GDF-15 Protein, Canine (His)

GDF-15 protein is an important member of the TGF-β family and plays a crucial role in cell growth, differentiation and immune regulation. His research has enhanced our understanding of the signaling pathways associated with the TGF-β superfamily and provided insights into its unique contribution to cellular homeostasis. GDF-15 Protein, Canine (His) is the recombinant canine-derived GDF-15 protein, expressed by E. coli , with N-His labeled tag.

The GDF-15 Protein is a significant member of the TGF-beta family, underscoring its crucial role in diverse cellular processes, including cell growth, differentiation, and immune regulation. As part of this family, GDF-15 likely shares conserved structural and functional features with related proteins, emphasizing its involvement in signaling pathways associated with the TGF-beta superfamily. The classification within the TGF-beta family underscores its specific designation within the broader context of growth factors, providing insights into its unique contributions to cellular homeostasis. The study of GDF-15 contributes to our understanding of its role in various physiological and pathological conditions, offering potential applications in cancer research, inflammation, and metabolic disorders. Further exploration of GDF-15's role holds promise for enhancing our knowledge of its contributions to both normal physiology and disease states.

1. Immobilized Canine GDF15, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-GDF15 Antibody, hFc Tag with the EC₅₀ of 6.7 ng/ml determined by ELISA.
2. Immobilized Canine GDF15, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC₅₀ of 48.3 ng/mL determined by ELISA.

Canine

E. coli

N-His

A0A8C0TNP6 (A197-V307)

484822  [NCBI]

ARDGCPLGEGRCCRLQSLRASLQDLGWANWVVAPRELDVRMCVGACPSQFRSANTHAQMQARLHGLNPDAAPAPCCVPASYEPVVLMHQDSDGRVSLTPFDDLVAKDCHCV

15-20 kDa under reduced (R) condition & 23-26 kDa under Non reduced (N) condition.

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of 50 mM HAc, pH 2.9. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in 50mM HAc, pH 2.9.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.