Search Result

Pathways Recommended:	Stem Cell/Wnt Neuronal Signaling JAK/STAT Signaling

Results for "

Wnt/β-catenin signal inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ERK (1) Wnt (83) β-catenin (62) Antibiotic (4) Apoptosis (10) Arf Family GTPase (1) Autophagy (10) Bacterial (4) Bcl-2 Family (1) c-Myc (2) Carbonic Anhydrase (1) Casein Kinase (2) CDK (7) E1/E2/E3 Enzyme (1) Fluorescent Dye (1) Glucocorticoid Receptor (2) GSK-3 (10) Histone Acetyltransferase (1) Histone Demethylase (1) HSP (1) JNK (1) Mitophagy (2) MMP (1) NF-κB (3) Organoid (8) P-glycoprotein (1) p38 MAPK (1) Parasite (4) PARP (5) Phosphodiesterase (PDE) (2) Porcupine (1) PROTACs (3) RANKL/RANK (6) Reactive Oxygen Species (2) Reference Standards (3) STAT (2) Survivin (2) Toll-like Receptor (TLR) (6)
By Research Areas:	Cancer (69) Cardiovascular Disease (3) Endocrinology (2) Infection (2) Inflammation/Immunology (20) Metabolic Disease (12) Neurological Disease (8)

By Targets:

ERK (1)

Wnt (83)

β-catenin (62)

Antibiotic (4)

Apoptosis (10)

Arf Family GTPase (1)

Autophagy (10)

Bacterial (4)

Bcl-2 Family (1)

c-Myc (2)

Carbonic Anhydrase (1)

Casein Kinase (2)

CDK (7)

E1/E2/E3 Enzyme (1)

Fluorescent Dye (1)

Glucocorticoid Receptor (2)

GSK-3 (10)

Histone Acetyltransferase (1)

Histone Demethylase (1)

HSP (1)

JNK (1)

Mitophagy (2)

MMP (1)

NF-κB (3)

Organoid (8)

P-glycoprotein (1)

p38 MAPK (1)

Parasite (4)

PARP (5)

Phosphodiesterase (PDE) (2)

Porcupine (1)

PROTACs (3)

RANKL/RANK (6)

Reactive Oxygen Species (2)

Reference Standards (3)

STAT (2)

Survivin (2)

Toll-like Receptor (TLR) (6)

By Research Areas:

Cancer (69)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (2)

Inflammation/Immunology (20)

Metabolic Disease (12)

Neurological Disease (8)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: Wnt β-catenin ERK ASK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115539

Windorphen	Wnt β-catenin Histone Acetyltransferase	Cancer
Windorphen is a *Wnt/β-catenin* signal inhibitor that specifically targets the function of the c-terminal transactivation domain of *β-catenin-1* but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP .

HY-120697

MSAB 25+ Cited Publications	Wnt β-catenin	Cancer
MSAB is a potent and selective inhibitor of *Wnt/β-catenin* signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells .

HY-121118

Coronaridine 1 Publications Verification	Wnt	Neurological Disease Cancer
Coronaridine, an iboga type alkaloid, inhibits the **wnt signaling** pathway by decreasing β-catenin expression .

HY-P5819

xStAx-VHLL	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL inhibits* the *Wnt/β-catenin* signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P5819A

xStAx-VHLL TFA	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL TFA inhibits* the *Wnt/β-catenin* signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-160489

PTK7/β-catenin-IN-2	β-catenin Wnt	Cancer
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of *PTK7/β-catenin*. It inhibits the binding of PTK7 to β-catenin (IC₅₀: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC₅₀ of 157.1 μM .

HY-P10392B

aStAx-35R TFA	β-catenin Wnt	Cancer
aStAx-35R TFA, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R TFA inhibits competitively the binding of β-catenin to TCF4. aStAx-35R TFA selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-169126

β-catenin modulator IIa-661	β-catenin Wnt	Cancer
β-catenin modulator IIa-661 is a *β-catenin* modulator that modulates β-catenin activity and inhibits the activity of the Wnt/wingless (wg) signaling pathway. β-catenin modulator IIa-661 can be utilized in cancer research .

HY-P10392

aStAx-35R	β-catenin Wnt	Cancer
aStAx-35R, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R inhibits competitively the binding of β-catenin to TCF4. aStAx-35R selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-N9647

Dalbinol	Wnt β-catenin Apoptosis	Cancer
Dalbinol is a rotenoid compound. Dalbinol can inhibit *Wnt/β-catenin* signaling pathway and promote *β-catenin* degradation. Dalbinol inhibits tumor cells proliferation and induces apoptosis. Dalbinol has antitumor activity .

HY-160493

PTK7/β-catenin-IN-6	Wnt β-catenin	Cancer
PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) .

HY-164520

PMED-1	Wnt	Cancer
PMED-1 is a *β-catenin* inhibitor that significantly reduces *β-catenin* activity in hepatoblastoma cells and various HCC cells, with an IC₅₀ value ranging from 4.87 to 32 μM. PMED-1 affects *Wnt* signaling by decreasing the interaction between *β-catenin* and CREB binding protein, thereby inhibiting cell proliferation. PMED-1 has potential applications in cancer research .

HY-12238

IWR-1 40+ Cited Publications endo-IWR 1; IWR-1-endo	Organoid Wnt	Inflammation/Immunology Cancer
IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting *Wnt/β-catenin* (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical **Wnt signaling*, namely translocation of β-catenin* to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 induces increase in Axin protein levels accompanied by elevated levels of β-catenin. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

HY-13815

KY02111 5 Publications Verification	Wnt	Cardiovascular Disease
KY02111 is a canonical **WNT signaling (β-catenin)** inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration .

HY-163409

CGK012	Wnt β-catenin	Inflammation/Immunology Cancer
CKG012 is an inhibitor for *Wnt/βcatenin* signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer .

HY-112799

DK419	Wnt β-catenin c-Myc CDK Survivin	Cancer
DK419 is a potent and orally active *Wnt/β-catenin* signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK .

HY-133180

YW1128	Wnt β-catenin	Metabolic Disease
YW1128 (compound 3a) is a potent *Wnt/β-Catenin* inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism .

HY-18959

CWP232228 5 Publications Verification	β-catenin Wnt	Cancer
CWP232228, a highly potent selective *Wnt/β-catenin* signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .

HY-108442

JW67 1 Publications Verification	Wnt	Cancer
JW67 inhibits the canonical *Wnt* signaling with an IC₅₀ of 1.17μM . JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of *Wnt* target genes. JW67 also inhibits colorectal cancer cell growth .

HY-160709

Wnt/β-catenin-IN-2	Wnt β-catenin	Cancer
Wnt/β-catenin-IN-2 (Compound 3235-0367) is a *Wnt/β-catenin* signaling pathway inhibitor, with IC₅₀ and K_D values of 7.1 and 2.5 μM, respectively. Wnt/β-catenin-IN-2 can be used for the research of cancer .

HY-12238G

IWR-1 endo-IWR 1; IWR-1-endo	Organoid Wnt	Inflammation/Immunology Cancer
IWR-1 (IWR-1-endo) (GMP) is the IWR-1 (HY-12238) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting *Wnt/β-catenin* (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical **Wnt signaling*, namely translocation of β-catenin* to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 induces increase in Axin protein levels accompanied by elevated levels of β-catenin. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

HY-157990

Wnt/β-catenin-IN-1	Wnt β-catenin	Cancer
Wnt/β-catenin-in-1 (compounds 17) is a *Wnt/β-catenin* signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors .

HY-138301

Miclxin 1 Publications Verification DS37262926	Wnt β-catenin Apoptosis	Cancer
Miclxin (DS37262926) is a potent inhibitor of mutant *β-catenin, involving in Wnt* signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex .

HY-155391

hCA/Wnt/β-catenin-IN-1	Carbonic Anhydrase P-glycoprotein Wnt β-catenin	Cancer
hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (K_i: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits *Wnt/β-catenin* signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line .

HY-162970

XD23	Wnt	Cancer
XD23 is a potent osteosarcoma inhibitor that works by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.

HY-168924

Wnt/β-catenin activator 1	Wnt β-catenin	Metabolic Disease
Wnt/β-catenin activator 1 (Compound 5m) is the orally active activator for *Wnt/β-catenin* signaling pathway, that arrests cell cycle at G1 phase, inhibits early proliferation of adipocytes, and inhibits adipogenesis in cell 3T3-L1 with an IC₅₀ of 330 nM. Wnt/β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities in high-fat diet fed Syrian golden hamster model .

HY-173482

TFAP4/Wnt/β-catenin-IN-1	Wnt β-catenin	Cancer
TFAP4/Wnt/β-catenin-IN-1 (Compound A61) is an orally active *TFAP4/Wnt/β-catenin* inhibitor. TFAP4/Wnt/β-catenin-IN-1 has significant anticancer activity against a variety of cancer cells (such as gastric cancer, lung cancer, breast cancer, etc.), and has the strongest anticancer activity against MGC-803 gastric cancer cells (IC₅₀: 3.92 μM). TFAP4/Wnt/β-catenin-IN-1 induces apoptosis and cell cycle arrest (S phase) in cancer cells by inhibiting the TFAP4/Wnt/β-catenin signaling pathway. TFAP4/Wnt/β-catenin-IN-1 can be used in the study of gastric cancer .

HY-16910

WIKI4 3 Publications Verification	PARP β-catenin Wnt	Cancer
WIKI4 is a potent tankyrase inhibitor with an IC₅₀ of 26 nM for TNKS2. WIKI4 potently inhibits *Wnt/β-catenin* signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on *Wnt/β-catenin* signaling by inhibiting the enzymatic activity of TNKS2 . WIKI4 is cytotoxic to SCLC cells with an IC₅₀ value of 0.02 μM .

HY-137454

Teplinovivint	Wnt β-catenin	Inflammation/Immunology
Teplinovivint is a potent *wnt/β-catenin* signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research .

HY-115543

β-catenin-IN-37	Wnt β-catenin	Cancer
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC₅₀ values of 20 μM and 31 μM, respectively .

HY-111460

15-Oxospiramilactone NC 043	Wnt	Cancer
15-Oxospiramilactone is a diterpene derivative. 15-Oxospiramilactone can inhibit *Wnt/β-catenin* signaling and tumorigenesis of colon cancer cells .

HY-145267

OM-153	PARP Wnt	Cancer
OM-153 is a potent and orally active tankyrase inhibitor with IC₅₀s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based *Wnt/β-catenin* signaling reporter activity with an IC₅₀ value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM .

HY-153214

YW2036	Wnt β-catenin	Cancer
YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC₅₀ value of 637 nM. YW2036 can be used in research of cancer .

HY-108441

CCT031374 hydrobromide	Wnt β-catenin	Cancer
CCT 031374 hydrobromid is a potent inhibitor of β-catenin/transcription factor (TCF) complex signaling. CCT031374 inhibits TCF-dependent transcription of genes of Wnt signaling pathway. CCT 031374 has antitumor activity .

HY-N0020

Echinacoside 5+ Cited Publications	Wnt Reactive Oxygen Species	Neurological Disease
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits **Wnt/β-catenin signaling*. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal* pathways. Antiosteoporotic activity .

HY-170496

Fluc-IN-1	Wnt	Cancer
Fluc-IN-1 (Compound 3) is an inhibitor for firefly luciferase with an IC₅₀ of 25 nM. Fluc-IN-1 inhibits *WNT/β-catenin* signaling pathway with an IC₅₀ of 33 nM (measuring by TOPFlash assay) .

HY-B0012

Pamidronic acid 1 Publications Verification	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of *Wnt* and *β-catenin*, and is applicable for research on osteoporosis and osteosarcoma .

HY-B0012B

Pamidronic acid sodium	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronic acid sodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid sodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid sodium can inhibit the signaling of *Wnt* and *β-catenin*, and is applicable for research on osteoporosis and osteosarcoma .

HY-117233

UU-T02 1 Publications Verification	β-catenin Wnt	Metabolic Disease Cancer
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction *(β-catenin/Tcf PPI)* with a K_i of 1.36 μM . UU-T02 inhibits canonical *Wnt* signaling and the growth of colorectal cancer cells .

HY-164547

WHN-88	Porcupine Wnt β-catenin	Cancer
WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of *Wnt* ligands, preventing their secretion and subsequent *Wnt/β-catenin* signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice .

HY-P10392AF

fStAx-35R TFA	Wnt β-catenin	Cancer
fStAx-35R TFA is the hydrocarbon-stapled peptide. fStAx-35R TFA inhibits *Wnt/β-catenin* signaling pathway by disrupting the β-catenin-TCF interaction. fStAx-35R TFA can be used in cancer research .

HY-17439

Salinomycin sodium salt 35+ Cited Publications Salinomycin sodium; Sodium salinomycin	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of *Wnt/β-catenin* signaling. Salinomycin sodium salt acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt shows selective activity against human cancer stem cells .

HY-15597

Salinomycin 35+ Cited Publications Procoxacin	Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of *Wnt/β-catenin* signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells .

HY-B0012A

Pamidronate disodium 1 Publications Verification CGP 23339A	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronate disodium (CGP 23339A), the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of *Wnt* and *β-catenin*, and is applicable for research on osteoporosis and osteosarcoma .

HY-B0730

Pamidronate disodium pentahydrate 1 Publications Verification	RANKL/RANK Toll-like Receptor (TLR) Wnt β-catenin	Metabolic Disease Inflammation/Immunology Cancer
Pamidronate disodium pentahydrate, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium pentahydrate significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium pentahydrate can inhibit the signaling of *Wnt* and *β-catenin*, and is applicable for research on osteoporosis and osteosarcoma .

HY-W010995

2,5-Dimethylcelecoxib	Wnt Survivin β-catenin	Cancer
2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the *Wnt/β-catenin* signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin .

HY-141891

M435-1279	Wnt E1/E2/E3 Enzyme	Cancer
M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the *Wnt/β-catenin* signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1 .

HY-D0961

Gallocyanine chloride	Fluorescent Dye Wnt β-catenin	Neurological Disease Inflammation/Immunology Cancer
Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits DKK1/LRP6 interaction (IC₅₀=6.38 μM), activates *Wnt* signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals .

HY-18285

Longdaysin	Wnt Casein Kinase ERK CDK	Cancer
Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC₅₀s of 5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively .

HY-108437

exo-IWR-1	Wnt	Infection Cancer
exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1 (HY-12238). IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway .

Cat. No.	Product Name	Type

HY-12238G

IWR-1 (GMP)

endo-IWR 1 (GMP); IWR-1-endo (GMP)

Fluorescent Dye

IWR-1 (IWR-1-endo) (GMP) is the IWR-1 (HY-12238) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 induces increase in Axin protein levels accompanied by elevated levels of β-catenin. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

Cat. No.	Product Name	Type

HY-12238G

IWR-1 (GMP)

endo-IWR 1 (GMP); IWR-1-endo (GMP)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P5819

xStAx-VHLL	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL inhibits* the *Wnt/β-catenin* signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P5819A

xStAx-VHLL TFA	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL TFA inhibits* the *Wnt/β-catenin* signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P10392B

aStAx-35R TFA	β-catenin Wnt	Cancer
aStAx-35R TFA, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R TFA inhibits competitively the binding of β-catenin to TCF4. aStAx-35R TFA selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-P10392AF

fStAx-35R TFA	Wnt β-catenin	Cancer
fStAx-35R TFA is the hydrocarbon-stapled peptide. fStAx-35R TFA inhibits *Wnt/β-catenin* signaling pathway by disrupting the β-catenin-TCF interaction. fStAx-35R TFA can be used in cancer research .

HY-P2272A

NLS-StAx-h TFA 1 Publications Verification	Wnt β-catenin	Cancer
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide *Wnt* signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells .

HY-P10810

QPH-FR	Wnt β-catenin	Cancer
QPH-FR, a quinoa peptide, is a leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) inhibitor. QPH-FR competitively suppresses the formation of the LGR5/RSPO1 complex by binding to LGR5. QPH-FR causes RNF43/ZNRF3 to ubiquitinate the FZD receptor, thereby suppressing the *Wnt/β-catenin* signaling pathway and exerting stemness inhibition .

HY-P10392

aStAx-35R	β-catenin Wnt	Cancer
aStAx-35R, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R inhibits competitively the binding of β-catenin to TCF4. aStAx-35R selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-P6441

KP-6	β-catenin Wnt	Inflammation/Immunology
KP-6, a polypeptide, is a *Wnt/β-catenin* signal inhibitor. KP-6 inhibits TGF-β and blocks rush fibrosis signal path crucial in vivo. KP-6 suppresses Renal tissues damage and renal fibrosis, and reverse the course of disease of chronic kidney disease (CKD) .

HY-P2272

NLS-StAx-h	Wnt β-catenin	Cancer
NLS-StAx-h is a selective, cell permeable, stapled peptide *Wnt* signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Wnt/β-catenin signal inhibitor

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Natural
Products