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Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) .
LD4172 is a PROTAC degrader for RIP kinase (RIPK1) with DC50 in nanomolare levels. LD4172 induces apoptosis in cell B16F10 with combination of TNF-α. LD4172 exhibits antitumor efficacy in mouse models . (Pink: ligand for target protein (HY-170613); Black: linker (HY-W012241); Blue: ligand for E3 ligase VHL (HY-112078))
Cirazoline (LD 3098) is a doul agonist of Presynaptic imidazoline receptors (R(i-pre)) and α-adrenoceptor (R(α)). Cirazoline (30 μM) suppresses M current in SCG neurons cultured overnight .
Cirazoline (hydrochloride) (Standard) is the analytical standard of Cirazoline (hydrochloride). This product is intended for research and analytical applications. Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) .
Dipiproverine (hydrochloride) is the hydrochloride form of Dipiproverine (HY-118524). Dipiproverine (hydrochloride) is an alpha-amino acid ester, an antispasmodic compound, which is used as an anticholinergic agent .
PTZ-LD is a phenothiazine (HY-Y0055)-based fluorescent probe for lipid droplets (LDs) detection. PTZ-LD is apparently emissive in LDs with high specificity. (Ex/Em=488/570-620 nm). PTZ-LD can be used for diabetic cataract (DC) research .
AIECbz-LD-C7 is an aggregation-induced emission (AIE) probe based on the conjugation of quinoline-malononitrile (QM) and carbazole. AIECbz-LD-C7 has excellent LD-specificity. AIECbz-LD-C7 can be used for tracking the dynamic changes of LDs and studying the association between LDs and lysosome/endoplasmic reticulum (ER) .
CD300LD Human Pre-designed siRNA Set A contains three designed siRNAs for CD300LD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Lactate Dehydrogenase (LDH), Chicken Heart (LAD, LD, L-LDH, (S)-Lactate, LDH) is a biological material or organic compound that can be used in life science research .
Lactate Dehydrogenase (LDH), Bovine Heart (LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase) is a biological material or organic compound that can be used in life science research .
Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae(LD50=0.15 ng/mg) and C. quinquefasciatus(LD50=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .
Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .
Ejaponine A (Compound 1) is an insecticidal sesquiterpene ester. Ejaponine A is obtained from the natural Euonymus japonicus. Ejaponine A has Mythimna separata killing activity (LD5089.2 μgg -1). Ejaponine A is used to kill Mythimna separata .
Bifenthrin (Standard) is the analytical standard of Bifenthrin. This product is intended for research and analytical applications. Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD50=0.15 ng/mg) and C. quinquefasciatus (LD50=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .
Demethoxyviridiol is a mycotoxin originally isolated from N. hinnuleum. Demethoxyviridiol induces lethality in day-old cockerels (LD50=4.2 mg/kg). Demethoxyviridiol is also an inhibitor of phosphatidylinositol 3-kinase (PI3K).
Antitubercular agent-30 is an antibacterial agent against Mycobacterium tuberculosis (MIC=50 μg/mL). Antitubercular agent-30 has little cytotoxic effect on murine macrophage cells (LD85=~100 μg/mL) .
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.
Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin LD50 for intraperitoneal injection in mice is greater than 300 mg/kg, and the LD50 is greater than 15,000 mg/kg .
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD50=39.9 μM. Eugenitin has low cytotoxicity (IC50 >131 μM) against several human cancer cell lines .
LND 623 is an inotropic aminosteroid with positive inotropic properties. LND 623 inhibits Na +/K + ATPase activity. The LD50 of LND 623 infused i.v. is around 45 mg/kg, a value ten times higher than the LD50 for Ouabain (HY-B1457) .
Leucanicidin is a macrolide bacterial metabolite originally isolated from S. halstedii. It is toxic to L. separata fourth instar larvae when used at a concentration of 20 ppm and to H. contortus, T. colubriformis, and O. circumcincta larvae (LD50s=0.23-0.42 μg/mL).
Beauvericin A is a cyclodepsipeptide and derivative of beauvericin originally isolated from B. bassiana that has diverse biological activities. It is active against M. tuberculosis (MIC=25 μg/mL) and P. falciparum (IC50=12 μg/mL).2 Beauvericin A is toxic to brine shrimp (LD100=32 μg/mL).
Lipophagy inducer 1 (Compound 2726.007) is a lipophagy inducer. Lipophagy inducer 1 has the primary activity of reducing lipid droplet accumulation and rescuing podocyte cell death. Lipophagy inducer 1 exerts its effects by activating lipophagy and regulating the LXR signaling pathway. Lipophagy inducer 1 can be used in the study of the treatment of diabetic nephropathy (DKD) and other diseases related to lipid metabolism disorders .
(+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with LD50 values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively .
SL44 is an agonist for human caseinolytic protease P (HsClpP), with an EC50 of 1.30 μM. SL44 inhibits the proliferation of LM3 with an IC50 of 3.1 μM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD50=400 mg/kg). SL44 exhibits good pharmacokinetic characters in rat models .
Farnesyl acetate is a sesquiterpene isolated from the leaves of Amomum gagnepainii. Farnesyl acetate has significant toxicity against red palm weevil larvae with a LD50 of 7867 ppm .
(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg .
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .
Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an LD50 of 2365 mg/kg in rats .
Saframycin S is an antibiotic with a racemomycin group that exhibits inhibitory activity against Ehrlich ascites tumors. The LD50 of Saframycin S in ddY mice is 3.2 mg/kg (i.p.) .
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an LD50 of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .
(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC50=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg .
Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows LD50 against Mythimna separata of 280.4 μg/mL .
EP009 is a JAK3 inhibitor that selectively inhibits IL-2-mediated JAK3 tyrosine phosphorylation (IC50=10-20 μM in Kit225 cells) without affecting IL-3-induced JAK2 phosphorylation (up to 50 μM in BaF/3 cells). EP009 significantly reduced Kit225 cell viability (72 h, LD50=5.0 μM) while having no effect on BaF/3 cells. .
iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC50 of 28 nM and a LD50 of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release .
Cepacin A is an acetylenic antibiotic. Cepacin A has antibacterial activity, with a MIC of 0.2 μg/mL against staphylococci. In addition, Cepacin A is somewhat toxic to mice, with an LD50 of 30 mg/kg when administered intraperitoneally .
Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral LD50 of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research .
Sorbitan trioleate is an orally active nonionic surfactant with low toxicity (LD≥200 mg/kg). Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
Glaucarubin is a bitter lactone found in Simaruba glauca. Glaucarubin can be used as an amœbicide for amebiasis research. Glaucarubin is well tolerated, with LD50s of 1,600 mg/kg for mice and 6,400 mg/kg for rats .
DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD50 of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect .
Diethylene glycol monobutyl ether acetate is an orally available high molecular weight glycol ether solvent that can be used as a coalescing agent for polyvinyl acetate (latex) coatings, the acute oral LD in mice and rats is about 7 g/kg .
(S)-DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD50 of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect .
Chalcomycin is a macrolide antibiotic, which exhibits antimicrobial activities against gram-positive Staphylococcus aureus and Streptococcus pyogenes. Chalcomycin protects mice from infection with a variety of staphylococci and streptococc, without significant toxicity (LD50 >2500 mg/kg) .
AB-163 is an alkylating agent with anti-tumor activity. AB-163 exerts LD50s of 198 (p.o.) and 159 (i.p.) mg/kg in ICR/Ha male mice and can be utilized in cancer research .
(+)-Neomenthol (Standard) is the analytical standard of (+)-Neomenthol. This product is intended for research and analytical applications. (+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with LD50 values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively[1].
Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an LD50 of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .
Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows LD50 against Mythimna separata of 1656.4 μg/mL .
Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC50 of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD50 of 65 mg/kg .
Mathemycin A has an inhibitory effect on pathogenic fungi. Mathemycin A inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL), and it inhibits JO8 in greenhouse (LD50 is 42 X 10 -6, LC90 is 500 X 10 -6) .
Isopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC50: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD50 in rats: > 5 mg/kg .
DTP348 is an inhibitor for carbonic anhydrase IX with a Ki of 8.3 nM in vitro and an IC50 of 19.26 μM in Xenopus oocytes. DTP348 exhibits slight toxicity in zebrafish embryos with LD50 of 3.5 mM. DTP348 can be used in the anti-cancer research .
Bactobolin hydrochloride (Compound 1) is an antibiotic, which inhibits Escherichia coli, Salmonella, Shigella, Staphylococcus and Bacillus subtilis, with MICs of 0.3-6.25 μg/mL. Bactobolin hydrochloride exhibits antitumor efficacy against leukemia, with a LD50 value of 6.25-12.5 mg/kg .
Bactobolin (Compound 1) is an antibiotic, which inhibits Escherichia coli, Salmonella, Shigella, Staphylococcus and Bacillus subtilis, with MICs of 0.3-6.25 μg/mL. Bactobolin exhibits antitumor efficacy against leukemia, with a LD50 value of 6.25-12.5 mg/kg .
Antibiotic DC 102 is a new glycosidic pyrrole(1,4)benzodiazepine antibiotic with a MIC value of 42 μg/mL target Bacillus subtilis No. 10707. Antibiotic DC 102 has an LD50 value of 1.5mg/mL(i.p) in mouse .
Anti-inflammatory agent 92 (compound LD4) is a porphyrin derivative. Anti-inflammatory agent 92 has anti-inflammatory properties. Anti-inflammatory agent 92 can alleviate ulcerative colitis by inhibiting the STAT3-EPHX2 axis .
Metsulfuron-methyl is a systemic sulfonylurea herbicide that has been widely used to control broadleaf weeds and annual grasses in rice, corn, wheat, and barley. Metsulfuron-methyl exhibits high herbicidal activity and low mammalian toxicity, with an LD50 for rats exceeding 5000 mg/kg .
Looplure (ENT-33266) is an insect attractant with acute toxicity studies in different animal models showing activity at oral and dermal median lethal doses (LD50) and median lethal concentrations (LC50) for fish with some values, and low toxicity in most cases except for some cases.
Norbormide shows vasoconstrictor activity by blocking calcium channel. The activity of Norbormide is species- and tissue-specific, endothelium independent, and is restricted to the peripheral arteries of rat. Norbormide is also a toxicant, and the oral LD50s in mouse, hamster, guinea pig and rabbit are 2250, 140, 620, and 1000 mg/kg .
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg) .
Fenclofenac (Standard) is the analytical standard of Fenclofenac. This product is intended for research and analytical applications. Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral LD50 of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research .
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral LD50 of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .
SARS-CoV-2-IN-86 (Compound 2734589) is a dual inhibitor of the methyltransferases nsp14 and nsp16 of SARS-CoV-2. SARS-CoV-2-IN-86 exhibits low toxicity with a LD50 of 700 mg/kg according to toxicity analysis predict .
ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor (IC50: 1135 nM). ALK-IN-31 exhibits excellent antiproliferative activity against lung cancer H2228 cells with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation in the G0/G1 phase by affecting mitochondrial function. ALK-IN-31 exerts its anti-tumor effect by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. ALK-IN-31 can be used in the study of non-small cell lung cancer (NSCLC) .
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99=0.06 μg/mL) and inhibits motility of adult worms (EC50=2 μM). Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s=0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg .
m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD50 of 1.97 μg/cm 3 .
Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a LD50 of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer .
Dinotefuran is an orally active and competitive inhibitor and insecticide targeting insect nicotinic acetylcholine receptors (nAChRs). Dinotefuran blocks neural signaling and induces neural dysfunction in insects. Dinotefuran binds to [ 3H]epibatidine in the neural cord membrane of American cockroach with an IC50 of 890 nM and to [ 3H]α-bungarotoxin with an IC50 of 36.1 μM. Dinotefuran exhibits knockdown activity (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Dinotefuran is mainly used for agricultural pest control, such as field control of piercing-sucking and chewing insects (e.g., aphids, planthoppers), while its environmental toxicological effects (e.g., oxidative stress and reproductive neurotoxicity on earthworms) are also a research focus to assess ecological risks .
Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5, and 200 μg/mL, respectively.1 Rugulotrosin A is inactive against Gram-negative bacteria.
Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C exhibits highly inhibitory effect against rotavirus replication .
A 924 is an amino acid derivative-based, orally active antitumor agent. A 924 is effective in inhibiting ascites tumors in rat models by intraperitoneal injection or oral administration. The LD50 of A 924 in mice is >1.5 g/kg and >4.5 g/kg by intraperitoneal injection or oral administration, respectively. A 924 does not cause teratogenicity or adverse reactions in normal or pregnant mice .
Maackiain (DL-Maackiain) is isolated from Maackia amurensis Rupr.et Maxim. Maackiain (DL-Maackiain) is a larvicidal agent against Aedes aegypti mosquito.xp Parasitol with a LD50 of 21.95 µg/mL . Maackiain (DL-Maackiain) induces fragmentations of DNA to oligonucleosomal-sized fragments that like a characteristic of apoptosis in the HL-60 cells .
HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD50 of greater than 500 mg/kg in male and female rats .
Tubeimoside III (Standard) is the analytical standard of Tubeimoside III (HY-N2542). This product is intended for research and analytical applications. Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an LD50 of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .
Zinc Gluconate is a zinc supplement in the form of a gluconate salt, which plays a role in various physiological processes such as immune function, wound healing, and olfaction. Zinc Gluconate has a LD50 of 39.6 mg/kg in mice (Tail vein injection). Zinc Gluconate can be used in the research of inflammation, zinc deficiency, colds, cancer, and nutritional supplements .
(-)-trans-Myrtanol is an antimicrobial and acaricide agent. (-)-trans-Myrtanol exhibits potent antimicrobial activities against harmful intestinal bacteria. (-)-trans-Myrtanol shows acaricidal activities for D. farinae, D. pteronyssinus, T. putrescentiae with LD50 values of 2.30 µg/cm 2, 2.22 µg/cm 2, 12.95 µg/cm 2, respectively .
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .
RAD51-IN-9 (Compound 3a) is a RAD51 inhibitor that can inhibit the binding of RAD51 to ssDNA with an IC50 of 17.85 μM. RAD51-IN-9 has a LD50 against HEK293 cells of 40.21 μM. RAD51-IN-9 can sensitize cells to Mitomycin C (HY-13316) .
Metsulfuron-methyl (Standard) is the analytical standard of Metsulfuron-methyl. This product is intended for research and analytical applications. Metsulfuron-methyl is a systemic sulfonylurea herbicide that has been widely used to control broadleaf weeds and annual grasses in rice, corn, wheat, and barley. Metsulfuron-methyl exhibits high herbicidal activity and low mammalian toxicity, with an LD50 for rats exceeding 5000 mg/kg .
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD50 of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with Ki of 304 μM .
m-Tolualdehyde (Standard) is the analytical standard of m-Tolualdehyde. This product is intended for research and analytical applications. m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD50 of 1.97 μg/cm 3 .
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO -), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO -. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor .
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD50 of 25 mg/kg .
Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with IC50 of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD50 is 91.2 mg/kg) .
MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg) .
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD50 of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) .
Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities. It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s=0.84 and 0.82 μg/mL, respectively). It is toxic to mice with an LD50 value of 0.3 mg/kg.
Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD50 of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].
N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .
N-Nonyldeoxynojirimycin (NN-DNJ) is a deoxynojirimycin derivative with a hydrophobic long chain. N-Nonyldeoxynojirimycin is an orally active inhibitor of acid α-glucosidase (IC50: 0.42 μM) and α-1,6-glucosidase (IC50: 8.4 μM). N-Nonyldeoxynojirimycin has activities of inhibiting glycogen breakdown, anti-virus and anti-tumor. N-Nonyldeoxynojirimycin also has insecticidal effects, with an LD50 of 5 mM for adults of Bemisia tabaci .
Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I and can cross the blood-brain barrier. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD50 of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies .
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
PAK4-IN-5 (Compound 12i) is a PAK4 inhibitor (IC50: 7.68 nM for PAK4, 1872.01 nM for PAK1). PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD50: >500 mg/kg for mice (p.o.) .
Tenuazonic acid- 13C10 is 13C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
Tenuazonic acid-d13 is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .
Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD50 of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].
Poloxamer 235 P85 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4600. Poloxamer 235 P85 exhibits acute and subchronic toxicity in albino rats with an oral LD50 of >34.6 g/kg. Poloxamer 235 P85 induces ocular irritation in rabbits .
(+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with LD50 values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively .
(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg .
Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .
Ejaponine A (Compound 1) is an insecticidal sesquiterpene ester. Ejaponine A is obtained from the natural Euonymus japonicus. Ejaponine A has Mythimna separata killing activity (LD5089.2 μgg -1). Ejaponine A is used to kill Mythimna separata .
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.
Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin LD50 for intraperitoneal injection in mice is greater than 300 mg/kg, and the LD50 is greater than 15,000 mg/kg .
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD50=39.9 μM. Eugenitin has low cytotoxicity (IC50 >131 μM) against several human cancer cell lines .
Farnesyl acetate is a sesquiterpene isolated from the leaves of Amomum gagnepainii. Farnesyl acetate has significant toxicity against red palm weevil larvae with a LD50 of 7867 ppm .
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .
Saframycin S is an antibiotic with a racemomycin group that exhibits inhibitory activity against Ehrlich ascites tumors. The LD50 of Saframycin S in ddY mice is 3.2 mg/kg (i.p.) .
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an LD50 of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .
(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC50=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg .
Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows LD50 against Mythimna separata of 280.4 μg/mL .
Cepacin A is an acetylenic antibiotic. Cepacin A has antibacterial activity, with a MIC of 0.2 μg/mL against staphylococci. In addition, Cepacin A is somewhat toxic to mice, with an LD50 of 30 mg/kg when administered intraperitoneally .
Glaucarubin is a bitter lactone found in Simaruba glauca. Glaucarubin can be used as an amœbicide for amebiasis research. Glaucarubin is well tolerated, with LD50s of 1,600 mg/kg for mice and 6,400 mg/kg for rats .
Chalcomycin is a macrolide antibiotic, which exhibits antimicrobial activities against gram-positive Staphylococcus aureus and Streptococcus pyogenes. Chalcomycin protects mice from infection with a variety of staphylococci and streptococc, without significant toxicity (LD50 >2500 mg/kg) .
(+)-Neomenthol (Standard) is the analytical standard of (+)-Neomenthol. This product is intended for research and analytical applications. (+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with LD50 values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively[1].
Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an LD50 of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .
Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows LD50 against Mythimna separata of 1656.4 μg/mL .
Mathemycin A has an inhibitory effect on pathogenic fungi. Mathemycin A inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL), and it inhibits JO8 in greenhouse (LD50 is 42 X 10 -6, LC90 is 500 X 10 -6) .
Isopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC50: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD50 in rats: > 5 mg/kg .
Bactobolin (Compound 1) is an antibiotic, which inhibits Escherichia coli, Salmonella, Shigella, Staphylococcus and Bacillus subtilis, with MICs of 0.3-6.25 μg/mL. Bactobolin exhibits antitumor efficacy against leukemia, with a LD50 value of 6.25-12.5 mg/kg .
Antibiotic DC 102 is a new glycosidic pyrrole(1,4)benzodiazepine antibiotic with a MIC value of 42 μg/mL target Bacillus subtilis No. 10707. Antibiotic DC 102 has an LD50 value of 1.5mg/mL(i.p) in mouse .
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg) .
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99=0.06 μg/mL) and inhibits motility of adult worms (EC50=2 μM). Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s=0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD50 of 1.97 μg/cm 3 .
Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5, and 200 μg/mL, respectively.1 Rugulotrosin A is inactive against Gram-negative bacteria.
Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C exhibits highly inhibitory effect against rotavirus replication .
Maackiain (DL-Maackiain) is isolated from Maackia amurensis Rupr.et Maxim. Maackiain (DL-Maackiain) is a larvicidal agent against Aedes aegypti mosquito.xp Parasitol with a LD50 of 21.95 µg/mL . Maackiain (DL-Maackiain) induces fragmentations of DNA to oligonucleosomal-sized fragments that like a characteristic of apoptosis in the HL-60 cells .
Tubeimoside III (Standard) is the analytical standard of Tubeimoside III (HY-N2542). This product is intended for research and analytical applications. Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an LD50 of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .
(-)-trans-Myrtanol is an antimicrobial and acaricide agent. (-)-trans-Myrtanol exhibits potent antimicrobial activities against harmful intestinal bacteria. (-)-trans-Myrtanol shows acaricidal activities for D. farinae, D. pteronyssinus, T. putrescentiae with LD50 values of 2.30 µg/cm 2, 2.22 µg/cm 2, 12.95 µg/cm 2, respectively .
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD50 of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with Ki of 304 μM .
m-Tolualdehyde (Standard) is the analytical standard of m-Tolualdehyde. This product is intended for research and analytical applications. m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD50 of 1.97 μg/cm 3 .
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO -), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO -. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor .
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD50 of 25 mg/kg .
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD50 of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) .
Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I and can cross the blood-brain barrier. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD50 of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies .
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
MIP-1 alpha/CCL3 protein, a monokine with inflammatory and chemokinetic properties, binds to CCR1, CCR4, and CCR5 receptors. Produced by CD8+ T-cells, it inhibits various strains of HIV-1, HIV-2, and SIV in a dose-dependent manner. Additionally, MIP-1 alpha/CCL3 self-associates and forms a heterodimer with MIP-1-beta(3-69). Animal-Free MIP-1 alpha/CCL3 Protein, Human (His) is the recombinant human-derived animal-FreeMIP-1 alpha/CCL3 protein, expressed by E. coli , with N-His. This product is for cell culture use only.
MIP-1 alpha/CCL3 protein, a monokine, displays inflammatory, pyrogenic, and chemokinetic properties.It induces potent chemotaxis in eosinophils and activates calcium release in neutrophils via high-affinity receptor binding.Animal-Free MIP-1 alpha/CCL3 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMIP-1 alpha/CCL3 protein, expressed by E.coli , with N-His labeled tag.This product is for cell culture use only.
MIP-1 alpha/CCL3 Protein, Mouse (His), an important chemokine, is a key regulator of immune microenvironment and primarily mediates the trafficking of immune cells in both inflammation and cancer. MIP-1 alpha/CCL3 Protein, Mouse (His) is a recombinant mouse CCL3 (A24-A92) expressed by E.coil with a N-6*His tag.
LD78-beta/CCL3L1 Protein, Human (HEK293 His) is a multiallelic copy number variable, which plays a crucial role in immunoregulatory and hosts defense through the production of macrophage inflammatory protein (MIP)-1α.
The GGACT protein uses its enzymatic activity to break cross-links between lysine and glutamate residues, actively promoting the degradation of proteins cross-linked by transglutaminase. In addition, GGACT catalyzes the formation of 5-oxo-L-proline from the substrate L-γ-glutamyl-L-ε-lysine. GGACT Protein, Human (HEK293, His) is the recombinant human-derived GGACT protein, expressed by HEK293 , with N-6*His labeled tag.
N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .
Tenuazonic acid-d13 is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
Tenuazonic acid- 13C10 is 13C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Sorbitan trioleate is an orally active nonionic surfactant with low toxicity (LD≥200 mg/kg). Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg .
CD300LD Human Pre-designed siRNA Set A contains three designed siRNAs for CD300LD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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