-
|
|
Apoptosis
|
Metabolic Disease
Cancer
|
|
Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca 2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus .
|
-
- HY-B0753R
-
|
S1702 (Standard); SE1702 (Standard)
|
Reference Standards
Potassium Channel
|
Cardiovascular Disease
|
|
Gliclazide (Standard) is the analytical standard of Gliclazide. This product is intended for research and analytical applications. Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Gliclazide is used as an antidiabetic .
|
-
- HY-N2189R
-
|
|
Reference Standards
Adenosine Receptor
|
Metabolic Disease
Inflammation/Immunology
|
|
Swertisin (Standard) is the analytical standard of Swertisin. This product is intended for research and analytical applications. Swertisin, a C-glucosylflavone isolated from Iris tectorum, is known to have antidiabetic, anti-inflammatory and antioxidant effects. Swertisin is an adenosine A1 receptor antagonist .
|
-
- HY-B1416A
-
-
- HY-N6858R
-
|
4-Hydroxy-L-isoleucine (Standard)
|
Reference Standards
Others
|
Metabolic Disease
|
|
4-Hydroxyisoleucine (Standard) is the analytical standard of 4-Hydroxyisoleucine. This product is intended for research and analytical applications. 4-Hydroxyisoleucine is an orally active amino acid that can be isolated from fenugreek seeds. 4-Hydroxyisoleucine displays insulinotropic and antidiabetic properties .
|
-
- HY-N0535R
-
|
Magnoflorine chloride (Standard); α-Magnoflorine chloride (Standard); Thalictrine chloride (Standard)
|
Reference Standards
Fungal
|
Infection
Metabolic Disease
|
|
(+)-Magnoflorine (chloride) (Standard) is the analytical standard of (+)-Magnoflorine (chloride). This product is intended for research and analytical applications. Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm . Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity .
|
-
- HY-B1416AR
-
|
|
Adrenergic Receptor
Imidazoline Receptor
|
Cardiovascular Disease
Metabolic Disease
|
|
Efaroxan (hydrochloride) (Standard) is the analytical standard of Efaroxan (hydrochloride). This product is intended for research and analytical applications. Efaroxan hydrochloride is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease .
|
-
- HY-N6945R
-
|
|
Reference Standards
Others
|
Metabolic Disease
Cancer
|
|
Mogroside IV (Standard) is the analytical standard of Mogroside IV. This product is intended for research and analytical applications. Mogroside IV, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .
|
-
- HY-15449
-
-
- HY-N0290R
-
|
|
Reference Standards
NF-κB
Keap1-Nrf2
Apoptosis
|
Cancer
|
|
Mangiferin (Standard) is the analytical standard of Mangiferin. This product is intended for research and analytical applications. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .
|
-
- HY-12611
-
|
GW-869682X
|
SGLT
|
Metabolic Disease
|
|
Sergliflozin etabonate (GW-869682X) is a potent and orally active sodium glucose cotransporter (SGLT2) inhibitor. Sergliflozin etabonate shows antidiabetic and antihyperglycemic effects. Sergliflozin etabonate significantly reduces non-fasting blood glucose levels in diabetic mice. Sergliflozin etabonate has the potential for the research of diabetes .
|
-
- HY-149676
-
|
|
Glycosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-42 (Compound 26) is a 9-O-berberrubine carboxylate derivative. α-Glucosidase-IN-42 has potent α-glucosidase inhibitory activities with an IC50 value in the range of 1.61 μM. α-Glucosidase-IN-42 can be used for the research of antidiabetic .
|
-
- HY-N5018R
-
|
Musizin (Standard)
|
Reference Standards
Parasite
AMPK
|
Infection
|
|
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.
|
-
- HY-W012634R
-
|
|
Reference Standards
Bacterial
|
Infection
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent .
|
-
- HY-N0036R
-
|
(+)-Costunolide (Standard); Costus lactone (Standard)
|
Reference Standards
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Costunolide (Standard) is the analytical standard of Costunolide. This product is intended for research and analytical applications. Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .
|
-
- HY-42680
-
|
D-(-)-Tagatose
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .
|
-
- HY-42680R
-
|
D-(-)-Tagatose (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Tagatose (Standard) is the analytical standard of D-Tagatose. This product is intended for research and analytical applications. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .
|
-
- HY-119322R
-
|
|
Potassium Channel
|
Metabolic Disease
|
|
Tifenazoxide (Standard) is the analytical standard of Tifenazoxide. This product is intended for research and analytical applications. Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial effect on glucose homeostasis .
|
-
- HY-B2099AR
-
|
|
AMPK
|
Cancer
|
|
Buformin (hydrochloride) (Standard) is the analytical standard of Buformin (hydrochloride). This product is intended for research and analytical applications. Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .
|
-
- HY-14894R
-
|
ASP1941 (Standard)
|
Reference Standards
SGLT
|
Metabolic Disease
|
|
Ipragliflozin (Standard) is the analytical standard of Ipragliflozin. This product is intended for research and analytical applications. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
|
-
- HY-16397R
-
|
|
Mitochondrial Metabolism
AMPK
Apoptosis
|
Metabolic Disease
Cancer
|
|
Phenformin (Standard) is the analytical standard of Phenformin. This product is intended for research and analytical applications. Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis .
|
-
- HY-Y1624
-
|
ADDP; SR 4077
|
Free Fatty Acid Receptor
PPAR
|
Metabolic Disease
|
|
1,1'-(Azodicarbonyl)-dipiperidine (ADDP) can be used in the condensation reaction of alcohols with acidic compounds. 1,1'-(Azodicarbonyl)-dipiperidine can also be used in the synthesis of GPR120 agonists with antidiabetic activity, as well as the synthesis of triple agonists for PPARα, PPARγ, and PPARδ. 1,1'-(Azodicarbonyl)-dipiperidine can be used in metabolic disease research .
|
-
- HY-160602
-
|
|
Free Fatty Acid Receptor
|
Metabolic Disease
|
|
CPL207280 is an orally active GPR40/FFA1 agonist with an antidiabetic effect. CPL207280 can effectively enhance glucose-stimulated insulin secretion and improve glucose tolerance in MIN6 pancreatic β-cells as well as in healthy Wistar Han rats and diabetic rat models. CPL207280 can be used for the research of type 2 diabetes .
|
-
- HY-N1510R
-
|
|
Reference Standards
Glycosidase
|
Metabolic Disease
|
|
Kaempferol 3-O-gentiobioside (Standard) is the analytical standard of Kaempferol 3-O-gentiobioside. This product is intended for research and analytical applications. Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. Kaempferol 3-O-gentiobioside possesses activity against α-glucosidase and displays carbohydrate enzyme inhibitory effect with an IC50 of 50.0 μM .
|
-
- HY-125911R
-
-
- HY-168594
-
|
|
Glycosidase
NOD-like Receptor (NLR)
|
Neurological Disease
Metabolic Disease
|
|
α-Glucosidase/NLRP3-IN-1 (Compound 8) is a dual inhibitor of α-glucosidase and NLRP3, exhibiting an IC50 of 6.6 μM against α-glucosidase and inhibiting NLRP3 in multiple cell lines at a concentration of 100 μM. α-Glucosidase/NLRP3-IN-1 demonstrates neuroprotective and antidiabetic properties, and can be utilized in relevant research .
|
-
- HY-14621R
-
|
Vanillylacetone (Standard); Gingerone (Standard)
|
Reference Standards
NF-κB
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Zingerone (Standard) is the analytical standard of Zingerone. This product is intended for research and analytical applications. Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells .
|
-
- HY-N11844
-
|
|
Amylases
|
Metabolic Disease
|
|
Quercetin 3-(6″-caffeoylsophoroside) is an orally active α-amylase inhibitor, with an IC50 of 73.66 μg/mL. Quercetin 3-(6″-caffeoylsophoroside) presents in thehydro-methanolic extract of Cardamine hirsuta Linn. Quercetin 3-(6″-caffeoylsophoroside) shows the antidiabetic activities by oxidative stress reduction and α-amylase inhibition. Quercetin 3-(6″-caffeoylsophoroside) can be used for diabetes mellitus research .
|
-
- HY-N0414R
-
|
Trigenolline (Standard)
|
Endogenous Metabolite
Ferroptosis
Apoptosis
HIV
Bacterial
Fungal
Reference Standards
|
Metabolic Disease
Cancer
|
|
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.
|
-
- HY-N0415R
-
|
Trigonelline hydrochloride (Standard)
|
Endogenous Metabolite
Ferroptosis
Apoptosis
HIV
Bacterial
Fungal
Reference Standards
|
Infection
Metabolic Disease
Cancer
|
|
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.
|
-
- HY-N0148AR
-
|
|
Amyloid-β
Autophagy
Apoptosis
Endogenous Metabolite
|
Neurological Disease
Cancer
|
|
Rutin (hydrate) (Standard) is the analytical standard of Rutin (hydrate). This product is intended for research and analytical applications. Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .
|
-
- HY-N0188R
-
|
|
Reference Standards
p38 MAPK
|
Inflammation/Immunology
Cancer
|
|
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .
|
-
- HY-171793
-
|
|
PPAR
|
Metabolic Disease
|
|
DN-108, a thiazolidinedione derivative, is an orally active peroxisome proliferator-activated receptor γ (PPARγ) agonist with antidiabetic effects. DN-108 improves hyperglycemia, hypertriglyceridemia and hyperinsulinemia in diabetic mouse models. DN-108 enhances tissue glucose uptake (e.g., increasing 2-deoxyglucose uptake in L6 muscle cells) and inhibits fatty acid synthase activity. DN-108 is promising for research of type 2 diabetes .
|
-
- HY-N9251R
-
|
|
Reference Standards
Others
|
Others
|
|
Isoferulic acid (Standard) is the analytical standard of Isoferulic acid. This product is intended for research and analytical applications. Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. Isoferulic acid also has anti-influenza virus activities.
|
-
- HY-100277R
-
|
SR-202 (Standard)
|
Reference Standards
PPAR
|
Metabolic Disease
|
|
Mifobate (Standard) is the analytical standard of Mifobate. This product is intended for research and analytical applications. Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects .
|
-
- HY-N2575R
-
|
|
Reference Standards
PKC
Bacterial
Parasite
HIV
VSV
VEGFR
Bcl-2 Family
Apoptosis
|
Infection
Metabolic Disease
Cancer
|
|
Hypocrellin A (Standard) is the analytical standard of Hypocrellin A. This product is intended for research and analytical applications. Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC50=0.27 μg/ml)[1][2][3][4][5][6][7][8][9].
|
-
- HY-N0148R
-
|
Rutoside (Standard); Quercetin 3-O-rutinoside (Standard)
|
Reference Standards
Amyloid-β
Autophagy
Apoptosis
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .
|
-
- HY-N0457R
-
|
Cichoric acid (Standard); Dicaffeoyltartaric acid (Standard)
|
Reference Standards
Reactive Oxygen Species (ROS)
Apoptosis
|
Metabolic Disease
Inflammation/Immunology
|
|
Chicoric acid (Standard) is the analytical standard of Chicoric acid. This product is intended for research and analytical applications. Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects .
|
-
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10959
-
-
- HY-P10341
-
|
|
GCGR
|
Metabolic Disease
|
|
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .
|
-
- HY-P3206
-
|
Thymulin; Thymic factor
|
ERK
|
Neurological Disease
Inflammation/Immunology
Endocrinology
|
|
Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .
|
-
- HY-P3206A
-
|
Thymulin acetate; Thymic factor acetate
|
ERK
|
Neurological Disease
Inflammation/Immunology
Endocrinology
|
|
Serum thymic factor acetate (Thymulin acetate) is the acetate salt form of Serum thymic factor (HY-P3206). Serum thymic factor acetate is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor acetate stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor acetate protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor acetate exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor acetate can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .
|
-
- HY-P10959A
-
-
- HY-P11233
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Acmopatide (Compound E-153) is a dual-acting GIP/GLP-1 receptor agonist. Acmopatide is used in anti-diabetic research .
|
-
- HY-P10952
-
-
- HY-101399R
-
|
γ-Glutamylphenylalanine (Standard)
|
Reference Standards
Endogenous Metabolite
|
Others
|
|
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .
|
-
- HY-P11271
-
-
- HY-P11237
-
|
|
GCGR
Insulin Receptor
|
Metabolic Disease
|
|
Enicepatide is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Enicepatide can be studied in antidiabetic research .
|
-
- HY-P11270
-
|
BG128
|
Insulin Receptor
GLP Receptor
|
Metabolic Disease
|
|
Relsipatide (BG128) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Enicepatide can be studied in antidiabetic research .
|
-
- HY-P1482R
-
|
Mating Factor α (Standard)
|
Sex Pheromone
Reference Standards
|
Endocrinology
|
|
Sarsasapogenin (Standard) is the analytical standard of Sarsasapogenin. This product is intended for research and analytical applications. Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N13759
-
-
-
- HY-N0009R
-
-
-
- HY-N15585
-
-
-
- HY-N13144
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- HY-N8438R
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- HY-N0184R
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- HY-N0628R
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- HY-N2555R
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- HY-N2302R
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- HY-101399R
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- HY-N1425R
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- HY-N6948R
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- HY-W013075R
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- HY-N2534
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- HY-N0502
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- HY-100618R
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- HY-N2486R
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- HY-N6257R
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- HY-120912R
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- HY-N2534R
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- HY-N4103
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- HY-N1504R
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- HY-N0393R
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Infection
Structural Classification
Flavonoids
Classification of Application Fields
Leguminosae
Source classification
Phenols
Plants
Glycyrrhiza uralensis Fisch.
Inflammation/Immunology
Disease Research Fields
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Reference Standards
PPAR
Reactive Oxygen Species (ROS)
Bacterial
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Glabridin (Standard) is the analytical standard of Glabridin. This product is intended for research and analytical applications. Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
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- HY-N0502R
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- HY-N4103R
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- HY-N0692R
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- HY-N2393R
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- HY-N0828R
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Structural Classification
Monophenols
other families
Stilbenes
Source classification
Phenols
Plants
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Reference Standards
Autophagy
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Pterostilbene (Standard) is the analytical standard of Pterostilbene. This product is intended for research and analytical applications. Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .
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- HY-N3841R
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- HY-N0367R
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- HY-N2447R
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- HY-Y0790
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p-Isopropylbenzaldehyde
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Structural Classification
Classification of Application Fields
Ketones, Aldehydes, Acids
Rudbeckia laciniata L.
Source classification
Umbelliferae
Plants
Endogenous metabolite
Disease Research Fields
Cancer
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α-synuclein
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Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL), α-glucosidase (IC50=0.5 mg/mL) and lipoxygenase (IC50=1370 μM). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .
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- HY-B1890R
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rel-Cianidanol (Standard); rel-Catechuic acid (Standard)
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Structural Classification
Source classification
Phenols
Polyphenols
Camellia sinensis (L.) O. Ktze.
Plants
Theaceae
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Reference Standards
COX
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(±)-Catechin (Standard) is the analytical standard of (±)-Catechin. This product is intended for research and analytical applications. (±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .
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- HY-N0755R
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Structural Classification
Rhus succedanea
Flavonoids
Flavones
Plants
Anacardiaceae
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Reference Standards
Insulin Receptor
GLUT
NF-κB
p38 MAPK
Autophagy
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Rhoifolin (Standard) is the analytical standard of Rhoifolin. This product is intended for research and analytical applications. Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .
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- HY-N7204
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Structural Classification
Chalcones
Monophenols
Flavonoids
Phenols
Umbelliferae
Plants
Ondetia linearis Benth.
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Monoamine Oxidase
Dopamine β-hydroxylase
Apoptosis
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4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .
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- HY-N4226R
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Structural Classification
Microorganisms
other families
Ketones, Aldehydes, Acids
Source classification
Plants
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Reference Standards
AP-1
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1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Standard) is the analytical standard of 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid. This product is intended for research and analytical applications. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function[1].
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- HY-Y0790R
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p-Isopropylbenzaldehyde (Standard)
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Structural Classification
Ketones, Aldehydes, Acids
Rudbeckia laciniata L.
Source classification
Umbelliferae
Plants
Endogenous metabolite
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α-synuclein
Reference Standards
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Cuminaldehyde Standard is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL) and α-glucosidase (IC50=0.5 mg/mL). Cuminaldehyde also inhibits the fibrillation of α-synuclein and prevents its aggregation Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .
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- HY-N0073R
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- HY-P1482R
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- HY-15097R
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- HY-N12354
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- HY-N2189R
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- HY-N6858R
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- HY-N0535R
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- HY-N6945R
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- HY-15449
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- HY-N0290R
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- HY-N5018R
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- HY-W012634R
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Microorganisms
Source classification
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Reference Standards
Bacterial
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Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent .
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- HY-N0036R
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- HY-42680
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- HY-42680R
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D-(-)-Tagatose (Standard)
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Structural Classification
Microorganisms
Source classification
Endogenous metabolite
Saccharides
Monosaccharides
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Reference Standards
Endogenous Metabolite
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D-Tagatose (Standard) is the analytical standard of D-Tagatose. This product is intended for research and analytical applications. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .
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- HY-N1510R
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- HY-125911R
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- HY-14621R
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- HY-N11844
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- HY-N0414R
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- HY-N0415R
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- HY-N0148AR
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Flavonols
Structural Classification
Flavonoids
other families
Source classification
Phenols
Polyphenols
Plants
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Amyloid-β
Autophagy
Apoptosis
Endogenous Metabolite
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Rutin (hydrate) (Standard) is the analytical standard of Rutin (hydrate). This product is intended for research and analytical applications. Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .
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- HY-N0188R
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Structural Classification
Monophenols
other families
Source classification
Coumarins
Phenols
Phenylpropanoids
Plants
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Reference Standards
p38 MAPK
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Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .
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- HY-N9251R
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- HY-N2575R
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- HY-N0148R
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- HY-N0457R
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-B0254S
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Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024)?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium?(KATP) channels among β cells of pancreatic islets of Langerhans .
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| Cat. No. |
Product Name |
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Classification |
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- HY-N4103
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Cholesterol
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Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .
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