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NCP2 Anchor can be used in the synthesis of exon jumping oligomer conjugates. The oligomer conjugates complement selected target sites in the human anti-muscular atrophy protein gene and induce exon 52 jumping. It can be used for research of muscular dystrophy .
Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) .
Amustaline (dihydrochloride) (Standard) is the analytical standard of Amustaline (dihydrochloride). This product is intended for research and analytical applications. Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) .
iHAC is an inhibitor HSP90-anchoring chimera, that covalently binds BRD4 ligand (+)-JQ-1 to HSP90, and inhibits the proliferation of cancer cells. iHAC activates the anti-tumor immune response, inhibits the recurrence and metastasis of 4T1 breast cancer in mouse models .
5-InoAz is an inositol analogue used as a metabolic probe for labeling the mycobacterial cell envelope. 5-InoAz integrates into cell envelope glycolipids [phosphatidylinositol mannoside (PIM), PIM-anchored lipomannan (LM), and lipoarabinomannan (LAM)] .
PKA/AKAP-IN-2 (15109) is a non-peptide inhibitor of the interaction between protein kinase A (PKA) and A kinase anchoring proteins (AKAP). PKA/AKAP-IN-2 can be utilized in research related to cAMP disturbance associated diseases .
Cholesterol-PEG2000-Biotin is a biotinylated and PEGylated form of cholesterol. Cholesterol-PEG2000-Biotin can be used as a lipid anchor to increase the density of phycoerythrin-conjugated streptavidin on the surface of mesenchymal stem cells .
PKA/AKAP-IN-1 (compound 15126) is a non-peptide inhibitor of the interaction between protein kinase A (PKA) and A kinase anchoring proteins (AKAP). PKA/AKAP-IN-1 can be utilized in research related to cAMP disturbance associated diseases .
Carbonic anhydrase inhibitor 13 (compound 7) is a potent carbonic anhydrase (CA) inhibitor, which features 3-methylthiazolo[3,2-a]benzimidazole moiety (as a tail) connected to the zinc anchoring benzenesulfonamide moiety via ureido linker .
Vanin-1-IN-2 is a potent vanin-1 inhibitor with an IC50 of 162 nM. Vanin-1 is a cell-surface-associated, glycosylphosphatidyl inositol (GPI)-anchored protein which is expressed at high levels in the kidney, liver, and small intestine .
Adamantane is a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be studied in pharmacological research to improve the lipophilicity and pharmacological properties of other active products .
Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium .
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .
G-6599 is a SMARCA2/A4 target-anchored monovalent degrader with DC50 values of 0.018 nM and 0.056 nM, respectively. G-6599 has degradation activity and anti-proliferative effects in AR-dependent prostate cancer cell lines .
Adamantane (Standard) is the analytical standard of Adamantane. This product is intended for research and analytical applications. Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
st-Ht31 ammonium is a membrane-permeable peptide inhibitor of?protein kinase A (PKA) anchoring. st-Ht31 ammonium induces robust cholesterol/phospholipid efflux. st-Ht31 ammonium completely reverses foam cell formation and restores the metabolic health of macrophage .
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .
C24:1 GD2 Ceramide (d18:1/24:1) is a sphingoid base linked to a fatty acid. C24:1 GD2 Ceramide (d18:1/24:1) interacts with other membrane lipids and allows GD2 to be tightly anchored to the cell surface .
Biotin-PEG-maleimide (MW 2000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 2000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
1-(2-Pyridylazo)-2-naphthol (1-Pyridylazo-2-naphthol) is an azo compound. 1-(2-Pyridylazo)-2-naphthol can be used as a chelating precipitant, flocculant, auxiliary complexing agent, and as a ligand for anchoring on other supports with the purpose of introducing
chelating property .
Biotin-PEG-maleimide (MW 3400) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 3400) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Adamantane-d16is the deuterium labeled Adamantane (HY-N2427). Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
Biotin-PEG-maleimide (MW 5000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 5000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research .
Biotin-PEG-maleimide (MW 1000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 1000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Mem-C1C18 is a polarity-sensitive fluorescent probe with excellent plasma membrane anchoring, high brightness and a sensitive response to environmental polarity by altering the fluorescence lifetime. Mem-C1C18 can be used to quantify changes in the polarity of the plasma membrane during iron death .
Phosphatidylethanolamine is an orally active phospholipid widely present in organisms. Phosphatidylethanolamine participates in the formation of autophagosome membrane as a lipid anchor of autophagy-related protein Atg8/LC3. Phosphatidylethanolamine enhances Autophagic flux, promotes cell differentiation, regulates lipid droplet fusion, delays aging, and also affects lipid metabolism and membrane integrity .
FMP-API-1 is an A-kinase anchoring protein (AKAP)-PKA interaction inhibitor. FMP-API-1 binds to the allosteric site of PKA R subunits and increases the activity of PKA and AQP2 in PKA-knockout cell lines of renal cortical collecting ducts (mpkCCD cells). FMP-API-1 has the potential for the study of nephrogenic diabetes insipidus (NDI) .
(2S)-2-Pyrrolidinemethanol ((S)-(+)-Prolinol; (S)-(+)-Pyrrolidin-2-ylmethanol; (S)-1-(Pyrrolidin-2-yl)methanol) reveals binucleophilic character and can be anchored to phthalonitrile derivative from both nitrogen and oxygen atoms. (2S)-2-Pyrrolidinemethanol can be utilized as chiral catalyst .
Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research .
Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections .
Tamrintamab (SC-003 mAb, SC-Mab003, SC34.28ss1) is an ADC Antibody targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab can be used in ovarian cancer research .
HIV gp120 (318-327) is a short sequence of the HIV-1 strain IIIB envelope peptide (rgpgrafvti) that corresponds to the conserved C-terminal region of the glycoprotein. HIV gp120 (318-327) is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIV gp120 (318-327) lacks the A2 anchor residues recognized by epitope-specific CTLs but has structural features that confer promiscuous A2 binding .
Pyrazole-3-carboxylic acid is an alternative anchoring group to carboxylic acid in phthalocyanine dyes. Pyrazole-3-carboxylic acid shows flexible coordination modes when coordinates with metal ions. Pyrazole-3-carboxylic acid can chelate to metal ions and form very stable complexes through its N and O atoms. Pyrazole-3-carboxylic acid can be used to synthesize derivatives that possess antibacterial, anti-inflammatory, ulcerogenic liability and antiproliferative activities .
RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer .
Naphthol AS-MX phosphate (NASTRp) is a small molecule inhibitor of the CREB (cyclic adenosine phosphate reaction element binding protein)-CBP (CREB binding protein) transcription factor complex. Naphthol AS-MX phosphate shows antitumor activity against lung cancer cells, inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchored independent growth in soft AGAR. Naphthol AS-MX phosphate can be used in the study of KRAS mutated lung cancer, especially for KRAS mutated lung cancer with poor chemotherapy resistance and prognosis .
K22 is an inhibitor of coronavirus RNA synthesis that specifically targets membrane-associated coronavirus RNA synthesis. K22 effectively blocks replication of multiple coronaviruses by inhibiting the critical step of viral replication complex anchoring to host cell membranes to form double-membrane vesicles (DMVs). K22 exhibits broad-spectrum antiviral activity against diverse coronaviruses, including Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Feline Coronavirus (FCoV), Mouse Hepatitis Virus (MHV), and Avian Infectious Bronchitis Virus (IBV) .
(2S)-2-Pyrrolidinemethanol (Standard) is the analytical standard of (2S)-2-Pyrrolidinemethanol. This product is intended for research and analytical applications. (2S)-2-Pyrrolidinemethanol ((S)-(+)-Prolinol; (S)-(+)-Pyrrolidin-2-ylmethanol; (S)-1-(Pyrrolidin-2-yl)methanol) reveals binucleophilic character and can be anchored to phthalonitrile derivative from both nitrogen and oxygen atoms. (2S)-2-Pyrrolidinemethanol can be utilized as chiral catalyst .
PFI-653 (Vanin-1-IN-1, compound 3) is a vanin-1 inhibitor that binds to plasma vanin-1 from mouse, rat, dog, and human. Vanin-1 is a cell surface-associated inositol (GPi) -anchored protein that plays important roles in metabolism and inflammation. PFI-653 inhibits vanin-1 from different species with IC50s of 6.85 nM (human recombinant plasma vanin-1), 9.0 nM (human plasma vanin-1), 24.5 nM (mouse recombinant vanin-1), and 53.4 nM (mouse plasma vanin-1) .
MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells .
5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems .
Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting) .
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .
1-(2-Pyridylazo)-2-naphthol (1-Pyridylazo-2-naphthol) is an azo compound. 1-(2-Pyridylazo)-2-naphthol can be used as a chelating precipitant, flocculant, auxiliary complexing agent, and as a ligand for anchoring on other supports with the purpose of introducing
chelating property .
Phosphatidylethanolamine is an orally active phospholipid widely present in organisms. Phosphatidylethanolamine participates in the formation of autophagosome membrane as a lipid anchor of autophagy-related protein Atg8/LC3. Phosphatidylethanolamine enhances Autophagic flux, promotes cell differentiation, regulates lipid droplet fusion, delays aging, and also affects lipid metabolism and membrane integrity .
(2S)-2-Pyrrolidinemethanol ((S)-(+)-Prolinol; (S)-(+)-Pyrrolidin-2-ylmethanol; (S)-1-(Pyrrolidin-2-yl)methanol) reveals binucleophilic character and can be anchored to phthalonitrile derivative from both nitrogen and oxygen atoms. (2S)-2-Pyrrolidinemethanol can be utilized as chiral catalyst .
Pyrazole-3-carboxylic acid is an alternative anchoring group to carboxylic acid in phthalocyanine dyes. Pyrazole-3-carboxylic acid shows flexible coordination modes when coordinates with metal ions. Pyrazole-3-carboxylic acid can chelate to metal ions and form very stable complexes through its N and O atoms. Pyrazole-3-carboxylic acid can be used to synthesize derivatives that possess antibacterial, anti-inflammatory, ulcerogenic liability and antiproliferative activities .
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biotin-PEG-maleimide (MW 2000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 2000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Biotin-PEG-maleimide (MW 3400) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 3400) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Biotin-PEG-maleimide (MW 5000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 5000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
Biotin-PEG-maleimide (MW 1000) is a PEG derivative consisting of a linear PEG chain with biotin attached to one end and maleimide modified to the other end. Biotin-PEG-maleimide (MW 1000) anchors drugs or targeting ligands to liposomes or polymer nanocarriers through the maleimide end, and the biotin end is used for in vitro purification or in vivo targeted release .
(2S)-2-Pyrrolidinemethanol (Standard) is the analytical standard of (2S)-2-Pyrrolidinemethanol. This product is intended for research and analytical applications. (2S)-2-Pyrrolidinemethanol ((S)-(+)-Prolinol; (S)-(+)-Pyrrolidin-2-ylmethanol; (S)-1-(Pyrrolidin-2-yl)methanol) reveals binucleophilic character and can be anchored to phthalonitrile derivative from both nitrogen and oxygen atoms. (2S)-2-Pyrrolidinemethanol can be utilized as chiral catalyst .
Acetyl tetrapeptide-3 is a synthetic peptide. Acetyl tetrapeptide-3 enhances the adhesion of hair follicles to the scalp but also promotes the development of new hair follicles. Acetyl tetrapeptide-3 stimulates the synthesis of collagen III in hair follicles. Acetyl tetrapeptide-3 combined with Biochanin A (HY-14595) and ginseng extracts, can stimulate dermal papilla extracellular matrix (ECM) proteins by increasing hydroxyproline, Collagen Type 3, and laminin, yielding a significant improvement in hair follicle size and hair anchoring .
st-Ht31 ammonium is a membrane-permeable peptide inhibitor of?protein kinase A (PKA) anchoring. st-Ht31 ammonium induces robust cholesterol/phospholipid efflux. st-Ht31 ammonium completely reverses foam cell formation and restores the metabolic health of macrophage .
Dby HY Peptide (608-622), mouse is a biological active peptide. (Dby HY Peptide, NAGFNSNRANSSRSS, is a HYAb epitope belonging to a well-conserved family of genes coding for known or putative RNA helicases and containing a core sequence with a DEAD (Asp-Glu-Ala-Asp) box peptide motif, hence the name Dby (Dead box RNA helicase Y). The single Phenylalanine in the sequence serves as the anchor point while FNSNRANSS most likely is the “core” sequence of this HYAb epitope.)
DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)
RWmix is a synthetic cell-penetrating peptide. The secondary amphiphilic nature of RWmix promotes cellular uptake, mainly due to the alternating arrangement of arginine and tryptophan. The presence of tryptophan enhances the anchoring of the peptide to the cell membrane, thereby improving its ability to penetrate the cell membrane. RWmix can be used for gene therapy and siRNA delivery research .
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .
HIV gp120 (318-327) is a short sequence of the HIV-1 strain IIIB envelope peptide (rgpgrafvti) that corresponds to the conserved C-terminal region of the glycoprotein. HIV gp120 (318-327) is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIV gp120 (318-327) lacks the A2 anchor residues recognized by epitope-specific CTLs but has structural features that confer promiscuous A2 binding .
RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer .
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium .
Tamrintamab (SC-003 mAb, SC-Mab003, SC34.28ss1) is an ADC Antibody targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab can be used in ovarian cancer research .
Adamantane is a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be studied in pharmacological research to improve the lipophilicity and pharmacological properties of other active products .
Adamantane (Standard) is the analytical standard of Adamantane. This product is intended for research and analytical applications. Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
C24:1 GD2 Ceramide (d18:1/24:1) is a sphingoid base linked to a fatty acid. C24:1 GD2 Ceramide (d18:1/24:1) interacts with other membrane lipids and allows GD2 to be tightly anchored to the cell surface .
CUTA protein is a trimeric membrane anchor protein of AChE and a homolog of the bacterial divalent cation chelator CutA1 protein. CUTA protein also interacts with BACE1 and inhibits APP beta processing and Aβ production. CutA Protein, Human (His) is the recombinant human-derived CutA protein, expressed by E. coli , with C-6*His labeled tag.
The MDGA2 protein is involved in cell-cell interactions, suggesting a role in important connections between cells. Its interaction with NLGN2 is facilitated by its Ig-like domain, specifically involving the formation of molecular associations with NLGN2 that may affect cell communication or adhesion. MDGA2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MDGA2 protein, expressed by HEK293 , with C-His labeled tag.
Genome polyprotein is a smaller protein chain of covalent linkages that is a key component of virus survival and replication.Zika virus E/Envelope Protein (HEK293, Fc) is the recombinant Virus-derived Zika virus E/Envelope protein, expressed by HEK293 , with C-hFc labeled tag.
Adamantane-d16is the deuterium labeled Adamantane (HY-N2427). Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
A-kinase anchor protein 14; A-kinase anchor protein 14; A-kinase anchor protein 28 kDa; AKAP14; AKAP28
WB, ICC/IF, IP
Human, Mouse, Rat
AKAP14 Antibody (YA3078) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3078), targeting AKAP14, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). AKAP14 Antibody (YA3078) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
AKAP8; AKAP95; A-kinase anchor protein 8; AKAP-8; A-kinase anchor protein 95 kDa; AKAP 95
WB, IHC-F, IHC-P, ICC/IF
Human, Mouse, Rat
AKAP95 Antibody (YA2696) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2696), targeting AKAP95, with a predicted molecular weight of 76 kDa (observed band size: 95 kDa). AKAP95 Antibody (YA2696) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum . Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Phosphatidylethanolamine is an orally active phospholipid widely present in organisms. Phosphatidylethanolamine participates in the formation of autophagosome membrane as a lipid anchor of autophagy-related protein Atg8/LC3. Phosphatidylethanolamine enhances Autophagic flux, promotes cell differentiation, regulates lipid droplet fusion, delays aging, and also affects lipid metabolism and membrane integrity .
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