CDX2 Antibody (YA4451)

CDX2 Antibody (YA4451) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CDX2. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

CDX2 is a transcription factor that regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). It binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity), as well as the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR to activate VDR transcription (By similarity). Additionally, CDX2 binds to and activates transcription of LPH (By similarity), and also activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). It further binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). CDX2 plays a crucial role in a broad range of functions, from early differentiation to the maintenance of the intestinal epithelial lining in both the small and large intestine, and preferentially binds to methylated DNA.

Q99626

Predicted band size: 34 kDa; Observed band size: 40 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CDX2 (AA: 1-180) expressed in E. Coli.