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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

U251 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (1) Apoptosis (6) Autophagy (2) c-Fms (1) Caspase (1) DGK (1) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Derivative (3) Ephrin Receptor (1) ERK (2) FAK (1) Fluorescent Dye (2) Furin (2) Glycosidase (1) HSP (1) Isotope-Labeled Compounds (2) MARK (1) Monoamine Oxidase (1) NF-κB (1) OLIG2 (1) PARP (1) PDGFR (1) Phosphatase (1) Pyruvate Kinase (2) Reactive Oxygen Species (ROS) (1) SARS-CoV (1) Topoisomerase (2) VEGFR (1)
By Research Areas:	Cancer (28) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (2)

By Targets:

Akt (1)

Antibiotic (1)

Apoptosis (6)

Autophagy (2)

c-Fms (1)

Caspase (1)

DGK (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

Drug Derivative (3)

Ephrin Receptor (1)

ERK (2)

FAK (1)

Fluorescent Dye (2)

Furin (2)

Glycosidase (1)

HSP (1)

Isotope-Labeled Compounds (2)

MARK (1)

Monoamine Oxidase (1)

NF-κB (1)

OLIG2 (1)

PARP (1)

PDGFR (1)

Phosphatase (1)

Pyruvate Kinase (2)

Reactive Oxygen Species (ROS) (1)

SARS-CoV (1)

Topoisomerase (2)

VEGFR (1)

By Research Areas:

Cancer (28)

Infection (3)

Inflammation/Immunology (2)

Metabolic Disease (1)

Neurological Disease (2)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-156418

KY386	DNA/RNA Synthesis	Cancer
KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC₅₀ of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC₅₀ of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability .

HY-124242

(S)-α-Methylbenzyl ricinoleamide	Drug Derivative	Cancer
(S)-α-Methylbenzyl ricinoleamide (compound (R,S)-3d) is a fatty acid amide. (S)-α-Methylbenzyl ricinoleamide shows antiproliferative activity, inhibits the growth of human ovarian cancer cells NCI-ADR/RES and glioma cells U251 with GI₅₀s of 1.9 μg/mL and 3.6 μg/mL, respectively .

HY-P991419

MSB-0254	VEGFR	Cancer
MSB-0254 is a human monoclonal antibody (mAb) targeting VEGFR2/KDR/CD309. MSB-0254 inhibits the invasion, migration, and vascular mimetic (VM) formation of U251 and primary glioma cells. MSB-0254 inhibits the growth of U251 and GL261 cell transplanted tumors. MSB-0254 reduces the expression of CD34, VEGFR2, Ki67, MMP2, MMP9, and CD34/PAS. MSB-0254 can be used in advanced solid tumors research .

HY-13768S1

Topotecan-d6	Isotope-Labeled Compounds Topoisomerase Autophagy	Cancer
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87 .

HY-13768S

Topotecan-d5 SKF 104864A-d₅; NSC 609669-d₅	Isotope-Labeled Compounds Topoisomerase Autophagy	Cancer
Topotecan-d₅ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC₅₀ values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87 .

HY-155532

10m/ZS44	Apoptosis	Cancer
10m/ZS44 is a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor. 10m/ZS44 significantly inhibits GBM tumor growth in a mouse xenograft model. 10m/ZS44 also activates the SIRT1/p53-mediated apoptosis pathway, thereby inhibiting the proliferation of U251 cells .

HY-163835

UniPR1454	Ephrin Receptor	Cancer
UniPR1454 targets EphA2 receptor, inhibits the EphA2-ephrin A1 interaction with an IC₅₀ of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251 .

HY-129932

Pyrrolidine ricinoleamide	Drug Derivative	Cancer
Pyrrolidine ricinoleamide ((R)-5d) is a fatty acid amide that exhibits effective antiproliferative activity against a series of cancer cells, including human glioma U251 cells. Pyrrolidine ricinoleamide can be used in cancer research .

HY-N15582

Perezone	Apoptosis	Inflammation/Immunology Cancer
Perezone is a sesquiterpenoid benzoquinone found in the roots of Acourtia species. Perezone inhibits the activity of leukemia cell line K-562 and human glioma cell line U-251 (IC₅₀: 6.83 μM). Perezone increases the expression of caspase 3, 8, and 9 genes associated with apoptosis. Perezone has antioxidant and anti-inflammatory activities .

HY-N10871

Neocryptomerin	SARS-CoV	Cancer
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell. Neocryptomerin has favorable binding affinities in the active pocket of SARS-CoV-2. Neocryptomerin is the leading compound of rational compounds against COVID-19 .

HY-173431

Dopamine D4 receptor ligand 3	Dopamine Receptor Reactive Oxygen Species (ROS)	Cancer
Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pK_i: 8.86). Dopamine D4 receptor ligand 3 has pIC₅₀ values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells .

HY-169476

Pyrrolidine linoleamide	Drug Derivative	Cancer
Pyrrolidine linoleamide is a derivative of linoleic acid amide with anticancer activity. Pyrrolidine linoleamide exhibits antiproliferative activity against a range of cancer cell lines, with IC₅₀ values of 12.0, 27.5, 7.7, 21.9, 36.6, 32.6, and 33.9 μg/mL against U251, MCF-7, NCI-ADR/RES, 786-0, NCI-H460, PC-3, and OVCAR-3 cell lines, respectively .

HY-168899

FAK-IN-24	FAK Apoptosis	Cancer
FAK-IN-24 (Compound 9f) is a FAK inhibitor (IC₅₀: 0.815 nM). FAK-IN-24 induces DNA damage and apoptosis. FAK-IN-24 has anti-glioblastoma activity. FAK-IN-24 inhibits proliferation of glioblastoma cell lines U87-MG (IC₅₀ = 15 nM) and U251 (IC₅₀ = 20 nM). FAK-IN-24 inhibits tumor growth in U87-MG xenograft model .

HY-175530

OLIG2-IN-1	OLIG2	Cancer
OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC₅₀ value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC₅₀ values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Others	Cancer
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

HY-12833

AMZ30 1 Publications Verification	Phosphatase Akt ERK	Others
AMZ30 is selective protein phosphatase methylesterase-1(PME-1) inhibitor with IC₅₀s of 600 nM and 3.5 µM in human cell lysates and in HEK 293T cells, respectively. AMZ30 shows >100-fold selectivity relative to other serine hydrolases. AMZ30 reduces the demethylated form of PP2A in living cells. AMZ30 attenuates muscle cell differentiation. AMZ30 increases the resistance of U87MG and U251MG glioblastoma cells to t-BHP-induced oxidative stress. AMZ30can be used for the study of glioblastoma .

HY-129440

N-(p-Coumaroyl) Serotonin	PDGFR ERK Caspase	Metabolic Disease Inflammation/Immunology
N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2 and caspase-8 with antioxidant, anti-atherosclerotic and anti-inflammatory properties. N-(p-Coumaroyl) Serotonin inhibits glioblastoma cells (U251MG, T98G) with IC₅₀ of 48-81 μM, while the IC₅₀ for normal fibroblasts is 181-197 μM. N-(p-Coumaroyl) Serotonin inhibits PDGF signaling (reducing receptor phosphorylation), blocks Ca ²⁺ influx, and induces apoptosis (activating caspase-8). N-(p-Coumaroyl) Serotonin can improve atherosclerosis and aortic wall enlargement, and can also be used in the study of glioblastoma .

HY-163290

HDAC-MB	Fluorescent Dye Monoamine Oxidase	Cancer
HDAC-MB a probe that is activated by HDAC6 and can detect and eliminate glioma cells through activation by HDAC6. HDAC-MB reveals antimetastatic and antiproliferative properties, inhibits glioma invasion and induces cellular apoptosis .

HY-163385

ALKBH1-IN-1	DNA Methyltransferase	Cancer
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC₅₀ of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA .

HY-N9292

Friedelin-3,4-lactone	Others	Cancer
Friedelin-3,4-lactone (Compound 4) is a triterpene can be isolated from the leaves of Garcia parViflora with weak antitumor activity .

HY-12768B

Sotuletinib dihydrochloride BLZ945 dihydrochloride	c-Fms	Neurological Disease Cancer
Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC₅₀=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research .

HY-175207

CHI3L1-IN-3	Glycosidase	Cancer
CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with K_ds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM .

HY-154988

MARK4 inhibitor 4	MARK	Neurological Disease Cancer
MARK4 inhibitor 4 is a MARK4 inhibitor with an IC₅₀ of 1.49 μM. MARK4 inhibitor 4 can be used in cancer and tau lesion-related research .

HY-N6722

Swainsonine 1 Publications Verification Tridolgosir	Apoptosis Antibiotic	Infection Cancer
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .

HY-168883

PKM2 modulator 2	Apoptosis Pyruvate Kinase	Cancer
PKM2 modulator 2 (compound C599) is a potent PKM2 inhibitor. PKM2 modulator 2 shows antiproliferative activity. PKM2 modulator 2 induces apoptosis. PKM2 modulator 2 has the potential for the research of glioblastoma .

HY-148174

JNJ-3790339	DGK	Cancer
JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC₅₀ of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation .

HY-168882

PKM2 modulator 1	Apoptosis Pyruvate Kinase	Cancer
PKM2 modulator 1 (compound C998) is a potent PKM2 inhibitor. PKM2 modulator 1 shows antiproliferative activity. PKM2 modulator 1 induces apoptosis. PKM2 modulator 1 has the potential for the research of glioblastoma .

HY-110147A

SSM3 tetraTFA	Furin	Infection
SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .

HY-110147B

SSM3 tetraTFA hydrate	Furin	Infection
SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC₅₀ and a K_i of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro .

HY-120115

PARPi-FL Olaparib-bodipy FL	PARP Fluorescent Dye	Cancer
PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance .

HY-113916

Onalespib lactate AT13387 lactate	HSP	Cancer
Onalespib lactate is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor with an K_d value of 0.71 nM. Onalespib lactate inhibits the proliferation, survival and migration. Onalespib lactate decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib lactate shows antitumor activity. Onalespib lactate has the potential for the research of non-small cell lung cancer (NSCLC) .

Cat. No.	Product Name	Target	Research Area