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Results for "

SP1

" in MedChemExpress (MCE) Product Catalog:

51

Inhibitors & Agonists

5

Peptides

31

Natural
Products

3

Recombinant Proteins

5

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-A0122
    Plicamycin
    Maximum Cited Publications
    45 Publications Verification

    Mithramycin A

    DNA/RNA Synthesis Bacterial Antibiotic Glutathione S-transferase Infection Cancer
    Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression [1] .
    Plicamycin
  • HY-10447

    EM-1421

    Survivin COX TNF Receptor Apoptosis Infection Inflammation/Immunology Cancer
    Terameprocol is an inhibitor targeting the Sp1 transcription factor, which can selectively inhibit the transcription of Sp1-dependent genes. Terameprocol exerts its effects by inhibiting Sp1-mediated gene transcription, such as reducing the expression of genes like CDC2, survivin and HMGB1, thereby arresting the cell cycle, inducing apoptosis, and suppressing the inflammatory response. Terameprocol exhibits anti-proliferative, pro-apoptotic, and anti-inflammatory activities and is currently mainly used in the research of diseases such as cancer and pulmonary arterial hypertension[1][2][3].
    Terameprocol
  • HY-P10603

    Antibiotic Bacterial Infection
    SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candida albicans, which can induce cell growth arrest at the mating type locus MTLa in Candida albicans. SP1 can be used in the study of the prevention and treatment of Candida albicans infection [1].
    SP1
  • HY-RS22994

    Small Interfering RNA (siRNA) Others

    Sp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sp1 Rat Pre-designed siRNA Set A
    Sp1 Rat Pre-designed siRNA Set A
  • HY-RS13600

    Small Interfering RNA (siRNA) Others

    SP1 Human Pre-designed siRNA Set A contains three designed siRNAs for SP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SP1 Human Pre-designed siRNA Set A
    SP1 Human Pre-designed siRNA Set A
  • HY-RS16562

    Small Interfering RNA (siRNA) Others

    Sp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sp1 Mouse Pre-designed siRNA Set A
    Sp1 Mouse Pre-designed siRNA Set A
  • HY-178143

    KLF Cancer
    Sp1-IN-1 is a selective specificity protein 1 (Sp1) inhibitor. Sp1-IN-1 inhibits the proliferation of Hela cells and MCF-7 cells. Sp1-IN-1 can be used to the studies of cervical cancer and breast cancer [1].
    Sp1-IN-1
  • HY-150536

    HIV HIV Protease Infection
    EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity [1].
    EP39
  • HY-120764

    HIV Infection
    PF-46396 is a potent HIV-1 inhibitor with an EC50 value of 0.206 µM. PF-46396 shows antiviral activity. PF-46396 inhibits the processing of capsid (CA)/spacer peptide 1 (SP1) (p25) Gag precursor proteins and blocks maturation of the viral core particle [1].
    PF-46396
  • HY-178021

    HDAC DNA/RNA Synthesis Apoptosis RAD51 Caspase Cancer
    HDAC1-IN-11 (Compound 6) is a HDAC1 inhibitor with an IC50 of 106.6  nM. HDAC1-IN-11 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC1-IN-11 has antitumor activity and sensitizes Etoposide (HY-13629) and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC1-IN-11 can be used for chemotherapy of cancers like NSCLC research [1].
    HDAC1-IN-11
  • HY-178022

    HDAC Apoptosis Caspase RAD51 DNA/RNA Synthesis Cancer
    HDAC6-IN-63 (Compound 7) is an orally active HDAC6 inhibitor with an IC50 of 145  nM. HDAC6-IN-63 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC6-IN-63 has antitumor activity and sensitizes Etoposide (HY-13629) and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC6-IN-63 can be used for chemotherapy of cancers like NSCLC research [1].
    HDAC6-IN-63
  • HY-N0842
    Bevirimat
    1 Publications Verification

    PA-457; MPC-4326; YK FH312

    Virus Protease Infection
    Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies [1] .
    Bevirimat
  • HY-N0842R

    PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)

    Reference Standards Virus Protease Infection
    Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].
    Bevirimat (Standard)
  • HY-100008
    Peretinoin
    5+ Cited Publications

    NIK333

    RAR/RXR SphK Autophagy HCV Infection Cancer
    Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 [1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM .
    Peretinoin
  • HY-P10336

    Serpin Neurological Disease Endocrinology
    Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function [1]. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects .
    Serpinin
  • HY-100008R

    NIK333 (Standard)

    Reference Standards RAR/RXR SphK Autophagy HCV Infection Cancer
    Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].
    Peretinoin (Standard)
  • HY-W040129
    Chromomycin A3
    1 Publications Verification

    DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase Infection Neurological Disease Cancer
    Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe [1] .
    Chromomycin A3
  • HY-W100287

    NF-κB p38 MAPK Interleukin Related IKK JNK β-catenin Wnt Neurological Disease Inflammation/Immunology Cancer
    Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer [1] .
    Murrayafoline A
  • HY-W040129R

    Reference Standards Bacterial Fungal Apoptosis Antibiotic Infection Neurological Disease Cancer
    Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe [1] .
    Chromomycin A3 (Standard)
  • HY-123036

    Bacterial Infection
    Renierone is an antibacterial metabolite found in the sponge Reniera sp. .
    Renierone
  • HY-N14206

    Others Others
    Cytosporin B is a minor component found in Cytospora sp .
    Cytosporin B
  • HY-N13149

    Antibiotic Bacterial Infection
    Tetromycin C1 is an antibiotic bactericide isolated from Streptomyces sp. .
    Tetromycin C1
  • HY-N16411

    Others Others
    Carneamide A is a prenylated indole alkaloid produced by a marine-derived Aspergillus sp .
    Carneamide A
  • HY-N14576

    Antibiotic Bacterial Infection
    Pyrrolomycins C is a member of the pyrrolomycin group of antibiotic found in the Actinosporangium sp .
    Pyrrolomycin C
  • HY-N8662

    Others Inflammation/Immunology
    Primulic acid II is a saponin isolated from root extract of Primula sp .
    Primulic acid II
  • HY-N14577

    Antibiotic Bacterial Infection
    Pyrrolomycins D is a member of the pyrrolomycin group of antibiotic found in the Actinosporangium sp .
    Pyrrolomycin D
  • HY-N13017

    Endogenous Metabolite Others
    Bhimanone is a bioinactive tetralone, which can be isolated from Streptomyces sp. .
    Bhimanone
  • HY-108993

    SNA-8073A; Rubiginone A2

    Others Others
    Fujianmycin B (SNA-8073A) is found in the strain of Streptomyces sp .
    Fujianmycin B
  • HY-N12266

    Others Others
    12-Hydroxyalbrassitriol is a drimane sesquiterpenoid that can be isolated from Penicillium sp .
    12-Hydroxyalbrassitriol
  • HY-N14403

    Cathepsin Infection
    6-Hydroxytetrangulol is a CPP32 protease inducer found in Streptomyces sp .
    6-Hydroxytetrangulol
  • HY-N14721

    CETP Metabolic Disease
    Erabulenol A is the inhibitor for cholesteryl ester transfer protein that can be isolated from Penicillum sp. .
    Erabulenol A
  • HY-N8391

    Others Others
    Hydroxysulochrin is a tea pollen growth inhibitor that can be isolated from Aureobasidium sp. .
    Hydroxysulochrin
  • HY-116077

    Others Others
    AB 5046B is a chlorosis-inducing substance can be isolated from Nodulisporium sp .
    AB 5046B
  • HY-120551

    Others Others
    Fructigenine A (compound 4) is a active product that can be isolated from marine-derived Penicillium sp. .
    Fructigenine A
  • HY-125458

    NO Synthase Others
    Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .
    Iromycin A
  • HY-114585A

    Glutathione S-transferase Others
    Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp .
    Sperabillin A dihydrochloride
  • HY-N6799

    Others Infection
    Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .
    Neosolaniol
  • HY-125538

    Endogenous Metabolite Inflammation/Immunology
    Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .
    Deoxybrevianamide E
  • HY-N12149

    Bacterial Infection
    Axinysone B can be isolated from Laurencia similis. Axinysone B has antibacterial activity against Staphylococcus sp. .
    Axinysone B
  • HY-N7078

    Others Others
    Spiculisporic acid is a γ-butenolide isolated from the cultue of Aspergillus sp . Spiculisporic acid is a microbial biosurfactant and has anti-oxidative stress actions .
    Spiculisporic acid
  • HY-N2657

    Others Others
    Flavone, 5,7-dihydroxy-3,4',8-trimethoxy-, diacetate is a Flavonoids product that can be isolated from the herbs of Micromelum sp. .
    Flavone, 5,7-dihydroxy-3,4',8-trimethoxy-, diacetate
  • HY-W353469

    Glucosylglycerol

    Endogenous Metabolite Others
    2-O-(α-D-Glucopyranosyl)glycerol (Glucosylglycerol) is a glycerol glycoside and can be isolated from the Marine Blue-green Alga Oscillatoria sp .
    2-O-(α-D-Glucopyranosyl)glycerol (55% in water)
  • HY-N6799R

    Reference Standards Others Infection
    Neosolaniol (Standard) is the analytical standard of Neosolaniol. This product is intended for research and analytical applications. Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp . Neosolaniol evokes robust anorectic response .
    Neosolaniol (Standard)
  • HY-N8339

    Antibiotic Bacterial Infection
    Decatromicin B is an antibiotic. Decatromicin B has potent antibacterial activities against both Gram-positive and Gram-negative bacteria. Decatromicin B can be isolated from Actimonadura sp. .
    Decatromicin B
  • HY-W006646

    Biochemical Assay Reagents Others
    Methyl 5-bromo-1H-pyrrole-2-carboxylate (Compound 7) is a pyrrole that can be isolated from marine sponges Lissodendotyx sp.
    Methyl 5-bromo-1H-pyrrole-2-carboxylate
  • HY-N0980

    Others Others
    1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid is a Alkaloids product that can be isolated from the herbs of Micromelum sp. .
    1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid
  • HY-P1330

    P2X Receptor Inflammation/Immunology
    Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp .
    Purotoxin 1
  • HY-N8849

    4-Methylayapin

    Fungal Infection
    4-Methyl-6,7-methylenedioxycoumarin (4-Methylayapin) is a Coumarin (HY-N0709) derivative. 4-Methyl-6,7-methylenedioxycoumarin exhibits antifungal activity against Pythium sp. .
    4-Methyl-6,7-methylenedioxycoumarin
  • HY-RS03522

    Small Interfering RNA (siRNA) Others

    DAND5 Human Pre-designed siRNA Set A contains three designed siRNAs for DAND5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DAND5 Human Pre-designed siRNA Set A
    DAND5 Human Pre-designed siRNA Set A
  • HY-P3805

    Neurokinin Receptor Cardiovascular Disease Neurological Disease
    [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP) .
    [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)

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