2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Cibotercept

Cibotercept  (Synonyms: KER-012)

Cat. No.: HY-P990733 Purity: 99.85%
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Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH.

For research use only. We do not sell to patients.

CAS No. : 2769700-97-0

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Cibotercept Related Antibodies

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Description

Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH[1][2].

IC50 & Target

MSTN/INHBA/GDF11
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • FPIA_[PROTEIN]2-FC
Biological Activity
  • Immobilized Activin A Protein, Human/Mouse/Rat (HEK293, HY-P70311) can bind Cibotercept. The EC50 for this effect is 32.97 ng/mL.
  • Immobilized GDF-11/BMP-11 Protein, Human (HEK293, solution, HY-P70222Y) can bind Cibotercept. The EC50 for this effect is 66.34 ng/mL.
Purity & Documentation
References
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Cibotercept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cibotercept2769700-97-0KER-012KER012KER 012TGF-beta/SmadTransforming growth factor betaInhibitorinhibitorinhibit

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