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MM

" in MedChemExpress (MCE) Product Catalog:

90

Inhibitors & Agonists

40

Biochemical Assay Reagents

4

Peptides

12

Inhibitory Antibodies

4

Natural
Products

5

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5

Antibodies

2

Click Chemistry

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99672

    MM 141; MM-005

    IGF-1R EGFR Cancer
    Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers .
    Istiratumab
  • HY-108003

    Apelin Receptor (APJ) Cardiovascular Disease
    MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.
    MM 07
  • HY-P2271

    Apelin Receptor (APJ) Cancer
    MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation .
    MM 54
  • HY-P3282

    Guanylate Cyclase Metabolic Disease
    MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C) .
    MM 419447
  • HY-105282

    MM 45289; A 82846A

    Antibiotic Bacterial Infection
    Eremomycin (MM 45289) is a potent glycopeptide antibiotic closely related to Vancomycin (HY-B0671). Eremomycin shows antibacterial activity in Staphylococcus spp. and Bacillus subtilis ATCC6633, with the MIC values of 0.03-1.6 μg/mL .
    Eremomycin
  • HY-101322A

    5-HT Receptor Neurological Disease
    MM 77 dihydrochloride is a potent postsynaptic antagonist of the 5-HT1A receptor. MM 77 dihydrochloride exhibits anxiolytic-like activity .
    MM 77 dihydrochloride
  • HY-129814

    Antibiotic Bacterial Infection
    MM 42842 free acid is a member of the monobactam family of β-lactam antibiotics .
    MM 42842 free acid
  • HY-P991524

    EGFR Cancer
    MM-111 is a bispecific antibody fusion protein targeting the ErbB2/ErbB3 oncogenic unit. MM-111 blocks activation of the PI3K pro-survival pathway. MM-111 binds to the ErbB2 receptor, which localizes the bispecific molecule to ErbB2 over-expressing tumor cells and promotes binding of the anti-ErbB3 arm to the ErbB3 receptor. MM-111 binding to ErbB3 results in inhibition of ErbB3 signaling by blocking the binding of the ErbB3 physiological ligand heregulin. MM-111 can be used for the study of ErbB2 over-expressing breast tumors .
    MM-111
  • HY-19554

    WDR5 Apoptosis Cancer
    MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia .
    MM-401
  • HY-100869

    WDR5 Cancer
    MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM .
    MM-589
  • HY-115004

    FAAH Neurological Disease
    MM-433593 is a potent and selective inhibitor of fatty acid amide hydrolase-1 (FAAH-1) that is orally administered to inhibit pain, inflammation, and related disorders. Pharmacokinetic studies of MM-433593 in macaques revealed a biphasic elimination profile with a rapid distribution phase and a slower elimination phase, with a systemic clearance of 8-11 mL/min/kg. MM-433593 exhibits moderate oral bioavailability (14-21%) and its metabolism primarily involves oxidation of the methyl group on the indole ring, resulting in a variety of sulfate, glucuronide, or glutathione-conjugated metabolites .
    MM-433593
  • HY-108530

    RAR/RXR Cancer
    MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .
    MM11253
  • HY-P991572

    EGFR Cancer
    MM-151 is a humanized IgG1 monoclonal antibody targeting EGFR. MM-151 binds multiple regions of the EGFR extracellular domain (ECD) and reduces its mutations in circulating cell-free tumor DNA with EGFR resistance. MM-151 significantly inhibits EGFR signaling and cell growth. MM-151 can be used for drug-resistant cancers research, such as colorectal, non-small cell lung and triple negative breast cancer .
    MM-151
  • HY-160972

    Cytochrome P450 Cancer
    MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC50 of 2.2 μM. MM0299 inhibits cell proliferation of Mut6 with an IC50 of 0.0182 μM, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol .
    MM0299
  • HY-16967

    G-quadruplex Cancer
    MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC50 value of <10 nM .
    MM41
  • HY-121725

    STAT Cancer
    MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines .
    MM-206
  • HY-148072

    SARS-CoV Infection
    MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .
    MM3122
  • HY-19554A
    MM-401 TFA
    1 Publications Verification

    WDR5 Apoptosis Cancer
    MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia .
    MM-401 TFA
  • HY-161167

    PROTACs Cancer
    MM-02-08 is the potent BRD4 degrader and binds to DDB1 .
    MM-02-08
  • HY-100869A

    WDR5 Cancer
    MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM .
    MM-589 TFA
  • HY-161166

    Others Others
    MM-02-57 is a covalent DDB1 CUL4A adaptor protein recruiter .
    MM-02-57
  • HY-P99630

    MM-302

    EGFR Cancer
    Gancotamab (MM-302) is a HER2-targeted antibody with antitumor activity. Gancotamab encapsulates Doxorubicin to facilitate its delivery to HER2-overexpressing tumor cells .
    Gancotamab
  • HY-125163

    8-O-Methyltetrangomycin; 6-Deoxy-8-O-methylrabelomycin

    Bacterial Antibiotic Infection
    MM 47755 (8-O-Methyltetrangomycin; 6-Deoxy-8-O-methylrabelomycin) is an antibiotic with antibacterial activity. MM 47755 can be isolated from Streptomyces .
    MM 47755
  • HY-147428

    MM-110; (±)​-18-Methoxycoronaridine

    nAChR Parasite Infection Neurological Disease
    Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC50 of 0.90 μM to combat addiction. Zolunicant can decrease the self-administration of several addictive agents including morphine, methamphetamine, nicotine, and ethanol in rat model. Zolunicant can be studied as a potential research for multiple forms of agent abuse . Zolunicant also reveals a potent leishmanicide effect against Leishmania amazonensis .
    Zolunicant
  • HY-12220
    MM-102
    4 Publications Verification

    HMTase Inhibitor IX

    WDR5 Apoptosis NF-κB TNF Receptor Interleukin Related Inflammation/Immunology Cancer
    MM-102 (HMTase Inhibitor IX) is a cell-permeable and tightly binding inhibitor of MLL1-WDR5 interaction (IC50=2.4 nM). MM-102 can specifically inhibit the growth and induce apoptosis of leukemia cells containing MLL1 fusion protein, and reduce renal fibrosis and inflammation in mice with ischemia-reperfusion injury. In addition, MM-102 also acts as an H3K4 histone methyltransferase inhibitor to improve the development of porcine somatic cell nuclear transfer (SCNT) embryos .
    MM-102
  • HY-100869B

    WDR5 Cancer
    MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM .
    MM-589 (racemic mixture ) TFA
  • HY-12220A
    MM-102 TFA
    4 Publications Verification

    HMTase Inhibitor IX TFA

    WDR5 Cancer
    MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki < 1 nM in WDR5 binding assay, which is >200 times more potent than the ARA peptide.
    MM-102 TFA
  • HY-103329

    MM22; Biotinylated N-arachidonoylethanolamine

    Cannabinoid Receptor Others
    b-AEA (MM22) is a biotinylated endocannabinoid analog with probe activity. b-AEA is able to accumulate intracellularly in a similar manner to the parent compound AEA. b-AEA does not interact with other components of the endocannabinoid system and therefore does not interfere with their function. b-AEA can be used to visualize the accumulation and intracellular distribution of endocannabinoids .
    b-AEA
  • HY-P99268

    SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody

    EGFR Apoptosis Cancer
    Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .
    Seribantumab
  • HY-150350

    Biochemical Assay Reagents Others
    20mM HEPES, 150 mM NaCl, 240mM Sucrose, pH 7.2 buffer is a commonly used antibody storage buffer.
    20mM HEPES, 150 mM NaCl, 240mM Sucrose, pH 7.2 buffer
  • HY-101400A

    dCTP (trisodium) solution (100MM); 2′-Deoxycytidine-5′-triphosphate (trisodium) solution (100MM)

    DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite Metabolic Disease
    Deoxycytidine triphosphate trisodium (dCTP trisodium) solution (100mM) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing .
    Deoxycytidine triphosphate (trisodium) solution (100mM)
  • HY-W008661

    dGTP (trisodium) solution (100MM); 2'-Deoxyguanosine-5'-triphosphate (trisodium) solution (100MM)

    DNA/RNA Synthesis Others
    Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .
    Deoxyguanosine triphosphate (trisodium) solution (100mM)
  • HY-W013715A

    dTTP (trisodium) solution (100MM)

    DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite Others
    Deoxythymidine-5'-triphosphate (dTTP) trisodium solution (100mM) is one of the four nucleoside triphosphates used in the synthesis of DNA .
    Deoxythymidine-5'-triphosphate (trisodium) solution (100mM)
  • HY-107372H

    UTP, 100MM Solution, PCR Grade; Uridine 5'-triphosphate, 100MM Solution, PCR Grade

    Biochemical Assay Reagents Inflammation/Immunology
    Uridine triphosphate, 100 mM Solution, PCR Grade (UTP, 100 mM Solution, PCR Grade) A solution prepared from uridine triphosphate at a concentration of 100 mM, free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. Uridine triphosphate (HY-107372) is a pyrimidine nucleoside triphosphate used as a substrate for RNA synthesis or as an energy source in metabolic reactions .
    Uridine triphosphate, 100mM Solution, PCR Grade
  • HY-113225H

    GTP, 100MM Solution, PCR Grade

    Biochemical Assay Reagents Cancer
    Guanosine triphosphate, 100 mM Solution, PCR Grade (GTP, 100 mM Solution, PCR Grade) is a 100 mM solution prepared with GTP. Guanosine triphosphate, 100 mM Solution, PCR Grade is free of DNase, RNase and phosphatase contamination and is suitable for molecular biology research .
    Guanosine triphosphate, 100mM Solution, PCR Grade
  • HY-141567A

    Pseudo-UTP trisodium solution (100MM)

    DNA/RNA Synthesis Others
    Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate. Pseudouridine 5'-triphosphate trisodium solution (100 mM) is substituted for UTP to improve the stability and translation efficiency of mRNA and reduce immunogenicity .
    Pseudouridine 5'-triphosphate trisodium solution (100mM)
  • HY-125818I

    Cytidine triphosphate, 100MM Solution, PCR Grade; 5'-CTP, 100MM Solution, PCR Grade

    Biochemical Assay Reagents Metabolic Disease
    Cytidine-5'-triphosphate, 100 mM Solution, PCR Grade (Cytidine triphosphate, 100mM Solution, PCR Grade) Cytidine-5'-triphosphate solution is 100 mM and free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. Cytidine-5'-triphosphate (HY-125818) is a nucleoside triphosphate that serves as a building block for the biosynthesis of nucleotides and nucleic acids and lipids. Cytidine triphosphate synthase can catalyze the conversion of UTP to 5'-CTP .
    Cytidine-5'-triphosphate, 100mM Solution, PCR Grade
  • HY-W011425B

    Nitrilotris(methylenephosphonic acid), 25MM Solution, PCR Grade

    Biochemical Assay Reagents Cancer
    NTPO, 25 mM Solution, PCR Grade (Nitrilotris(methylenephosphonic acid), 25 mM Solution, PCR Grade) A 25 mM solution prepared from NTPO (HY-W011425) free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. NTPO is a DNA damage inducer that causes genomic DNA damage and breaks, activating ATR-mediated cell cycle checkpoints. The DNA damage effect of NTPO can be eliminated by base excision repair (BER) but not nucleotide excision repair (NER) .
    NTPO, 25mM Solution, PCR Grade
  • HY-Y1977

    Biochemical Assay Reagents Others
    100mM Pro-Ac, 20 mM Arg, pH 5.0 buffer is a biochemical reagent.
    100mM Pro-Ac, 20 mM Arg, pH 5.0 buffer
  • HY-B2176I

    Adenosine 5'-triphosphate, 100MM Solution, PCR Grade

    Biochemical Assay Reagents Metabolic Disease
    ATP, 100 mM Solution, PCR Grade (Adenosine 5'-triphosphate, 100 mM Solution, PCR Grade) A solution prepared from ATP with a concentration of 100 mM and free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. ATP (HY-B2176) is an important substance for energy storage and metabolism in the body, providing energy for metabolism and acting as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation .
    ATP, 100mM Solution, PCR Grade
  • HY-137694B

    DNA/RNA Synthesis Others
    ddTTP trisodium solution (100mM) is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing .
    ddTTP (trisodium) solution (100mM)
  • HY-W096178B

    Biochemical Assay Reagents Others
    Silica sand, 1-2mm is a by-product obtained from the industries like paint, paper, rubber etc .
    Silica sand, 1-2mm
  • HY-W096178C

    Biochemical Assay Reagents Others
    Silica sand, 2-7mm is a by-product obtained from the industries like paint, paper, rubber etc .
    Silica sand, 2-7mm
  • HY-136841

    CDK Cancer
    SLM6 is a sangivamycin-like molecule. SLM6 is a CDK9 inhibitor. SLM6 inhibits CDK9/cyclin K and CDK9/cyclin T1 kinase activity with IC50s of 280 nM and 133 nM, respectively. SLM6 also inhibits CDK1/cyclin B and CDK2/ cyclin A with IC50s of less than 300 nM. SLM6 induces apoptosis in multiple myeloma (MM) cells .
    SLM6
  • HY-134393B

    N6-Methyl-ATP (trisodium) solution (100MM)

    GSK-3 Others
    6-Me-ATP (N6-Methyl-ATP) trisodium solution (100mM) is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
    6-Me-ATP (trisodium) solution (100mM)
  • HY-W008661A

    dGTP trisodium,100 MM Solution,PCR Grade; 2'-Deoxyguanosine-5'-triphosphate trisodium,100 MM Solution,PCR Grade

    Biochemical Assay Reagents Others
    Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication. Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is provided in the form of aqueous solution .
    Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade
  • HY-W010771A

    dCTP trisodium,100 MM Solution,PCR Grade; 2′-Deoxycytidine-5′-triphosphate trisodium,100 MM Solution,PCR Grade

    Biochemical Assay Reagents Others
    Deoxycytidine triphosphate trisodium,100 mM Solution,PCR Grade (dCTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication. This product is provided in the form of aqueous solution .
    Deoxycytidine triphosphate trisodium,100 mM Solution,PCR Grade
  • HY-W013715B

    dTTP trisodium,100 MM Solution,PCR Grade

    Biochemical Assay Reagents Others
    Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade (dTTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication and can be used for PCR analysis. This product is provided in the form of aqueous solution .
    Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade
  • HY-158586

    Biochemical Assay Reagents DNA/RNA Synthesis Others
    3'-Azido-ddATP sodium solution (100mM) is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .
    3'-Azido-ddATP sodium solution (100mM)
  • HY-W017068B

    2'-Deoxyuridine-5'-triphosphate trisodium,100 MM Solution,PCR Grade

    Biochemical Assay Reagents Others
    dUTP trisodium,100 mM Solution,PCR Grade (2'-Deoxyuridine-5'-triphosphate trisodium,100 mM Solution,PCR Grade) is a highly stable nucleotide that can participate in the biosynthesis of DNA and is suitable for various conventional molecular biology experiments. This product is provided in the form of aqueous solution .
    dUTP trisodium,100 mM Solution,PCR Grade

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