1. Search Result
Search Result
Results for "

adduct

" in MedChemExpress (MCE) Product Catalog:

121

Inhibitors & Agonists

1

Screening Libraries

5

Fluorescent Dye

14

Biochemical Assay Reagents

2

Peptides

20

Natural
Products

12

Isotope-Labeled Compounds

3

Click Chemistry

12

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-21623

    Biochemical Assay Reagents Others
    Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a catalyst. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct stabilizes intermediates and reduces activation energy in coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can be used in Suzuki-Miyaura coupling reactions .
    Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct
  • HY-W273413

    NBD-H

    Fluorescent Dye Cancer
    4-Hydrazino-7-nitro-benzofurazan hydrazine adduct is a fluorescent reagent for protein labeling.
    4-Hydrazino-7-nitro-benzofurazan hydrazine adduct
  • HY-139093A

    Drug Derivative Others
    Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005) .
    Paracetamol-cysteine TFA
  • HY-137064

    iGluR Neurological Disease
    Memantine lactose adduct is a lactose adduct of Memantine (HY-B0591) and an intermediate in the synthesis of adamantane amine antibiotics .
    Memantine lactose adduct
  • HY-157173

    Biochemical Assay Reagents Inflammation/Immunology
    Mannosamine–biotin adduct is a hapten. Mannosamine–biotin adduct conjugated to hsIgG significantly reduces antibody immune responses against hsIgG .
    Mannosamine-biotin adduct
  • HY-157175

    Biochemical Assay Reagents Others
    Mannosamine-lipoic acid adduct is a hapten. Mannosamine-lipoic acid adduct with hsIgG conjugation significantly reduces the antibody immune response against hsIgG .
    Mannosamine–lipoic acid adduct
  • HY-157174

    Others Inflammation/Immunology
    Mannosamine-desthiobiotin adduct (compound MDTBA) is a carrier immunogenicity-reducing hapten that reduces the immunogenicity of protein carriers upon conjugation to available free amines on the carrier protein surface. Conjugation of Mannosamine-desthiobiotin adduct to hsIgG significantly (>1-fold) reduced the immunogenicity of hsIgG. Mannosamine-desthiobiotin adduct can be used in antigen design research .
    Mannosamine–desthiobiotin adduct
  • HY-163036

    Biochemical Assay Reagents Inflammation/Immunology
    Glucosamine-biotin adduct is a hapten and can be conjugated to hsIgG .
    Glucosamine–biotin adduct
  • HY-167538

    Biochemical Assay Reagents Others
    sn-Glycero-3-phosphocholine 1:1 cadmium chloride adduct is a biochemical reagent.
    sn-Glycero-3-phosphocholine 1:1 cadmium chloride adduct
  • HY-W582827

    Biochemical Assay Reagents Endogenous Metabolite
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is a highly efficient catalyst with excellent cross-coupling activity. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is widely used in organic synthesis and can be used to promote various reactions to build complex molecular structures. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) has good adaptability to temperature and reaction conditions, which enables it to exhibit excellent catalytic performance in different reaction systems.
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE)
  • HY-69014

    DNA/RNA Synthesis Endogenous Metabolite Cancer
    2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase .
    2-O-Methylcytosine
  • HY-139093

    Drug Derivative Others
    Paracetamol-cysteine is a Paracetamol-cysteine Paracetamol protein adduct (PPA) and is formed when paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .
    Paracetamol-cysteine
  • HY-114713

    4-POBN

    Biochemical Assay Reagents Others
    POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts .
    POBN
  • HY-69014R

    DNA/RNA Synthesis Endogenous Metabolite Cancer
    2-O-Methylcytosine (Standard) is the analytical standard of 2-O-Methylcytosine. This product is intended for research and analytical applications. 2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase .
    2-O-Methylcytosine (Standard)
  • HY-W683760

    (2S)-N'-Nitrosonornicotine

    DNA/RNA Synthesis Cancer
    N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts .
    N-Nitrosonornicotine
  • HY-W016433

    DNA/RNA Synthesis Others
    2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .
    2-Aminofluorene
  • HY-W016433R

    DNA/RNA Synthesis Others
    2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .
    2-Aminofluorene (Standard)
  • HY-D2871

    Biochemical Assay Reagents Neurological Disease
    DAyne is a Dopamine (DA)-mimetic probe. DAyne covalently binds to proteins modified by dopamine oxidation products (e.g., dopaquinone, DQ) to form adducts. DAyne is promising for research of Parkinson’s disease (PD), particularly neurotoxicity, protein modification, and related pathways (e.g., endoplasmic reticulum stress, cytoskeletal instability) caused by dopamine dysregulation .
    DAyne
  • HY-119983

    DBC

    Cytochrome P450 Cancer
    7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites .
    7H-Dibenzo[c,g]carbazole
  • HY-159103

    Aminoacyl-tRNA Synthetase Infection
    LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota .
    LeuRS-IN-2
  • HY-U00279

    DNA/RNA Synthesis Cancer
    Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine has cytotoxicity towards most cells .
    Nitracrine
  • HY-U00279A

    DNA/RNA Synthesis Cancer
    Nitracrine dihydrochloride hydrate inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine dihydrochloride hydrate, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine dihydrochloride hydrate has cytotoxicity towards most cells .
    Nitracrine dihydrochloride hydrate
  • HY-173391

    4-HNE-GSH TFA

    Drug Metabolite Metabolic Disease
    4-Hydroxy nonenal glutathione (4-HNE-GSH) TFA is the primary metabolite of 4-Hydroxy-2-nonenal. 4-Hydroxy nonenal glutathionea TFA is a marker of oxidative stress in rat liver and hepatocytes. 4-Hydroxy nonenal glutathione TFA efficiently prevents formation of DNA adducts with 4-Hydroxy-2-nonenal in human cells .
    4-Hydroxy nonenal glutathione TFA
  • HY-W013053

    DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene

    DNA/RNA Synthesis Apoptosis MDM-2/p53 Cancer
    Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .
    Dibenz[a,h]anthracene
  • HY-U00279B

    DNA/RNA Synthesis Cancer
    Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect .
    Nitracrine hydrochloride
  • HY-128463
    N-tert-Butyl-α-phenylnitrone
    2 Publications Verification

    COX Reactive Oxygen Species (ROS) Neurological Disease Metabolic Disease Inflammation/Immunology
    N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .
    N-tert-Butyl-α-phenylnitrone
  • HY-W013053R

    DBA (Standard); 1,2,5,6-Dibenzanthracene (Standard); Benzo[k]tetraphene (Standard)

    DNA/RNA Synthesis Apoptosis Reference Standards MDM-2/p53 Cancer
    Dibenz[a,h]anthracene (Standard) is the analytical standard of Dibenz[a,h]anthracene. This product is intended for research and analytical applications. Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .
    Dibenz[a,h]anthracene (Standard)
  • HY-W141077

    Biochemical Assay Reagents Others
    1-Nitrosopyrrolidine is a molecule that primarily interacts with DNA and proteins, leading to the formation of DNA adducts and protein adducts.
    1-Nitrosopyrrolidine
  • HY-W303135

    Biochemical Assay Reagents Others
    EMPO is a free radical scavenger. EMPO is stable in phosphate buffers at physiological pH, its superoxide spin adducts are more durable and no hydroxyl adducts are produced when decaying. EMPO can be used in the study of free radicals .
    EMPO
  • HY-147740

    DNA Alkylator/Crosslinker Cancer
    WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslinkadduct half-lives of 12.5 h. WEHI-150 forms covalent adducts at CpG sequences and exhibits a preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks. Formaldehyde-activated WEHI-150 shows Concentration-dependent transcription blockages. WEHI-150 can mediate covalent adducts that are independent of interactions with the N-2 of guanine and is capable of adduct formation at novel DNA sequences .
    WEHI-150
  • HY-W141077R

    Biochemical Assay Reagents Reference Standards Others
    1-Nitrosopyrrolidine (Standard) is the analytical standard of 1-Nitrosopyrrolidine. This product is intended for research and analytical applications. 1-Nitrosopyrrolidine is a molecule that primarily interacts with DNA and proteins, leading to the formation of DNA adducts and protein adducts.
    1-Nitrosopyrrolidine (Standard)
  • HY-111375
    Azoxymethane
    10+ Cited Publications

    AOM

    DNA Alkylator/Crosslinker Cancer
    Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.
    Azoxymethane
  • HY-N6828

    Others Metabolic Disease
    Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .
    Monocrotaline N-Oxide
  • HY-W094755

    3-Nitropyrene

    DNA Stain Others
    1-Nitropyrene is a DNA probe whose metabolites can form nucleic acid adducts with DNA .
    1-Nitropyrene
  • HY-118517

    (E)-α-Hydroxy tamoxifen; α-OHTAM

    Drug Metabolite Cancer
    α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts .
    α-Hydroxytamoxifen
  • HY-129480

    Drug Intermediate Others
    Vertilmicin sulfate combines with FMOC-Cl to form the Vertilmicin-FMOC-Cl adduct, and can be used for the determination of glucosamine sulfate in plasma .
    Vertilmicin sulfate
  • HY-116870

    Parasite Infection
    Vamidothion is a polar organophosphorus insecticide and acaricide with biological activity against insects and mites. Vamidothion is degraded by human serum albumin (HSA) and promotes adduct formation with tyrosine residues. The phosphate amino acid adducts formed after the reaction of vamidothion with HSA are detected by liquid chromatography quadrupole-Orbitrap mass spectrometry. The metabolites of vamidothion can be used in forensic toxicology to help determine deaths caused by organophosphorus poisoning .
    Vamidothion
  • HY-W587780

    SMX-NO

    Biochemical Assay Reagents Inflammation/Immunology
    Sulfamethoxazole-NO (SMX-NO) is the major immunogen in sulfonamide allergy, producing modest ascorbic acid depletion and hemoglobin adduct formation. Sulfamethoxazole-NO haptens tissue proteins and is immunogenic in rodents .
    Sulfamethoxazole-NO
  • HY-B0306

    Protionamide

    Bacterial Infection
    Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a Km value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy .
    Prothionamide
  • HY-W110776

    Bis(8-quinolinolato)zinc(II) hydrate; Zinc 8-hydroxyquinolinate

    Biochemical Assay Reagents Others
    Zinc oxinate (Zinc 8-hydroxyquinolinate) is a metal chelator that stabilizes zinc complexes by forming pentacoordinate or hexacoordinate adducts. Zinc oxinate is promising for research of zinc quantification .
    Zinc oxinate
  • HY-116073

    Biochemical Assay Reagents Metabolic Disease
    L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .
    L-Penicillamine
  • HY-124489
    2-Hydroxyestradiol
    2 Publications Verification

    Endogenous Metabolite Metabolic Disease
    2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .
    2-Hydroxyestradiol
  • HY-116832

    NO Synthase Cancer
    Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .
    Retrorsine N-oxide
  • HY-156883

    Cytochrome P450 Others
    Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a Ki value of 5.4 μM. Dasatinib analog-1 blocks the formation of glutathione adducts .
    Dasatinib analog-1
  • HY-W016286
    2,6-Dithiopurine
    2 Publications Verification

    2,6-Dimercaptopurine

    Biochemical Assay Reagents Cancer
    2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .
    2,6-Dithiopurine
  • HY-129846

    Biochemical Assay Reagents Others
    IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols .
    IBTP iodide
  • HY-W016286R

    Biochemical Assay Reagents Cancer
    2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .
    2,6-Dithiopurine (Standard)
  • HY-N6828R

    Reference Standards Others Metabolic Disease
    Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .
    Monocrotaline N-Oxide (Standard)
  • HY-B0306S

    Protionamide-d5

    Isotope-Labeled Compounds Bacterial Infection
    Prothionamide-d5 is deuterium labeled Prothionamide (HY-B0306). Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a Km value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy .
    Prothionamide-d5
  • HY-13036A

    Btk Cancer
    IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
    IBT6A

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

 

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

 

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: