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Results for "

AS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (1) 5-HT Receptor (7) ABA Receptor (1) Acyltransferase (1) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Akt (5) Aldose Reductase (1) Androgen Receptor (2) Antibiotic (4) Apoptosis (4) Aurora Kinase (2) Autophagy (3) Bacterial (2) Bcl-2 Family (1) Bcr-Abl (2) Biochemical Assay Reagents (30) Btk (1) Caspase (1) CDK (3) Collagen (1) Cytochrome P450 (4) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Drug Intermediate (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (2) EAAT (1) EGFR (1) Endogenous Metabolite (2) Epigenetic Reader Domain (3) Factor Xa (1) Filovirus (2) FLT3 (2) Fluorescent Dye (2) Free Fatty Acid Receptor (1) Fungal (1) GHSR (1) GLUT (1) GPR119 (4) Histone Acetyltransferase (1) Histone Demethylase (1) Histone Methyltransferase (6) Interleukin Related (2) IRAK (2) Isotope-Labeled Compounds (4) JAK (1) JNK (3) LDLR (1) Leukotriene Receptor (1) Ligands for E3 Ligase (1) Lipase (1) LPL Receptor (1) MEK (2) MicroRNA (8) Microtubule/Tubulin (1) Mucin (1) Nucleoside Antimetabolite/Analog (2) p38 MAPK (1) Parasite (2) PCSK9 (1) Phosphatase (4) PI3K (7) PKC (1) Potassium Channel (3) Prostaglandin Receptor (2) RANKL/RANK (2) Ras (1) ROCK (1) SARS-CoV (3) Serotonin Transporter (1) Small Interfering RNA (siRNA) (4) STAT (7) Topoisomerase (2) Transthyretin (TTR) (1) TRP Channel (2) Virus Protease (1) Wnt (1) β-catenin (1) β-glucuronidase (1)
By Research Areas:	Cancer (54) Cardiovascular Disease (5) Endocrinology (2) Infection (10) Inflammation/Immunology (22) Metabolic Disease (13) Neurological Disease (20)
Click Chemistry:	Labeling and Fluorescence Imaging (1)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) Nucleosides and their Analogs (1) MicroRNAs (8) Aptamers (4) miRNA inhibitors (2) siRNA drugs (4) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (5)

156

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14761

Bentamapimod 5+ Cited Publications AS 602801	JNK	Cancer
Bentamapimod (AS 602801) is an ATP-competitive JNK inhibitor with IC₅₀ of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively.

HY-147081

AS 1411 AGRO-100	Histone Methyltransferase Bcl-2 Family	Cancer
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .

HY-114379

AS2717638 1 Publications Verification	LPL Receptor	Neurological Disease Inflammation/Immunology
AS2717638 is a highly selective, brain-penetrant and orally active lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC₅₀ value of 38 nM. AS2717638 is highly selective and shows no significant antagonistic activity against other LPA receptors (LPA1, LPA2, and LPA3). AS2717638 can be used in the research of pain and neuroinflammation-related diseases .

HY-141430

AS-85	Histone Methyltransferase	Cancer
AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC₅₀=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the K_d value of 0.78 μM .

HY-11010

AS601245 5+ Cited Publications	JNK	Neurological Disease Inflammation/Immunology Cancer
AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC₅₀s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .

HY-123046

AS1708727 3 Publications Verification	Autophagy	Metabolic Disease Cancer
AS1708727 is an orally active Foxo1 inhibitor, with EC₅₀ values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively .

HY-100596

AS1842856 Maximum Cited Publications 65 Publications Verification	Autophagy	Metabolic Disease
AS1842856, a specific Foxo1 inhibitor (IC₅₀=30 nM), potently suppresses autophagy . AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1 .

HY-147081A

AS 1411 sodium AGRO-100 sodium	DNA/RNA Synthesis	Cancer
AS1411 sodium is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. It has anti-tumor activity.

HY-172553

AS-0017445	Virus Protease SARS-CoV	Infection
AS-0017445 is an inhibitor targeting the main protease of both the current coronavirus and the virus that caused the Middle East Respiratory Syndrome (MERS) outbreak. AS-0017445 inhibits the viral protein processing in host cells and thus prevents viral replication .

HY-141429C

AS-99	Histone Methyltransferase Apoptosis	Cancer
AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 μM, K_d= 0.89 μM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-N8329

AS-2077715	Fungal Antibiotic	Infection
AS-2077715 is an antifungal agent that shows inhibitory activity against the Trichophyton species. AS-2077715 can be obtained from the fermentation broth of Capnodium sp. 339855. AS-2077715 can be used to study fungal infections .

HY-10109

AS-605240 5 Publications Verification	PI3K Autophagy	Cancer
AS-605240 is a specific and orally active inhibitor of the PI3Kγ, with an IC₅₀ of 8 nM, and a K_i of 7.8 nM.

HY-103142

AS19	5-HT Receptor	Neurological Disease
AS19 is a potent, selective 5-HT₇ receptor agonist with an IC₅₀ value of 0.83 nM and a K_i of 0.6 nM. AS19 is selective for 5-HT₇ over 5-HT_1A, 5-HT_1B, 5-HT_1D, and 5-HT_5A receptors (K_is = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia .

HY-18992

AS2444697	IRAK	Inflammation/Immunology
AS2444697 is an orally active IRAK-4 inhibitor with an IC₅₀ of 21 nM . AS2444697 potently inhibits human and rat IRAK-4 activity. AS2444697 exhibits renoprotective effects through anti-inflammatory action .

HY-13531

AS-604850 1 Publications Verification	PI3K	Cancer
AS-604850 is a potent, selective and ATP-competitive PI3Kγ inhibitor with an IC₅₀ value of 0.25 μM and a K_i value of 0.18 μM. AS-604850 shows isoform selective inhibitor of PI3Kγ with over 30-fold selectivity for PI3Kδ and β, and 18-fold selectivity over PI3Kα, respectively .

HY-33009

AS057278	Others	Neurological Disease
AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC₅₀ value of 0.91 μM and EC₅₀ of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia .

HY-100614

AS1517499 30+ Cited Publications	STAT	Inflammation/Immunology Cancer
AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC₅₀ of 21 nM.

HY-126675A

AS2863619 2 Publications Verification	CDK STAT	Inflammation/Immunology
AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3 ⁺ regulatory T (T_reg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC₅₀s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene .

HY-143221

AS-Inclisiran sodium	PCSK9	Cardiovascular Disease
AS-Inclisiran sodium is the antisense of Inclisiran. Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran can be used for hyperlipidemia and cardiovascular disease (CVD) research .

HY-146883

As-358	Filovirus	Infection
As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC₅₀s of 47.5 μM and 3.7 μM .

HY-118388

AS604872	Prostaglandin Receptor	Endocrinology
AS604872 is an orally active, potent and selective prostaglandin F2α receptor (FP) antagonist with a K_i of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour .

HY-107535

AS1269574	GPR119 TRP Channel	Metabolic Disease
AS1269574 is a potent, orally available GPR119 agonist, with an EC₅₀ of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes .

HY-123790

AS2541019	PI3K	Inflammation/Immunology
AS2541019 is a PI3Kδ (p110δ) inhibitor. AS2541019 inhibits B cell activation and proliferation, and suppresses xenograft antibody production .

HY-10109A

AS-605240 potassium	PI3K Akt	Inflammation/Immunology
AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC₅₀: 8 nM; K_i: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC₅₀ values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC₅₀ values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice .

HY-117446

AS-1669058	GPR119	Metabolic Disease
AS-1669058 is a GPR119 agonist and a potential inhibitor of type 2 diabetes. AS-1669058 induces insulin secretion in response to high blood glucose levels in vitro and in vivo and increases insulin promoter activity. In animal studies, AS-1669058 improved glucose tolerance and reduced blood glucose levels in db/db mice .

HY-126807

AS1907417	GPR119	Metabolic Disease
AS1907417 is a novel GPR119 agonist with an oral activity. AS1907417 is a modified form of AS1269574. AS1907417 has antihyperglycemic and can be used in the research of type 2 diabetes .

HY-169857A

AS2690168 hydrochloride	RANKL/RANK	Others
AS2690168 hydrochloride is an orally active RANKL signal transduction inhibitor which suppresses RANKL-induced osteoclastogenesis of RAW264 cells. AS2690168 can be utilized in research related to pathological osteolysis .

HY-18284

AS1938909	Akt GLUT Phosphatase	Others
AS1938909 is a compound that inhibits SHIP2 activity. It can selectively inhibit SHIP2, increase Akt phosphorylation, and regulate glucose metabolism. Its effect is related to upregulating GLUT1 gene expression.

HY-150621

AS1134900	β-catenin Wnt	Cancer
AS1134900 is a highly selective uncompetitive allosteric inhibitor of NADP ⁺-dependent malic enzyme 1 (ME1) with an IC₅₀ of 0.73 μM. AS1134900 can be used in the study of cancer .

HY-12663

AS2521780	PKC	Inflammation/Immunology
AS2521780 is a novel PKCθ selective inhibitor with an IC₅₀ of 0.48 nM.

HY-124382

AS1928370	TRP Channel	Neurological Disease
AS1928370 is a novel and central nervous system (CNS) penetrant TRPV1 antagonist and can prevent ligand-induced activation in vivo. AS1928370 is a promising agent for neuropathic pain treatment research .

HY-19292

AS-601811	5 alpha Reductase	Endocrinology
AS-601811(compound 47) is a 5alpha-reductase 1 inhibitor with the IC₅₀ of 20 nM and can be used for study of alopecia and hirsutism .

HY-153609

AS-Patisiran sodium	Transthyretin (TTR) Small Interfering RNA (siRNA)	Neurological Disease
AS-Patisiran sodium is an antisense strand of Patisiran. Patisiran is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran can be used for the research of hereditary TTR amyloidosis .

HY-146883A

As-358 hydrochloride	Filovirus	Infection
As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC₅₀s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety .

HY-118521

AS-041164	PI3K	Inflammation/Immunology
AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC₅₀ of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC₅₀s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects .

HY-129340

AS-183	Acyltransferase	Cardiovascular Disease
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia .

HY-101946

AS-35	Leukotriene Receptor	Inflammation/Immunology
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC₅₀ values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.

HY-118803

AS1468240	Factor Xa	Others
AS1468240 is an orally active inhibitor for anticoagulant factor Xa (fXa), that inhibits human fXa with IC₅₀ of 8.7 nM. AS1468240 prolongs the coagulation time in mice .

HY-13532

AS-252424 4 Publications Verification	PI3K	Cancer
AS-252424 is a potent and selective PI3Kγ inhibitor with an IC₅₀ of 30±10 nM.

HY-108519

AS1892802	ROCK	Neurological Disease
AS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain .

HY-114056

AS115	Others	Cancer
AS115 is a potent and selective KIAA1363 inactivator with IC₅₀ value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues .

HY-123187

AS2553627	JAK	Cardiovascular Disease
AS2553627 is a type of JAK inhibitor, with IC₅₀ values of 0.46, 0.30, 0.14, and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively. AS2553627 can inhibit the proliferation of human and rat T cells stimulated by IL-2, with IC₅₀ values of 2.4 and 4.3 nM, respectively. AS2553627 can reduce cardiac allograft vasculopathy and fibrosis in a rat heart transplant model, effectively extending survival rates. AS2553627 can be used to prevent acute and chronic rejection in heart transplants .

HY-18686

AS1949490 1 Publications Verification	Phosphatase Akt	Metabolic Disease
AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC₅₀ values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes .

HY-134772

AS1810722	STAT Cytochrome P450	Inflammation/Immunology
AS1810722 is an orally active and potent STAT6 inhibitor with an IC₅₀ of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .

HY-15314

Ranirestat 1 Publications Verification AS-3201	Aldose Reductase	Neurological Disease Metabolic Disease
Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC₅₀s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a K_i of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .

HY-134909

AS-136A	DNA/RNA Synthesis	Infection
AS-136A is an orally active non-nucleoside inhibitor of the measles virus RNA-dependent RNA polymerase (RdRp) with an IC₅₀ of 2 µM for measles virus .

HY-141429A

AS-99 TFA 1 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 μM, K_d= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-169857

AS2690168 (freebase)	RANKL/RANK	Others
AS2690168 freebase is an orally active RANKL signal transduction inhibitor which suppresses RANKL-induced osteoclastogenesis of RAW264 cells. AS2690168 can be utilized in research related to pathological osteolysis .

HY-10982A

Amonafide dihydrochloride AS1413 dihydrochloride	Topoisomerase	Others
Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR) .

HY-10403A

(aS)-PH-797804	p38 MAPK	Inflammation/Immunology
(aS)-PH-797804 is a selective p38 MAPK inhibitor with IC₅₀ values for p38 α /β of 26 nM and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity .

Cat. No.	Product Name	Type

HY-D0164

Naphthol AS-BI	Dyes
Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.

HY-113823

Naphthol AS-G	Fluorescent Dyes/Probes
Naphthol AS-G is an active compound. Naphthol ASG can be used for a series of synthetic organic pigments (SOP’s) research .

HY-D1520

Naphthol AS-GR phosphate disodium	Fluorescent Dyes/Probes
Naphthol AS-GR phosphate disodium is substrates for acid and alkaline phosphatases. Naphthol AS-GR phosphate disodium has an intense green fluorescence used in histochemical studies .

Cat. No.	Product Name	Type

HY-NP013

Oxidized low density lipoprotein (mouse) Mouse ox-LDL	Native Proteins
Oxidized low density lipoprotein (mouse) is an oxidized low density lipoprotein (LDL). Oxidized low density lipoprotein (mouse) induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration .

HY-20302

(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid	Biochemical Assay Reagents
(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-131475

Naphthol AS-BI phosphate	Enzyme Substrates
Naphthol AS-BI phosphate is a substrate for acid and alkaline phosphatase and can be used in fluorescence assays. Naphthol AS-BI phosphate is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W415909

Maltulose monohydrate 4-O-α-D-Glucopyranosyl-D-fructose monohydrate	Carbohydrates
Maltulose monohydrate (4-O-α-D-Glucopyranosyl-D-fructose monohydrate) can be used as an energy source for bacteria. Maltulose monohydrate is a biomaterial or organic compound that can be used in life science research .

HY-W115721

Rhodizonic acid disodium Sodium rhodizonate dibASic	Indicators
Rhodizonic acid disodium (Sodium rhodizonate dibasic) can be used as an indicator in the volumetric determination of barium and sulfates. Rhodizonic acid disodium is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W787630

Naphthol AS phosphate disodium salt	Cell Assay Reagents
Naphthol AS phosphate disodium salt is a biochemical assay reagent.

HY-130767

Naphthol AS-TR phosphate

Enzyme Substrates

Naphthol AS-TR Phosphate is a water-soluble dye commonly used as an enzyme substrate in various biochemical assays to detect alkaline phosphatase activity. Naphthol AS-TR Phosphate has unique chemical properties that allow it to be hydrolyzed by alkaline phosphatase to form a colored product that can be detected spectrophotometrically. This makes it a useful tool for monitoring enzyme activity in biological samples such as serum or urine.

HY-W420462

Naphthol AS-BI phosphate sodium	Surfactants
Naphthol AS-BI phosphate (sodium) is a biochemical assay reagent.

HY-20302R

(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid (Standard)	Biochemical Assay Reagents
(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid (Standard) is the analytical standard of (2S,3AS,7aS)-Octahydroindole-2-carboxylic acid. This product is intended for research and analytical applications. (2S,3AS,7aS)-Octahydroindole-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145671

3A-Amino-3A-deoxy-(2AS,3AS)-β-cyclodextrin 3A-Amino-3A-deoxy-(2AS,3AS)-beta-cyclodextrin	Biochemical Assay Reagents
3A-Amino-3A-deoxy-(2AS,3AS)-β-cyclodextrin Hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145532

3A-Amino-3A-deoxy-(2AS,3AS)-α-cyclodextrin 3A-Amino-3A-deoxy-(2AS,3AS)-alpha-cyclodextrin	Carbohydrates
3A-Amino-3A-deoxy-(2AS,3AS)-α-cyclodextrin Hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145571

3A-Amino-3A-deoxy-(2AS,3AS)-γ-cyclodextrin 3A-Amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin	Biochemical Assay Reagents
3A-Amino-3A-deoxy-(2AS,3AS)-γ-cyclodextrin Hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-137833

Naphthol AS-BI glucuronide Naphthol AS-BI β-D-glucuronide	Carbohydrates
Naphthol AS-BI β-D-Glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W713875

Naphthol AS-MX phosphate disodium salt	Cell Assay Reagents
Naphthol AS-MX phosphate disodium salt is a biochemical assay reagent.

HY-131475A

Naphthol AS-BI phosphate disodium hydrate	Carbohydrates
Naphthol AS-BI phosphate (disodium hydrate) is used as a substrate for determining the activity of both alkaline and acidic phosphatases; it can also be used to measure the activity of individual cell acid phosphatase.

HY-Y0102

Thiosalicylic acid 2-Mercaptobenzoic acid	Drug Delivery
Thiosalicylic acid (2-Mercaptobenzoic acid) is a stabilizer that can be used in the synthesis of metal nanoparticles. Thiosalicylic acid is a biomaterial or organic compound that can be used in life science research .

HY-W110542P

Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor PEGDA (MW 4000), MEHQ AS inhibitor	3D Bioprinting
Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor (PEGDA (MW 4000), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 4000), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .

HY-W110542N

Poly(ethylene glycol) diacrylate (MW 250),MEHQ as inhibitor PEGDA (MW 250),MEHQ AS inhibitor	3D Bioprinting
Poly(ethylene glycol) diacrylate (MW 250), MEHQ as inhibitor (PEGDA (MW 250), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 250), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .

HY-W110542O

Poly(ethylene glycol) diacrylate (MW 575),MEHQ as inhibitor PEGDA (MW 575),MEHQ AS inhibitor	3D Bioprinting
Poly(ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor (PEGDA (MW 575), MEHQ as inhibitor) is a derivative of polyethylene glycol. Poly(ethylene glycol) diacrylate (MW 575), MEHQ as inhibitor can be used in the formation of a cross-linked polymers .

HY-W554423

Naphthol AS-BI β-D-galactopyranoside	Biochemical Assay Reagents
Naphthol AS-BI β-D-galactopyranoside is a biochemical assay reagent.

HY-43747

α-Acetobromoglucose, contains 1% CaCO3 as stabilizer Acetobromo-α-D-glucose, contains 1% CaCO3 AS stabilizer; Acetobromo-alpha-D-glucose, contains 1% CaCO3 AS stabilizer	Carbohydrates
α-Acetobromoglucose, contains 1% CaCO3 as stabilizer (Acetobromo-α-D-glucose, contains 1% CaCO3 as stabilizer) is a glycosyl donor that can be used for the synthesis of other active compounds .

HY-137854

Naphthol AS-BI N-acetyl-β-D-glucosaminide	Enzyme Substrates
Naphthol AS-BI N-acetyl-β-D-glucosaminide acts as a substrate and reacts directly with N-acetyl-β-glucosaminidase enzyme. Naphthol AS-BI N-acetyl-β-D-glucosaminide can detect and localize the active region of N-acetyl-β-glucosaminidase enzyme visually .

HY-W342268

Naphthol AS-D acetate 3-(O-tolylcarbamoyl)naphthalen-2-yl acetate	Cell Assay Reagents
Naphthol AS-D acetate (3-(O-tolylcarbamoyl)naphthalen-2-yl acetate) is used in histological studies as a histochemical substrate for esterase localization .

HY-W719646

Naphthol AS phosphate, 99%(TLC） 3-Hydroxy-2-naphthanilide phosphate, 99%(TLC）	Enzyme Substrates
Naphthol AS phosphate, 99%(TLC) is a histochemical substrate for acidic and alkaline phosphatases.

HY-131474

Naphthol AS-D chloroacetate，98% (TLC) 3-Hydroxy-2-naphthoic-o-toluidide chloroacetate,98% (TLC)	Enzyme Substrates
Naphthol AS-D chloroacetate, 98% (TLC) (3-Hydroxy-2-naphthoic-o-toluidide chloroacetate, 98% (TLC)) is a substrate for esterase histochemical localization.

Cat. No.	Product Name	Target	Research Area

HY-P99591

Sontuzumab AS1402; huHMFG-1	Mucin	Cancer
Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a K_d of ~1 nM. Sontuzumab can be used for the research of breast cancer .

HY-P991162

Tilrekimig	Interleukin Related	Inflammation/Immunology
Tilrekimig is a monoclonal antibody targeting human interleukin 4 (IL-4), interleukin 13 (IL-13), and TSLP (thymic stromal lymphopoietin). Tilrekimig is promising for research of allergic and inflammatory diseases, such as asthma and atopic dermatitis .

HY-P990186

Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2)	Inhibitory Antibodies	Others
Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) is a mouse-derived IgG2c, κ type antibody inhibitor, targeting to mouse MHC Class II.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8329

AS-2077715	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal Antibiotic
AS-2077715 is an antifungal agent that shows inhibitory activity against the Trichophyton species. AS-2077715 can be obtained from the fermentation broth of Capnodium sp. 339855. AS-2077715 can be used to study fungal infections .

HY-129340

AS-183	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia .

HY-N2841

Alnusdiol (-)-(AS,3''S,5''S)-Alnusdiol; (-)-Alnusdio	Structural Classification Alnus japonica (Thunb.) Steud. Source classification Phenols Polyphenols Plants Betulaceae	Others
Alnusdiol ((-)-(aS,3''S,5''S)-Alnusdiol) is a product that can be isolated from Citrus limon .

HY-N10922

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Celastrus Plants	Others
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC₅₀s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively .

HY-N10906

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone .

HY-N11163

(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate	Structural Classification Terpenoids Source classification Diterpenoids Plants Compositae Glycyrrhiza lepidota Pursh	Others
(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate (compound 7a) is a clerodane diterpene .

Species:	Human (6)
Tag:	His (5) GST (1)
Source:	HEK293 (2) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P7794

	CD158d/KIR2DL4 Protein, Human (HEK293, His) rHuCD158d, His; Killer Cell Immunoglobulin-Like Receptor 2DL4; CD158 Antigen-Like Family Member D; KIR-103AS; MHC ClASs I NK Cell Receptor KIR103AS; CD158d; KIR2DL4; KIR103AS	Human	HEK293
	CD158d/KIR2DL4 Protein, Human (HEK293, His) is a recombinant human CD158d expressed in HEK 293 cells with a His tag at the N-terminus. CD158d/KIR2DL4 Protein is an NK cell-activating receptor with inhibitory potential.

HY-P71134

	WARS Protein, Human (His) WARS also known AS Tryptophanyl-tRNA synthetASe; Interferon-induced protein 53.	Human	E. coli
	WARS includes isomer 1, isomer 2, T1-TrpRS and T2-TrpRS, and has aminoacylation activity, except T2-TrpRS. Unlike isoform 1, isoform 2, T1-TrpRS and T2-TrpRS, exhibit vasostatic activity. WARS Protein, Human (His) is the recombinant human-derived WARS protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7868

	Cystatin A/CSTA Protein, Human (His) rHuCystatin-A, His; Cystatin-A; Cystatin-AS; Stefin-A; CSTA; STF1; STFA	Human	E. coli
	Cystatin A (CSTA) protein is an intracellular thiol protease inhibitor critical for desmosome-mediated intercellular adhesion, especially in the epidermis. Its role as a protease inhibitor is essential for regulating cellular proteolytic activity. Cystatin A/CSTA Protein, Human (His) is the recombinant human-derived Cystatin A/CSTA protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71682

	14-3-3 eta Protein, Human (GST) 14-3-3 protein eta; Brain protein 14-3-3; eta isoform; HGNC:12853; Protein AS1; YWHA 1; YWHA1; Ywhah	Human	E. coli
	YWHAH proteins are adapter proteins in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and regulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity and interacts with nuclear hormone receptors (AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP, THRA) and cofactors. 14-3-3 eta Protein, Human (GST) is the recombinant human-derived YWHAH protein, expressed by E. coli , with N-GST labeled tag.

HY-P71369

	TINAGL1 Protein, Human (HEK293, His) Tubulointerstitial nephritis antigen-like (TINAGL1); also known AS Glucocorticoid-inducible protein 5; Oxidized LDL-responsive gene 2 protein; TIN Ag-related protein; Tubulointerstitial nephritis antigen-related protein; GIS5; LCN7; OLRG2 and TINAGL	Human	HEK293
	TINAGL1 Protein, implicated in adrenocortical zonation, may regulate distinct adrenal cortex zones and repress CYP11B1 gene expression in adrenocortical cells. As a member of the non-catalytic peptidase C1 family, its distinctive function does not involve enzymatic activity. Unraveling TINAGL1's molecular pathways could offer insights into its role in adrenal physiology, shedding light on its potential to manipulate adrenal function. TINAGL1 Protein, Human (HEK293, His) is the recombinant human-derived TINAGL1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704109

	KAAG1 Protein, Human (His) KAAG1; RU2AS	Human	E. coli

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Cat. No.	Product Name	Chemical Structure

HY-A0130S

Sulfalene-13C6
Sulfalene- ¹³C₆ is the ¹³C₆ labeled Sulfalene. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial .

HY-W654262

10α-Methoxy-9,10-dihydrolysergol-d3
10α-Methoxy-9,10-dihydrolysergol-d₃ is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .

HY-W106164AS

((2S,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol-d2
d₂ is a deuterium labeled ((2S,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol.

HY-A0052S

(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4
(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d₄ is deuterated labeled (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80525

	14-3-3 eta Antibody (YA838) 14-3-3 protein eta; 1433F_HUMAN; Brain protein 14-3-3; eta isoform; HGNC:12853; Protein AS1; Tyrosine 3/tryptophan 5 monooxygenASe activation protein eta polypeptide; YWHA 1; YWHA1; Ywhah.	WB	Human, Mouse, Rat
	14-3-3 eta Antibody (YA838) is a non-conjugated and Mouse origined monoclonal antibody about 28 kDa, targeting to 14-3-3 eta (5F2). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P82425

	AS160 Antibody (YA2170) AS160; NIDDM5	WB, IP	Human
	AS160 Antibody (YA2170) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2170), targeting AS160, with a predicted molecular weight of 147 kDa (observed band size: 160 kDa). AS160 Antibody (YA2170) can be used for WB, IP experiment in human background.

HY-P84754

	CDX2 Antibody (YA4451) CDX3; CDX-3; CDX2/AS	IHC-P, FC, ELISA	Human

HY-P83015

	Cystatin A Antibody (YA2760) CSTA; STF1; STFA; Cystatin-A; Cystatin-AS; Stefin-A	WB, FC	Human, Mouse, Rat
	Cystatin A Antibody (YA2760) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2760), targeting Cystatin A, with a predicted molecular weight of 11 kDa (observed band size: 11 kDa). Cystatin A Antibody (YA2760) can be used for WB, FC experiment in human, mouse, rat background.

HY-P83915

	HLA-B Antibody (YA3612) AS; HLAB; Bw-47; Bw-50; SPDA1; B-4901; B-5001; HLA-Cw	WB, IHC-P, ICC/IF, FC, ELISA	Human

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Cat. No.	Product Name		Classification

HY-147081

AS 1411 AGRO-100		Aptamers
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .

HY-143221

AS-Inclisiran sodium		siRNAs siRNA drugs
AS-Inclisiran sodium is the antisense of Inclisiran. Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran can be used for hyperlipidemia and cardiovascular disease (CVD) research .

HY-153609

AS-Patisiran sodium		siRNAs siRNA drugs
AS-Patisiran sodium is an antisense strand of Patisiran. Patisiran is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran can be used for the research of hereditary TTR amyloidosis .

HY-132610A

Givosiran sodium 1 Publications Verification ALN-AS1 sodium		siRNAs siRNA drugs
Givosiran sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran sodium can be used for the research of acute intermittent porphyria .

HY-132610

Givosiran 1 Publications Verification ALN-AS1		siRNAs siRNA drugs
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria .

HY-147081A

AS 1411 sodium AGRO-100 sodium		Aptamers
AS1411 sodium is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. It has anti-tumor activity.

HY-160046

AS2 sodium		Aptamers
AS2 sodium is an ssDNA aptamer (Kd: 0.7 nM) for prostate-specific antigen (PSA). AS2 sodium does not bind non-specifically to the anti-target and has the potential to be used in diagnostic systems for prostate cancer detection .

HY-147081B

AS 1411 triethylamine AGRO-100 triethylamine		Aptamers
AS1411 (AGRO-100) triethylamine is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. AS1411 triethylamine has anti-tumor activity.

HY-RS01052

AS3MT Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
AS3MT Human Pre-designed siRNA Set A contains three designed siRNAs for AS3MT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-R01659A

hsa-miR-548as-5p agomir		MicroRNAs miRNA agomirs
hsa-miR-548as-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01659A

hsa-miR-548as-5p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-548as-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01659

hsa-miR-548as-5p mimic		MicroRNAs miRNA mimics
hsa-miR-548as-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01659

hsa-miR-548as-5p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-548as-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R01658

hsa-miR-548as-3p mimic		MicroRNAs miRNA mimics
hsa-miR-548as-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01658

hsa-miR-548as-3p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-548as-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R01658A

hsa-miR-548as-3p agomir		MicroRNAs miRNA agomirs
hsa-miR-548as-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01658A

hsa-miR-548as-3p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-548as-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-148130

Rugonersen RG6091; RO7248824		Antisense Oligonucleotides
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium		Antisense Oligonucleotides
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-W061531

(3aR,5R,6aS)-5-(((tert-Butyldiphenylsilyl)oxy)methyl)-2,2-dimethyldihydrofuro[2,3-d][1,3]dioxol-6(3aH)-one		Nucleosides and their Analogs
5-O-TBDPS-1,2-di-O-isopropy lidene-3-keto-alpha-D-xylofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

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