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Skeletal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Acetyl-CoA Carboxylase (2) Adenosine Receptor (3) Adrenergic Receptor (4) Akt (9) AMPK (6) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Antibiotic (1) Antifolate (1) Apoptosis (12) Atg8/LC3 (2) ATP Citrate Lyase (2) Autophagy (5) Bacterial (5) Biochemical Assay Reagents (4) Calcium Channel (8) Carbonic Anhydrase (1) CaSR (2) CDK (1) Chloride Channel (1) Cholinesterase (ChE) (4) Cytochrome P450 (2) DNA/RNA Synthesis (2) Drug Derivative (1) Drug Metabolite (3) Dystrophin (1) E1/E2/E3 Enzyme (2) Endogenous Metabolite (28) ERK (6) Estrogen Receptor/ERR (1) FGFR (1) Fluorescent Dye (1) Free Fatty Acid Receptor (2) Fungal (1) GABA Receptor (2) GLUT (4) Glycosidase (1) Guanylate Cyclase (1) HMG-CoA Reductase (HMGCR) (1) iGluR (4) Influenza Virus (4) Insulin Receptor (1) Isotope-Labeled Compounds (5) Lactate Dehydrogenase (1) Liposome (1) MAP3K (4) MDM-2/p53 (1) MicroRNA (1) Mitochondrial Metabolism (4) mTOR (1) Myosin (7) Na+/K+ ATPase (1) nAChR (6) NF-κB (2) Notch (1) P2X Receptor (2) P2Y Receptor (2) p38 MAPK (1) p62 (2) Parasite (6) PDHK (1) Peptide-Drug Conjugates (PDCs) (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phosphorylase (3) PI3K (2) PKA (4) PKC (2) PPAR (2) Proteasome (1) Pyk2 (1) ROS Kinase (4) SOD (1) Sodium Channel (2) Succinate Dehydrogenase (1) TGF-beta/Smad (1) TGF-β Receptor (1) TRP Channel (2) TSH Receptor (1) Wnt (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (14) Endocrinology (7) Infection (15) Inflammation/Immunology (16) Metabolic Disease (52) Neurological Disease (46)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Nucleotides and their Analogs (2) Cationic Lipids (1)

147

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Mephenoxalone	Others	Neurological Disease
Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc .

BTS 2 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 µM for actin- and Ca ²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Cardiovascular Disease Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

Reldesemtiv 1 Publications Verification CK-2127107	Calcium Channel	Cardiovascular Disease
Reldesemtiv (CK-2127107) is a selective, orally active and next-generation *fast skeletal* muscle troponin** activator (FSTA). Reldesemtiv selectively activates fast skeletal myofibrils with an EC₅₀ of 3.4 μM. Reldesemtiv increases exercise performance in a heart failure model .

wt hMLN TFA	Calcium Channel	Others
wt hMLN (TFA) is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

Chlorphenesin carbamate Maolate; U 19646	Others	Neurological Disease
Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant, as well as a derivate of Chlorphenesin (HY-A0133). Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation . Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels . Antinociceptive effect .

Sevasemten EDG-5506	Myosin	Others
Sevasemten is an orally active, selective allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models .

*Creatine Kinase MM (CK-MM), Human Skeletal* Muscle** CK-MM, CKMM	Biochemical Assay Reagents	Others
Creatine Kinase MM (CK-MM), Human Skeletal Muscle (CK-MM, CKMM) is a biological material or organic compound that can be used in life science research .

Mephenoxalone (Standard)	Biochemical Assay Reagents	Neurological Disease
Mephenoxalone (Standard) is the analytical standard of Mephenoxalone. This product is intended for research and analytical applications. Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc .

Chlorphenesin carbamate (Standard)	iGluR	Neurological Disease
Chlorphenesin carbamate (Standard) is the analytical standard of Chlorphenesin carbamate. This product is intended for research and analytical applications. Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant. Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation . Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels . Antinociceptive effect .

Mephenesin	iGluR	Neurological Disease
Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm .

MuRF1-IN-2	Bacterial E1/E2/E3 Enzyme	Inflammation/Immunology
MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor. MuRF1-IN-2 can be used for research of muscle wasting conditions, of skeletal or cardial muscle atrophy .

MRS5663	Adenosine Receptor	Cardiovascular Disease
MRS5663 (Compound 3a) is an A3AR agonist, with an EC₅₀ of 5.62 nM for β-arrestin2 recruitment assay. MRS5663 has a cytoprotective effect on skeletal muscle ischemia-reperfusion injury/claudication model .

Mivacurium dichloride	nAChR	Neurological Disease
Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell .

Clenbuterol hydrochloride 3 Publications Verification NAB-365 hydrochloride	Adrenergic Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage .

PTP1B-IN-22	Phosphatase	Metabolic Disease
PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes .

Clenbuterol (hydrochloride) (Standard)	Adrenergic Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
Clenbuterol (hydrochloride) (Standard) is the analytical standard of Clenbuterol (hydrochloride). This product is intended for research and analytical applications. Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage .

RX 67668	Cholinesterase (ChE)	Neurological Disease
RX 67668 is a potent cholinesterase inhibitor with an IC₅₀ of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue .

Mivacurium (dichloride) (Standard)	nAChR	Neurological Disease
Mivacurium (dichloride) (Standard) is the analytical standard of Mivacurium (dichloride). This product is intended for research and analytical applications. Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell .

L-Lactate Dehydrogenase (L-LDH), pig muscle	Lactate Dehydrogenase	Metabolic Disease
L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC₅₀ values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes .

MRS2693 ammonium	P2Y Receptor NF-κB ERK Apoptosis	Inflammation/Immunology
MRS2693 ammonium is the ammonium dalt form of MRS2693 (HY-117356). MRS2693 ammonium is a selective agonist for P2Y6 with an EC₅₀ of 0.015 μM. MRS2693 ammonium protects C2C12 skeletal muscle cells from TNFα-induced apoptosis. MRS2693 ammonium reduces the activation of NF-kB, activates the ERK1/2 pathway, and has a cytoprotective effect on mouse ischemia-reperfusion injury model [2].

Guanosine 5'-triphosphate trisodium salt 5+ Cited Publications 5'-GTP trisodium salt	Endogenous Metabolite DNA/RNA Synthesis	Others
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

SB-236057	5-HT Receptor	Others
SB-236057 is an inverse agonist of the 5-HT_1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis .

Sabinene 2 Publications Verification	p38 MAPK	Others
Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways .

2'-Aminoacetophenone o-aminoacetophenone	Bacterial Apoptosis Atg8/LC3 p62 Autophagy	Infection Inflammation/Immunology
2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .

2'-Aminoacetophenone (Standard)	Bacterial Apoptosis Atg8/LC3 p62 Autophagy	Infection Inflammation/Immunology
2'-Aminoacetophenone (Standard) is the analytical standard of 2'-Aminoacetophenone. This product is intended for research and analytical applications. 2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .

Sodium creatine phosphate dibasic tetrahydrate Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate	Endogenous Metabolite	Metabolic Disease
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

TCL053	Liposome	Neurological Disease
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .

Doxefazepam SAS-643	GABA Receptor	Neurological Disease
Doxefazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsan and skeletal muscle relaxant properties.

Laudexium methylsulfate	Others	Neurological Disease
Laudexium methylsulfate is a neuromuscular blocking agent or skeletal muscle relaxant and a nondepolarizing neuromuscular blocking agent.

L-Alloisoleucine 1 Publications Verification (3R)-LS-Isoleucine	Endogenous Metabolite	Metabolic Disease
L-Alloisoleucine is a stereoisomer of L-isoleucine. L-Alloisoleucine can be used in skeletal muscle research .

(±)-Hexanoylcarnitine chloride DL-Hexanoylcarnitine chloride	Endogenous Metabolite	Metabolic Disease
(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways .

Fluvastatin lactone	Drug Derivative HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Cancer
Fluvastatin lactone, a lactone form of Fluvastatin (HY-14664), induces myotoxicity in human skeletal muscle cells .

Torbafylline HWA 448	Phosphodiesterase (PDE)	Cancer
Torbafylline is a PDE inhibitor. Torbafylline mitigates protein breakdown in rat skeletal muscle following burns by activating the PDE4/cAMP/EPAC/PI3K/Akt signaling pathway. Torbafylline suppresses the increased ubiquitin-proteasome-dependent protein degradation observed in the skeletal muscles of rats susceptible to cancer and sepsis .

L-Norleucine (S)-2-Aminohexanoic acid; (S)-Norleucine	Influenza Virus Endogenous Metabolite	Infection Cancer
L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

wt hMLN	Calcium Channel	Others
wt hMLN is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

Cyclobenzaprine hydrochloride MK130 hydrochloride	5-HT Receptor Parasite	Infection Neurological Disease
Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT₂ receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases

MuRF1-IN-1	E1/E2/E3 Enzyme	Neurological Disease
MuRF1-IN-1 is a muscle ring finger 1 (MuRF1) inhibitor that attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia .

Cyclobenzaprine (hydrochloride) (Standard) MK130 hydrochloride (Standard)	5-HT Receptor	Neurological Disease
Cyclobenzaprine (MK130) hydrochloride (Standard) is the analytical standard of Cyclobenzaprine (MK130) hydrochloride. This product is intended for research and analytical applications. Cyclobenzaprine hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases

GLPG0492 5+ Cited Publications	Androgen Receptor	Others
GLPG0492 is a non-steroidal selective androgen receptor modulator (potency 12 nM). GLPG0492 has the potential for the research of musculo-skeletal diseases such as sarcopenia and cachexia .

Cytembena	DNA/RNA Synthesis	Cancer
Cytembena is inhibitor for replicative DNA synthesis, purine synthesis and tetrahydrofolate formylase activity. Cytembena ameliorates ovarian or breast cancer, relieves the pain from skeletal metastases .

Ajuga Turkestanica Extract	Notch Wnt	Metabolic Disease
Ajuga Turkestanica Extract is a muscle grass extract. Ajuga Turkestanica Extract can increase Notch and Wnt signaling in triceps brachii, and has potential skeletal muscle protection. .

Heptanoyl-L-carnitine chloride	Endogenous Metabolite	Metabolic Disease
Heptanoyl-L-carnitine chloride (trans-3,4-methylene-heptanoylcarnitine) is an acylcarnitine. Heptanoyl-L-carnitine chloride causes exercise-induced alterations in the human metabolome in plasma and skeletal muscle tissue .

Phosphorylase b	Phosphorylase	Metabolic Disease
Phosphorylase b is one of the two forms of phosphorylase present in skeletal muscle. The other is Phosphorylase a, which can be transformed into one another. The conversion process requires the addition of divalent metal ions and ATP .

Cat. No.	Product Name	Type

HY-147332

TCL053	Drug Delivery
TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle .

HY-W011012

Adenosine 5'-monophosphate disodium

5+ Cited Publications

Enzyme Substrates

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-W127670

Decamethonium iodide

Cell Assay Reagents

Decamethonium (iodide) is an organic compound containing ammonium and iodide ions. It is commonly used as a neuromuscular blocking agent in anesthesia to induce muscle relaxation during surgery. Decamethonium Iodide acts by binding to nicotinic acetylcholine receptors (nAChRs) in the neuromuscular junction, causing depolarization block and subsequent skeletal muscle paralysis. In addition, it can also serve as a reference standard for pharmacological studies of nAChRs.

HY-W011012R

Adenosine 5'-monophosphate (disodium) (Standard)

Enzyme Substrates

Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

Cat. No.	Product Name	Target	Research Area

HY-P6013A

wt hMLN TFA	Calcium Channel	Others
wt hMLN (TFA) is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

HY-P0222

PKI(5-24) 3 Publications Verification	PKA	Others
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-P1604A

ATX-II TFA	Sodium Channel	Inflammation/Immunology
ATX-II TFA is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na ⁺skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

HY-P2048A

MOTS-c(human) acetate	AMPK GLUT	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
MOTS-c (human) acetate is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) acetate inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) acetate has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

HY-P10643

Skeletal muscle-targeted peptide MSP	Peptides	Infection
Skeletal muscle-targeted peptide MSP is a 7-amino-acid (ASSLNIA) muscle-targeting peptide (MTP). Skeletal muscle-targeted peptide MSP can target the virus through a different binding ligand to the muscle. Skeletal muscle-targeted peptide MSP can be used for the research of diseases of the heart and skeletal muscles .

HY-P6013

wt hMLN	Calcium Channel	Others
wt hMLN is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

HY-16498

Tigapotide PCK-3145	Apoptosis	Cancer
Tigapotide (PCK-3145) is an anti-tumour peptide that reduces the development of skeletal metastases associated with prostate cancer. Tigapotide induces apoptosis and reduces tumour parathyroid hormone-related peptide (PTHrP) levels .

HY-P0222A

PKI(5-24) TFA	PKA	Others
PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a K_i of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .

HY-P4580

Suc-Ala-Ala-Pro-Phe-SBzl	Proteasome	Others
Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin (HY-108910). Suc-Ala-Ala-Pro-Phe-SBzl can be hydrolyzed by glycine (R208G) .

HY-P1604

ATX-II	Sodium Channel	Inflammation/Immunology
ATX-II is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na ⁺skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

HY-P10870

Pep1-DNP conjugate 9	Peptide-Drug Conjugates (PDCs) FGFR Apoptosis	Cancer
Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to FGFR1 with K_D of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models .

Cat. No.	Product Name	Target	Research Area

HY-P99388

Trevogrumab REGN-1033	TGF-beta/Smad	Metabolic Disease
Trevogrumab (REGN-1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake .

Species:	Human (5) Mouse (2) Cynomolgus (1)
Tag:	His (7) SUMO (1) Myc (1) GST (1)
Source:	HEK293 (1) E. coli Cell-free (1) P. pastoris (2) Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P75732

	Enolase 3/ENO3 Protein, Human (His) Beta-enolase; Enolase 3; MSE; Skeletal muscle enolase	Human	E. coli
	Enolase 3/ENO3 protein acts as a glycolytic enzyme, promoting the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In addition to its role in glycolysis, ENO3 appears to play a crucial role in the development and regeneration of striated muscle. Enolase 3/ENO3 Protein, Human (His) is the recombinant human-derived Enolase 3/ENO3 protein, expressed by E. coli , with N-His labeled tag.

HY-P72273

	MUSK Protein, Human (P.pastoris, His) Muscle, Skeletal receptor tyrosine-protein kinase; CMS9; FADS; MDK4; Muscle; MuSK;	Human	P. pastoris
	MUSK protein is a receptor tyrosine kinase that plays a crucial role in the formation and maintenance of the neuromuscular junction (NMJ). After LRP4 recruits AGRIN, MUSK phosphorylates and activates, affecting gene expression, coordinating actin cytoskeletal reorganization, and clustering acetylcholine receptors (AChR) in the postsynaptic membrane. MUSK Protein, Human (P.pastoris, His) is the recombinant human-derived MUSK protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71568

	MUSK Protein, Mouse (Myc, His-SUMO) Musk; Nsk2; Muscle; Skeletal receptor tyrosine-protein kinase; EC 2.7.10.1; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor	Mouse	E. coli
	MUSK protein is a receptor tyrosine kinase that plays a critical role in the formation of the neuromuscular junction (NMJ).MUSK is activated by the AGRIN-LRP4 complex and regulates the NMJ through gene expression, actin cytoskeleton reorganization, and acetylcholine receptor (AChR) clustering.MUSK Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived MUSK protein, expressed by E.coli , with C-Myc, N-SUMO, N-10*His labeled tag.

HY-P703680

	*Musk (muscle, skeletal* receptor tyrosine-protein kinase) Protein, Cynomolgus (HEK293, His)**	Cynomolgus	HEK293

HY-P704098

	MLC1 Protein, Chicken Myosin light chain 1; Skeletal muscle isoform; Alkali myosin light chain 1; MLC-1; Myosin light chain 1f; Myosin light chain alkali 1; Myosin light chain A1; Skeletal-muscle myosin L-1 light chain; Gal d 7	Others	E. coli

HY-P702578

	Sialidase-2 Protein, Mouse (P.pastoris, His) Neu2; Sialidase-2; EC 3.2.1.18; Cytosolic sialidase; Mouse Skeletal muscle sialidase; MSS; Murine thymic sialidase; MTS; N-acetyl-alpha-neuraminidase 2	Mouse	P. pastoris
	Sialidase-2 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Sialidase-2, expressed by P. pastoris , with N-10*His labeled tag. ,

HY-P704183

	ATP2A1 Protein, Human (Cell-Free, His) SERCA1; SR Ca2+; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch Skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca2+	Human	E. coli Cell-free

HY-P704169

	SLC25A4 Protein, Human (His) ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/Skeletal muscle isoform T1; Adenine nucleotide translocator 1; Solute carrier family 25 member 4	Human	E. coli

HY-P702665

	PHKG1 Protein, Human (Active, sf9, GST) PHKG1; phosphorylase kinase, gamma 1 (muscle); phosphorylase kinase, gamma 1 (muscle); phosphorylase b kinase gamma catalytic chain, Skeletal muscle isoform; phosphorylase kinase gamma; phosphorylase kinase subunit gamma-1; EC 2.7.11.19	Human	Sf9 insect cells
	PHKG1 is the catalytic subunit of phosphorylase b kinase (PHK), which plays a key role in the neural and hormonal regulation of glycogenolysis (glycogen breakdown) by phosphorylating and activating glycogen phosphorylase. PHKG1 Protein, Human (Active, sf9, GST) is the recombinant human-derived PHKG1, expressed by Sf9 insect cells , with GST labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-113354S

Anserine-d4

Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].

HY-B1901S

Eperisone-d10 hydrochloride

Eperisone-d₁₀ (hydrochloride) is the deuterium labeled Eperisone hydrochloride. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[1][2 [3].

HY-B1283S

Mephenesin-d3
Mephenesin-d₃ is deuterium labeled Mephenesin. Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm .

HY-B0740S

Cyclobenzaprine-d3 hydrochloride
Cyclobenzaprine-d₃ (hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

HY-Y0017S

L-Norleucine-d9
L-Norleucine-d₉ is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.

HY-B0740S3

Cyclobenzaprine-d3-1 hydrochloride

Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT₂ receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases

HY-113354S1

Anserine-d4 hydrochloride

Anserine-d₄ hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81258

	*alpha Skeletal* Muscle Actin Antibody (YA930)** ACTA1; ACTA; Actin; alpha Skeletal muscle; Alpha-actin-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	alpha Skeletal Muscle Actin Antibody (YA930) is a mouse-derived non-conjugated IgG antibody (Clone NO.: YA930), targeting alpha Skeletal Muscle Actin, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). alpha Skeletal Muscle Actin Antibody (YA930) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P81258A

	*alpha Skeletal* Muscle Actin Antibody (YA931)** ACTA1; ACTA; Actin; alpha Skeletal muscle; Alpha-actin-1	IHC-P	Human
	alpha Skeletal Muscle Actin Antibody (YA931) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA931), targeting alpha Skeletal Muscle Actin. alpha Skeletal Muscle Actin Antibody (YA931) can be used for IHC-P experiment in human background.

HY-P82252

	ACTN3 Antibody (YA1997) ACTN3; Alpha-actinin-3; Alpha-actinin Skeletal muscle isoform 3; F-actin cross-linking protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	ACTN3 Antibody (YA1997) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1997), targeting ACTN3, with a predicted molecular weight of 103 kDa (observed band size: 103 kDa). ACTN3 Antibody (YA1997) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P82087

	Troponin I Antibody (YA1832) TNNI2; Troponin I; fast Skeletal muscle; Troponin I; fast-twitch isoform	WB, IP	Human, Mouse, Rat
	Troponin I Antibody (YA1832) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1832), targeting Troponin I, with a predicted molecular weight of 21 kDa (observed band size: 21 kDa). Troponin I Antibody (YA1832) can be used for WB, IP experiment in human, mouse, rat background.

HY-P82186

	SERCA2 ATPase Antibody (YA1931) ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch Skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	SERCA2 ATPase Antibody (YA1931) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1931), targeting SERCA2 ATPase, with a predicted molecular weight of 115 kDa (observed band size: 115 kDa). SERCA2 ATPase Antibody (YA1931) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, rat background.

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Cat. No.	Product Name		Classification

HY-15964

Tirasemtiv 1 Publications Verification CK-2017357		Alkynes
Tirasemtiv is an activator of the fast skeletal muscle troponin complex. Tirasemtiv is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-12695

Guanosine 5'-triphosphate trisodium salt 5+ Cited Publications 5'-GTP trisodium salt		Nucleotides and their Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .