2. Others PI3K/Akt/mTOR Stem Cell/Wnt Autophagy
  3. Reference Standards Organoid GSK-3 Wnt β-catenin Autophagy
  4. Laduviglusib monohydrochloride (Standard)

Laduviglusib monohydrochloride (Standard)  (Synonyms: CHIR-99021 monohydrochloride (Standard); CT99021 monohydrochloride (Standard))

Cat. No.: HY-10182AR
Handling Instructions Technical Support

Laduviglusib (monohydrochloride) (Standard) is the analytical standard of Laduviglusib (monohydrochloride). This product is intended for research and analytical applications. Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy.

For research use only. We do not sell to patients.

Laduviglusib monohydrochloride (Standard)

Laduviglusib monohydrochloride (Standard) Chemical Structure

CAS No. : 1797989-42-4

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100 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
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Information

Laduviglusib (monohydrochloride) (Standard) is the analytical standard of Laduviglusib (monohydrochloride). This product is intended for research and analytical applications. Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

501.80

Formula

C22H19Cl3N8
CAS No.
SMILES

N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Laduviglusib monohydrochloride (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Laduviglusib monohydrochloride (Standard)1797989-42-4CHIR-99021 monohydrochloride (Standard)CT99021 monohydrochloride (Standard)Reference StandardsOrganoidGSK-3Wntβ-cateninAutophagyGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninInhibitorinhibitorinhibit

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