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Results for "

NLRP3 inflammasome activation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) Akt (2) AMPK (2) Amyloid-β (1) Antibiotic (2) Apoptosis (17) Aquaporin (1) Autophagy (10) Bacterial (2) Biochemical Assay Reagents (1) Caspase (2) Cholinesterase (ChE) (3) COX (1) Deubiquitinase (2) DNA/RNA Synthesis (2) Dopamine Receptor (1) Drug Metabolite (2) E1/E2/E3 Enzyme (1) Endogenous Metabolite (12) Enterovirus (2) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (2) Fungal (2) GPR55 (2) HDAC (2) Histone Acetyltransferase (2) HIV (4) HMG-CoA Reductase (HMGCR) (2) IKK (1) Influenza Virus (2) Interleukin Related (20) Isotope-Labeled Compounds (3) Keap1-Nrf2 (6) LXR (2) Microtubule/Tubulin (3) Mitochondrial Metabolism (1) Molecular Glues (1) NEKs (2) NF-κB (26) NO Synthase (3) NOD-like Receptor (NLR) (82) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (4) P-glycoprotein (2) P2X Receptor (2) P2Y Receptor (1) p38 MAPK (2) Parasite (3) PARP (2) Phosphodiesterase (PDE) (2) PI3K (2) Potassium Channel (2) Pyroptosis (14) Reactive Oxygen Species (ROS) (19) Reference Standards (20) Reverse Transcriptase (4) Sirtuin (2) Sodium Channel (4) Tau Protein (1) TGF-beta/Smad (6) TNF Receptor (3) TREM receptor (2) URAT1 (1) γ-Glutamyl Transferase (GGT) (1)
By Research Areas:	Cancer (22) Cardiovascular Disease (24) Infection (13) Inflammation/Immunology (91) Metabolic Disease (17) Neurological Disease (20)

By Targets:

Adenosine Receptor (2)

Akt (2)

AMPK (2)

Amyloid-β (1)

Antibiotic (2)

Apoptosis (17)

Aquaporin (1)

Autophagy (10)

Bacterial (2)

Biochemical Assay Reagents (1)

Caspase (2)

Cholinesterase (ChE) (3)

COX (1)

Deubiquitinase (2)

DNA/RNA Synthesis (2)

Dopamine Receptor (1)

Drug Metabolite (2)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (12)

Enterovirus (2)

Farnesyl Transferase (1)

Fatty Acid Synthase (FASN) (2)

Ferroptosis (2)

Fungal (2)

GPR55 (2)

HDAC (2)

Histone Acetyltransferase (2)

HIV (4)

HMG-CoA Reductase (HMGCR) (2)

IKK (1)

Influenza Virus (2)

Interleukin Related (20)

Isotope-Labeled Compounds (3)

Keap1-Nrf2 (6)

LXR (2)

Microtubule/Tubulin (3)

Mitochondrial Metabolism (1)

Molecular Glues (1)

NEKs (2)

NF-κB (26)

NO Synthase (3)

NOD-like Receptor (NLR) (82)

Nuclear Factor of activated T Cells (NFAT) (1)

Nucleoside Antimetabolite/Analog (4)

P-glycoprotein (2)

P2X Receptor (2)

P2Y Receptor (1)

p38 MAPK (2)

Parasite (3)

PARP (2)

Phosphodiesterase (PDE) (2)

PI3K (2)

Potassium Channel (2)

Pyroptosis (14)

Reactive Oxygen Species (ROS) (19)

Reference Standards (20)

Reverse Transcriptase (4)

Sirtuin (2)

Sodium Channel (4)

Tau Protein (1)

TGF-beta/Smad (6)

TNF Receptor (3)

TREM receptor (2)

URAT1 (1)

γ-Glutamyl Transferase (GGT) (1)

By Research Areas:

Cancer (22)

Cardiovascular Disease (24)

Infection (13)

Inflammation/Immunology (91)

Metabolic Disease (17)

Neurological Disease (20)

111

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: FAP LAG-3 VISTA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139064

NPBA	Potassium Channel	Neurological Disease Inflammation/Immunology
NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, is a tandem pore domain weak inward rectifying K ⁺ channel (TWIK2) channel blocker. NPBA suppresses NLRP3 inflammasome activation in macrophages .

HY-149604

NLRP3-IN-21 1 Publications Verification	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-21 (compound L38) is a **NLRP3 inflammasome** inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly .

HY-168009

NLRP3-IN-45	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-45 (D6) is an inhibitor of *NLRP3* inflammasome activation, inhibiting the activity of IL-1β (IC₅₀=41.79 nM). NLRP3-IN-45 exerts its effects without affecting the initial stage of *NLRP3* inflammasome activation. NLRP3-IN-45 specifically inhibits the activation of *NLRP3* inflammasome in the LPS-induced acute lung injury (ALI) mouse model .

HY-157147

NLRP3-IN-24	TNF Receptor Interleukin Related	Inflammation/Immunology
NLRP3-IN-24 (Compounds 15a) is an inhibitor against *NLRP3. NLRP3-IN-24 has an inhibitory effect on the activation* of NLRP3 inflammasome .

HY-161669

NLRP3-IN-40	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-40 (compound 32) is an inhibitor of the inflammasome NLRP3, which blocks NLRP3 activation induced by multiple agonists without altering NLRC4 or AIM2 inflammasomes .

HY-163497

NLRP3-IN-38	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
NLRP3-IN-38 (Compound 18) is an inhibitor for NOD-like receptor protein 3 (NLRP3), that inhibits NLRP3 inflammasome activation with an EC₅₀ of 23 nM .

HY-163695

NLRP3-IN-41	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-41 (compd S-9) is an orally active and brain-penetrant *NLRP3* inhibitor with anti-inflammatory activities, anti-neuroinflammatory effect and without obvious cytotoxicity. NLRP3-IN-41 inhibits the priming and activation stages of the NLRP3 inflammasome and can be used for inflammasome-related diseases research .

HY-162901

NLRP3-IN-48	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-48 is an *NLRP3* inhibitor. NLRP3-IN-48 targets the NLRP3 protein, affecting the assembly of the NLRP3 inflammasome and thereby inhibiting its activation. NLRP3-IN-48 has anti-inflammatory activity in a mouse model of acute colitis induced by DSS .

HY-170233

NLRP3-IN-75	NOD-like Receptor (NLR) Interleukin Related NF-κB	Inflammation/Immunology
NLRP3-IN-75 is an orally active *NLRP3* inhibitor. NLRP3-IN-75 suppresses IL-1β secretion (IC₅₀ = 23 nM). NLRP3-IN-75 selectively inhibits *NLRP3* activation by disrupting inflammasome assembly without affecting NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 exhibits superior efficacy in acute peritonitis, diabetic kidney disease and IBD models .

HY-163756

NLRP3-IN-43	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-43 (compound II-8) is a poteny inhibitor of *NLRP3* inflammasome activation that binds to the LRR domain, and disrupts *NLRP3-NEK7* interaction .

HY-169227

NLRP3-IN-55	Pyroptosis NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-55 (Compound 19) is a potent *NLRP3* inhibitor (IC₅₀ = 0.34 μM). NLRP3-IN-55 directly targets the NLRP3 protein (K_D = 0.45 μM), blocking the assembly and activation of the NLRP3 inflammasome, leading to anti-inflammatory effects and inhibition of cellular pyroptosis .

HY-103666

CY-09 35+ Cited Publications	NOD-like Receptor (NLR)	Inflammation/Immunology
CY-09 is a selective and direct *NLRP3* inhibitor. CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of **NLRP3 inflammasome** assembly and activation .

HY-171589

NLRP3-IN-77	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology Cancer
NLRP3-IN-77 (Compound 7n) is a potent **NLRP3 inflammasome** inhibitor. NLRP3-IN-77 inhibits the viability of THP-1 cells with an IC₅₀ value of 5.36 nM. NLRP3-IN-77 can effectively reduce the secretion of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3-IN-77 is promising for research of diseases related to the abnormal activation of the NLRP3 inflammasome, such as cancer and inflammatory diseases .

HY-172102

NLRP3-IN-68	NO Synthase NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-68 (Compound 2d) is a 1,3,4-oxadiazole derivative. NLRP3-IN-68 has strong anti-inflammatory and antioxidant activities, which can inhibit inflammatory cytokines secretion, iNOS expression and *NLRP3* inflammasome activation. NLRP3-IN-68 can be used in the research of anti-inflammatory drugs .

HY-168561

NLRP3-IN-58	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of **NLRP3 inflammasome with an IC₅₀** of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM .

HY-163358

SLC3037 1 Publications Verification	NOD-like Receptor (NLR) NEKs	Cardiovascular Disease Neurological Disease Inflammation/Immunology
SLC3037 is a *NLRP3* inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. SLC3037 can be used for research of gout, cardiovascular diseases, metabolic syndrome or neurodegenerative diseases .

HY-159718

NLRP3-IN-46	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-46 (Compound 3k) activates neuro-immunomodulatory cholinergic anti-inflammatory pathway, and thus inhibits *NLRP3* inflammasome activation. NLRP3-IN-46 inhibits Uric acid sodium (HY-B2130A)-induced IL-1β production in THP-1 cells, and can be used in gouty arthritis research .

HY-170218

NLRP3-IN-76	NOD-like Receptor (NLR) Interleukin Related NF-κB NO Synthase	Inflammation/Immunology
NLRP3-IN-76 is an orally active *NLRP3* inhibitor. NLRP3-IN-76 inhibits the production of NO, and the mRNA levels of proinflammatory cytokines (iNOS, IL-6, IL-1β and TNFα). NLRP3-IN-76 shows anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and NF-κB signaling pathway. NLRP3-IN-76 ameliorates DSS (HY-116282C)-induced colitis and can be used for research of inflammatory bowel diseases (IBD) .

HY-174312

NLRP3-IN-81	NOD-like Receptor (NLR) Pyroptosis Caspase Interleukin Related	Inflammation/Immunology
NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against *NLRP3* inflammasome-dependent pyroptosis with an EC₅₀ of 0.029 μM against cell pyroptosis induced by Nigericin (HY-127019). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes .

HY-168089

NLRP3-IN-49	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-49 (compound Z48) is a potent and specific *NLRP3* inhibitor (IC₅₀=0.26 μM in THP-1 cells, IC₅₀=0.21 μM in mouse bone marrow macrophages). NLRP3-IN-49 can directly bind to *NLRP3* protein (K_d=1.05 μM), effectively preventing the assembly and activation of *NLRP3* inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 can be used in the study of inflammatory bowel disease .

HY-131040

NLRP3-IN-NBC6	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-NBC6 is a potent, selective **NLRP3 inflammasome inhibitor (IC₅₀*= 574 nM) that acts independently of Ca ²⁺. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome* activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) .

HY-157554

ZM640	NOD-like Receptor (NLR)	Inflammation/Immunology
ZM640 is a *NLRP3* inhibitor. ZM640 enhances IL-1β release mediated by NLRP3 inflammasome activation in THP-1 cells. ZM640 shows low cytotoxicity .

HY-N9921

Antcin A	Pyroptosis NOD-like Receptor (NLR)	Inflammation/Immunology
Antcin A is a potent *NLRP3* inhibitor that inhibits the assembly and activation of the *NLRP3* inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease .

HY-172778

HNW005	NOD-like Receptor (NLR) URAT1	Metabolic Disease Inflammation/Immunology
HNW005 is a dual inhibitor of *NLRP3* inflammasome and urate transporter 1 (URAT1). It has a K_D value of 204.6 nM and an IC₅₀ of 1.7 μM for inhibiting NLRP3 inflammasome activation, and an IC₅₀ of 6.4 μM for inhibiting uric acid transmembrane transport. When administered at a dose of 2 mg/kg in vivo, HNW005 can achieve a uric acid reduction rate of 64.8%. It can exert anti - inflammatory, analgesic, and uric acid - lowering activities by inhibiting the activation of *NLRP3* inflammasome and uric acid transmembrane transport. HNW005 can be used in the research of gouty arthritis .

HY-170836

NLRP3-IN-69	NOD-like Receptor (NLR) NF-κB NO Synthase COX Interleukin Related	Inflammation/Immunology
NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κB p65 and the formation of **NLRP3 inflammasome*. NLRP3-IN-69 inhibits LPS (HY-D1056)-induced overexpression of IL-1β, iNOS and COX-2, inhibits NO generation (IC₅₀*=5.66 μM), thereby exhibiting anti-inflammatory activity .

HY-W158030

2-Guanidinobezimidazole 2GBI	NOD-like Receptor (NLR)	Cancer
2-Guanidinobezimidazole is a selective agonist of *NLRP3, with a K_D* value of 1.29 μM to His-GFP-NLRP3. 2-Guanidinobezimidazole binds directly to the LRR domain of NLRP3, promoting inflammasome assembly and activation. 2-Guanidinobezimidazole promotes anti-tumor immunity, inhibits tumor growth, and overcome immune checkpoint blockade (ICB) resistance .

HY-158093

NIC-12	NOD-like Receptor (NLR)	Inflammation/Immunology
NIC-12 is a potent *NLRP3* inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages .

HY-161329

NLRP3-IN-32	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) NF-κB IKK	Inflammation/Immunology
NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential *NLRP3* inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65 and the nuclear translocation of p65, thereby inhibiting NF-κB signaling .

HY-N10359

Isoandrographolide	NOD-like Receptor (NLR)	Inflammation/Immunology
Isoandrographolide possesses cell differentiation inducing and hepatoprotective effect. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice .

HY-162877

AZD4144	NOD-like Receptor (NLR) Interleukin Related Potassium Channel	Inflammation/Immunology
AZD4144 is an orally active *NLRP3* inhibitor (EC₅₀: 0.082 μM). AZD4144 effectively inhibits the release of IL-1β when NLRP3 is overactivated, exerting an anti-inflammatory effect. AZD4144 has low inhibitory effect on hERG and low cardiotoxicity. AZD4144 has the potential to study diseases and conditions associated with NLRP3 inflammasome activation .

HY-173555

HDAC6-IN-54	HDAC NOD-like Receptor (NLR)	Inflammation/Immunology
HDAC6-IN-54 (Compound 9m) is a highly selective HDAC6 (histone deacetylase 6) inhibitor with an IC₅₀ value of 0.021 μM. HDAC6-IN-54 blocks the activation of the NLRP3 inflammasome, which alleviates symptoms of NLRP3 inflammasome-related diseases such as acute peritonitis, inflammatory bowel disease, and psoriasis .

HY-158024A

(S)-NDT-19795	NOD-like Receptor (NLR)	Cardiovascular Disease Others Neurological Disease Metabolic Disease Inflammation/Immunology
(S)-NDT-19795 is a potent *NLRP3* inflammasome inhibitor. (S)-NDT-19795 blocks *NLRP3* activation by inhibiting *NLRP3* ATPase activity, thereby reducing the levels of pro-inflammatory cytokines IL-1β and IL-18. (S)-NDT-19795 can be used in the study of neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and autoimmune diseases .

HY-162150

Azalamellarin N 1 Publications Verification AZL-N	Pyroptosis	Inflammation/Immunology
Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of *NLRP3* inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. Inhibitory potency against different pyroptosis inducers: Nigericin (HY-127019) > R837 (HY-B0180) .

HY-107541

O-1602 2 Publications Verification	GPR55	Neurological Disease
O-1602 is an agonist of GPR55 (G protein-coupled receptor 55). O-1602 reduces the number and activation of hippocampal microglia induced by METH (methamphetamine). O-1602 decreases the expression levels of NLRP3 inflammasome proteins, including NLRP3, ASC and Caspase-1 .

HY-111662

Fc 11a-2	NOD-like Receptor (NLR)	Inflammation/Immunology
Fc 11a-2, a benzimidazole compound, is an orally active and potent **NLRP3 inflammasome** inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis .

HY-N0218

Benzoylmesaconine 1 Publications Verification Mesaconine 14-benzoate	NF-κB Interleukin Related	Inflammation/Immunology
Benzoylmesaconine is a monoester-type alkaloid and is the most abundant component of Wutou decoction, which is widely used in China for rheumatoid arthritis. Benzoylmesaconine exhibits potent anti-inflammatory properties by inhibiting NF-κB. Benzoylmesaconine can suppress *NLRP3* inflammasome activation by inhibiting IL-1β secretion and GSDMD-N protein expression. Benzoylmesaconine reduces intracellular K ⁺ efflux and disrupts NLRP3 inflammasome assembly .

HY-N12941

Macarangin	Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)	Inflammation/Immunology
Macarangin can be isolated from propolis. Macarangin has DPPH radical-scavenging activity and shows anti-inflammatory activities via inhibiting the activation process of *NLRP3* inflammasome .

HY-148258

GDC-2394	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
GDC-2394 is an orally active and selective *NLRP3* inhibitor, and also inhibits IL-1β with IC₅₀s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation .

HY-120920

UNC9995	Dopamine Receptor	Inflammation/Immunology
UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing *β-arrestin2-NLRP3* interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions .

HY-107541R

O-1602 (Standard)	GPR55 Reference Standards	Neurological Disease
O-1602 (Standard) is the analytical standard of O-1602. This product is intended for research and analytical applications. O-1602 is an agonist of GPR55 (G protein-coupled receptor 55). O-1602 reduces the number and activation of hippocampal microglia induced by METH (methamphetamine). O-1602 decreases the expression levels of NLRP3 inflammasome proteins, including NLRP3, ASC and Caspase-1 .

HY-N3005

Britannin 1 Publications Verification	Apoptosis Autophagy NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology Cancer
Britannin is an *NLRP3* inhibitor with an IC₅₀ of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the *NLRP3* inflammasome by blocking the interaction between *NLRP3* and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics .

HY-132831

Selnoflast 1 Publications Verification Somalix; RO-7486967; IZD334	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Selnoflast (RO7486967), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule *NLRP3* inflammasome inhibitor. Selnoflast is a potent inhibitor of IL-1β release stimulated by *NLRP3* activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease .

HY-132831B

Selnoflast potassium Somalix potassium; RO-7486967 potassium; IZD334 potassium	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Selnoflast potassium (RO7486967 potassium), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule *NLRP3* inflammasome inhibitor. Selnoflast potassium is a potent inhibitor of IL-1β release stimulated by *NLRP3* activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast potassium is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease .

HY-117532

PenCB PCB 118	Pyroptosis	Cancer
PenCB (PCB 118) could induces pyroptosis by priming and activating NFκB-dependent NLRP3 inflammasome. PCB 118 induces oxidative stress and pyroptosis are dependent on Aryl hydrocarbon receptor (AhR) activation and subsequent cytochrome P450 1A1 upregulation .

HY-P2776

Hexokinase, microorganism	Endogenous Metabolite	Metabolic Disease
Hexokinase (ScHEX1) (EC 2.7.1.1) is a glycolytic enzyme hexokinase that is inhibited by n-acetylglucosamine. Inhibition of Hexokinase (ScHEX1) by n-acetylglucosamine leads to its separation from the mitochondrial outer membrane, resulting in activation of NLRP3 inflammasome .

HY-173154

NK7-902	Molecular Glues NEKs	Inflammation/Immunology
NK7-902 is a CRBN molecular glue degrader of NEK7. NK7-902 fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 shows activity in murine systems .

HY-132831A

Selnoflast calcium Somalix calcium; RO-7486967 calcium; IZD334 calcium	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Selnoflast calcium (RO7486967 calcium), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule *NLRP3* inflammasome inhibitor. Selnoflast calcium is a potent inhibitor of IL-1β release stimulated by *NLRP3* activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast calcium is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease .

HY-100581

CORM-3 2 Publications Verification	NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces *NLRP3* inflammasome activation .

HY-B0004

Doxofylline	Adenosine Receptor Phosphodiesterase (PDE) Reactive Oxygen Species (ROS)	Inflammation/Immunology
Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm .

HY-16059

Arglabin (+)-Arglabin	NOD-like Receptor (NLR) Farnesyl Transferase Autophagy	Inflammation/Immunology Cancer
Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a **NLRP3 inflammasome** inhibitor. Arglabin shows anti-inflammatory and antitumor activities . The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene .

Cat. No.	Product Name

HY-L175

Inflammasomes related Compound Library

112 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 112 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Type

HY-16569B

Colchicine,suitable for plant cell culture

Cell Assay Reagents

Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture .

Cat. No.	Product Name	Target	Research Area

HY-P3211

Nangibotide 3 Publications Verification LR12	TREM receptor NF-κB NOD-like Receptor (NLR) Interleukin Related Apoptosis	Cardiovascular Disease Inflammation/Immunology
Nangibotide (LR12) is a synthetic peptide and TREM-1 receptor inhibitor. Nangibotide inhibits NF-κB and *NLRP3* inflammasome activation and reduces the release of pro-inflammatory factors (such as IL-1β, IL-8). Nangibotide inhibits Apoptosis. Nangibotide reduces excessive inflammatory responses and protects tissues (liver, lung) from damage. Nangibotide can be used in the researches for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure .

HY-P3211A

Nangibotide TFA 3 Publications Verification LR12 TFA	TREM receptor NF-κB NOD-like Receptor (NLR) Interleukin Related Apoptosis	Cardiovascular Disease Inflammation/Immunology
Nangibotide TFA (LR12 TFA) is a synthetic peptide and TREM-1 receptor inhibitor. Nangibotide TFA inhibits NF-κB and *NLRP3* inflammasome activation and reduces the release of pro-inflammatory factors (such as IL-1β, IL-8). Nangibotide TFA inhibits Apoptosis. Nangibotide TFA reduces excessive inflammatory responses and protects tissues (liver, lung) from damage. Nangibotide TFA can be used in the researches for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0218

Benzoylmesaconine 1 Publications Verification Mesaconine 14-benzoate	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Ranunculaceae Source classification Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	NF-κB Interleukin Related
Benzoylmesaconine is a monoester-type alkaloid and is the most abundant component of Wutou decoction, which is widely used in China for rheumatoid arthritis. Benzoylmesaconine exhibits potent anti-inflammatory properties by inhibiting NF-κB. Benzoylmesaconine can suppress *NLRP3* inflammasome activation by inhibiting IL-1β secretion and GSDMD-N protein expression. Benzoylmesaconine reduces intracellular K ⁺ efflux and disrupts NLRP3 inflammasome assembly .

HY-N3005

Britannin 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy NOD-like Receptor (NLR) Pyroptosis
Britannin is an *NLRP3* inhibitor with an IC₅₀ of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the *NLRP3* inflammasome by blocking the interaction between *NLRP3* and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics .

HY-16059

Arglabin (+)-Arglabin	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Apios americana Medik. Plants Compositae Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR) Farnesyl Transferase Autophagy
Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a **NLRP3 inflammasome** inhibitor. Arglabin shows anti-inflammatory and antitumor activities . The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene .

HY-N6051

(-)-Maackiain	Infection Structural Classification Monophenols Classification of Application Fields Leguminosae Terpenoids Source classification Phenols Diterpenoids Sophora flavescens Aiton Plants Disease Research Fields	Fungal NOD-like Receptor (NLR) NF-κB
(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .

HY-N6712

Thiolutin 3 Publications Verification Acetopyrrothin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics	Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)
Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the **NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome** activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC) ^{[1][2][3][4][5]}.

HY-N2485

4'-Methoxyresveratrol 1 Publications Verification 4'-O-Methylresveratrol	Structural Classification Stilbenes Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	NF-κB NOD-like Receptor (NLR)
4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation .

HY-N2157

Pteryxin 1 Publications Verification (+)-Pteryxin	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Plants Achillea atrata L.	Cholinesterase (ChE) NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS) Nuclear Factor of activated T Cells (NFAT) p38 MAPK
Pteryxin ((+)-Pteryxin) is an orally active multi-target inhibitor that targets NF-κB, MAPK, *NLRP3* inflammasome, and Nrf2/ARE pathways. Pteryxin is also a BChE inhibitor (IC₅₀=12.96 μg/mL) with a low inhibitory efficiency on AChE. Pteryxin inhibits the Ca ²⁺-calcineurin-NFATc1 pathway by blocking NF-κB/MAPK signaling, inhibiting NLRP3 inflammasome activation, and reducing ROS generation, and activates Nrf2-mediated antioxidant enzyme expression. Pteryxin has anti-inflammatory, antioxidant, and osteoclastogenesis inhibitory activities. Pteryxin can be used in the study of inflammatory diseases, osteoporosis, diabetes, and Alzheimer's disease .

HY-N9921

Antcin A	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Pyroptosis NOD-like Receptor (NLR)
Antcin A is a potent *NLRP3* inhibitor that inhibits the assembly and activation of the *NLRP3* inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease .

HY-N10359

Isoandrographolide	Andrographis paniculata (Burm. F.) Nees Classification of Application Fields Acanthaceae Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology	NOD-like Receptor (NLR)
Isoandrographolide possesses cell differentiation inducing and hepatoprotective effect. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice .

HY-N12941

Macarangin	Structural Classification Flavonols Flavonoids Animals Source classification	Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)
Macarangin can be isolated from propolis. Macarangin has DPPH radical-scavenging activity and shows anti-inflammatory activities via inhibiting the activation process of *NLRP3* inflammasome .

HY-N0696

Sipeimine 2 Publications Verification Imperialine	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Classification of Application Fields Source classification Other Diseases Fritillaria ussuriensis Maxim. Plants Disease Research Fields	PI3K NF-κB Akt NOD-like Receptor (NLR) Pyroptosis Ferroptosis
Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and *NLRP3* inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .

HY-N0633

Muscone 3 Publications Verification	Cardiovascular Disease Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	P-glycoprotein Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and *NLRP3* inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate .

HY-N0496

Ruscogenin 5 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Cardiovascular Disease Structural Classification Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids	NOD-like Receptor (NLR)
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .

HY-N6712R

Thiolutin (Standard) Acetopyrrothin (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Reference Standards Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)
Thromycin (Standard) is the analytical standard of thromycin (HY-N6712). Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the **NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome** activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC) ^{[1][2][3][4][5]}.

HY-116084

Trimethylamine N-oxide 5 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Microorganisms Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-113224

Desmosterol 5 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite LXR Fatty Acid Synthase (FASN) Interleukin Related Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)
Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism . Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of *NLRP3*. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases .

HY-108915

Trimethylamine N-oxide dihydrate 5 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-N6051R

(-)-Maackiain (Standard)	Structural Classification Monophenols Leguminosae Terpenoids Source classification Phenols Diterpenoids Sophora flavescens Aiton Plants	Reference Standards Fungal NOD-like Receptor (NLR) NF-κB
(-)-Maackiain (Standard) is the analytical standard of (-)-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .

HY-N0806

Sweroside 1 Publications Verification	Filago spathulata Presl. Structural Classification Monophenols Classification of Application Fields Labiatae Phenols Metabolic Disease Plants Disease Research Fields	Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP
Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, *NLRP3* inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .

HY-N0696R

Sipeimine (Standard) Imperialine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Liliaceae Source classification Fritillaria ussuriensis Maxim. Plants	Reference Standards PI3K NF-κB Akt NOD-like Receptor (NLR) Pyroptosis Ferroptosis
Sipeimine (Standard) is the analytical standard of Sipeimine (HY-N0696R). Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and *NLRP3* inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .

HY-N0496R

Ruscogenin (Standard)	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Source classification Plants Steroids	Reference Standards NOD-like Receptor (NLR)
Ruscogenin (Standard) is the analytical standard of Ruscogenin. This product is intended for research and analytical applications. Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .

HY-N0633R

Muscone (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	P-glycoprotein Reference Standards Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)
Muscone (Standard) is the analytical standard of Muscone. This product is intended for research and analytical applications. Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate .

HY-N2485R

4'-Methoxyresveratrol (Standard) 4'-O-Methylresveratrol (Standard)	Structural Classification Stilbenes Rheum palmatum L. Polygonaceae Source classification Phenols Polyphenols Plants	Reference Standards NF-κB NOD-like Receptor (NLR)
4'-Methoxyresveratrol (Standard) is the analytical standard of 4'-Methoxyresveratrol. This product is intended for research and analytical applications. 4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation .

HY-N0408

Picroside II 1 Publications Verification	Infection Structural Classification Iridoids Neurological Disease Classification of Application Fields Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	NF-κB Reactive Oxygen Species (ROS) Apoptosis Influenza Virus
Picroside II is an antioxidant with oral activity that can reduce the production of ROS and protect the blood-brain barrier (BBB) after CI/R injury, offering neuroprotective effects. Picroside II has antioxidant, immune-regulating, antiviral properties, and inhibits apoptosis. Picroside II alleviates the inflammatory response in sepsis by suppressing the activation of the *NLRP3* inflammasome and NF-κB pathways .

HY-113224R

Desmosterol (Standard)	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Endogenous metabolite Steroids	Reference Standards Endogenous Metabolite LXR Fatty Acid Synthase (FASN) Interleukin Related Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)
Desmosterol (Standard) is the analytical standard of Desmosterol. This product is intended for research and analytical applications. Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1][2][3].

HY-N0806R

Sweroside (Standard)	Filago spathulata Presl. Structural Classification Monophenols Labiatae Phenols Plants	Reference Standards Keap1-Nrf2 AMPK Sirtuin NF-κB NOD-like Receptor (NLR) Pyroptosis Apoptosis Autophagy PARP
Sweroside (Standard) is the analytical standard of Sweroside (HY-N0806). This product is intended for research and analytical applications. Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, *NLRP3* inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields .

HY-113298

Citraconic acid 2 Publications Verification Methylmaleic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)
Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the *NLRP3* inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .

HY-116084R

Trimethylamine N-oxide (Standard)	Structural Classification Natural Products Microorganisms Other disease Source classification Disease markers Endogenous metabolite Cancer	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide (Standard) is the analytical standard of Trimethylamine N-oxide. This product is intended for research and analytical applications. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-N0671

Rhapontin 2 Publications Verification Rhaponiticin	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and AMPK activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits *NLRP3* inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

HY-101092

QS-21 5 Publications Verification Stimulon	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the *NLRP3* inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

HY-108915R

Trimethylamine N-oxide dihydrate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide (dihydrate) (Standard) is the analytical standard of Trimethylamine N-oxide (dihydrate). This product is intended for research and analytical applications. Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-113298R

Citraconic acid (Standard) Methylmaleic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)
Citraconic acid (Methylmaleic acid) (Standard) is the analytical standard of Citraconic acid (HY-113298). This product is intended for research and analytical applications. Citraconic acid is an orally active inhibitor targeting the *NLRP3* inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .

HY-16569

Colchicine Maximum Cited Publications 44 Publications Verification	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the *NLRP3* inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-W016586R

Acivicin (Standard) AT-125 (Standard); U-42126 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Reference Standards Parasite γ-Glutamyl Transferase (GGT)
Articaine (Standard) is the analytical standard of Articaine. This product is intended for research and analytical applications. Articaine (Hoe-045 free base) is an amide agent that can suppress or relieve pain. containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway .

HY-N0671R

Rhapontin (Standard) 2 Publications Verification Rhaponiticin (Standard)	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Plants Disease Research Fields Cancer	Reference Standards Apoptosis
Rhapontin (Standard) is the analytical standard of Rhapontin (HY-N0671). This product is intended for research and analytical applications. Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and AMPK activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits *NLRP3* inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis .

HY-N0194

Asiatic acid 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	Apoptosis Parasite
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-W019670

N4-Acetylcytidine 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Histone Acetyltransferase Enterovirus NOD-like Receptor (NLR)
N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain *NLRP3* inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity .

HY-16569R

Colchicine (Standard)	Structural Classification Natural Products other families Source classification Plants	Reference Standards Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-N0194R

Asiatic acid (Standard)	Triterpenes Structural Classification Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants	Reference Standards Apoptosis Parasite
Asiatic acid (Standard) is the analytical standard of Asiatic acid. This product is intended for research and analytical applications. Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-N0408R

Picroside II (Standard)	Structural Classification Iridoids Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell	Reference Standards NF-κB Reactive Oxygen Species (ROS) Apoptosis Influenza Virus
Picroside II (Standard) is the analytical standard of Picroside II. This product is intended for research and analytical applications. Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways . Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities .

HY-B2176R

ATP (Standard) Adenosine 5'-triphosphate (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Reference Standards Endogenous Metabolite
ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation . In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs . ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner . ATP promotes neutrophil chemotaxis in vitro . In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo . ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo .

Cat. No.	Product Name	Chemical Structure

HY-116084S

Trimethylamine N-oxide-d9

1 Publications Verification

Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-W753593

N4-Acetylcytidine-13C5

N4-Acetylcytidine- ¹³C₅ is the ¹³C-labeled N4-Acetylcytidine (HY-W019670). N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity .

HY-116084S1

Trimethylamine-N-oxide-13C3

Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-W722562

Trimethylamine oxide-15N

Trimethylamine oxide- ¹⁵N is the deuterium labeled Trimethylamine N-oxide (HY-116084). Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-B0116S

Stavudine-d4
Stavudine-d₄ is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis .

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