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Results for "

TGFβ

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TGF-β Receptor (61) Adrenergic Receptor (2) Akt (6) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (1) Antibiotic (3) Apoptosis (17) Autophagy (2) Bacterial (6) Bcl-2 Family (1) Bcr-Abl (1) Biochemical Assay Reagents (1) c-Fms (1) Calcium Channel (10) Caspase (1) CCR (3) CD73 (1) Collagen (2) COX (2) Cytochrome P450 (2) DNA/RNA Synthesis (8) Dopamine β-hydroxylase (2) DYRK (1) EGFR (1) Endogenous Metabolite (4) FGFR (2) FLT3 (2) Formyl Peptide Receptor (FPR) (1) Fungal (1) FXR (1) Glutathione Peroxidase (1) Glycosidase (1) HDAC (2) Hippo (MST) (1) HSP (1) Integrin (4) Interleukin Related (2) Isotope-Labeled Compounds (2) JAK (1) JNK (1) Keap1-Nrf2 (1) MAP4K (3) MDM-2/p53 (1) Mitochondrial Metabolism (1) MMP (1) mTOR (3) Myosin (1) NADPH Oxidase (1) NF-κB (8) Organoid (4) p38 MAPK (3) Parasite (7) PD-1/PD-L1 (4) PDGFR (3) Phosphatase (1) Phosphodiesterase (PDE) (2) PI3K (6) Potassium Channel (2) PROTACs (1) Protease Activated Receptor (PAR) (2) PTEN (1) RAR/RXR (1) Reactive Oxygen Species (1) Reference Standards (2) Sodium Channel (7) Src (4) STAT (2) TAM Receptor (1) TGF-beta/Smad (57) Toll-like Receptor (TLR) (2) TRP Channel (1) VD/VDR (1) VEGFR (2) Wnt (5) β-catenin (1)
By Research Areas:	Cancer (88) Cardiovascular Disease (15) Endocrinology (4) Infection (16) Inflammation/Immunology (74) Metabolic Disease (10) Neurological Disease (9)
Oligonucleotides:	Antisense Oligonucleotides (6)

162

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: TGF-β Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128437

TGFβ-IN-5	TGF-β Receptor	Inflammation/Immunology
TGFβ-IN-5(Compd 12) is a TGFβ inhibitor useful for the study of fibroproliferative diseases associated with TGF-β signaling .

HY-151427

TGFβ1-IN-1 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
TGFβ1-IN-1 (compound 42) is a potent, orally active *TGF-β1* inhibitor. TGFβ1-IN-1 inhibits the upregulation of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in liver fibrosis disease studies .

HY-146434

TGFβ-IN-2 1 Publications Verification	TGF-beta/Smad	Inflammation/Immunology
TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC₅₀ of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration .

HY-163536

TGF-β1/Smad3-IN-1	TGF-beta/Smad	Inflammation/Immunology
TGF-β1/Smad3-IN-1 (Compound 5aa) is an inhibitor of the *TGF-β1/Smad3* signaling pathway(IC₅₀=1.07 μM). TGF-β1/Smad3-IN-1 possesses antifibrotic activity and oral potency .

HY-P990107

*Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β* Antibody (1D11.16.8)**	TGF-β Receptor	Inflammation/Immunology
Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) is an anti-mouse/human/rat/monkey/hamster/canine/bovine IgG antibody inhibitor of *TGF-β* . The recommend isotype control of Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8): Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-142967

TGFβ-IN-1	TGF-β Receptor	Cancer
TGFβ-IN-1 is an antitumor growth and metastasis agent through inhibiting the transforming growth factor‑β signaling pathway.

HY-151954

TGFβ1-IN-2	TGF-β Receptor	Inflammation/Immunology
TGFβ1-IN-2 is a diarylacylhydrazones derivative that effectively suppresses the activation and proliferation of fibroblasts. TGFβ1-IN-2 can be used for idiopathic pulmonary fibrosis (IPF) research .

HY-151955

TGFβ1-IN-3	TGF-β Receptor	Inflammation/Immunology
TGFβ1-IN-3 is a diarylacylhydrazones derivative that effectively suppresses the activation and proliferation of fibroblasts. TGFβ1-IN-3 can be used for idiopathic pulmonary fibrosis (IPF) research .

HY-137918

TGF-βRI inhibitor 3	Src TGF-β Receptor Anaplastic lymphoma kinase (ALK)	Others
TGF-βRI inhibitor 3 (Compound 9ac) is a selective *TGF-β* inhibitor. TGF-βRI inhibitor 3 can effectively inhibit the *TGF-β* signaling pathway. TGF-βRI inhibitor 3 has IC₅₀ values of 13 μM and 0.63 μM for c-Src kinase and ALK5 kinase, respectively .

HY-161398

TGFβRII-IN-3	TGF-β Receptor TGF-beta/Smad	Cancer
TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) (IC₅₀ = 4.1 μM). TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research .

HY-P2294

pm26TGF-β1 peptide	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P2294A

pm26TGF-β1 peptide TFA 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P10634

P17 Peptide	TGF-beta/Smad	Others
P17 Peptide is a human TGF-β1 inhibitory peptide. P17 Peptide can block woodchuck TGF-β1 activity .

HY-P99020

Fresolimumab 1 Publications Verification GC1008	TGF-beta/Smad	Metabolic Disease Inflammation/Immunology Cancer
Fresolimumab (GC1008) is a human monoclonal antibody against *TGF-β* that neutralizes all mammalian active subtypes of *TGF-β. The binding affinity of Fresolimumab to TGF-β2* is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with ⁸⁹Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease .

HY-118810

BIO-013077-01	TGF-β Receptor	Cancer
BIO-013077-01 is a pyrazole *TGF-β* inhibitor .

HY-146693

CJJ300	TGF-β Receptor	Cancer
CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC₅₀ of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex .

HY-142118A

Trabedersen sodium AP 12009 sodium	TGF-beta/Smad	Cancer
Trabedersen sodium is an antisense oligodeoxynucleotide that specifically inhibits *TGF-β2* (TGF-beta/Smad). Trabedersen sodium can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .

HY-P991084

TQB-2858	PD-1/PD-L1	Cancer
TQB-2858 is a bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with the extracellular domain of TGF-β receptor. TQB-2858 has a high affinity for PD-L1, TGF-β1, and TGF-β3 and exhibited high PD-L1 target occupancy. TQB-2858 can be used for the study of osteosarcoma and alveolar soft part sarcoma (ASPS) .

HY-142118

Trabedersen AP 12009	TGF-beta/Smad	Cancer
Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits *TGF-β2* (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .

HY-101275

EMT inhibitor-1 2 Publications Verification	Hippo (MST) TGF-beta/Smad Wnt	Cancer
EMT inhibitor-1 is an inhibitor of of Hippo, *TGF-β, and Wnt* signaling pathways with antitumor activities.

HY-100347A

SRI-011381 hydrochloride 40+ Cited Publications	TGF-beta/Smad	Neurological Disease
SRI-011381 hydrochloride is an orally active *TGF-β* signaling agonist, exhibits neuroprotective effects .

HY-100347

SRI-011381 40+ Cited Publications	TGF-beta/Smad	Neurological Disease
SRI-011381 is an orally active *TGF-β* signaling agonist, exhibits neuroprotective effects .

HY-13226A

Galunisertib monohydrate	TGF-β Receptor	Cancer
Galunisertib monohydrate is an oral and selective TGF-β receptor type I (TGF-βRI) kinase inhibitor with an IC₅₀ of 56 nM.

HY-137063

(+)-ITD-1	TGF-beta/Smad TGF-β Receptor	Cardiovascular Disease
(+)-ITD-1 is an inhibitor for *TGF-β, that inhibits the TGF-β2 with an IC₅₀* of 0.46 μM. (+)-ITD-1 promotes the degradation of TGF-b type II receptor (TGFBR2) and the differentiation of cardiomyocyte, and inhibits the mesoderm formation in the early differentiation stage of mouse embryonic stem cells (mESCs) .

HY-W684904

LY550410	TGF-β Receptor	Cancer
LY550410 is a small-molecule ATP-competitive inhibitor against *type I TGF-β* receptor kinase*, which contains heteroaryl rings for potent binding to the kinase-domain active site. LY550410 modulates TGF-β* signalling, thereby regulates gene expression and ultimately cell growth. LY550410 is promising for research of cancers .

HY-12075

LY2109761 50+ Cited Publications	TGF-β Receptor Autophagy	Cancer
LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with K_is of 38 nM and 300 nM, respectively.

HY-13226

Galunisertib 45+ Cited Publications LY2157299	TGF-β Receptor	Cancer
Galunisertib (LY2157299) is an oral and selective TGF-β receptor type I (TGF-βRI) kinase inhibitor with an IC₅₀ of 56 nM.

HY-P3971

H-Leu-Ser-Lys-Leu-OH	TGF-beta/Smad	Inflammation/Immunology
H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on *TGF-β1* activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK (HY-P3970), can block the signal transduction of *TGF-β1*, and prevent the progression of hepatic damage and fibrosis .

HY-P99944

SHR-1701 Retlirafusp alfa	PD-1/PD-L1 TGF-β Receptor	Cancer
SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and *TGF-β* for cancer research .

HY-123409

Nicousamide	TGF-β Receptor	Metabolic Disease
Nicousamide is a potent inhibitor of TGF-β RII phosphorylation. Nicousamide can be used to study renal fibrosis in animal models of diabetic nephropathy .

HY-N10577

Chlorfortunone A	TGF-beta/Smad	Cancer
Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity .

HY-W105318

Pentabromophenol PBP	TGF-beta/Smad Apoptosis	Cancer
Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the *TGF-β* signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs) .

HY-P99963

Sudubrilimab HS636	PD-1/PD-L1	Cancer
Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment .

HY-P3970C

KQFK	TGF-β Receptor	Others
KQFK is an inactive control of KRFK (HY-P3970). KRFK is a peptide derived from TSP-1 that can activate *TGF-β* .

HY-78349

A 77-01 1 Publications Verification	TGF-β Receptor	Cancer
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC₅₀ of 25 nM .

HY-P99841

Dalutrafusp alfa AGEN-1423; GS-1423	CD73 TGF-β Receptor	Inflammation/Immunology Cancer
Dalutrafusp alfa (AGEN-1423; GS-1423) is a specific bifunctional antibody against CD73 and *TGF-β*, which is involved in the immunosuppressive pathway .

HY-150169

THRX-144644	TGF-β Receptor	Cancer
THRX-144644 is a Lung-restricted ALK5 inhibitor with an IC₅₀ value of 0.14 nM. THRX-144644 avoids systemic toxicities associated with TGFβ pathway inhibition .

HY-N10438

Ganodermaones B	Integrin	Inflammation/Immunology
Ganodermaones B (Compound 2) is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .

HY-N3674

Dalbergioidin	TGF-beta/Smad	Inflammation/Immunology
Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC₅₀ of 20 mM .

HY-N2092

Atractylodinol	Bacterial	Infection Cancer
Atractylodinol, an antimicrobial, is a PRRSV (porcine reproductive and respiratory syndrome virus) inhibitor. Atractylodinol inhibits TGF-β receptor I recycling by binding to vimentin (K_D of 454 nM) and inducing the formation of filamentous aggregates .

HY-137561

Bexotegrast PLN-74809	Integrin	Inflammation/Immunology
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with K_d of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC₅₀ values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung .

HY-W015300

Suberic acid Octanedioic acid	Endogenous Metabolite Akt TGF-β Receptor p38 MAPK	Metabolic Disease
Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the *TGF-β* and MAPK signaling pathways. Suberic acid inhibits skin dryness .

HY-P991487

LASN01	Interleukin Related	Inflammation/Immunology
LASN01 is a human IgG1 monoclonal antibody (mAb) targeting IL-11RA. LASN01 inhibits IGF-1 and IL-11-induced hyaluronic acid (HA) release and TGFβ-stimulated procollagen in orbital fibroblasts. LASN01 can be used in thyroid eye disease (TED) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-10326

GW788388 15+ Cited Publications	TGF-β Receptor	Cancer
GW788388 is a potent and selective inhibitor of ALK5 with IC₅₀ of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor.

HY-P990009

Nisevokitug NIS-793	TGF-beta/Smad	Cancer
Nisevokitug (NIS-793) is a human, IgG2λ antibody targeting TGF-β (TGFB1/TGFB2). Nisevokitug is expressed by CHO-K1 cells .

HY-100347S

SRI-011381-d5	Isotope-Labeled Compounds TGF-beta/Smad	Neurological Disease
SRI-011381-d₅ is the deuterium labeled SRI-011381 (HY-100347). SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

HY-158821

ISTH0036	TGF-beta/Smad	Others
ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), can be use in the study of primary open angle glaucoma (POAG), and wet age-related macular degeneration.

HY-158821A

ISTH0036 sodium	TGF-beta/Smad	Others
ISTH0036 sodium, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), can be use in the study of primary open angle glaucoma (POAG) , and wet age-related macular degeneration.

HY-13013

SIS3 80+ Cited Publications	TGF-beta/Smad	Inflammation/Immunology
(E)-SIS3 is a potent and selective inhibitor of Smad3 with an IC₅₀ of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 .

HY-N6985

Baccatin III 1 Publications Verification	Others	Cancer
Baccatin III is an orally available, selective inhibitor of the *TGF-β1* signaling pathway and myeloid-derived suppressor cell (MDSC) activation. Baccatin III targets the AKT/STAT6 and Smad2/3 pathways, blocking TGF-β1-induced fibroblast differentiation and MDSC-mediated immunosuppression. Baccatin III exerts anti-inflammatory and anti-fibrotic effects by inhibiting macrophage activation and extracellular matrix deposition, and shows potential in the treatment of pulmonary fibrosis and cancer in terms of regulating the tumor immune microenvironment[1][2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015300

Suberic acid Octanedioic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite Akt TGF-β Receptor p38 MAPK
Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the *TGF-β* and MAPK signaling pathways. Suberic acid inhibits skin dryness .

HY-N6985

Baccatin III 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Others
Baccatin III is an orally available, selective inhibitor of the *TGF-β1* signaling pathway and myeloid-derived suppressor cell (MDSC) activation. Baccatin III targets the AKT/STAT6 and Smad2/3 pathways, blocking TGF-β1-induced fibroblast differentiation and MDSC-mediated immunosuppression. Baccatin III exerts anti-inflammatory and anti-fibrotic effects by inhibiting macrophage activation and extracellular matrix deposition, and shows potential in the treatment of pulmonary fibrosis and cancer in terms of regulating the tumor immune microenvironment[1][2].

HY-N0012

Glycitin 2 Publications Verification Glycitein 7-O-β-glucoside	Infection Structural Classification Monophenols Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Plants Disease Research Fields Isoflavones	Bacterial
Glycitin (Glycitein 7-O-β-glucoside) is a natural isoflavone with antibacterial, antiviral, anticancer, anti-inflammation, anti-aging and estrogenic effects. Glycitin may regulate osteoblasts through TGF-β or AKT signaling pathways in bone marrow stem cells (BMSCs) .

HY-N0267

Hypaconitine 2 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Ranunculaceae Source classification Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	NF-κB Potassium Channel Calcium Channel
Hypaconitine inhibits the KCNH2 current with an IC₅₀ of 8.1 nM, and exhibits cardiotoxicity. Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in A549 cell through the inhibition of NF-κB nuclear translocation. Hypaconitine acts as the neuromuscular blocker. Hypaconitine is orally active .

HY-N10577

Chlorfortunone A	Structural Classification Terpenoids Sesquiterpenes Chloranthaceae Plants Chloranthus fortunei (A. Gray) Solms-Laub	TGF-beta/Smad
Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity .

HY-N10438

Ganodermaones B	Other Terpenoids Structural Classification Microorganisms Classification of Application Fields Terpenoids Source classification Inflammation/Immunology Disease Research Fields	Integrin
Ganodermaones B (Compound 2) is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .

HY-N3674

Dalbergioidin	Structural Classification Leguminosae Source classification Phenols Polyphenols Plants Phaseolus vulgaris Linn.	TGF-beta/Smad
Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC₅₀ of 20 mM .

HY-N2092

Atractylodinol	Structural Classification Natural Products Source classification Plants Compositae Erythrina sigmoidea Hua	Bacterial
Atractylodinol, an antimicrobial, is a PRRSV (porcine reproductive and respiratory syndrome virus) inhibitor. Atractylodinol inhibits TGF-β receptor I recycling by binding to vimentin (K_D of 454 nM) and inducing the formation of filamentous aggregates .

HY-N6679A

10,11-Dehydrocurvularin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Phenols Polyphenols Disease Research Anticancer Disease Research Fields	HSP TGF-beta/Smad
10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity .

HY-W015300R

Suberic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
Suberic acid (Standard) is the analytical standard of Suberic acid. This product is intended for research and analytical applications. Suberic acid is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the *TGF-β* and MAPK signaling pathways. Suberic acid inhibits skin dryness .

HY-113604

Pentabromopseudilin	Structural Classification Natural Products Source classification Marine natural products Marine microorganism	TGF-β Receptor
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of *transforming growth factor-β (TGF-β)* activity. PBrP can be used for the research of fibrotic diseases and cancer .

HY-N0012R

Glycitin (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Glycine max (L.) merr Source classification Phenols Plants Isoflavones	Bacterial
Glycitin (Standard) is the analytical standard of Glycitin. This product is intended for research and analytical applications. Glycitin (Glycitein 7-O-β-glucoside) is a natural isoflavone with antibacterial, antiviral, anticancer, anti-inflammation, anti-aging and estrogenic effects. Glycitin may regulate osteoblasts through TGF-β or AKT signaling pathways in bone marrow stem cells (BMSCs) .

HY-N0267R

Hypaconitine (Standard)	Alkaloids Structural Classification Other Alkaloids Ranunculaceae Source classification Aconitum carmichaeli Debx. Plants	Reference Standards NF-κB Potassium Channel Calcium Channel
Hypaconitine (Standard) is the analytical standard of Hypaconitine. This product is intended for research and analytical applications. Hypaconitine inhibits the KCNH2 current with an IC₅₀ of 8.1 nM, and exhibits cardiotoxicity. Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in A549 cell through the inhibition of NF-κB nuclear translocation. Hypaconitine acts as the neuromuscular blocker. Hypaconitine is orally active .

HY-W012977

3,3-Dimethyl-1-butanol DMB; Neohexanol	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	TGF-beta/Smad NF-κB Endogenous Metabolite
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and *TGF-β1/Smad3*. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) .

HY-N1584

Halofuginone Maximum Cited Publications 11 Publications Verification RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of *TGF-β* activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1346

Robinin 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Plants Vigna unguiculata Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR) Apoptosis
Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .

HY-N2589

Isosaponarin	Structural Classification Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae	TGF-β Receptor Collagen
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

HY-N3405

Lariciresinol	Structural Classification Human Gut Microbiota Metabolites Source classification Lignans Arabidopsis thaliana Phenylpropanoids Plants Brassicaceae Endogenous metabolite	Glycosidase Bcl-2 Family Apoptosis TGF-β Receptor NF-κB Fungal
Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC₅₀ of 6.97 μM; K_i of 0.046 μM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates *TGF-β* and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity .

HY-N1584A

Halofuginone hydrobromide Maximum Cited Publications 11 Publications Verification RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of *TGF-β* activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-W105272R

2′-Deoxyadenosine 5′-monophosphate disodium (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584R

Halofuginone (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Source classification Saxifragaceae Plants	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-A0183

Phosphatidylserine Phospholipids, phosphatidylserines; Serine glycerophosphatides	Animals Source classification	Akt TGF-β Receptor
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing *TGF-β* secretion and inhibiting immune responses .

HY-N1346R

Robinin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Plants Vigna unguiculata	Toll-like Receptor (TLR) Apoptosis
Robinin (Standard) is the analytical standard of Robinin. This product is intended for research and analytical applications. Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .

HY-N1584AR

Halofuginone (hydrobromide) (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Source classification Saxifragaceae Plants	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of *TGF-β* activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N0847

Micheliolide 5+ Cited Publications	Structural Classification Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-128483

Fusaric acid	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, *TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen* deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-128483R

Fusaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, *TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen* deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

Cat. No.	Product Name	Chemical Structure

HY-B0673S

Pirfenidone-d5
Pirfenidone-d₅ is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities .

HY-B0673S1

Deupirfenidone
Deupirfenidone-d₃ is the deuterium labeled Pirfenidone (HY-B0673). Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities .

HY-100347S

SRI-011381-d5
SRI-011381-d₅ is the deuterium labeled SRI-011381 (HY-100347). SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

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Species:	Human (9) Mouse (1) Rat (1) Cynomolgus (1) Canine (1)
Tag:	His (9) Avi (6) Fc (2)
Source:	HEK293 (9) E. coli (4)


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