2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. N-Nitrosonornicotine

N-Nitrosonornicotine  (Synonyms: (2S)-N'-Nitrosonornicotine)

Cat. No.: HY-W683760 Purity: 99.97%
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N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts.

For research use only. We do not sell to patients.

N-Nitrosonornicotine Chemical Structure

N-Nitrosonornicotine Chemical Structure

CAS No. : 16543-55-8

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Based on 1 publication(s) in Google Scholar

Other Forms of N-Nitrosonornicotine:

N-Nitrosonornicotine Related Antibodies

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Description

N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts[1][2].

Molecular Weight

177.20

Formula

C9H11N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=NN1[C@H](C2=CN=CC=C2)CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (470.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6433 mL 28.2167 mL 56.4334 mL
5 mM 1.1287 mL 5.6433 mL 11.2867 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6433 mL 28.2167 mL 56.4334 mL 141.0835 mL
5 mM 1.1287 mL 5.6433 mL 11.2867 mL 28.2167 mL
10 mM 0.5643 mL 2.8217 mL 5.6433 mL 14.1084 mL
15 mM 0.3762 mL 1.8811 mL 3.7622 mL 9.4056 mL
20 mM 0.2822 mL 1.4108 mL 2.8217 mL 7.0542 mL
25 mM 0.2257 mL 1.1287 mL 2.2573 mL 5.6433 mL
30 mM 0.1881 mL 0.9406 mL 1.8811 mL 4.7028 mL
40 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5271 mL
50 mM 0.1129 mL 0.5643 mL 1.1287 mL 2.8217 mL
60 mM 0.0941 mL 0.4703 mL 0.9406 mL 2.3514 mL
80 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
100 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.4108 mL
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N-Nitrosonornicotine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Nitrosonornicotine16543-55-8(2S)-N'-NitrosonornicotineDNA/RNA SynthesisDNA adductstobacco-specific nitrosaminescarcinogenicmutagenicC3AInhibitorinhibitorinhibit

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