2. PI3K/Akt/mTOR TGF-beta/Smad Stem Cell/Wnt
  3. PTEN TGF-beta/Smad Akt
  4. CIB-L43

CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration.

For research use only. We do not sell to patients.

CIB-L43 Chemical Structure

CIB-L43 Chemical Structure

CAS No. : 1082942-70-8

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Based on 1 publication(s) in Google Scholar

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Description

CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration[1].

Molecular Weight

304.36

Formula

C15H16N2O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(C1=C(N=C(C2=CC=C(C=C2)N3CCOCC3)S1)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.93 mg/mL (29.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2856 mL 16.4279 mL 32.8558 mL
5 mM 0.6571 mL 3.2856 mL 6.5712 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2856 mL 16.4279 mL 32.8558 mL 82.1396 mL
5 mM 0.6571 mL 3.2856 mL 6.5712 mL 16.4279 mL
10 mM 0.3286 mL 1.6428 mL 3.2856 mL 8.2140 mL
15 mM 0.2190 mL 1.0952 mL 2.1904 mL 5.4760 mL
20 mM 0.1643 mL 0.8214 mL 1.6428 mL 4.1070 mL
25 mM 0.1314 mL 0.6571 mL 1.3142 mL 3.2856 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CIB-L431082942-70-8PTENTGF-beta/SmadAktPhosphatase and tensin homologMMAC1Transforming growth factor betaPKBProtein kinase BTRBPTRBP-DicerSmad7Inhibitorinhibitorinhibit

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