Search Result
Results for "
Malic acid
" in MedChemExpress (MCE) Product Catalog:
10
Biochemical Assay Reagents
9
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-Y1311
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Hydroxybutanedioic acid; E 296
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Endogenous Metabolite
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Others
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Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that occurs naturally in fruits like apples and pears with oral activities. Malic acid plays a role in many sour or tangy foods. Malic acid is an intermediate in the citric acid cycle .
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- HY-Y1311R
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Hydroxybutanedioic acid (Standard); E 296 (Standard)
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Reference Standards
Endogenous Metabolite
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Others
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Malic acid (Standard) is the analytical standard of Malic acid. This product is intended for research and analytical applications. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.
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- HY-W250303A
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Hydroxybutanedioic acid disodium hydrate; Disodium DL-malate hydrate; E 296 disodium hydrate
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Biochemical Assay Reagents
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Others
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Malic acid disodium hydrate is an organic compound that is commonly used as a food additive, buffering agent, and nutritional supplement. It contains sodium and malic acid. Malic acid disodium hydrate has a variety of properties that make it suitable for these applications, including the ability to enhance food flavor, improve texture, and regulate acidity. In addition, due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance, Malic acid disodium hydrate can be used as a dietary supplement .
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- HY-Y1311S
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Hydroxybutanedioic acid-d3; E 296-d3
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Endogenous Metabolite
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Others
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Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods .
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- HY-W250303
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Hydroxybutanedioic acid disodium salt; E 296 disodium salt
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Biochemical Assay Reagents
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Others
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Sodium DL-Malate is an organic compound commonly used as a food additive, buffer and nutritional supplement. It contains sodium and malic acid. Malic acid disodium salt has several properties suitable for these applications, including the ability to enhance food flavor, improve texture and regulate acidity. Additionally, it can be used as a dietary supplement due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance.
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- HY-20558
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- HY-20558R
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D-Malic acid (Standard)
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Reference Standards
Endogenous Metabolite
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Metabolic Disease
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D-(+)-Malic acid (Standard) is the analytical standard of D-(+)-Malic acid. This product is intended for research and analytical applications. D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .
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- HY-N3328
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Others
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Others
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Malic acid 4-Me ester is a Miscellaneous product that can be isolated from the herbs of Saccharum sinense .
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- HY-Y1311G
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Hydroxybutanedioic acid; E 296
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Endogenous Metabolite
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Others
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Malic acid (GMP) is Malic acid (HY-Y1311) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that occurs naturally in fruits like apples and pears with oral activities. Malic acid plays a role in many sour or tangy foods. Malic acid is an intermediate in the citric acid cycle .
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- HY-W747213
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Malic acid, 3-METHYL-, DIETHYL ESTER-13C
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Isotope-Labeled Compounds
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Others
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Diethyl 2-hydroxy-3-methylsuccinate- 13C (MALIC ACID, 3-METHYL-, DIETHYL ESTER- 13C) is the 13C-labeled Diethyl 2-hydroxy-3-methylsuccinate (HY-W502469).
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- HY-16743A
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Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)
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Glucosylceramide Synthase (GCS)
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Metabolic Disease
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Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .
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- HY-N13713
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Others
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Others
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Benzoyl (S)-(-)-malic acid is a benzoyl malate ester compound that can be found in Medicago sativa .
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- HY-124861
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- HY-Y1069
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(S)-Hydroxybutanedioic acid; (S)-E 296; L-Malic acid
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Endogenous Metabolite
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Metabolic Disease
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(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
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- HY-Y1069R
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(S)-Hydroxybutanedioic acid (Standard); (S)-E 296 (Standard); L-Malic acid (Standard)
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Reference Standards
Endogenous Metabolite
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Metabolic Disease
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(S)-Malic acid (Standard) is the analytical standard of (S)-Malic acid. This product is intended for research and analytical applications. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
In Vitro: It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L. casei. Furthermore, deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid, thus indicating that the cognate TC system regulates and is essential for the expression of ME. Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose, whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose .
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- HY-Y1069S
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(S)-Hydroxybutanedioic acid-d3; (S)-E 296-d3; L-Malic acid-d3
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Endogenous Metabolite
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Metabolic Disease
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(S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive .
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- HY-Y1069S3
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(S)-Hydroxybutanedioic acid-13C4; (S)-E 296-13C4; L-Malic acid-13C4
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Isotope-Labeled Compounds
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Others
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(S)-Malic acid- 13C4 is the 13C labeled S-Malic acid (HY-Y1069) .
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- HY-59354S
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DNA/RNA Synthesis
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Cancer
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Maleic hydrazide-d2 is the deuterium labeled Maleic hydrazide . Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
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- HY-Y0367S
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Maleic-2,3-d2 acid
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Bacterial
Endogenous Metabolite
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Infection
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Maleic Acid-d2 is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .
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- HY-59354R
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Reference Standards
DNA/RNA Synthesis
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Cancer
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Maleic hydrazide (Standard) is the analytical standard of Maleic hydrazide. This product is intended for research and analytical applications. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
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- HY-128900
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Endogenous Metabolite
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Others
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11-cis-Vaccenyl acetate is male-specific lipid that mediates aggregation behavior in both male and female flies, which activates a few dozen olfactory neurons located in T1 sensilla on the antenna of both male and female flies .
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- HY-59354
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DNA/RNA Synthesis
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Cancer
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Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
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- HY-Y0367R
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Reference Standards
Endogenous Metabolite
Bacterial
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Infection
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Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
IC50 & Target: GAD .
In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .
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- HY-W673589
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2-Me-C26
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Insecticide
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Infection
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2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone. It has been found in the cuticle of M. dasystomus females, but not males, where it contributes to the mating behavior of males, as well as in D. melanogaster females where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.
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- HY-15284B
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PCR 4099 (Maleic acid)
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P2Y Receptor
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Cardiovascular Disease
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Prasugrel (PCR 4099) Maleic acid is a thienopyridine and proagent, inhibits platelet function. Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .
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- HY-P2809
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MDH; EC 1.1.1.37
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Endogenous Metabolite
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Metabolic Disease
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Malate dehydrogenase (EC 1.1.1.37) (MDH) catalyzes the mutual conversion of oxaloacetate and malate, and is associated with the oxidation/reduction of dinucleotide coenzymes .
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- HY-W004338
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- HY-116047
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p-Methoxybenzylacetone
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Others
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Others
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Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant .
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- HY-Y0367
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- HY-59354S1
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1,2-Dihydro-3,6-pyridazine-13C4-dione; 3,6-Dihydroxypyridazine-13C4; 3,6-Pyridazine-13C4-diol; Maleic hydrazide-13C4
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Isotope-Labeled Compounds
DNA/RNA Synthesis
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Cancer
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1,2-Dihydropyridazine-3,6-dione-3,4,5,6- 13C4 (1,2-Dihydro-3,6-pyridazine- 13C4-dione) is 13C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
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- HY-P5719
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Bacterial
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Infection
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Andropin is a male-specific antibacterial peptide that can be found in Drosophila melanogaster .
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- HY-116948
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Drug Derivative
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Cancer
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Azo-mustard is a nitrogen mustard derivative with mutagenic effects in Drosophila melanogaster males .
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- HY-W014885
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Sex Pheromone
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Endocrinology
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Decyl acetate is a synthetic pheromone attracting male false codling moths (Cryptophlebia leucotreta) .
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- HY-W749562
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- HY-W040313
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- HY-N6977
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Others
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Infection
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Ascr#3 is a type of pheromone found in the beautiful nematode, and when mixed with ascr#2, it can act as a male attractant and also induce the formation of dauer (the dormant larval stage). Ascr#3 can counteract the effects caused by male-enriched Ascr#10 .
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- HY-W243653
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- HY-W780813
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- HY-W780803
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Parasite
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Endocrinology
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(Z,E)-9,12-Tetradecadienol is a synthetic enhancer of male Ephestia cautella attraction .
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- HY-N12936
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Others
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Endocrinology
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(Z)-5-Tetradecenyl acetate is a sex pheromone for male mottled rustic moths (Euxoa tessellata (Harris)) .
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- HY-W127723
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Biochemical Assay Reagents
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Others
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Fluoresceinamine Maleic Acid Monoamide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-18996
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- HY-W780808
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- HY-W780790
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Sex Pheromone
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Others
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(Z,Z)-3,13-Octadecadienyl acetate is a compound that can be isolated from the pheromone gland extracts of female S. bicingulata moths. (Z,Z)-3,13-Octadecadienyl acetate is essential for attraction of male S. bicingulata moths. (Z,Z)-3,13-Octadecadienyl acetate can be used as bait to trap male moths .
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- HY-W587916
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- HY-101812
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Others
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Metabolic Disease
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Terbufibrol has been shown highly active in reducing serum total cholesterol (TC) levels in the normal and hypercholesterolemic male rat.
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- HY-W745644
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Parasite
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Endocrinology
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(Z)-7-Hexadecenal is a sex pheromone that attracts male insects, isolated from female Heliothis virescens moths .
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- HY-113415
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- HY-W009688
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Drug Intermediate
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Inflammation/Immunology
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Dibutyl maleate, the diester of the Maleic Acid, can be used as an intermediate of pharmaceutical synthesis. Dibutyl maleate can enhance contact sensitization to Fluorescein isothiocyanate in mice .
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- HY-N12924
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Others
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Endocrinology
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Ethyl 3-octenoate is an insect sex pheromone capable of attracting male Mediterranean fruit flies (Ceratitis capitata Wied.) .
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- HY-W250305
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Biochemical Assay Reagents
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Others
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Calcium malate is an organic compound containing calcium and malic acid. It is commonly used as a dietary supplement to provide the body with calcium and malic acid, which are important for maintaining healthy bones, teeth and muscles. Calcium malate has several properties that make it suitable for these applications, including high solubility and bioavailability compared to other forms of calcium supplementation. Additionally, it is used as a food additive to enhance the acidity and flavor of certain products.
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- HY-116047R
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p-Methoxybenzylacetone (Standard)
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Others
Reference Standards
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Others
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Anisylacetone (Standard) is the analytical standard of Anisylacetone. This product is intended for research and analytical applications. Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant .
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- HY-N12895
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(Z,Z)-Gossyplure
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Others
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Endocrinology
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(Z)-7,11-Hexadecadienyl acetate is a female sex pheromone used to attract male insects, isolated from Plutella xylostella .
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- HY-N15312
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Sex Pheromone
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Others
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(4Z)-4-Nonenal is a sex pheromone found in Male Tropical West African Shield Bug, Sphaerocoris annulus .
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- HY-N7099
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Q-lure
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Insecticide
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Others
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Cue-lure (Q-lure) is a melon fly attractant. Cue-lure provides a short-term mating advantage to male Bactrocera cucurbitae .
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- HY-W780779
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Insecticide
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Endocrinology
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(Z)-12-Nonadecen-9-one is a sex pheromone attractive to male raspberry bud moths (Heterocrossa rubophaga) .
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- HY-116047S
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p-Methoxybenzylacetone-d5
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Isotope-Labeled Compounds
Others
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Others
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Anisylacetone-d5 (p-Methoxybenzylacetone-d5) is deuterium labeled Anisylacetone. Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant .
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- HY-W392258A
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Biochemical Assay Reagents
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Infection
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Poly(methyl vinyl ether-alt-maleic anhydride) (MW 1080000) can be used to prepare antibacterial hydrogels with good mechanical strength and excellent swelling ability .
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- HY-W392258
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Biochemical Assay Reagents
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Infection
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Poly(methyl vinyl ether-alt-maleic anhydride) (MW 216000) can be used to prepare antibacterial hydrogels with good mechanical strength and excellent swelling ability .
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- HY-139741
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DNA/RNA Synthesis
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Others
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cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc) provides an avenue for developing a nonhormonal male contraceptive by blocking of GRTH/DDX25 phosphorylation.
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- HY-W613915
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Sex Pheromone
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Endocrinology
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(±)-Ipsdienol is a sex pheromone with an inducing effect on male spruce beetles (Dendroctonus rufipennis Kirby), which can be isolated from the subspecies of spruce beetles (Ips tridens Mannerheim) .
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- HY-W751152
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GABA Receptor
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Cancer
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α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses .
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- HY-W674057
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Sex Pheromone
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Endocrinology
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(Z)-3-Dodecen-1-ol is an insect sex pheromone capable of attracting male sweet potato weevils (Cylas formicarius elegantulus) .
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- HY-137593A
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ε-NADP+ trisodium
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Drug Derivative
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Metabolic Disease
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N6-Etheno-nicotinamide dinucleotide phosphate (ε-NADP+) trisodium, a structural analogue of the NADP(+), is a maize malic enzyme inhibitor with a Ki of 1.01 μM .
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- HY-N6976
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Others
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Infection
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Ascr#8 is an dauer-inducing ascaroside isolated from Caenorhabditis elegans, synergizes with ascr#2 and ascr#3, and strongly enhances male attraction .
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- HY-W322222
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Sex Pheromone
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Endocrinology
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Ethyl (E,Z)-2,4-decadienoate is a pheromone that induces an electroshock response in male cold moths (Sensilla Auricillica) and can be isolated from host plants .
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- HY-113415A
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Endogenous Metabolite
Drug Metabolite
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Endocrinology
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Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. Testosterone is the main male sex hormone which determination is useful for assessment of androgen status .
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- HY-177141
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- HY-21196A
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Phosphatase
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Metabolic Disease
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Potassium perfluorohexanesulfonate is an orally active surfactant found in sera of the general population. Potassium perfluorohexanesulfonate induces adaptive hepatocellular hypertrophy, decreases serum cholesterol and increases alkaline phosphatase in male mice .
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- HY-N12889
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Others
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Others
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(E,Z)-4,6-Hexadecadien-1-ol is a insect sex pheromone, which is used to attract male pest Stathmopoda masinissa of persimmon trees .
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- HY-W583749
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Estrogen Receptor/ERR
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Endocrinology
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6:2 Cl-PFAES is reproductively toxic. 6:2 Cl-PFAES can cause elevated serum estradiol and vitellogenin levels in adult males and impair embryonic development in offspring .
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- HY-172299
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Melanocortin Receptor
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Endocrinology
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Delmadinone acetate is an orally active compound that can control estrus and ovulation in female and male pets. Delmadinone acetate causes adrenal suppression from inhibition of release of ACTH from the pituitary gland .
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- HY-24238
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Cytochrome P450
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Others
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DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6) that markedly reduces nicotine self-administration in both male and female mice.
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- HY-N12882
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Others
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Others
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(Z)-10-Hexadecen-1-ol is a insect sex pheromones, which can be secreted by some female nocturnal moths, or by the heads of male bumblebees (Bombus spp.) .
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- HY-18996R
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Chloride Channel
Mitochondrial Metabolism
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Cancer
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Adjudin (Standard) is the analytical standard of Adjudin. This product is intended for research and analytical applications. Adjudin is an extensively studied male contraceptive with a superior mitochondria-inhibitory effect. Adjudin is also a potent Cl- channel blocker.
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- HY-150621
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β-catenin
Wnt
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Cancer
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AS1134900 is a highly selective uncompetitive allosteric inhibitor of NADP +-dependent malic enzyme 1 (ME1) with an IC50 of 0.73 μM. AS1134900 can be used in the study of cancer .
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- HY-P10472
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GnRH Receptor
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Endocrinology
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Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .
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- HY-120989
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Endogenous Metabolite
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Metabolic Disease
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Methyl 7(Z)-hexadecenoate is a sex pheromone produced by Trogoderma glabrum. Methyl 7(Z)-hexadecenoate can elicit attractive and sexually excitatory responses in Trogoderma glabrum males .
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- HY-156280
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RAR/RXR
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Endocrinology
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RARα antagonist 1 (compound 21) is an orally active and selective retinoic acid receptor α(RARα) antagonist, with the IC50 of 4.6nM .
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- HY-123056A
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Autophagy
Apoptosis
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Others
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EAD1 TFA is an aluminum-activated malate transporter with activity in regulating corn ear development. EAD1 TFA is preferentially expressed in the xylem of immature ears and localized across the plasma membrane. The EAD1 TFA transports malic acid in the apical part of developing inflorescences, and its deletion results in reduced malic acid content in this part. The overexpression of EAD1 TFA was significantly positively correlated with ear length and the number of kernels per row. EAD1 TFA serves as a potential genetic resource to help improve grain yield in maize .
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- HY-134108
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Others
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Endocrinology
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(3E,13Z)-Octadecadien-1-ol is a female sex pheromone attracting males, isolated from female Sequoia resin moths (Synanthedon sequoiae) .
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- HY-W778833
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Others
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Endocrinology
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(Z)-11-Octadecen-1-ol is a marking secretion deposited by wasps on repeated flight paths, isolated from the paired labial glands of North American male bumblebees .
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- HY-145461
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5-Hydroxy lenalidomide
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Drug Metabolite
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Others
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Hydroxy lenalidomide (5-Hydroxy lenalidomide) is a metabolite of lenalidomide that is present as a minor component in plasma and excreta, accounting for less than 5% of the total radioactivity, following oral administration of lenalidomide in healthy male subjects.
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- HY-W717924
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Endogenous Metabolite
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Endocrinology
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(Z)-14-Methyl-8-hexadecenal is a sex pheromone that can induce mating responses in male Trogoderma beetles, isolated from the spiracular exhalation distillates of female beetles .
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- HY-N12896
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ENT-35163
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Others
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Endocrinology
|
|
(7Z)-7-Hexadecen-1-ol (ENT-35163) is a sex pheromone that inhibits male attraction, isolated from female Euxoa tessellata (Harris) .
|
-
- HY-N12938
-
|
|
Others
|
Endocrinology
|
|
(Z)-7-Hexadecenyl acetate is a pheromone used for capturing male tobacco budworm moths (Heliothis virescens), which can be isolated from the brush glands or hair pencils on the abdomen or hind wings of insects .
|
-
- HY-118861
-
|
(E)-Clomiphene; trans-Clomiphene; Enclomifene
|
Estrogen Receptor/ERR
|
Metabolic Disease
Endocrinology
|
|
Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
|
-
- HY-118861B
-
|
(E)-Clomiphene hydrochloride; trans-Clomiphene hydrochloride; Enclomifene hydrochloride
|
Estrogen Receptor/ERR
|
Metabolic Disease
Endocrinology
|
|
Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
|
-
- HY-W747088
-
|
|
Sex Pheromone
|
Endocrinology
|
|
(2Z,13Z)-Octadecadienyl acetate is a female pheromone that attracts male clearwing moths and disrupts mating, isolated from Japanese persimmon clearwing moths (Synanthedon tenuis (Lepidoptera: Sesiidae)) .
|
-
- HY-N12920
-
|
Z3-12:Ac
|
Others
|
Endocrinology
|
|
(Z)-3-Dodecenyl acetate (Z3-12:Ac) is a specific sex pheromone attracting females, isolated from pentane extracts of mature unmated male yellow mealworm beetles .
|
-
- HY-B0035B
-
|
Sulfadimidine 100 µg/mL in acetonitrile; Sulfadimerazine 100 µg/mL in acetonitrile
|
Bacterial
Cytochrome P450
HBV
Biochemical Assay Reagents
|
Others
|
|
Sulfamethazine 100 μg/mL in acetonitrile (Sulfadimidine 100 μg/mL in acetonitrile) is an antimicrobial agent that induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex-dependent pharmacokinetics and is metabolized by CYP2C11 in males.
|
-
- HY-N8028
-
|
|
Others
|
Cancer
|
|
Quercetin-3-O-sambubioside is a monomeric compound found in Eucommia ulmoides male flowers. Quercetin-3-O-sambubioside promotes the stimulation of the nerve center. Antioxidant and anticancer activities .
|
-
- HY-N12883
-
|
|
Others
|
Endocrinology
|
|
(E,E)-11,13-Hexadecadien-1-ol is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) .
|
-
- HY-119332
-
|
|
Endogenous Metabolite
|
Endocrinology
|
|
3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey .
|
-
- HY-148163
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Polystyrene sulfonic acid (30% in water) is a potentially toxic hazardous substance. Polystyrene-derived microplastics (PS-MPs) are harmful to zebrafish hearts and induce male reproductive toxicity in mice. MCE offers Polystyrene products in solution packaging .
|
-
- HY-118861A
-
|
(E)-Clomiphene citrate; trans-Clomiphene citrate; Enclomifene citrate
|
Estrogen Receptor/ERR
|
Metabolic Disease
Endocrinology
|
|
Enclomiphene ((E)-Clomiphene) citrate is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene citrate can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
|
-
- HY-115684
-
|
Undecan-2-ol
|
Endogenous Metabolite
|
Others
|
|
2-Undecanol (Undecan-2-ol) is a male specific volatile identified from the sap beetle Lobiopa insularis. 2-undecanol is a flower emitted volatile, used by various species of Hymenoptera as a pheromone component .
|
-
- HY-P5883
-
|
tatM2NX
|
TRP Channel
|
Neurological Disease
|
|
TAT-M2NX (tatM2NX) is a TRPM2 inhibitor with specific neuroprotective activity in male mice. TAT-M2NX can be used to study ischemic neuronal damage .
|
-
- HY-109517
-
|
DNA from calf thymus, Thymonucleic acid
|
DNA/RNA Synthesis
|
Inflammation/Immunology
Cancer
|
|
Calf thymus DNA (DNA from calf thymus) is high quality double-stranded template DNA isolated from the thymus of male and female calves. Calf thymus DNA can be used for the research of the interaction between DNA and agents .
|
-
- HY-W040156
-
|
|
Fungal
|
Infection
|
|
Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
- HY-156481
-
|
|
Cytochrome P450
|
Others
|
|
SU-8000 is an inhibitor that selectively targets 17α-hydroxylase and C17-20-lyase in rat testes. When administered to pregnant rats, SU-8000 can cause hypospadias in male fetuses .
|
-
- HY-W087952
-
|
|
Drug Intermediate
|
Endocrinology
|
|
(R)-(-)-2-Butanol is the isomer of 2-Butanol, which is found in the females of the white grub beetle, Dasylepida ishigakiensis, to attract males. (R)-(-)-2-Butanol is an intermediate of pharmaceutical synthesis by coupling .
|
-
- HY-115826
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
AB-163 is an alkylating agent with anti-tumor activity. AB-163 exerts LD50s of 198 (p.o.) and 159 (i.p.) mg/kg in ICR/Ha male mice and can be utilized in cancer research .
|
-
- HY-N6974
-
|
Ascaroside C6
|
Endogenous Metabolite
|
Endocrinology
|
|
Ascr#2 (Ascaroside C6) is an ascaroside isolated from Caenorhabditis elegans, potently promotes dauer formation, and also acts as a potent male attractant combined with Ascr#3 (HY-N6977) at low concentration .
|
-
- HY-117158
-
|
|
Adrenergic Receptor
|
Others
|
|
SKF 89748 is an α1-adrenergic receptor agonist with the activity of inhibiting food and water intake. SKF 89748 inhibits food and water intake in adult male rats with an ED50 of 0.37mg/kg for inhibiting food intake.
|
-
- HY-N12899
-
|
|
Others
|
Endocrinology
|
|
9-trans-Hexadecenol is a male sex pheromone that can be isolated from the labial glands of Scandinavian bumblebees (Bombus pratorum & Bombus lapidarius). 9-trans-Hexadecenol leaves marks unpredictably on small areas along the edges of birch leaves .
|
-
- HY-W108649
-
|
|
Drug Derivative
|
Endocrinology
|
|
(R)-1-Amino-3-chloropropan-2-ol hydrochloride is a derivative of 3-chloro-l,2 propanediol (α-chlorohydrin). 3-chloro-l,2 propanediol (a-chlorohydrin) is a male chemosterilant .
|
-
- HY-N12910
-
|
|
Others
|
Endocrinology
|
|
(Z)-9-Hexadecenyl acetate is a female sex pheromone isolated from 3-day-old female Mamestra configurata. (Z)-9-Hexadecenyl acetate can induce an electroantennographic response and attract 2-day-old male moths .
|
-
- HY-119069
-
|
|
Dopamine Receptor
|
Neurological Disease
|
|
FAUC 3019 is a partial agonist of dopamine D(4) receptors and has the activity of promoting penile erection. FAUC 3019 has a strong stimulatory effect on penile erection in male rats at low concentrations. The biological activity of FAUC 3019 makes it a promising compound candidate .
|
-
- HY-N7099R
-
|
Q-lure (Standard)
|
Insecticide
Reference Standards
|
Others
|
|
Cue-lure (Standard) is the analytical standard of Cue-lure (HY-N7099). This product is intended for research and analytical applications. Cue-lure (Q-lure) is a melon fly attractant. Cue-lure provides a short-term mating advantage to male Bactrocera cucurbitae .
|
-
- HY-Y0284
-
|
|
Apoptosis
|
Endocrinology
|
|
Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments .
|
-
- HY-N12888
-
|
|
Others
|
Others
|
|
4E,6Z,10Z-Hexadecatrien-1-ol is the component of insect sex pheromone components of the cocoa pod borer (Conopomorpha cramerella, or Acrocercop cramerella), which plays a role in attracting male moths .
|
-
- HY-W336192
-
|
|
Endogenous Metabolite
|
Endocrinology
|
|
(3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate is a sex pheromone capable of attracting male South American tomato pinworms (Scrobipalpuloides absoluta), which can be isolated from the tomato pest .
|
-
- HY-W142432
-
|
|
Biochemical Assay Reagents
β-catenin
Wnt
Arginase
TGF-beta/Smad
mTOR
Akt
ERK
Atg8/LC3
p62
Autophagy
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .
|
-
- HY-110157
-
|
|
Estrogen Receptor/ERR
|
Neurological Disease
|
|
AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease .
|
-
- HY-N15531
-
|
|
Estrogen Receptor/ERR
|
Inflammation/Immunology
Cancer
|
|
Icariside D1 (Compound 9) is a flavonoid glycoside compound with antioxidant and anti-inflammatory activities, which is found in plants such as Epimedium. Icariside D1 is also a regulator of estrogen receptors. Icariside D1 is promising for research of osteoporosis, male infertility and female reproductive dysfunction and cancers .
|
-
- HY-114501
-
|
|
Parasite
|
Endocrinology
|
|
Z3-Dodecenyl E2-butenoate is a female sex pheromone produced by the sweet potato weevil, C. formicarius. It has been used to bait and trap male sweet potato weevils to manage population counts in agriculture fields with reduced use of insecticides.
|
-
- HY-N12909
-
|
Z9,E12-14:Ald
|
Others
|
Endocrinology
|
|
(Z,E)-9,12-Tetradecadienal (Z9,E12-14:Ald) is a female pheromone that can induce an electroantennographic response in male antennae, isolated from the sex pheromone extracts of Plodia interpunctella (lepidoptera: pyralidae) .
|
-
- HY-164535
-
|
AMG 133
|
Antibody-Drug Conjugates (ADCs)
GLP Receptor
|
Metabolic Disease
|
|
Maridebart cafraglutide (AMG 133) is an antibody-peptide conjugate acting as a GLP-1 receptor agonist and an antagonist of the GIP receptor. Maridebart cafraglutide reduces body weight and improve metabolic markers in male obese mice and cynomolgus monkeys. Maridebart cafraglutide is promising for research of obesity .
|
-
- HY-N12939
-
|
|
Others
|
Endocrinology
|
|
(11Z,13Z)-Hexadecadien-1-ol is an insect sex pheromone attractive to male navel orangeworm moths (Amyeloistransitella), a secretion of the moth Z11, which can be isolated from Z13-16:Ald analogs .
|
-
- HY-101337
-
|
RS 21361 free base
|
Adrenergic Receptor
|
Inflammation/Immunology
|
|
Imiloxan (RS 21361) is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan produces a dose-related reversal of Guanoxabenz (HY-U00123)-induced maximal mydriasis in male rats. Imiloxan has the potential for acute kidney injury research .
|
-
- HY-101337A
-
|
RS 21361
|
Adrenergic Receptor
|
Metabolic Disease
|
|
Imiloxan (RS 21361) hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride produces a dose-related reversal of Guanoxabenz (HY-U00123)-induced maximal mydriasis in male rats. Imiloxan hydrochloride has the potential for acute kidney injury research .
|
-
- HY-P0037
-
|
Org 30850ANT
|
Others
GnRH Receptor
|
Endocrinology
|
|
Org-30850 is a potent LHRH antagonist designed for treating hormone-dependent disorders. In animal studies, a single subcutaneous dose effectively inhibited ovulation in rats and significantly reduced testosterone levels in male rats for up to 48 hours post-administration. Daily doses of Org-30850 in female rats suppressed estrous cycles, decreased uterine and ovarian weights, and lowered estradiol and FSH serum levels. In male rats, prolonged treatment resulted in reversible reductions in gonadal function and testosterone levels, with almost complete recovery observed after cessation of treatment. Unlike comparable LHRH antagonists, Org-30850 exhibited minimal injection site irritation and no edematous reactions, suggesting a more favorable therapeutic profile .
|
-
- HY-W780787
-
|
E3,Z13-18:Ac
|
Insecticide
|
Endocrinology
|
|
(E,Z)-3,13-Octadecadienyl acetate (E3,Z13-18:Ac) is an insect sex pheromone that elicits attraction in male lesser peachtree borers (Lesser Peachtree Borer), which can be isolated from female lesser peachtree borers .
|
-
- HY-W751152R
-
|
|
Others
Reference Standards
|
Cancer
|
|
α,β-Thujone (Standard) is the analytical standard of α,β-Thujone. This product is intended for research and analytical applications. α,β-Thujone is a component of the essential oils of some plants. α,β-Thujone causes cancers in male rats and induces seizures in the highest doses .
|
-
- HY-126114
-
|
|
COX
Interleukin Related
Bacterial
Fungal
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility .
|
-
- HY-171460
-
|
|
Glucocorticoid Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
Win 45164 is an orally active glucocorticoid receptor (Glucocorticoid Receptor) ligand with the activity of inhibiting the pituitary - adrenal axis. It can promote liver glycogen deposition and thymus involution in adrenalectomized male rats. Meanwhile, Win 45164 has anti - inflammatory effects. It can be used in the research of inflammatory and neurological diseases .
|
-
- HY-W127447
-
|
Maleic acid sodium
|
Biochemical Assay Reagents
|
Others
|
|
Maleate trihydrate sodiumIt is an organic compound belonging to the salt class. It is formed from the neutralization reaction between maleic acid and sodium hydroxide and has a slightly bitter taste. Maleate trihydrate sodiumIt has a variety of applications in industrial settings, especially as an intermediate in the synthesis of various chemicals and polymers. Additionally, it is used in the food and beverage industry as a buffer, flavor enhancer and preservative.
|
-
- HY-123095
-
|
JBIR 100
|
Antibiotic
Bacterial
Proton Pump
|
Infection
Inflammation/Immunology
Endocrinology
|
|
TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis .
|
-
- HY-W040156R
-
|
|
Fungal
Reference Standards
|
Infection
|
|
Oxadixyl (Standard) is the analytical standard of Oxadixyl. This product is intended for research and analytical applications. Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
- HY-W747105
-
|
|
Sex Pheromone
|
Endocrinology
|
|
(2E,13Z)-Octadecadienyl acetate is an insect sex pheromone capable of attracting clearwing moths (Synanthedon tipul(formis (Clerck)) or raspberry crown borers (Pennisetia marginata (Harris)). (2E,13Z)-Octadecadienyl acetate can induce strong responses in male antennae .
|
-
- HY-W109323
-
|
(E)-8-Dodecen-1-yl acetate; trans-8-Dodecenyl acetate
|
Olfactory Receptor
|
Infection
|
|
(E)-8-Dodecenyl ((E)-8-Dodecen-1-yl; trans-8-Dodecenyl) acetate is a sex pheromone targeting the olfactory receptors of male Gymnandrosoma aurantianum moths. acting as an agonist. (E)-8-Dodecenyl acetate is promising for research of agricultural pests .
|
-
- HY-162565
-
|
|
STK33
CDK
RET
|
Endocrinology
|
|
CDD-2807 is an inhibitor for serine/threonine kinase 33 (STK33) with IC50 of 9.2 nM. CDD-2807 exhibits no significant toxicity in mice and can cross the blood-testis barrier without accumulating in the brain. CDD-2807 induces a reversible contraceptive effect and has potential for the development of the male contraceptive .
|
-
- HY-101040R
-
|
Q203 (Standard); IAP6 (Standard)
|
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Oxadixyl (Standard) is the analytical standard of Oxadixyl. This product is intended for research and analytical applications. Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
- HY-N6996S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Methyl Eugenol- 13C,d3 is the 13C- and deuterium labeled Methyl Eugenol. Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly .
|
-
- HY-32004
-
|
|
Endogenous Metabolite
Parasite
Hydroxycarboxylic Acid Receptor (HCAR)
|
Infection
|
|
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (KI = 0.073 μM for hCA IX; KI = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity .
|
-
- HY-D0843
-
|
NEM
|
Cathepsin
Deubiquitinase
Apoptosis
|
Others
|
|
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .
|
-
- HY-157429
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
25N-N1-Nap (compound 16) is a β-arrestin-biased 5-HT2A agonist. 25N-N1-Nap antagonizes phencyclidine induced hyperactivity in Male C57BL/6 J mice .
|
-
- HY-Y0284R
-
|
|
Apoptosis
Reference Standards
|
Endocrinology
|
|
Diethyl phthalate (Standard) is the analytical standard of Diethyl phthalate. This product is intended for research and analytical applications. Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments .
|
-
- HY-151798
-
|
|
Adenylate Cyclase
|
Others
|
|
TDI-11861 is an orally active soluble sAC inhibitor optimized and designed based on TDI-10229 (HY-132298), with an IC50 of 3.3 nM and a KD of 1.4 nM. TDI-11861 has advantages such as high affinity, slow dissociation, and good pharmacokinetics. TDI-11861 can be used for research on male contraception and related sAC pharmacology .
|
-
- HY-173053
-
|
|
HDAC
Fungal
|
Infection
|
|
HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD50 of greater than 500 mg/kg in male and female rats .
|
-
- HY-G0008AR
-
|
Mebeverine metabolite O-desmethyl Mebeverine alcohol hydrochloride (Standard)
|
Reference Standards
Adrenergic Receptor
Drug Metabolite
|
Metabolic Disease
|
|
Diethyl phthalate (Standard) is the analytical standard of Diethyl phthalate. This product is intended for research and analytical applications. Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments .
|
-
- HY-155478
-
|
|
Androgen Receptor
|
Cancer
|
|
Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor (Androgen Receptor) potent inhibitor (IC50=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD). Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice .
|
-
- HY-126114R
-
|
|
COX
Interleukin Related
Bacterial
Fungal
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Lupeol acetate (Standard) is the analytical standard of Lupeol acetate. This product is intended for research and analytical applications. Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility .
|
-
- HY-E70558A
-
|
|
5 alpha Reductase
|
Endocrinology
|
|
5α-Reductase, Rat (Sprague-Dawley) Testis is the enzyme responsible for the conversion of testosterone into 5-alpha dihydrotestosterone (DHT), which is a potent androgen involved in male sexual differentiation.5α-reductase enzyme family is comprised of 3 subfamilies and 5 isoenzyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L .
|
-
- HY-E70558
-
|
|
5 alpha Reductase
|
Endocrinology
|
|
5α-reductase, Rat(Sprague-Dawley) Liver is the enzyme responsible for the conversion of testosterone into 5-alpha dihydrotestosterone (DHT), which is a potent androgen involved in male sexual differentiation.5α-reductase enzyme family is comprised of 3 subfamilies and 5 isoenzyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L .
|
-
- HY-32351B
-
|
3-epi-25-Hydroxy cholecalciferol
|
PTHR
|
Endocrinology
|
|
3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
|
-
- HY-164032
-
|
7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate
|
GnRH Receptor
|
Endocrinology
|
|
Dimethandrolone undecanoate (7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate) exhibits withrogens and progesterone activity. Dimethandrolone undecanoate inhibits production of gonadotropins, suppresses testosterone production, and thus inhibits sperm production. Dimethandrolone undecanoate is potent for development of male hormone contraceptives .
|
-
- HY-B1986
-
|
4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
|
Androgen Receptor
Drug Metabolite
|
Metabolic Disease
Endocrinology
|
|
p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women .
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-
- HY-Y1117
-
|
|
Apoptosis
TGF-β Receptor
NF-κB
COX
NADPH Oxidase
ROS Kinase
|
Neurological Disease
Inflammation/Immunology
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|
Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models .
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- HY-W741191
-
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Endogenous Metabolite
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Endocrinology
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(2E,13Z)-Octadecadienal is an insect sex pheromone capable of attracting clearwing moths (Synanthedon tipulformis (Clerck)) or raspberry crown borers (Pennisetia marginata (Harris))). (2E,13Z)-Octadecadienal can be isolated from (2E,13Z)-Octadecadienyl acetate, which induces strong responses in male antennae .
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-
- HY-155995
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MK-905
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Biochemical Assay Reagents
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Cancer
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Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) .
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-
- HY-B2141
-
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NO Synthase
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
Others
Metabolic Disease
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|
Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats .
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-
- HY-155659
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Nuclear Hormone Receptor 4A/NR4A
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Neurological Disease
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|
4A7C-301 is a Nurr1 agonist with robust neuroprotective effects in vitro. 4A7C-301 significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models. 4A7C-301 can be used for the research of Parkinson’s disease .
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-
- HY-177298
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|
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Phosphodiesterase (PDE)
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Others
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|
PDE5-IN-15 (compound 21) is a xanthine derivative and PDE5 inhibitor, with IC50 values of 0.002, 0.180, 2.85 and 2.22 μM against hPDE5, bPDE6, bPDE1 and hPDE3, respectively. PDE5-IN-15 has good oral bioavailability in dogs. PDE5-IN-15 can be used in research on male erectile dysfunction .
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- HY-122485
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|
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Bacterial
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Infection
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|
α-Copaene is a potent attractant for male Mediterranean fruit flies Ceratitis capitata.α-Copaene can be found as a minor component in the essential oils of various plant species. α-Copaene can inhibit bacterial growth with a minimum inhibitory concentration of 0.5-1 μL/mL. α-Copaene suppresses biofilm formation by decreasing the hydrophobicity of the cell surface. α-Copaene can be used as an oviposition promoter of Bactrocera oleae .
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-
- HY-133823
-
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C16:1 (cis-11/trans-11) Fatty acid
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Endogenous Metabolite
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Metabolic Disease
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|
11-Hexadecenoic acid is a monounsaturated fatty acid. 11-cis-Hexadecenoic acid and 11-trans-hexadecenoic acid have been found in ewe milk fat, and levels of each increase with dietary lipid supplementation of linseed, sunflower, olive, or fish oils. 11-trans-Hexadecenoic acid has also been found in intramuscular fat samples isolated from male and female foals. This product is a mixture of 11-cis- and 11-trans-hexadecenoic acids.
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-
- HY-162866
-
|
|
Autophagy
|
Metabolic Disease
|
CXM102 is an autophagy activator. CXM102 can induce autophagy in aged BMSCs, leading to the rejuvenation of BMSCs and preferential differentiation into osteoblasts. CXM102 promotes the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. CXM102 can stimulate bone synthesis metabolism in middle-aged male mice, reduce bone marrow adipocytes, delay bone loss, lower serum inflammation levels, decrease organ fibrosis, and extend the lifespan of the mice .
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-
- HY-N2466
-
|
MT-I; [Nle4,D-Phe7]-α-MSH
|
Melanocortin Receptor
|
Neurological Disease
Cancer
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|
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction .
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-
- HY-13699
-
|
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GnRH Receptor
PERK
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Others
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|
NBI-42902 is an orally active, potent functional and competitive antagonist of GnRH receptor with an IC50 value of 0.79 nM, a Ki value of 0.56 nM, respectively. NBI-42902 inhibits GnRH-stimulated inositol phosphate (IP) accumulation, Ca 2+ flux, and ERK1/2 activation. NBI-42902 inhibits serum luteinizing hormone (LH) in castrated male macaques. NBI-42902 can be used for research on sex-hormone-related diseases .
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-
- HY-143546
-
|
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RET
|
Cancer
|
|
RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-pass transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, and the maintenance of homeostasis in the nervous, endocrine, hematopoietic, and male reproductive systems. RET-IN-9 has the potential for the research of RET-related disease including non-small cell lung cancer and medullary thyroid cancer (extracted from patent WO2021115457A1, compound 29) .
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-
- HY-B1986R
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|
4,4'-DDE (Standard); p,p'-Dichlorodiphenyldichloroethylene (Standard)
|
Reference Standards
Androgen Receptor
Drug Metabolite
|
Metabolic Disease
Endocrinology
|
|
p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women .
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-
- HY-P2446
-
|
APTAA-LHRH
|
GnRH Receptor
|
Endocrinology
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ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
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-
- HY-32351BR
-
|
3-epi-25-hydroxy Cholecalciferol (Standard)
|
PTHR
Reference Standards
|
Endocrinology
|
|
3-epi-Calcifediol (Standard) is the analytical standard of 3-epi-Calcifediol. This product is intended for research and analytical applications. 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
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-
- HY-137547
-
|
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Prostaglandin Receptor
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Metabolic Disease
|
|
20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.
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-
- HY-117081
-
|
|
Endogenous Metabolite
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Others
|
|
C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .
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-
- HY-D0889
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
-
- HY-W040074
-
|
Diglycine hydrochloride hydrate; Gly-Gly (HCl H2O)
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
-
- HY-119420
-
|
|
Antibiotic
Apoptosis
Caspase
JNK
p38 MAPK
TNF Receptor
ERK
NF-κB
Mitochondrial Metabolism
|
Inflammation/Immunology
Cancer
|
|
Acetoxycycloheximide is an antibiotic with antitumor activity. Acetoxycycloheximide a protein synthesis inhibitor. Acetoxycycloheximide significantly induces activation of procaspase-3 and subsequent apoptosis mediated by the Cytochrome c from mitochondria via activation of JNK pathway. Acetoxycycloheximide triggers the downregulation of cell surface TNF-R1 via the activation of ERK and p38 MAPK, thereby preventing activation of the NF-κB signaling pathway by TNF-α. Acetoxycycloheximide is much more toxic to female rats than to males. Acetoxycycloheximide can be used for inflammatory and immune diseases and cancers research .
|
-
- HY-W747104
-
|
|
Others
|
Endocrinology
|
|
(9E)-Tetradecen-1-ol is a pheromone that has no significant sexual attraction when used alone and can be secreted from the abdomen of the female Bertha armyworm moth (Mamestra configurata (Walker)). Isolate in tip extract to get in isolate. Another pheromone (Z)-11-hexadecen-1-ol was also isolated at the same time. Only when the two pheromones are mixed do they show male attraction (the ratio of C16:C14 in the mixture is about 19:1). optimal) .
|
-
- HY-N12885
-
|
|
Others
|
Endocrinology
|
|
(11Z,13E)-Hexadecadienal is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) when mixed with (11Z,13Z)-hexadecadien-1-ol, (11Z,13E)-hexadecadien-1-ol, (3Z,6Z,9Z,12Z,15Z)-tricosapentaene (C23 pentaene) .
|
-
- HY-106591A
-
|
Vinylcyclohexene diepoxide
|
Apoptosis
Reactive Oxygen Species (ROS)
PI3K
Akt
mTOR
|
Endocrinology
|
|
4-Vinylcyclohexene dioxide (4-Vinylcyclohexene diepoxide) is an orally active metabolite of 4-vinylcyclohexene. 4-Vinylcyclohexene dioxide induces Apoptosis, increases intracellular ROS, and activates the PI3K/Akt/mTOR pathway. 4-Vinylcyclohexene dioxide selectively damages small ovarian follicles, inhibits granulosa cell function, and disrupts the male reproductive system. 4-Vinylcyclohexene dioxide can be used in the study of premature ovarian insufficiency, reproductive toxicity, and related fertility disorders .
|
-
- HY-113058
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.
|
-
- HY-78035
-
|
Methylmaleic anhydride
|
Biochemical Assay Reagents
|
Others
|
|
Citraconic anhydride (Methylmaleic anhydride) is a derivative of maleic anhydride (HY-Z0060) and novel antigen retrieval solution. Citraconic anhydride reversibly blocks protein amino groups, stabilizing specific enzymes and improving their catalytic performance. Citraconic anhydride reacts with free amino groups on proteins (especially lysine residues), converting positively charged NH3 + into carboxyl groups, thereby disrupting methylene bridge crosslinks caused by Formaldehyde during antigen retrieval. Citraconic anhydride functionalizes Isotactic polypropylene. Citraconic anhydride precisely responds to pH changes to achieve reversible modification. Citraconic anhydride is irritating to skin and eyes .
|
-
- HY-131708A
-
|
|
HDAC
Parasite
|
Infection
|
|
FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25/29/2/11/282 nM, respectively.) and inhibits Class III HDAC isoforms at nanomolar concentrations .
|
-
- HY-W679754
-
|
PFTrDA
|
TSH Receptor
|
Infection
|
|
Perfluorotridecanoic acid (PFTrDA) is a perfluoroalkyl substance (PFAS). Embryo larval exposure of PFTrDA induces yolk sac edema and increases mRNA expression of thyroid hormone synthesis genes, including tshβ, in zebrafish when used at concentrations of 0.1 and 0.3 mg/L, respectively. PFTrDA (10 mg/kg) decreases serum testosterone and luteinizing hormone levels, testis palmitic acid, linoleic acid, and oleic acid levels, and the number of Leydig cells in rats in late puberty. Maternal plasma levels of PFTrDA during gestation are positively associated with the development of eczema in female, but not male, infants, and liver levels of PFTrDA are higher in cancerous human livers compared with non-cancerous human livers. It has been found in marine mammals.
|
-
- HY-123035
-
|
|
HSP
Akt
EGFR
|
Endocrinology
|
|
Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research .
|
-
- HY-N7690
-
|
|
Calcium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
3,5,7,3’,4’-Pentamethoxyflavone is a Ca 2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .
|
-
- HY-D0889R
-
|
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
-
- HY-131708
-
|
|
HDAC
Parasite
|
Infection
|
|
FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations .
|
-
- HY-N7690R
-
|
|
Calcium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .
|
-
- HY-172661
-
|
|
Thyroid Hormone Receptor
Interleukin Related
LDLR
|
Infection
Metabolic Disease
|
|
KYLO-0603 is an orally active, selective THR-β agonist (EC50: 31.07 nM). KYLO-0603 has significant activity in lowering serum cholesterol and low-density lipoprotein cholesterol. KYLO-0603 upregulates the expression of THR-regulated genes (including iodothyronine deiodinase 1 (Dio1), malic enzyme 1 (Me1), and thyroid hormone response (Thrsp) gene) and inhibits the expression of inflammatory and fibrotic genes (low-density lipoprotein receptor (LDL-R) gene) by activating THR-β receptors. KYLO-0603 can be used to treat metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis research .
|
-
- HY-W677042
-
|
5α-Androst-16-en-3α-ol
|
GABA Receptor
|
Neurological Disease
|
|
α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50=0.4 μM). α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice .
|
-
- HY-145751
-
|
7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one
|
Cytochrome P450
Mitochondrial Metabolism
|
Metabolic Disease
Cancer
|
|
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .
|
-
- HY-W679754R
-
|
PFTrDA (Standard)
|
TSH Receptor
Reference Standards
|
Infection
|
|
Pentacosafluorotridecanoic Acid (Standard) is the analytical standard of Pentacosafluorotridecanoic Acid. This product is intended for research and analytical applications. Perfluorotridecanoic acid (PFTrDA) is a perfluoroalkyl substance (PFAS). Embryo larval exposure of PFTrDA induces yolk sac edema and increases mRNA expression of thyroid hormone synthesis genes, including tshβ, in zebrafish when used at concentrations of 0.1 and 0.3 mg/L, respectively. PFTrDA (10 mg/kg) decreases serum testosterone and luteinizing hormone levels, testis palmitic acid, linoleic acid, and oleic acid levels, and the number of Leydig cells in rats in late puberty. Maternal plasma levels of PFTrDA during gestation are positively associated with the development of eczema in female, but not male, infants, and liver levels of PFTrDA are higher in cancerous human livers compared with non-cancerous human livers. It has been found in marine mammals.
|
-
- HY-175640
-
|
|
Pyroptosis
Reactive Oxygen Species (ROS)
Interleukin Related
Caspase
|
Cardiovascular Disease
|
|
Troponin-IN-1 is a troponin inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056)-induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury .
|
-
- HY-N13195
-
|
|
5 alpha Reductase
|
Others
|
|
(15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one shows a 5a-reductase inhibitory activity with an IC50 value of 41.9 μM. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one inhibits the growth of the ventral prostate induced by testosterone in rat. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is promising for research of benign prostatic hyperplasia (BPH) as well as other 5α-dihydrotestosterone (DHT)-related disorders, such as acne and male pattern baldness .
|
-
- HY-W130878
-
|
|
Complement System
Toll-like Receptor (TLR)
NF-κB
|
Inflammation/Immunology
|
|
4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR))/IκBα/NF-κB pathway .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-Y1311G
-
|
Hydroxybutanedioic acid (GMP); E 296 (GMP)
|
Fluorescent Dye
|
|
Malic acid (GMP) is Malic acid (HY-Y1311) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that occurs naturally in fruits like apples and pears with oral activities. Malic acid plays a role in many sour or tangy foods. Malic acid is an intermediate in the citric acid cycle .
|
-
- HY-W127723
-
|
|
Dyes
|
|
Fluoresceinamine Maleic Acid Monoamide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
| Cat. No. |
Product Name |
Type |
-
- HY-W250303A
-
|
Hydroxybutanedioic acid disodium hydrate; Disodium DL-malate hydrate; E 296 disodium hydrate
|
Buffer Reagents
|
|
Malic acid disodium hydrate is an organic compound that is commonly used as a food additive, buffering agent, and nutritional supplement. It contains sodium and malic acid. Malic acid disodium hydrate has a variety of properties that make it suitable for these applications, including the ability to enhance food flavor, improve texture, and regulate acidity. In addition, due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance, Malic acid disodium hydrate can be used as a dietary supplement .
|
-
- HY-W250303
-
|
Hydroxybutanedioic acid disodium salt; E 296 disodium salt
|
Biochemical Assay Reagents
|
|
Sodium DL-Malate is an organic compound commonly used as a food additive, buffer and nutritional supplement. It contains sodium and malic acid. Malic acid disodium salt has several properties suitable for these applications, including the ability to enhance food flavor, improve texture and regulate acidity. Additionally, it can be used as a dietary supplement due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance.
|
-
- HY-W392258
-
|
|
Cell Assay Reagents
|
|
Poly(methyl vinyl ether-alt-maleic anhydride) (MW 216000) can be used to prepare antibacterial hydrogels with good mechanical strength and excellent swelling ability .
|
-
- HY-113058
-
|
|
Biochemical Assay Reagents
|
|
3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.
|
-
- HY-78035
-
|
Methylmaleic anhydride
|
Biochemical Assay Reagents
|
|
Citraconic anhydride (Methylmaleic anhydride) is a derivative of maleic anhydride (HY-Z0060) and novel antigen retrieval solution. Citraconic anhydride reversibly blocks protein amino groups, stabilizing specific enzymes and improving their catalytic performance. Citraconic anhydride reacts with free amino groups on proteins (especially lysine residues), converting positively charged NH3 + into carboxyl groups, thereby disrupting methylene bridge crosslinks caused by Formaldehyde during antigen retrieval. Citraconic anhydride functionalizes Isotactic polypropylene. Citraconic anhydride precisely responds to pH changes to achieve reversible modification. Citraconic anhydride is irritating to skin and eyes .
|
-
- HY-Y1311G
-
|
Hydroxybutanedioic acid (GMP); E 296 (GMP)
|
Biochemical Assay Reagents
|
|
Malic acid (GMP) is Malic acid (HY-Y1311) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that occurs naturally in fruits like apples and pears with oral activities. Malic acid plays a role in many sour or tangy foods. Malic acid is an intermediate in the citric acid cycle .
|
-
- HY-W250305
-
|
|
Biochemical Assay Reagents
|
|
Calcium malate is an organic compound containing calcium and malic acid. It is commonly used as a dietary supplement to provide the body with calcium and malic acid, which are important for maintaining healthy bones, teeth and muscles. Calcium malate has several properties that make it suitable for these applications, including high solubility and bioavailability compared to other forms of calcium supplementation. Additionally, it is used as a food additive to enhance the acidity and flavor of certain products.
|
-
- HY-W392258A
-
|
|
Cell Assay Reagents
|
|
Poly(methyl vinyl ether-alt-maleic anhydride) (MW 1080000) can be used to prepare antibacterial hydrogels with good mechanical strength and excellent swelling ability .
|
-
- HY-W127447
-
|
Maleic acid sodium
|
Buffer Reagents
|
|
Maleate trihydrate sodiumIt is an organic compound belonging to the salt class. It is formed from the neutralization reaction between maleic acid and sodium hydroxide and has a slightly bitter taste. Maleate trihydrate sodiumIt has a variety of applications in industrial settings, especially as an intermediate in the synthesis of various chemicals and polymers. Additionally, it is used in the food and beverage industry as a buffer, flavor enhancer and preservative.
|
-
- HY-W040074
-
|
Diglycine hydrochloride hydrate; Gly-Gly (HCl H2O)
|
Buffer Reagents
|
|
Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1917A
-
|
|
Peptides
|
Inflammation/Immunology
|
|
Uty HY Peptide (246-254) TFA, derived from the ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome (UTY) protein as an H-Y epitope, H-YD b, is a male-specific transplantation antigen H-Y .
|
-
- HY-P5883
-
|
tatM2NX
|
TRP Channel
|
Neurological Disease
|
|
TAT-M2NX (tatM2NX) is a TRPM2 inhibitor with specific neuroprotective activity in male mice. TAT-M2NX can be used to study ischemic neuronal damage .
|
-
- HY-N2466
-
|
MT-I; [Nle4,D-Phe7]-α-MSH
|
Melanocortin Receptor
|
Neurological Disease
Cancer
|
|
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction .
|
-
- HY-D0889
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
-
- HY-P5719
-
|
|
Bacterial
|
Infection
|
|
Andropin is a male-specific antibacterial peptide that can be found in Drosophila melanogaster .
|
-
- HY-139741
-
|
|
DNA/RNA Synthesis
|
Others
|
|
cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc) provides an avenue for developing a nonhormonal male contraceptive by blocking of GRTH/DDX25 phosphorylation.
|
-
- HY-P10472
-
|
|
GnRH Receptor
|
Endocrinology
|
|
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .
|
-
- HY-P1917
-
|
|
Peptides
|
Inflammation/Immunology
|
|
Uty HY Peptide (246-254), derived from the ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome (UTY) protein as an H-Y epitope, H-YD b, is a male-specific transplantation antigen H-Y .
|
-
- HY-P0037
-
|
Org 30850ANT
|
Peptides
GnRH Receptor
|
Endocrinology
|
|
Org-30850 is a potent LHRH antagonist designed for treating hormone-dependent disorders. In animal studies, a single subcutaneous dose effectively inhibited ovulation in rats and significantly reduced testosterone levels in male rats for up to 48 hours post-administration. Daily doses of Org-30850 in female rats suppressed estrous cycles, decreased uterine and ovarian weights, and lowered estradiol and FSH serum levels. In male rats, prolonged treatment resulted in reversible reductions in gonadal function and testosterone levels, with almost complete recovery observed after cessation of treatment. Unlike comparable LHRH antagonists, Org-30850 exhibited minimal injection site irritation and no edematous reactions, suggesting a more favorable therapeutic profile .
|
-
- HY-P2446
-
|
APTAA-LHRH
|
GnRH Receptor
|
Endocrinology
|
|
ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
|
-
- HY-D0889R
-
|
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-Y1311
-
-
-
- HY-Y1311R
-
-
-
- HY-20558
-
-
-
- HY-20558R
-
-
-
- HY-Y1069
-
-
-
- HY-Y1069R
-
|
(S)-Hydroxybutanedioic acid (Standard); (S)-E 296 (Standard); L-Malic acid (Standard)
|
Human Gut Microbiota Metabolites
Immune System Disorder
Microorganisms
Ketones, Aldehydes, Acids
Source classification
Disease markers
Nervous System Disorder
Endogenous metabolite
|
Reference Standards
Endogenous Metabolite
|
|
(S)-Malic acid (Standard) is the analytical standard of (S)-Malic acid. This product is intended for research and analytical applications. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
In Vitro: It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L. casei. Furthermore, deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid, thus indicating that the cognate TC system regulates and is essential for the expression of ME. Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose, whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose .
|
-
-
- HY-128900
-
-
-
- HY-N3328
-
-
-
- HY-N13713
-
-
-
- HY-Y0367R
-
|
|
Immune System Disorder
Ketones, Aldehydes, Acids
Source classification
Disease markers
Endogenous metabolite
|
Reference Standards
Endogenous Metabolite
Bacterial
|
|
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
IC50 & Target: GAD .
In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .
|
-
-
- HY-W004338
-
-
-
- HY-116047
-
-
-
- HY-Y0367
-
-
-
- HY-P5719
-
-
-
- HY-W014885
-
-
-
- HY-W749562
-
-
-
- HY-W040313
-
-
-
- HY-N6977
-
-
-
- HY-W243653
-
-
-
- HY-W780813
-
-
-
- HY-W780803
-
-
-
- HY-N12936
-
-
-
- HY-W780808
-
-
-
- HY-W587916
-
-
-
- HY-W745644
-
-
-
- HY-113415
-
-
-
- HY-W009688
-
-
-
- HY-N12924
-
-
-
- HY-116047R
-
-
-
- HY-N12895
-
-
-
- HY-N15312
-
-
-
- HY-W780779
-
-
-
- HY-W613915
-
-
-
- HY-W751152
-
-
-
- HY-W674057
-
-
-
- HY-N6976
-
-
-
- HY-W322222
-
-
-
- HY-113415A
-
-
-
- HY-N12889
-
-
-
- HY-N12882
-
-
-
- HY-120989
-
-
-
- HY-134108
-
-
-
- HY-W778833
-
-
-
- HY-W717924
-
-
-
- HY-N12896
-
-
-
- HY-N12938
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
(Z)-7-Hexadecenyl acetate is a pheromone used for capturing male tobacco budworm moths (Heliothis virescens), which can be isolated from the brush glands or hair pencils on the abdomen or hind wings of insects .
|
-
-
- HY-W747088
-
-
-
- HY-N12920
-
-
-
- HY-N8028
-
-
-
- HY-N12883
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
(E,E)-11,13-Hexadecadien-1-ol is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) .
|
-
- HY-119332
-
-
- HY-115684
-
-
- HY-109517
-
-
- HY-W040156
-
|
|
Natural Products
Microorganisms
Source classification
|
Fungal
|
|
Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
- HY-W087952
-
-
- HY-N6974
-
-
- HY-N12899
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
9-trans-Hexadecenol is a male sex pheromone that can be isolated from the labial glands of Scandinavian bumblebees (Bombus pratorum & Bombus lapidarius). 9-trans-Hexadecenol leaves marks unpredictably on small areas along the edges of birch leaves .
|
-
- HY-N12910
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
(Z)-9-Hexadecenyl acetate is a female sex pheromone isolated from 3-day-old female Mamestra configurata. (Z)-9-Hexadecenyl acetate can induce an electroantennographic response and attract 2-day-old male moths .
|
-
- HY-N12888
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
4E,6Z,10Z-Hexadecatrien-1-ol is the component of insect sex pheromone components of the cocoa pod borer (Conopomorpha cramerella, or Acrocercop cramerella), which plays a role in attracting male moths .
|
-
- HY-W336192
-
-
- HY-N15531
-
-
- HY-N12909
-
|
Z9,E12-14:Ald
|
Natural Products
Animals
Source classification
|
Others
|
|
(Z,E)-9,12-Tetradecadienal (Z9,E12-14:Ald) is a female pheromone that can induce an electroantennographic response in male antennae, isolated from the sex pheromone extracts of Plodia interpunctella (lepidoptera: pyralidae) .
|
-
- HY-N12939
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
(11Z,13Z)-Hexadecadien-1-ol is an insect sex pheromone attractive to male navel orangeworm moths (Amyeloistransitella), a secretion of the moth Z11, which can be isolated from Z13-16:Ald analogs .
|
-
- HY-W780787
-
|
E3,Z13-18:Ac
|
Natural Products
Animals
Source classification
|
Insecticide
|
|
(E,Z)-3,13-Octadecadienyl acetate (E3,Z13-18:Ac) is an insect sex pheromone that elicits attraction in male lesser peachtree borers (Lesser Peachtree Borer), which can be isolated from female lesser peachtree borers .
|
-
- HY-W751152R
-
-
- HY-126114
-
-
- HY-123095
-
-
- HY-W040156R
-
|
|
Natural Products
Microorganisms
Source classification
|
Fungal
Reference Standards
|
|
Oxadixyl (Standard) is the analytical standard of Oxadixyl. This product is intended for research and analytical applications. Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process .
|
-
- HY-W747105
-
|
|
Natural Products
Animals
Source classification
|
Sex Pheromone
|
|
(2E,13Z)-Octadecadienyl acetate is an insect sex pheromone capable of attracting clearwing moths (Synanthedon tipul(formis (Clerck)) or raspberry crown borers (Pennisetia marginata (Harris)). (2E,13Z)-Octadecadienyl acetate can induce strong responses in male antennae .
|
-
- HY-32004
-
-
- HY-D0843
-
|
NEM
|
Microorganisms
Source classification
|
Cathepsin
Deubiquitinase
Apoptosis
|
|
N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .
|
-
- HY-126114R
-
-
- HY-Y1117
-
-
- HY-W741191
-
|
|
Natural Products
Animals
Source classification
|
Endogenous Metabolite
|
|
(2E,13Z)-Octadecadienal is an insect sex pheromone capable of attracting clearwing moths (Synanthedon tipulformis (Clerck)) or raspberry crown borers (Pennisetia marginata (Harris))). (2E,13Z)-Octadecadienal can be isolated from (2E,13Z)-Octadecadienyl acetate, which induces strong responses in male antennae .
|
-
- HY-122485
-
-
- HY-133823
-
|
C16:1 (cis-11/trans-11) Fatty acid
|
Microorganisms
Source classification
|
Endogenous Metabolite
|
|
11-Hexadecenoic acid is a monounsaturated fatty acid. 11-cis-Hexadecenoic acid and 11-trans-hexadecenoic acid have been found in ewe milk fat, and levels of each increase with dietary lipid supplementation of linseed, sunflower, olive, or fish oils. 11-trans-Hexadecenoic acid has also been found in intramuscular fat samples isolated from male and female foals. This product is a mixture of 11-cis- and 11-trans-hexadecenoic acids.
|
-
- HY-117081
-
-
- HY-D0889
-
|
|
Classification of Application Fields
Ketones, Aldehydes, Acids
Source classification
Metabolic Disease
Endogenous metabolite
Disease Research Fields
|
Endogenous Metabolite
|
|
Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
-
- HY-W747104
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
(9E)-Tetradecen-1-ol is a pheromone that has no significant sexual attraction when used alone and can be secreted from the abdomen of the female Bertha armyworm moth (Mamestra configurata (Walker)). Isolate in tip extract to get in isolate. Another pheromone (Z)-11-hexadecen-1-ol was also isolated at the same time. Only when the two pheromones are mixed do they show male attraction (the ratio of C16:C14 in the mixture is about 19:1). optimal) .
|
-
- HY-N12885
-
|
|
Natural Products
Animals
Source classification
|
Others
|
|
(11Z,13E)-Hexadecadienal is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) when mixed with (11Z,13Z)-hexadecadien-1-ol, (11Z,13E)-hexadecadien-1-ol, (3Z,6Z,9Z,12Z,15Z)-tricosapentaene (C23 pentaene) .
|
-
- HY-113058
-
|
|
Microorganisms
Source classification
|
Endogenous Metabolite
|
|
3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.
|
-
- HY-N7690
-
|
|
Flavonoids
Classification of Application Fields
Flavones
Metabolic Disease
Plants
Disease Research Fields
Zingiberaceae
|
Calcium Channel
|
|
3,5,7,3’,4’-Pentamethoxyflavone is a Ca 2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .
|
-
- HY-D0889R
-
|
|
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
|
Reference Standards
Endogenous Metabolite
|
|
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .
|
-
- HY-N7690R
-
|
|
Flavonoids
Flavones
Plants
Zingiberaceae
|
Calcium Channel
|
|
3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .
|
-
- HY-145751
-
|
7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one
|
Source classification
Endogenous metabolite
Steroids
|
Cytochrome P450
Mitochondrial Metabolism
|
|
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .
|
-
- HY-N13195
-
|
|
Triterpenes
Microorganisms
Terpenoids
Source classification
|
5 alpha Reductase
|
|
(15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one shows a 5a-reductase inhibitory activity with an IC50 value of 41.9 μM. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one inhibits the growth of the ventral prostate induced by testosterone in rat. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is promising for research of benign prostatic hyperplasia (BPH) as well as other 5α-dihydrotestosterone (DHT)-related disorders, such as acne and male pattern baldness .
|
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| Cat. No. |
Compare |
Product Name |
Species |
Source |
Compare Products
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* This product has been "discontinued".
Optimized version of product available:
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-Y1311S
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Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods .
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- HY-Y1069S
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1 Publications Verification
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(S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive .
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- HY-Y1069S3
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(S)-Malic acid- 13C4 is the 13C labeled S-Malic acid (HY-Y1069) .
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- HY-Y0367S
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Maleic Acid-d2 is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .
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- HY-W747213
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Diethyl 2-hydroxy-3-methylsuccinate- 13C (MALIC ACID, 3-METHYL-, DIETHYL ESTER- 13C) is the 13C-labeled Diethyl 2-hydroxy-3-methylsuccinate (HY-W502469).
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- HY-59354S
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Maleic hydrazide-d2 is the deuterium labeled Maleic hydrazide . Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
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- HY-59354S1
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1,2-Dihydropyridazine-3,6-dione-3,4,5,6- 13C4 (1,2-Dihydro-3,6-pyridazine- 13C4-dione) is 13C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
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- HY-116047S
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Anisylacetone-d5 (p-Methoxybenzylacetone-d5) is deuterium labeled Anisylacetone. Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant .
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- HY-N6996S
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Methyl Eugenol- 13C,d3 is the 13C- and deuterium labeled Methyl Eugenol. Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly .
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Classification |
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- HY-Y1069
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(S)-Hydroxybutanedioic acid; (S)-E 296; L-Malic acid
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Flavoring Agents
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(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
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