Search Result

Isoforms Recommended:	CDK1

Results for "

Cdk1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (2) Akt (3) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (50) Aryl Hydrocarbon Receptor (1) ATM/ATR (2) Aurora Kinase (3) Autophagy (8) Bacterial (1) Bcl-2 Family (4) c-Myc (1) Casein Kinase (1) Caspase (5) CDK (150) CFTR (1) COX (1) Cyclin G-associated Kinase (GAK) (1) DNA/RNA Synthesis (2) DYRK (1) Endogenous Metabolite (1) Ephrin Receptor (1) ERK (3) FGFR (2) GSK-3 (24) HBV (2) HDAC (1) Histone Demethylase (1) HIV (2) HSP (1) HSV (1) IRAK (1) Isotope-Labeled Compounds (2) Itk (1) JAK (2) JNK (1) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (1) Lipoxygenase (1) MAP4K (1) MEK (2) MELK (1) Molecular Glues (2) mTOR (2) NEKs (2) NF-κB (2) Orthopoxvirus (2) p38 MAPK (2) PERK (1) Phosphatase (1) PI3K (5) PKC (3) Polo-like Kinase (PLK) (2) PROTACs (4) Raf (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Reverse Transcriptase (1) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (4) SphK (1) Src (1) STAT (1) ULK (1) VEGFR (3) Wee1 (4) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (155) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (6)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (4)

166

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115924

CDK1-IN-1	CDK	Cancer
CDK1-IN-1 is a potent *CDK1* inhibitor (CDK1/CycB IC₅₀=161.2 nM) with potential antiproliferative activity and selectivity for cancer tissues. CDK1-IN-1 induces apoptosis in p53 dependent manner through the intrinsic apoptotic pathway. CDK1-IN-1 is a potential targeted antitumor agent ^[1].

HY-168673

CDK1-IN-6	CDK	Cancer
CDK1-IN-6 (Ligand 3) is a potent *CDK1* inhibitor. CDK1-IN-6 has the potential for the research of cancer ^[1].

HY-112463

CDK1-IN-2	CDK	Cancer
CDK1-IN-2 is a *CDK1* inhibitor (IC₅₀: 5.8 μM) ^[1].

HY-RS02349

Cdk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CDK	Others
Cdk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cdk1 Mouse Pre-designed siRNA Set A Cdk1 Mouse Pre-designed siRNA Set A

HY-RS02350

Cdk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CDK	Others
Cdk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cdk1 Rat Pre-designed siRNA Set A Cdk1 Rat Pre-designed siRNA Set A

HY-RS02348

CDK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CDK	Others
CDK1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDK1 Human Pre-designed siRNA Set A CDK1 Human Pre-designed siRNA Set A

HY-176189

CDK1-IN-7	CDK	Cancer
CDK1-IN-7 (compound M7) is a potent *CDK1* inhibitor. CDK1-IN-7 inhibits the proliferation and migration of HCT116 and Lovo cells. CDK1-IN-7 can be used in the study of colorectal cancer ^[1].

HY-151409

CDK1-IN-5	CDK	Cancer
CDK1-IN-5 (10h) is a selective *CDK1* inhibitor with IC₅₀s of 42.19, 188.71 and 354.15 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-5 inhibits growth of cancer cells by affecting cell cycle. CDK1-IN-5 can be used for the research of cancer ^[1].

HY-151407

CDK1-IN-3	CDK	Cancer
CDK1-IN-3 (8g) is a selective *CDK1* inhibitor with IC₅₀s of 36.8, 305.17 and 369.37 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-3 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-3 can be used for the research of cancer ^[1].

HY-151408

CDK1-IN-4	CDK	Cancer
CDK1-IN-4 (10d) is a selective *CDK1* inhibitor with IC₅₀s of 44.52, 624.93 and 135.22 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN4 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-4 can be used for the research of cancer ^[1].

HY-147646

CDK1/Cyc B-IN-1	CDK Apoptosis	Cancer
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC₅₀ of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines ^[1].

HY-E70656

CDK1/CycO Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycO Recombinant Human Active Protein Kinase is an ortholog of CDK1 ^[1].

HY-E70655

CDK1/CycE2 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycE2 Recombinant Human Active Protein Kinase is an ortholog of CDK1 ^[1].

HY-E70651

CDK1/CycA1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycA1 Recombinant Human Active Protein Kinase is an ortholog of CDK1 ^[1].

HY-E70654

CDK1/CycE1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycA1 Recombinant Human Active Protein Kinase is an ortholog of CDK1 ^[1].

HY-E70653

CDK1/CycB1 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycB1 Recombinant Human Active Protein Kinase is an ortholog of CDK1. CDK1/cyclin B1 complexes initiates mitotic entry by phosphorylating a multitude of proteins to condense chromosomes, disrupt the nuclear envelope, and enable microtubules polymerization to attach and to segregate the chromosomes ^[1].

HY-146253

CDK1/2/4-IN-1	CDK Apoptosis Bcl-2 Family Caspase	Cancer
CDK1/2/4-IN-1 (compound 3a) is a potent *CDK* inhibitor with IC₅₀ values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research ^[1].

HY-47733

CDK1/2/4-IN-2	CDK	Cancer
WAY-643018 (Compound 2), an indazolecarboxamide derivative, is a *CDK1, CDK2, and CDK4* inhibitor. CDK1/2/4-IN-2 has the potential for cancer research ^[1].

HY-112462

Cdk1/2 Inhibitor III	CDK	Cancer
Cdk1/2 Inhibitor III (compound 3n) is a highly potent and selective Cdk1/cyclin B and Cdk2/cyclin A inhibitor of with IC₅₀s of 0.6 nM and 0.5 nM, respectively. Cdk1/2 Inhibitor III shows selectivity over VEGF-R2 (IC₅₀ of 32 nM), GSK-3β (IC₅₀ of 140 nM), and a other kinases. Cdk1/2 Inhibitor III inhibits in cell proliferation with IC₅₀s of 20 nM, 35 nM and 92 nM for HCT-116, HeLa, and A375 cells, respectively ^[1].

HY-E70652

CDK1/CycA2 Recombinant Human Active Protein Kinase	CDK	Cancer
CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK4/CycD2 Recombinant Human Active Protein Kinase is an ortholog of CDK1 ^[1].

HY-147901

*KDM1/CDK1-IN-1*	Histone Demethylase CDK Apoptosis Caspase	Cancer
KDM1/CDK1-IN-1 (compound 4) is a potent *KDM1* and *CDK1* inhibitor, with IC₅₀ values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC₅₀ values of 16.34, 3.45 and 7.79 μM, respectively ^[1].

HY-15569

NU6102	CDK	Cancer
NU6102 is a potent *CDK1* and *CDK2* inhibitor with IC₅₀s of 9.5 nM and 5.4 nM for *CDK1/cyclinB* and *CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2* over CDK4 (IC₅₀ of 1.6 μM), DYRK1A (IC₅₀ of 0.9 μM), PDK1 (IC₅₀ of 0.8 μM) and ROCKII (IC₅₀ of 0.6 μM) ^[1] .

HY-118976

CGP-74514 hydrochloride CGP-74514A	CDK Apoptosis	Cancer
CGP-74514 hydrochloride is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC₅₀: 25 nM). CGP-74514 hydrochloride inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G₂/M phase and induces tumor cell apoptosis. CGP-74514 hydrochloride is promising for research of bladder cancer ^[1] .

HY-110359

CGP-74514 dihydrochloride	CDK Apoptosis	Cancer
CGP-74514 dihydrochloride is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC₅₀=25 nM). CGP-74514 dihydrochloride inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G₂/M phase and induces tumor cell apoptosis. CGP-74514 dihydrochloride is promising for research of bladder cancer ^[1] .

HY-115565

CGP-74514	CDK Apoptosis	Cancer
CGP-74514 (Compound 13) is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC₅₀=25 nM). CGP-74514 inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G₂/M phase and induces tumor cell apoptosis. CGP-74514 is promising for research of bladder cancer ^[1] .

HY-114779

N9-Isopropylolomoucine	CDK	Cancer
N9-Isopropylolomoucine is a mitotic cyclin dependent kinase (CDK) inhibitor. N9-Isopropylolomoucine targets CCNB 1/CDK1 and can be used for cancer research ^[1].

HY-103647

K00546	CDK VEGFR GSK-3	Cancer
K00546 is a potent *CDK1* and *CDK2* inhibitor with IC₅₀s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. K00546 is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC₅₀s of 8.9 nM and 29.2 nM, respectively ^[1] .

HY-P11028

M1-20	CDK	Cancer
M1-20 is a *CDK1* inhibitor. M1-20 promotes CDK1 ubiquitination by CUL4-DDB1-DCAF1 complexes and degradation through the proteasome pathway. M1-20 abolishes the formation of CDK1/CCNB1 complexes. M1-20 has significant anticancer activity of spontaneous breast cancer in FVB/N MMTV-PyVT mice model ^[1].

HY-N12625A

(S)-(-)-O-Demethylbuchenavianine	CDK	Cancer
(S)-(-)-O-Demethylbuchenavianine (Compound (S)-(−)-1) is a flavonoidal alkaloids. (S)-(-)-O-Demethylbuchenavianine is a potent *CDK* inhibitor, with IC₅₀ values of 0.03 and 0.05 μM for CDK1 and CDK5, respectively ^[1].

HY-123369

BMI-1026	CDK Apoptosis	Cancer
BMI-1026 is a cyclin-dependent kinase 1 (Cdk1) inhibitor with IC₅₀ of 2.3 nM. BMI-1026 induces apoptosis by arresting the G2-M phase ^[1].

HY-12529

Ro-3306 50+ Cited Publications	CDK Apoptosis	Cancer
Ro-3306 is a potent and selective inhibitor of *CDK1, with K_is of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK*2/cyclin E, respectively.

HY-122609

XO44 PF-6808472	CDK	Cancer
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in *CDK2 and CDK1. XO44 also labels CDK4* proteins in cells ^[1] .

HY-13816

NU6027	CDK ATM/ATR	Cancer
NU6027 is a potent and ATP-competitive inhibitor of both *CDK1* and *CDK2, with K_is of 2.5 μM and 1.3 μM, respectively. NU6027 is also a potent inhibitor of ATR* and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner ^[1] .

HY-10329

JNJ-7706621 4 Publications Verification	Aurora Kinase CDK Apoptosis	Cancer
JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits *CDK1* and *CDK2, with IC₅₀s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A* and aurora-B, respectively ^[1] .

HY-118310

Xylocydine	CDK	Cancer
Xylocydine is an inhibitor of *CDK1/2, inhibiting CDK* function in various apoptotic processes. Xylocydine specifically blocks CDK1 and CDK2 activity with IC50 of 1.4 nM and 61 nM, respectively. In addition, Xylocydine downregulates phosphorylated nucleolin and retinoblastoma protein levels. ^[1].

HY-112394

2-Cyanoethylalsterpaullone	GSK-3 CDK	Cancer
2-Cyanoethylalsterpaullone (compound 7) is an Alsterpaullone (HY-108359) derivative, which exhibits potent and selective inhibitory activities against CDK1/Cyclin B and GSK-3β (GSK-3β: IC₅₀=0.8 nM; CDK1/Cyclin B: IC₅₀=0.23 nM) ^[1].

HY-103381

NSC693868	CDK GSK-3	Cancer
NSC693868 is a selective inhibitor of *CDK1* and *CDK5* with IC₅₀s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC₅₀ of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways ^[1].

HY-103221

MeBIO	Aryl Hydrocarbon Receptor GSK-3 CDK	Others
MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC₅₀ of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively ^[1].

HY-10580

GSK 3 Inhibitor IX 10+ Cited Publications 6-Bromoindirubin-3'-oxime; BIO; MLS 2052	GSK-3 CDK Apoptosis	Cancer
GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and *CDK1-cyclinB* complex with IC₅₀s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively.

HY-170306

LZ9	CDK	Cancer
LZ9 is a ATP-competitive *CDK1* and *CDK2* inhibitor. LZ9 has the potential for the research of colorectal cancer (CRC) ^[1] .

HY-124719

hSMG-1 inhibitor 11j 5+ Cited Publications	PI3K mTOR GSK-3 CDK	Cancer
hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of *hSMG-1, with an IC₅₀* of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC₅₀=50 nM), PI3Kα/γ (IC₅₀=92/60 nM) and *CDK1/CDK2* (IC₅₀=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer ^[1].

HY-P5428

Cdc2 kinase substrate	CDK	Others
Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)

HY-10005

Flavopiridol 45+ Cited Publications HMR-1275; Alvocidib; L86-8275	CDK Autophagy HIV Apoptosis	Cancer
Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of *CDKs, inhibiting CDK1, CDK2, CDK4 with IC₅₀*s of 30, 170, 100 nM, respectively.

HY-168519

STAT3-IN-36	STAT	Cancer
STAT3-IN-36 (compound 11g) is a triple-target inhibitor targeting LRPPRC, STAT3, and *CDK1* with anticancer activity. STAT3-IN-36 binds to LRPPRC, STAT3, and CDK1, exerting a stronger anticancer effect than TMF (HY-N6818) or Capecitabine (HY-B0016). STAT3-IN-36 inhibits HGC27 cells with IC₅₀ 1.8 μM. ^[1].

HY-18629

SU9516 4 Publications Verification	CDK Autophagy Apoptosis	Cancer
SU9516 is a potent *CDK2* inhibitor, with an IC₅₀ of 22 nM, and also shows inhibitory effects on CDK1 and CDK4, with IC₅₀s of 40, 200 nM, respectively.

HY-P2480

Histone H1-derived Peptide	CDK	Others
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity ^[1] .

HY-10006

Flavopiridol Hydrochloride 45+ Cited Publications Alvocidib Hydrochloride; L86-8275 Hydrochloride; HMR-1275 Hydrochloride	CDK Autophagy HIV	Cancer
Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of *CDK, competing with ATP to inhibit CDKs* including CDK1, CDK2, CDK4 with IC₅₀s of 30, 170, 100 nM, respectively.

HY-10492

Dinaciclib 45+ Cited Publications SCH 727965	CDK Apoptosis	Cancer
Dinaciclib (SCH 727965) is a potent inhibitor of *CDK, with IC₅₀s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9*, respectively ^[1].

HY-50914

AZD5597	CDK	Cancer
AZD5597 is an inhibitor of *CDK* with IC₅₀ values of both 2 nM for *CDK1* and *CDK2*. AZD5597 can inhibit the proliferation of tumor cells and has anti-tumor activity ^[1].

HY-13266A

BS-181 hydrochloride 5 Publications Verification	CDK	Cancer
BS-181 hydrochloride is a highly selective *CDK7* inhibitor with IC₅₀ of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.

Cat. No.	Product Name	Target	Research Area

HY-P2480

Histone H1-derived Peptide	CDK	Others
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity ^[1] .

HY-P11028

M1-20	CDK	Cancer
M1-20 is a *CDK1* inhibitor. M1-20 promotes CDK1 ubiquitination by CUL4-DDB1-DCAF1 complexes and degradation through the proteasome pathway. M1-20 abolishes the formation of CDK1/CCNB1 complexes. M1-20 has significant anticancer activity of spontaneous breast cancer in FVB/N MMTV-PyVT mice model ^[1].

HY-P5428

Cdc2 kinase substrate	CDK	Others
Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12625A

(S)-(-)-O-Demethylbuchenavianine	Structural Classification Alkaloids Flavonoids Flavones Other Alkaloids Buchenavia macrophylla Spruce ex Eichler Combretaceae Source classification Plants	CDK
(S)-(-)-O-Demethylbuchenavianine (Compound (S)-(−)-1) is a flavonoidal alkaloids. (S)-(-)-O-Demethylbuchenavianine is a potent *CDK* inhibitor, with IC₅₀ values of 0.03 and 0.05 μM for CDK1 and CDK5, respectively ^[1].

HY-N11774

Euphornin	Structural Classification Natural Products Source classification Euphorbia helioscopia L. Euphorbiaceae Plants	Apoptosis Caspase
Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin induces apoptosis via caspase-mediated pathways. Euphornin induces cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein ^[1].

HY-N5072

Desmethylglycitein 2 Publications Verification 4',6,7-Trihydroxyisoflavone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to *CDK1* and *CDK2* in vivo, resulting in the suppresses CDK1 and CDK2 activity ^[1]. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-B0255

Adefovir dipivoxil 1 Publications Verification GS 0840	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	HBV Orthopoxvirus HSV DNA/RNA Synthesis ATM/ATR CDK
Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the *KCTD12-CDK1* interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer ^[1] .

HY-N12625

(R)-(+)-O-Demethylbuchenavianine	Structural Classification Alkaloids Flavonoids Flavones Other Alkaloids Buchenavia macrophylla Spruce ex Eichler Combretaceae Source classification Plants	CDK DYRK GSK-3
(R)-(+)-O-Demethylbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK). (R)-(+)-O-Demethylbuchenavianine inhibits CDK1, CDK5, glycogen synthase kinase-3 (GSK3), cdc2-like kinase (CLK1) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), with IC₅₀s of 1.1, 0.95, >10, >10 and >10 μM, respectively ^[1].

HY-N11439

Albanol B	Structural Classification Natural Products Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	CDK Akt ERK Apoptosis Bacterial
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates *CDK1* expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and *ERK1/2* ^[1].

HY-N5072R

Desmethylglycitein (Standard)	Structural Classification Flavonoids Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Plants Isoflavones	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity ^[1]. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-B0255R

Adefovir dipivoxil (Standard) GS 0840 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards HBV Reverse Transcriptase Orthopoxvirus Endogenous Metabolite
Adefovir dipivoxil (Standard) is the analytical standard of Adefovir dipivoxil. This product is intended for research and analytical applications. Adefovir dipivoxil is an orally active adenosine analog and Adefovir prodrug. Adefovir dipivoxil inhibits DNA synthesis, activates the ATR signaling pathway, and disrupts the *KCTD12-CDK1* interaction. Adefovir dipivoxil has antiviral activity against PRV, HBV, and orthopoxviruses. Adefovir dipivoxil has inhibitory effects on both lamivudine-resistant and wild-type strains. Adefovir dipivoxil has antitumor activity against lung and colon cancer ^[1] .

Recombinant Proteins Recommended:

Cyclin Dependent Kinase 1 (CDK1)

Species:	Human (7) Mouse (1)
Tag:	His (6) GST (7) Flag (3)
Source:	Sf9 insect cells (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P75668

	CDK1 Protein, Human (sf9, GST) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1 Protein, Human (sf9, GST) is the recombinant human-derived CDK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P74257

	CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST) Cyclin-dependent kinase 1; Cdk1; CDC2; G1/S-specific cyclin-E1; CCNE1	Human	Sf9 insect cells
	The FGF-9 protein undergoes autoproteolysis and cholesterol attachment in the endoplasmic reticulum. It acts as a morphogen during development, inducing ventral cell fate, participating in limb bud patterning, and aiding in axon guidance. FGF-9 binds to the PTCH1 receptor and activates target gene transcription when in association with SMO, while PTCH1 represses SMO signaling in the absence of FGF-9. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST) is a recombinant protein dimer complex containing human-derived CDK1-CCNE1 Heterodimer protein, expressed by Sf9 insect cells , with N-10*His, N-GST labeled tag. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST), has molecular weight of ~109.7 (60.4+49.3) kDa.

HY-P702779

	CDK1 Protein, Human (sf9) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1 Protein, Human (sf9) is the recombinant human-derived CDK1, expressed by Sf9 insect cells, with tag-free. The total length of CDK1 Protein, Human (sf9) is 297 a.a..

HY-P75669

	CDK1 Protein, Mouse (sf9, His-GST) Cyclin-dependent kinase 1; Cdk1; p34 protein kinase; CDC2; CDC28A; CdkN1; P34CDC2	Mouse	Sf9 insect cells
	The CDK1 protein centrally controls the eukaryotic cell cycle, coordinating the G2-M transition and mitotic events. It interacts with a variety of cell cycle proteins, phosphorylates a variety of substrates, and affects cell cycle regulation, DNA repair, and apoptosis. CDK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702671

	CDK1-CCNA2 Protein, Human (sf9, GST, His) Cdk1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNA2 Protein, Human (sf9, GST, His) is the recombinant human-derived CDK1-CCNA2, expressed by Sf9 insect cells, with N-His, N-GST labeled tag.

HY-P702673

	CDK1-CCNE1 Protein, Human (sf9, GST, His, Flag) Cdk1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNE1 Protein, Human (sf9, GST, His, Flag) is the recombinant human-derived CDK1-CCNE1, expressed by Sf9 insect cells, with N-GST, N-Flag, N-His labeled tag.

HY-P702674

	CDK1-CCNE2 Protein, Human (sf9, GST, His, Flag) Cdk1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNE2 Protein, Human (sf9, GST, His, Flag) is the recombinant human-derived CDK1-CCNE2, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P702736

	CDK1-CCNB1 Protein, Human (sf9, GST, Flag, His) Cdk1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNB1 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK1-CCNB1, expressed by Sf9 insect cells, with N-GST, N-Flag, N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-15777AS

Ribociclib-d6 hydrochloride
Ribociclib-d₆ (hydrochloride) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex ^[1].

HY-15777S1

Ribociclib-d8
Ribociclib-d₈ is the deuterium labeled Ribociclib ^[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex .

HY-15777S

Ribociclib-d6
Ribociclib-d₆ is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC₅₀ values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex ^[1].

HY-176174S

CDK2-IN-46
CDK2-IN-46 (compound 5g) is a selective *CDK2* inhibitor with an IC₅₀ of 0.3 nM. CDK2-IN-46 has a selectivity of >200-fold for CDK1, CDK7, CDK9, CDK4, and CDK6. CDK2-IN-46 shows improves rat and cyno pharmacokinetic profiles ^[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80611

	CDK1 Antibody (YA516) 1 Publications Verification Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, IP	Human
	CDK1 Antibody (YA516) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK1.

HY-P80796

	*Phospho-CDK1* (Tyr15) Antibody** Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB	Human, Mouse, Rat
	Phospho-CDK1 (Tyr15) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-CDK1 (Tyr15).

HY-P80076

	CDK2 Antibody (YA514) Cdc2 related protein kinase; CDC28; CDC2A; Cdk 2; Cdk1; Cdk2; Cdk2_HUMAN ; CdkN2; MPF; p33(Cdk2) antibody;	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
	CDK2 Antibody (YA514) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK2.

HY-P80797

	*Phospho-CDK1/2/3 (Thr14) Antibody (YA218)* CDC2; CDC28A; P34CDC2	WB, IP	Human, Hamster
	Phospho-CDK1/2/3 (Thr14) Antibody (YA218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CDK1/2/3 (Thr14).

HY-P83973

	CDK1 Antibody (YA3670) CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; Cdk1	WB, ICC/IF, FC, ELISA	Human
	CDK1 Antibody (YA3670) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CDK1.

HY-P86404

	CDK1 Antibody (YA6096) Cdk1; CDC2; CDC28A; CdkN1; P34CDC2; Cyclin-dependent kinase 1; Cdk1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse,
	CDK1 Antibody (YA6096) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK1.

HY-P82827

	*Phospho-CDK1/2 (Thr14) Antibody (YA2572)* CdkN2; p33(Cdk2)	WB, IHC-P, IP	Human
	Phospho-CDK1/2 (Thr14) Antibody (YA2572) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-CDK1/2 (Thr14).

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Cat. No.	Product Name		Classification

HY-122609

XO44 PF-6808472		Alkynes
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in *CDK2 and CDK1. XO44 also labels CDK4* proteins in cells ^[1] .

HY-116423

JH295		Alkynes
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint ^[1]. JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-116423A

JH295 hydrate		Alkynes
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC₅₀ of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint ^[1]. JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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