Plexin B2 Protein, Human (HEK293, His)

Plexin B2 is a cell surface receptor for SEMA4C, SEMA4D, and SEMA4G and is involved in glutamatergic synapse development and SEMA4A-mediated excitatory synapse development. Plexin B2 activates downstream RHOA and ERBB2 phosphorylation, which is critical for promoting neuronal differentiation and migration. Plexin B2 Protein, Human (HEK293, His) is the recombinant human-derived Plexin B2 protein, expressed by HEK293 , with C-His labeled tag.

Plexin B2 (PLXNB2) serves as a cell surface receptor for SEMA4C, SEMA4D, and SEMA4G, playing a crucial role in cell-cell signaling. It is involved in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins induces downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248.' PLXNB2 is essential for normal differentiation and migration of neuronal cells during brain corticogenesis, contributing to normal embryonic brain development, and regulating the migration of cerebellar granule cells in the developing brain. Additionally, it plays a pivotal role in RHOA activation, leading to changes in the actin cytoskeleton, and participates in axon guidance, invasive growth, and cell migration. PLXNB2 may modulate the activity of RAC1 and CDC42, existing as both a monomer and a heterodimer with PLXNB1. Furthermore, it interacts with SEMA4C, SEMA4D, SEMA4G, MET, ARHGEF11, ARHGEF12, and possibly MST1R.

Human

HEK293

C-His

O15031-1 (L20-R1160)

23654  [NCBI]

LRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKR

150-180 kDa

Greater than 90% as determined by reduced SDS-PAGE.

<1 EU/μg, determined by LAL method.