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Results for "

AP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (6) Adenosine Receptor (1) Aldose Reductase (1) Apoptosis (1) Dengue Virus (1) FABP (5) HDAC (1) Nucleoside Antimetabolite/Analog (1) PKA (1) PPAR (3) RAR/RXR (1) SARS-CoV (2) Small Interfering RNA (siRNA) (12) Wnt (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (5) Infection (3) Metabolic Disease (7) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (8) siRNAs (12)

Inhibitors & Agonists

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Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123940

SGC-AAK1-1	Wnt AAK1	Cancer
SGC-AAK1-1 is a potent and selective *AAK1 (AP2* associated kinase 1) inhibitor with an IC₅₀ of 270 nM and a K_i** of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1 .

HY-101503

HTS01037 1 Publications Verification	FABP	Metabolic Disease
HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a K_i of 0.67 μM.

HY-134367

Ap2A disodium	Adenosine Receptor PKA Apoptosis	Cardiovascular Disease
Ap2A (disodium) is a symmetrical dinucleoside polyphosphate. Ap2A (disodium) can promote the growth of vascular smooth muscle cells .

HY-RS00785

AP2A2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP2A2 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP2A2 Human Pre-designed siRNA Set A AP2A2 Human Pre-designed siRNA Set A

HY-RS00784

AP2A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP2A1 Human Pre-designed siRNA Set A AP2A1 Human Pre-designed siRNA Set A

HY-RS00787

AP2M1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP2M1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2M1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP2M1 Human Pre-designed siRNA Set A AP2M1 Human Pre-designed siRNA Set A

HY-RS00786

AP2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP2B1 Human Pre-designed siRNA Set A AP2B1 Human Pre-designed siRNA Set A

HY-RS00788

AP2S1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP2S1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2S1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP2S1 Human Pre-designed siRNA Set A AP2S1 Human Pre-designed siRNA Set A

HY-RS22390

Ap2m1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ap2m1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ap2m1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ap2m1 Mouse Pre-designed siRNA Set A Ap2m1 Mouse Pre-designed siRNA Set A

HY-N7661

4β-Hydroxywithanolide E	PPAR	Metabolic Disease
4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression .

HY-147083

SGC-AAK1-1N	AAK1	Cancer
SGC-AAK1-1N is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor, with an IC₅₀ of 1.8 μM .

HY-159931

HW161023	AAK1	Neurological Disease
HW161023 (compound 5) is an orally active AP2-associated protein kinase 1 (AAK1) inhibitor with IC₅₀ values of 5.4 nM and 11.9 μM aganist of AAK1and hERG, respectively. HW161023 inhibits the pain in chronic constriction injury of the sciatic nerve rat model .

HY-128671

6-Thioinosine 6TI; 6-MercAPtopurine riboside	Nucleoside Antimetabolite/Analog	Metabolic Disease
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα ^[2].

HY-N10361

Drupanin	RAR/RXR PPAR Aldose Reductase	Cancer
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers ^[2] .

HY-101903A

BMS-309403 sodium Maximum Cited Publications 15 Publications Verification	FABP	Cardiovascular Disease Metabolic Disease
BMS-309403 sodium is a potent, orally active, and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor, with K_is of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 sodium interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 sodium improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells ^[2] .

HY-101903

BMS-309403 Maximum Cited Publications 15 Publications Verification	FABP	Cardiovascular Disease Metabolic Disease
BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with K_is of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells ^[2] .

HY-121579

L-764406	PPAR	Others
L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC₅₀=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs .

HY-101903R

BMS-309403 (Standard)	FABP	Cardiovascular Disease Metabolic Disease
BMS-309403 (Standard) is the analytical standard of BMS-309403. This product is intended for research and analytical applications. BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells[1][2][3].

HY-101903AR

BMS-309403 sodium (Standard)	FABP	Cardiovascular Disease Metabolic Disease
BMS-309403 (sodium) (Standard) is the analytical standard of BMS-309403 (sodium). This product is intended for research and analytical applications. BMS-309403 sodium is a potent, orally active, and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor, with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 sodium interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 sodium improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells[1][2][3].

HY-RS19275

Atp6ap2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atp6ap2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atp6ap2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atp6ap2 Mouse Pre-designed siRNA Set A Atp6ap2 Mouse Pre-designed siRNA Set A

HY-RS01215

ATP6AP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATP6AP2 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP6AP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATP6AP2 Human Pre-designed siRNA Set A ATP6AP2 Human Pre-designed siRNA Set A

HY-RS20627

Cdk2ap2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cdk2ap2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdk2ap2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cdk2ap2 Mouse Pre-designed siRNA Set A Cdk2ap2 Mouse Pre-designed siRNA Set A

HY-RS25764

Atp6ap2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atp6ap2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atp6ap2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atp6ap2 Rat Pre-designed siRNA Set A Atp6ap2 Rat Pre-designed siRNA Set A

HY-RS02379

CDK2AP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDK2AP2 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK2AP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDK2AP2 Human Pre-designed siRNA Set A CDK2AP2 Human Pre-designed siRNA Set A

HY-RS01968

CASP8AP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CASP8AP2 Human Pre-designed siRNA Set A contains three designed siRNAs for CASP8AP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CASP8AP2 Human Pre-designed siRNA Set A CASP8AP2 Human Pre-designed siRNA Set A

HY-159879

AAK1-IN-6	AAK1 Dengue Virus	Infection
AAK1-IN-6 (Compound 23) is an inhibitor of AP-2-associated protein kinase 1 (AAK1, IC₅₀ = 12 nM) with antiviral activity against the dengue virus (DNEV2, EC₅₀ = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC₅₀ = 0.30 μM). AAK1-IN-6 can be utilized in antiviral research .

HY-169405

AAK1/HDACs-IN-1	AAK1 HDAC SARS-CoV	Infection
AAK1/HDACs-IN-1 (Compound 12) is the dual inhibitor for AAK1 and HDAC, that inhibits AAK1, HDAC1, and HDAC6 with IC₅₀s of 15.9, 148.6, and 5.2 nM, respectively. AAK1/HDACs-IN-1 inhibits SARS-CoV-2 infection, suppresses the endocytosis of ACE2-SARS-CoV-2 complex, as well as AP2M1-ACE2 interaction .

HY-161261

SARS-CoV-2-IN-81	AAK1 SARS-CoV	Infection
SARS-CoV-2-IN-81 (compound 12e) is a potent AAK1 inhibitor with an IC₅₀ value of 9.38 nM. SARS-CoV-2-IN-81 shows anti-viral property against *SARS-CoV-2. SARS-CoV-2-IN-81 attenuates AAK1-induced phosphorylation of AP2M1 threonine 156 and disrupts the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS*-CoV-2 infection .

HY-159857

Gp(2′-5′)Ap sodium Gp(2′-5′)AP(3′) sodium; 2'5'-GpAP sodium; Guanylyl-(2′→5′)-3′-adenylic acid sodium	Others
Gp(2′-5′)Ap sodium is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases. Due to its linear conformation, 2’5’GpAp is intended to serve as a negative control for 2’3’-cGAMP in type I IFN induction assays.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10361

Drupanin	Monophenols Animals Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	RAR/RXR PPAR Aldose Reductase
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers ^[2] .

HY-N7661

4β-Hydroxywithanolide E	Source classification Plants Solanaceae Steroids	PPAR
4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression .

Species:	Human (4)
Tag:	His (4) SUMO (1)
Source:	HEK293 (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P76728

	AP-2 gamma/TFAP2C Protein, Human (His) Transcription factor AP-2 gamma; Transcription factor ERF-1	Human	E. coli
	The AP-2 gamma/TFAP2C protein is a sequence-specific DNA-binding factor that complexly regulates gene transcription by binding to enhancer elements. It recognizes the consensus sequence 5'-GCCNNNGGC-3' and activates genes critical for multiple developmental functions. AP-2 gamma/TFAP2C Protein, Human (His) is the recombinant human-derived AP-2 gamma/TFAP2C protein, expressed by E. coli , with N-His labeled tag.

HY-P72100

	ATP6AP2 Protein, Human (His-SUMO) APT6M8 9; APT6M8-9; ATP6AP2; ATP6IP2; ATP6M8-9; ATPase H+; -transporting lysosomal accessory protein 2;	Human	E. coli
	The multifunctional ATP6AP2 protein serves as a cellular receptor for renin and prorenin, contributing to lysosomal V-ATPase assembly and endolysosomal acidification. It participates in renin-dependent reactions, activates ERK1/2, and may enhance the catalytic efficiency of renin in the renin-angiotensin system. ATP6AP2 Protein, Human (His-SUMO) is the recombinant human-derived ATP6AP2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P72099

	ATP6AP2 Protein, Human (His) APT6M8 9; APT6M8-9; ATP6AP2; ATP6IP2; ATP6M8-9; ATPase H+; -transporting lysosomal accessory protein 2; ATPase H+; -transporting lysosomal-interacting protein 2; ATPase H+ transporting lysosomal accessory protein 2; ATPase; H+ transporting; lysosomal vacuolar proton pump; membrane sector associated protein M8 9;	Human	E. coli
	The multifunctional ATP6AP2 protein serves as a cellular receptor for renin and prorenin, contributing to lysosomal V-ATPase assembly and endolysosomal acidification. It participates in renin-dependent reactions, activates ERK1/2, and may enhance the catalytic efficiency of renin in the renin-angiotensin system. ATP6AP2 Protein, Human (His) is the recombinant human-derived ATP6AP2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7850

	CDK2AP2 Protein, Human (HEK293, His) rHuCyclin-dependent kinase 2-associated protein 2/CDK2AP2, His; Cyclin-dependent kinase 2-associated protein 2; CDK2-associated protein 2; DOC-1-related protein; DOC-1R; CDK2AP2; DOC1R	Human	HEK293
	The CDK2AP2 protein is an important component of the NuRD complex and actively participates in chromatin remodeling. It inhibits the G1/S phase transition by inhibiting CDK2 and preventing the interaction of CDK2 with cyclin E or A. CDK2AP2 Protein, Human (HEK293, His) is the recombinant human-derived CDK2AP2 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83361

	AP2M1 Antibody (YA3106) AP-2 complex subunit mu; AP-2 mu chain; AdAPter-related protein complex 2 subunit mu; AdAPtin-mu2; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50	WB	Human, Mouse, Rat
	AP2M1 Antibody (YA3106) is a non-conjugated IgG antibody, targeting AP2M1, with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). AP2M1 Antibody (YA3106) can be used for WB experiment in human, mouse, rat background.

HY-P82364

	AP2 alpha Antibody (YA2109) AP-2; BOFS; AP2TF; TFAP2; AP-2alpha	WB, IP	Rat
	AP2 alpha Antibody (YA2109) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2109), targeting AP2 alpha, with a predicted molecular weight of 48 kDa (observed band size: 48 kDa). AP2 alpha Antibody (YA2109) can be used for WB, IP experiment in rat background.

HY-P82387

	AP2S1 Antibody (YA2132) AP17; AP17 delta; AP2s1; CLAPS2; Sigma2 adAPtin	WB, IP, FC	Human, Mouse, Rat
	AP2S1 Antibody (YA2132) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2132), targeting AP2S1, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). AP2S1 Antibody (YA2132) can be used for WB, IP, FC experiment in human, mouse, rat background.

HY-P83704

	*Transcription factor AP2* alpha Antibody (YA3441)** Activating enhancer binding protein 2 alpha antibody; Activating enhancer-binding protein 2-alpha antibody; Activator protein 2 antibody; AP 2 transcription factor antibody; AP 2alpha antibody; AP-2 antibody; AP-2 transcription factor antibody; AP2 antibody; AP2 Transcription Factor antibody; AP2-alpha antibody; AP2A_HUMAN antibody; AP2TF antibody; BOFS antibody; FLJ51761 antibody; TFAP 2 antibody; TFAP 2A antibody; TFAP2 antibody; TFAP2A antibody; Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha) antibody; Transcription factor AP-2-alpha antibody; Transcription factor AP2 alpha antibody	WB, IHC-P, IHC-F	Human, Mouse, Rat
	Transcription factor AP2 alpha Antibody is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3441), targeting Transcription factor AP2 alpha, with a predicted molecular weight of 48 kDa (observed band size: 48 kDa). Transcription factor AP2 alpha Antibody (YA3441) can be used for WB, IF-Cell, IHC-P experiment in human, Mouse, Rat background.

HY-P81397

	*Transcription Factor AP 2* gamma Antibody (YA1142)** ERF1; TFAP2G; hAP-2g; AP2-GAMMA	IHC-P	Human
	Transcription Factor AP 2 gamma Antibody (YA1142) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1142), targeting Transcription Factor AP 2 gamma. Transcription Factor AP 2 gamma Antibody (YA1142) can be used for IHC-P experiment in human background.

HY-P82368

	*Phospho-AP2M1 (Thr156) Antibody (YA2113)* AP-2 complex subunit mu; AP-2 mu chain; AdAPter-related protein complex 2 subunit mu; AdAPtin-mu2; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50	WB	Human
	Phospho-AP2M1 (Thr156) Antibody (YA2113) is a non-conjugated IgG antibody, targeting Phospho-AP2M1 (Thr156), with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Phospho-AP2M1 (Thr156) Antibody (YA2113) can be used for WB experiment in human background.